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SHR Neuro Cancer Cardio Lipid Metab Microb
Dahaba, AA; Suljevic, I; Bornemann, H; Wu, X; Metzler, H.
No regional difference in cisatracurium dose-response and time-course-of-action between patients in China and Bosnia.
Br J Anaesth. 2011; 106(3): 331-335.
Doi: 10.1093/bja/aeq369
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- Co-authors Med Uni Graz
- Bornemann-Cimenti Helmar
- Metzler Helfried
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- Abstract:
- Background. Variability in drug response could result from a variety of genetic and environmental factors that are often hard to define or quantify. A number of studies demonstrated regional geographic variations in potency of neuromuscular blocking agents (NMBAs). The aim of our study was to compare dose-response and time-course-of-action of cisatracurium besylate, an NMBA eliminated via the Hoffman degradation, in two countries with different life habits, diet, and ambient conditions; being Han Chinese in China and Caucasians in Bosnia. Methods. Neuromuscular block of cisatracurium 20 mu g kg(-1), followed by four incremental 10 mu g kg(-1) doses, and the remainder of 100 mu g kg(-1) was evaluated using the Relaxometer mechanomyograph (Groningen University, Groningen, The Netherlands). Dose-response curves were created using log-dose-probit-response transformation. Results. There were no significant differences in cisatracurium mean (95% confidence intervals) ED50, ED90, and ED95 (effective doses for 50%, 90%, and 95% first twitch depression) in Caucasian [39.1 (35.7-42.3), 50.6 (45.5-54.3), and 54.4 (49.8-58.9) mu g kg(-1)] compared with Chinese patients [39.2 (35.1-43.1), 52.4 (47.9-56.8), and 56.9 (52.8-61.9) mu g kg(-1)], respectively. There were no significant differences in mean (SD) Dur(25) and Dur(0.9) (time until 25% first twitch and 0.9 train-of-four ratio recoveries) in Caucasian [47.1 (6.4) and 77.5 (9.1) min)] compared with Chinese patients [(45.9 (4.7) and 72.3 (9.1) min)], respectively. Conclusions. Cisatracurium dose-response relationship and time-course-of-action were not influenced by geographic location. Thus, cisatracurium would not require dose adjustments between patients living in the two geographic locations.
- Find related publications in this database (using NLM MeSH Indexing)
- Adult -
- Asian Continental Ancestry Group - statistics and numerical data
- Atracurium - administration and dosage
- Atracurium - ethnology
- Atracurium - ethnology
- Dose-Response Relationship, Drug -
- European Continental Ancestry Group - statistics and numerical data
- Humans -
- Middle Aged -
- Neuromuscular Junction - drug effects
- Neuromuscular Nondepolarizing Agents - administration and dosage
- Find related publications in this database (Keywords)
- equipment, mechanomyograph
- monitoring, neuromuscular function
- neuromuscular block, cisatracurium