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SHR Neuro Krebs Kardio Lipid Stoffw Microb

Klingenberg, R; Leiherer, A; Dobrev, D; Kaski, JC; Levkau, B; März, W; Sossalla, S; von Eckardstein, A; Drexel, H.
Ceramides in cardiovascular disease: emerging role as independent risk predictors and novel therapeutic targets
CARDIOVASC RES. 2025; Doi: 10.1093/cvr/cvaf093
Web of Science PubMed FullText FullText_MUG

 

Co-Autor*innen der Med Uni Graz

März Winfried

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Abstract:

Ceramides are bioactive lipid mediators involved in apoptosis, inflammation, and fibrosis. This narrative review provides a concise overview of the emerging role of ceramides in cardiovascular disease with an emphasis on atherosclerotic vascular disease and heart failure, suggesting the potential use of ceramides in risk stratification and as putative therapeutic targets. Recent developments based on observational evidence and genetic associations, including Mendelian randomization studies in humans, are summarized and put into context with experimental evidence for the role of ceramides in human and animal models of disease. Emerging scores composed of ceramides and phosphatidylcholines that are based on the length and desaturation of the N-acyl chains are discussed in the light of novel data demonstrating age- and sex-specific differences. Also reviewed is the structural heterogeneity of the sphingoid bases, including non-conventional sphingolipids that are increasingly recognized for their importance in health and disease. Lastly, novel targets and potential modalities for tissue-specific transfer of drugs are discussed.

Find related publications in this database (Keywords)

Ceramides

Atherosclerotic vascular disease

Heart failure

Risk stratification

Therapy

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