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Carbonell-Estrany, X; SimÃµes, EA; Fullarton, JR; Ferdynus, C; Gouyon, JB; European RSV Risk Factor Study Group.
Validation of a model to predict hospitalization due to RSV of infants born at 33-35 weeks' gestation.
J Perinat Med. 2010; 38(4): 411-417. Doi: 10.1515/JPM.2010.074
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Study Group Members Med Uni Graz:: Resch Bernhard
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Abstract:: BACKGROUND: A model to predict hospitalization due to respiratory syncytial virus (RSV) of infants born at 33- 35 weeks' gestation was developed using seven risk factors from the Spanish FLIP study "birth +/-10 weeks from the beginning of the RSV season", "birth weight", "breast fed or=2 years", "number of family members with atopy", "number of family members with wheezing", and "gender". The aim of this study was to validate the model using French data. METHODS: The FLIP model [predictive accuracy 71%, receiver operating characteristic (ROC) 0.791] was tested against the French data (77 hospitalized infants with RSV born at 33-35 weeks and 154 age-matched controls) using discriminatory function analysis by applying the FLIP coefficients to the French data and by generating the seven variable model from the French data. RESULTS: Applying the FLIP coefficients to the French dataset, the model correctly classified 69% of cases (ROC 0.627). The predictive power increased to 73% (ROC 0.654) when "number of siblings >or=2 years" was substituted for "number of children at school". The number needed to treat (NNT) in order to prevent 70% of hospitalizations was 18. The model derived using French data could correctly classify 62% of cases in the French data (ROC 0.658). CONCLUSIONS: The model was successfully validated and may potentially optimize immunoprophylaxis in French infants born at 33-35 week's gestation.
Find related publications in this database (using NLM MeSH Indexing): Case-Control Studies -; Databases, Factual -; Female -; France -; Gestational Age -; Hospitalization -; Humans -; Infant -; Infant, Newborn -; Infant, Premature -; Models, Biological -; Pregnancy -; Respiratory Syncytial Virus Infections - therapy; Respiratory Syncytial Virus, Human -; Risk Factors -
Find related publications in this database (Keywords): Hospitalization; immunoprophylaxis; predictive model validation; premature infants; respiratory syncytial virus; risk factors