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Selected Publication:
Zenz, W; Bodó, Z; Plotho, J; Streif, W; Male, C; Bernert, G; Rauter, L; Ebetsberger, G; Kaltenbrunner, K; Kurnik, P; Lischka, A; Paky, F; Ploier, R; Höfler, G; Mannhalter, C; Muntean, W.
Factor V Leiden and prothrombin gene G 20210 A variant in children with ischemic stroke.
Thromb Haemost. 1998; 80(5):763-766
Doi: 10.1055/s-0037-1615355
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- Leading authors Med Uni Graz
- Zenz Werner
- Co-authors Med Uni Graz
- Höfler Gerald
- Muntean Eugen
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- Abstract:
- OBJECTIVE: To investigate if the factor V Leiden mutation (F-V-LM) and/or the prothrombin gene G 20210 A variant (P-G20210A-V) are risk factors for acute stroke in Austrian children. PATIENTS: 33 children with acute ischemic stroke documented by computer tomography and/or magnetic resonance imaging of the brain were enrolled in an open multicenter survey. RESULTS: 6/33 children had F-V-LM (5 heterozygous, 1 homozygous). This represents 18% (95% CI: 6.7-39.9%) of our pediatric stroke population and thus exceeds the expected prevalence in the Austrian population of 4,6% (Fischer's exact test, p = 0.01). F-V-LM was not found in 11 children with neonatal stroke but in 6/22 children with stroke after the neonatal period. 5/6 children with F-V-LM had an underlying disorder that is a risk factor for stroke in children. The P-G20210A-V was detected in 1/26 (3.85%; 95% CI: 0.1-21.4%) patients. Comparison of the prevalence of P-G20210A-V in our study with that in the general population of Austria of 1% revealed no statistical significance (Fischer's exact test, p = 0.38). CONCLUSION: Our data suggest that the F-V-LM is a risk factor for acute stroke in Austrian children beyond the neonatal period. The P-G20210A-V apparently does not represent a risk factor for stroke in Austrian children.
- Find related publications in this database (using NLM MeSH Indexing)
- Activated Protein C Resistance - epidemiology
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- Child - epidemiology
- Child, Preschool - epidemiology
- Factor V - genetics
- Female - genetics
- Gene Frequency - genetics
- Genetic Predisposition to Disease - genetics
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- Humans - genetics
- Infant - genetics
- Infant, Newborn - genetics
- Male - genetics
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- Regulatory Sequences, Nucleic Acid - genetics
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