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Gulia, A; Saggini, A; Wiesner, T; Fink-Puches, R; Argenyi, Z; Ferrara, G; Müller, CS; Vale, E; Cerroni, L.
Clinicopathologic features of early lesions of primary cutaneous follicle center lymphoma, diffuse type: implications for early diagnosis and treatment.
J Am Acad Dermatol. 2011; 65(5):991-1000 Doi: 10.1016/j.jaad.2010.06.059
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Leading authors Med Uni Graz: Cerroni Lorenzo
Co-authors Med Uni Graz: Fink-Puches Regina; Wiesner Thomas
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Abstract:: Data on early lesions of primary cutaneous follicle center lymphoma (PCFCL), diffuse type are very limited. We sought to elucidate the early clinicopathologic features of PCFCL, diffuse type. Clinical, histologic, immunohistologic, molecular, and fluorescence in situ hybridization data from 24 patients with early lesions of PCFCL, diffuse type (male:female = 19:5; median age: 57 years) were determined. Lesions consisted mostly of solitary or clustered papules and small nodules located on the trunk (21 cases), arm (two cases), and scalp (one case). In 3 patients small papules were located at a distance from the main affected area. All biopsy specimens from early lesions showed aggregates of medium and large centrocytes admixed with small lymphocytes without formation of clear-cut lymph follicles. Staining for Bcl-2 was positive in only 7 cases, one revealing also a rearranged BCL2 signal by fluorescence in situ hybridization. Data on treatment and follow-up were available for 22 patients. At last examination 13 patients were in complete remission (median follow-up: 60 months), 6 were alive with skin disease alone (median follow-up: 60 months), two were alive with skin disease and bone-marrow or lymph node involvement, respectively, and one died of unrelated causes while in complete remission. The retrospective study and the fact that patients were treated at different institutions are limitations. Early lesions of PCFCL, diffuse type present with characteristic clinicopathologic features. Dermatologists should be alert particularly to the early clinical manifestations of this lymphoma and to the presence of small, inconspicuous lesions at a distance from the main affected area in order to plan treatment properly. Copyright © 2010 American Academy of Dermatology, Inc. Published by Mosby, Inc. All rights reserved.
Find related publications in this database (using NLM MeSH Indexing): Adult -; Aged -; Aged, 80 and over -; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biomarkers, Tumor -; Biopsy -; Bone Marrow Transplantation -; Combined Modality Therapy -; Early Diagnosis -; Female -; Follow-Up Studies -; Genes, bcl-2 -; Head and Neck Neoplasms - diagnosis Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - genetics Head and Neck Neoplasms - pathology Head and Neck Neoplasms - surgery; Humans -; Lymphoma, Follicular - diagnosis Lymphoma, Follicular - drug therapy Lymphoma, Follicular - genetics Lymphoma, Follicular - pathology Lymphoma, Follicular - radiotherapy Lymphoma, Follicular - surgery; Lymphoma, Non-Hodgkin - diagnosis Lymphoma, Non-Hodgkin - drug therapy Lymphoma, Non-Hodgkin - genetics Lymphoma, Non-Hodgkin - pathology Lymphoma, Non-Hodgkin - radiotherapy Lymphoma, Non-Hodgkin - surgery; Male -; Middle Aged -; Remission Induction -; Retrospective Studies -; Scalp -; Skin Neoplasms - diagnosis Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - pathology Skin Neoplasms - surgery; Torso -
Find related publications in this database (Keywords): Crosti lymphoma; cutaneous lymphoma; early diagnosis; fluorescence in situ hybridization; primary cutaneous B-cell lymphoma; primary cutaneous follicle center lymphoma