Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Etschmaier, K; Becker, T; Eichmann, TO; Schweinzer, C; Scholler, M; Tam-Amersdorfer, C; Poeckl, M; Schuligoi, R; Kober, A; Chirackal, Manavalan, AP; Rechberger, GN; Streith, IE; Zechner, R; Zimmermann, R; Panzenboeck, U.
Adipose triglyceride lipase affects triacylglycerol metabolism at brain barriers.
J Neurochem. 2011; 119(5):1016-28
Doi: 10.1111/j.1471-4159.2011.07498.x
[OPEN ACCESS]
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Etschmaier Karoline
- Panzenboeck Ute
- Co-authors Med Uni Graz
- Becker Tatjana
- Chirackal Manavalan Anil Paul
- Eichmann Thomas
- Kober Alexandra
- Scholler Monika
- Schuligoi Rufina
- Schweinzer Cornelia Katrin
- Tam-Amersdorfer Carmen
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- Currently, little is known about the role of intracellular triacylglycerol (TAG) lipases in the brain. Adipose triglyceride lipase (ATGL) is encoded by the PNPLA2 gene and catalyzes the rate-limiting step of lipolysis. In this study, we investigated the effects of ATGL deficiency on brain lipid metabolism in vivo using an established knock-out mouse model (ATGL-ko). A moderate decrease in TAG hydrolase activity detected in ATGL-ko versus wild-type brain tissue was accompanied by a 14-fold increase in TAG levels and an altered composition of TAG-associated fatty acids in ATGL-ko brains. Oil Red O staining revealed a severe accumulation of neutral lipids associated to cerebrovascular cells and in distinct brain regions namely the ependymal cell layer and the choroid plexus along the ventricular system. In situ hybridization histochemistry identified ATGL mRNA expression in ependymal cells, the choroid plexus, pyramidal cells of the hippocampus, and the dentate gyrus. Our findings imply that ATGL is involved in brain fatty acid metabolism, particularly in regions mediating transport and exchange processes: the brain-CSF interface, the blood-CSF barrier, and the blood-brain barrier.
- Find related publications in this database (using NLM MeSH Indexing)
- Animals - administration & dosage
- Blood-Brain Barrier - enzymology, metabolism
- Brain - enzymology, metabolism
- Disease Models, Animal - administration & dosage
- Female - administration & dosage
- Lipase - deficiency, genetics, physiology
- Lipid Metabolism - genetics
- Male - administration & dosage
- Mice - administration & dosage
- Mice, Inbred C57BL - administration & dosage
- Mice, Knockout - administration & dosage
- Triglycerides - metabolism
- Find related publications in this database (Keywords)
- ATGL
- PNPLA2
- brain barriers
- cerebral lipid metabolism
- fatty acid metabolism
- lipid droplets