Medizinische Universität Graz - Research portal
Selected Publication:
SHR Neuro Cancer Cardio Lipid Metab Microb
Wagner, D; Kniepeiss, D; Schaffellner, S; Jakoby, E; Mueller, H; Fahrleitner-Pammer, A; Tscheliessnigg, KH; Iberer, F.
Sirolimus has a potential to influent viral recurrence in HCV positive liver transplant candidates.
Int Immunopharmacol. 2010; 10(8): 990-993.
Doi: 10.1016/j.intimp.2010.05.006
Web of Science
PubMed
FullText
FullText_MUG
- Leading authors Med Uni Graz
- Wagner Doris
- Co-authors Med Uni Graz
- Fahrleitner-Pammer Astrid
- Iberer Florian
- Jakoby Estrella
- Kniepeiss Daniela
- Müller Helmut
- Schaffellner Silvia
- Stiegler Philipp
- Tscheliessnigg Karlheinz
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- Abstract:
- There is in vitro proof that mTOR proteins play a role in protecting HCV infected cells from apoptosis. The aim of this cohort study was to evaluate the effect of sirolimus as an mTOR inhibitor on hepatitis C recurrence in liver transplant recipients. Hepatitis C virus positive patients were followed prospectively regarding transaminases, immunosuppressive target levels, HCV RNA and influence of donor and recipient factors on viral recurrence and survival. Viral recurrence was defined as elevated liver enzymes combined with active hepatitis diagnosed on the basis of increasing viral load and/or biopsy-proven HCV relapse in the transplanted organ. Sixty-seven HCV positive patients were included: 39 received a regimen including sirolimus; 28 patients received calcineurin inhibitors. Sirolimus patients showed a significant decrease in the HCV PCR levels (p<0.05). Survival of the sirolimus patients was significantly higher (p<0.03) than in the other patient cohort. Sirolimus has been shown to be a potent immunosuppressive agent after liver transplantation, though nothing is known about its effect on HCV. This analysis suggests that sirolimus has potential to suppress viral recurrence in HCV positive liver transplant candidates.
- Find related publications in this database (using NLM MeSH Indexing)
- Cohort Studies -
- Follow-Up Studies -
- Hepacivirus - physiology
- Hepatitis, Viral, Human - immunology Hepatitis, Viral, Human - mortality Hepatitis, Viral, Human - pathology Hepatitis, Viral, Human - physiopathology Hepatitis, Viral, Human - therapy
- Humans -
- Liver - drug effects Liver - immunology Liver - metabolism Liver - pathology Liver - virology
- Liver Transplantation -
- Male -
- Middle Aged -
- Recurrence -
- Sirolimus - administration and dosage
- Survival Analysis -
- Transaminases - genetics Transaminases - metabolism
- Viral Load - drug effects
- Virus Activation - drug effects
- Virus Replication - drug effects
- Waiting Lists -
- Find related publications in this database (Keywords)
- Liver transplantation
- HCV recurrence
- Sirolimus
- mTOR inhibition