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Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Reishofer, G; Koschutnig, K; Enzinger, C; Ischebeck, A; Keeling, S; Stollberger, R; Ebner, F.
Automated macrovessel artifact correction in dynamic susceptibility contrast magnetic resonance imaging using independent component analysis.
Magn Reson Med. 2011; 65(3): 848-857.
Doi: 10.1002/mrm.22660
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- Leading authors Med Uni Graz
- Reishofer Gernot
- Co-authors Med Uni Graz
- Ebner Franz
- Enzinger Christian
- Koschutnig Karl
- Stollberger Rudolf
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- Abstract:
- Dynamic susceptibility contrast-MRI is the most commonly used functional MRI-based method for studying changes in cerebral perfusion. However, several studies indicated a systematic overestimation of perfusion parameters compared with other imaging modalities related to the high sensitivity of dynamic susceptibility contrast-MRI for blood flow in large vessels. In this study, we therefore suggest an improved, automated, robust, and efficient method allowing for generating hemodynamic parameter maps where signal influence from large vessels is minimized. Based on independent component analysis, this fully automated approach corrects dynamic susceptibility contrast-MRI data without any user interaction, thus making a clinical applicability possible. The accuracy of the proposed method was tested in 10 patients with cerebrovascular disease. Application of our correction algorithm resulted in a significant reduction of the effect of macrovessel signal on hemodynamic parameters like the cerebral blood flow and the cerebral blood volume compared with uncorrected data. As desired, our method specifically corrected for macrovessel artifacts in cortical grey matter tissue, leaving white matter tissue parameters largely unaffected. This may increase sensitivity and reliability of detecting perfusion abnormalities in patient groups, in particular with regard to stroke and other cerebrovascular disorders. Copyright © 2010 Wiley-Liss, Inc.
- Find related publications in this database (using NLM MeSH Indexing)
- Aged -
- Artifacts -
- Carotid Stenosis - complications
- Cerebral Arteries - pathology
- Contrast Media -
- Female -
- Humans -
- Image Enhancement - methods
- Ischemic Attack, Transient - diagnosis
- Magnetic Resonance Angiography - methods
- Male -
- Meglumine - diagnostic use
- Organometallic Compounds - diagnostic use
- Principal Component Analysis -
- Reproducibility of Results -
- Sensitivity and Specificity -
- Find related publications in this database (Keywords)
- perfusion-weighted MRI
- independent component analysis
- bolus tracking
- cerebral blood flow
- cerebral blood volume