Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Dahle, DO; Mjen, G; Oqvist, B; Scharnagl, H; Weihrauch, G; Grammer, T; März, W; Abedini, S; Norby, GE; Holme, I; Fellström, B; Jardine, A; Holdaas, H.
Inflammation-associated graft loss in renal transplant recipients.
Nephrol Dial Transplant. 2011; 26(11):3756-3761
Doi: 10.1093/ndt/gfr163
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- Co-authors Med Uni Graz
- März Winfried
- Scharnagl Hubert
- Weihrauch Gisela
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- Abstract:
- Background. Although short-term graft survival has improved substantially in renal transplant recipients, long-term graft survival has not improved over the last decades. The lack of knowledge of specific causes and risk factors has hampered improvements in long-term allograft survival. There is an uncertainty if inflammation is associated with late graft loss. Methods. We examined, in a large prospective trial, the inflammation markers high-sensitivity C-reactive protein (hsCRP) and interleukin-6 (IL-6) and their association with chronic graft dysfunction. We collected data from the Assessment of Lescol in Renal Transplant trial, which recruited 2102 maintenance renal transplant recipients. Results. Baseline values were hsCRP 3.8 +/- 6.7 mg/L and IL-6 2.9 +/- 1.9 pg/mL. Adjusted for traditional risk factors, hsCRP and IL-6 were independently associated with death-censored graft loss, the composite end points graft loss or death and doubling of serum creatinine, graft loss or death. Conclusion. The inflammation markers hsCRP and IL-6 are associated with long-term graft outcomes in renal transplant recipients.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Anticholesteremic Agents - therapeutic use
- C-Reactive Protein - metabolism
- Creatinine - blood
- Double-Blind Method -
- Fatty Acids, Monounsaturated - therapeutic use
- Female -
- Follow-Up Studies -
- Glomerular Filtration Rate -
- Graft Rejection - blood Graft Rejection - etiology Graft Rejection - mortality
- Humans -
- Indoles - therapeutic use
- Inflammation - blood Inflammation - etiology Inflammation - mortality
- Interleukin-6 - blood
- Kidney Diseases - complications Kidney Diseases - drug therapy Kidney Diseases - surgery
- Kidney Function Tests -
- Kidney Transplantation - adverse effects
- Male -
- Middle Aged -
- Postoperative Complications -
- Prognosis -
- Prospective Studies -
- Survival Rate -
- Transplantation, Homologous -
- Find related publications in this database (Keywords)
- ALERT
- high-sensitivity CRP
- inflammation
- interleukin-6
- renal allograft survival