Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Amann, R; Donnerer, J; Lembeck, F.
Ruthenium red selectively inhibits capsaicin-induced release of calcitonin gene-related peptide from the isolated perfused guinea pig lung.
Neurosci Lett. 1989; 101(3):311-315
Doi: 10.1016/0304-3940(89)90551-X
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- Co-Autor*innen der Med Uni Graz
- Donnerer Josef
- Lembeck Fred
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- Abstract:
- In the present study the influence of Ruthenium red on capsaicin- and bradykinin-evoked neuropeptide release from primary afferent neurons was investigated in the guinea pig. Perfusion of the isolated guinea pig lung in vitro with a capsaicin (1 microM)-containing physiological salt solution increased the amount of calcitonin gene-related peptide-like immunoreactivity (CGRP-IR) in the outflow more than 20-fold. Ruthenium red (RR: 1 microM, 10 microM) dose-dependently reduced capsaicin-induced release of CGRP-IR. Addition of bradykinin (1 microM) to the perfusate induced a 3-fold increase of CGRP-IR in the outflow, which was not significantly reduced by 10 microM RR. These results suggest that RR represents a rather specific antagonist of capsaicin's action on sensory neurons.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals -
- Bradykinin - pharmacology
- Calcitonin Gene-Related Peptide - pharmacology
- Capsaicin - pharmacology
- Drug Interactions - pharmacology
- Guinea Pigs - pharmacology
- Lung - innervation
- Neurons, Afferent - drug effects
- Neuropeptides - metabolism
- Ruthenium - pharmacology
- Ruthenium Red - pharmacology