Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Mahla, E; Metzler, H; Tantry, US; Gurbel, PA.
Controversies in Oral Antiplatelet Therapy in Patients Undergoing Aortocoronary Bypass Surgery.
Ann Thorac Surg. 2010; 90(3): 1040-1051.
Doi: 10.1016/j.athoracsur.2010.04.041
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Mahla Elisabeth
- Co-authors Med Uni Graz
- Metzler Helfried
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- Abstract:
- Oral antiplatelet therapy with aspirin and clopidogrel is a major strategy to prevent thrombotic events in patients with acute coronary syndromes and patients undergoing percutaneous coronary interventions. Although this therapy is associated with both short- and long-term clinical efficacy, irreversible platelet inhibition and ischemic events associated with premature withdrawal especially in patients treated with drug-eluting stents constitute a particular limitation in patients undergoing surgery. The current review article is focused on the central role of platelets in the occurrence of ischemic events, the significance of antiplatelet therapy, the potential hazards of drug withdrawal in patients needing coronary artery bypass grafting, and future perspectives.
- Find related publications in this database (using NLM MeSH Indexing)
- Administration, Oral -
- Aspirin - administration and dosage
- Clinical Trials as Topic -
- Coronary Artery Bypass - adverse effects
- Humans -
- Piperazines - administration and dosage
- Platelet Aggregation Inhibitors - administration and dosage
- Pyridines - administration and dosage
- Thiophenes - administration and dosage
- Thrombosis - etiology
- Ticlopidine - administration and dosage