Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wohlkoenig, C; Leithner, K; Deutsch, A; Hrzenjak, A; Olschewski, A; Olschewski, H.
Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells.
Cancer Lett. 2011; 308(2): 134-143.
Doi: 10.1016/j.canlet.2011.03.014
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Olschewski Horst
- Wohlkönig Christoph
- Co-authors Med Uni Graz
- Deutsch Alexander
- Hrzenjak Andelko
- Leithner Katharina
- Olschewski Andrea
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- Abstract:
- Hypoxia frequently occurs in solid tumors and is known to contribute to chemotherapy resistance. However, the mechanisms leading to chemotherapy resistance are not entirely known. We investigated hypoxia-induced resistance to cisplatin in NSCLC cell lines. We show that chronic moderate hypoxia induced resistance to cisplatin in NSCLC cells without involvement of selection pressure. Our data suggest that stabilization of the hypoxia-inducible factor 1 alpha and down-regulation of the pro-apoptotic protein BAX play a role in this process. Furthermore, we provide evidence that hypoxia-induced resistance to cisplatin is not due to the reduced growth rate of cancer cells under hypoxic conditions.
- Find related publications in this database (using NLM MeSH Indexing)
- Antineoplastic Agents - pharmacology
- Apoptosis -
- Blotting, Western -
- Cell Hypoxia -
- Cell Line, Tumor -
- Cell Proliferation - drug effects
- Cell Survival -
- Cisplatin - pharmacology
- Drug Resistance, Neoplasm -
- Humans -
- Lung Neoplasms - pathology
- Reverse Transcriptase Polymerase Chain Reaction -
- Find related publications in this database (Keywords)
- Cisplatin
- Apoptosis
- Re-oxygenation
- Growth rate