Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Jarai, R; Mahla, E; Perkmann, T; Jarai, R; Archan, S; Tentzeris, I; Huber, K; Metzler, H.
Usefulness of pre-operative copeptin concentrations to predict post-operative outcome after major vascular surgery.
Am J Cardiol. 2011; 108(8):1188-1195
Doi: 10.1016/j.amjcard.2011.06.024
Web of Science
PubMed
FullText
FullText_MUG
- Co-authors Med Uni Graz
- Farzi Sylvia Ingrid
- Mahla Elisabeth
- Metzler Helfried
- Altmetrics:
- Dimensions Citations:
- Plum Analytics:
- Scite (citation analytics):
- Abstract:
- The aim of this study was to investigate whether preoperative determination of plasma copeptin levels in addition to plasma N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) could help improve risk stratification in patients who undergo major vascular surgery. One hundred ninety-eight consecutive patients who underwent major vascular surgery (58.6% infrainguinal aortic reconstruction, 23.7% abdominal aortic aneurysm surgery, 17.7% carotid endarterectomy) were included in this study. Patients were monitored for in-hospital and long-term (2-years) major adverse cardiac events, consisting of cardiac death, nonfatal myocardial infarction, and emergent coronary revascularization. Overall, 40 patients (20.2%) reached the primary end point, and most of these events occurred during the index hospital stay (n = 18 [45%]). In univariate Cox regression analysis, increasing concentrations of copeptin were significant determinants of outcome as a continuous variable (hazard ratio [HR] 1.012, p = 0.005) and as a dichotomized variable according to the recommended cutoff of 14.0 pmol/L (HR 4.116, p <0.001). Subgroup analyses revealed that especially patients at low estimated risk according to plasma NT-pro-BNP levels were at significantly higher risk for worse outcomes with higher copeptin levels (HR 5.983, p = 0.002). In multivariate Cox regression analysis, copeptin concentrations >14 pmol/L were significant independent predictors of outcome (HR 2.842, p = 0.002) in addition to type of surgery, history of myocardial infarction, elevated levels of cardiac troponin T, and NT-pro-BNP levels. In conclusion, the results of this study suggest that preoperative determination of this new biomarker could substantially improve prediction of perioperative and postoperative outcomes in vascular surgery patients.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Aged - epidemiology
- Biological Markers - blood
- Female -
- Follow-Up Studies -
- Glycopeptides - blood
- Humans -
- Incidence -
- Male -
- Postoperative Complications - blood
- Predictive Value of Tests -
- Preoperative Care - methods
- Prevalence -
- Prognosis -
- Prospective Studies -
- Protein Precursors -
- Risk Assessment - methods
- Vascular Diseases - blood
- Vascular Surgical Procedures -