Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Trbušić, M; Riederer, M; Vučić, M; Lovričević, I; Krušlin, B; Gauster, M; Mohrenz, S; Berghold, A; Tiran, B; Degoricija, V; Frank, S.
Increased expression of endothelial lipase in symptomatic and unstable carotid plaques.
J Neurol. 2012; 259(3):448-456
Doi: 10.1007/s00415-011-6198-3
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- Leading authors Med Uni Graz
- Frank Sasa
- Riederer Monika
- Co-authors Med Uni Graz
- Berghold Andrea
- Gauster Martin
- Tiran Beate
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- Abstract:
- The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ(2) test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ(2) test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Aged -
- Aged, 80 and over -
- Antigens, CD - metabolism
- Antigens, Differentiation, Myelomonocytic - metabolism
- Body Mass Index -
- Carotid Arteries - pathology
- Carotid Stenosis - complications
- Echocardiography, Doppler, Color - methods
- Endarterectomy, Carotid - methods
- Endothelial Cells - enzymology
- Female -
- Gene Expression Regulation, Enzymologic - physiology
- Humans -
- Lipase - metabolism
- Magnetic Resonance Angiography -
- Male -
- Middle Aged -
- Receptors, Cell Surface - metabolism
- Renin - metabolism
- Retrospective Studies -
- Find related publications in this database (Keywords)
- Endothelial lipase
- Carotid artery plaque
- High density lipoprotein
- Inflammation
- Atherosclerosis
- Macrophages