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Matzi, V; Maier, A; Sankin, O; Lindenmann, J; Rehak, P; Smolle-Jüttner, FM.
5-Aminolaevulinic acid compared to polyhematoporphyrin photosensitization for photodynamic therapy of malignant bronchial and esophageal stenosis: clinical experience.
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY. 2004; 1(2): 137-143. Doi: 10.1016/S1572-1000(04)00040-7
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Leading authors Med Uni Graz: Matzi Veronika; Smolle-Juettner Freyja-Maria
Co-authors Med Uni Graz: Lindenmann Jörg; Maier Alfred; Rehak Peter; Sankin Oliver
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Abstract:: Background and objective: Polyhematoporphyrins (PhP) as sensitizers for photodynamic therapy (PDT) in malignant bronchial and esophageal stenosis carry the risk of prolonged photosensitivity of the skin. New line sensitizers such as 5-aminolaevulinic acid (ALA) with low rates of skin phototoxicity appear to be promising alternatives. The aim of this study was to evaluate the efficacy of ALA compared to PhP for PDT regarding phototoxicity of the skin, reduction of tumour stenosis and tumour length and Karnofsky performance status. Patients and methods: After diagnostic work-up, photosensitization was done in 38 patients with ALA (60 mg/kg body weight, oral, 6-8 h prior to PDT) and in 51 patients with PhP (2 mg/kg body weight, i.v., 48 h before PDT). The light dose was calculated as 300 J/cm fibre tip. Light at 630 nm was applied using a pumped dye laser. In both groups, additional hyperbaric oxygenation was applied at a level of 2 bar absolute pressure. Results: Improvement regarding stenosis diameter, tumour length and Karnofsky performance status could be obtained in both treatment arms with a significant difference in favour of the PhP-group, P = 0.00073; 0.000014, and 0.00015, respectively. No sunburn or other major treatment related complications occurred in either treatment arms. Conclusion: Photosensitization with PhP compared to ALA seems to be more effective in PDT of malignant bronchial and esophageal stenosis. (c) 2004 Elsevier B.V. All rights reserved.
Find related publications in this database (Keywords): 5-Aminolaevulinic acid; Polyhematoporphyrin and malignant bronchial and esophageal stenosis