Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Gewählte Publikation:
Leighton, GE; Griesbacher, T; Hill, RG; Hughes, J.
Antagonism of central and peripheral anorectic effects of caerulein by L-364,718.
Eur J Pharmacol. 1989; 161(2-3):255-258
Doi: 10.1016/0014-2999(89)90855-8
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- Co-Autor*innen der Med Uni Graz
- Griesbacher Thomas
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- Abstract:
- The reduction in food intake induced by i.p. injections of the cholecystokinin (CCK) analogue caerulein was antagonised by a low dose (0.25 mumol/kg s.c.) of the selective CCK antagonist L-364,718. To block the anorectic effect of centrally administered caerulein a dose of 25 mumol/kg of L-364,718 was required, demonstrating that central CCK receptors can be blocked effectively in the rat by choosing appropriate doses of L-364,718.
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