Medizinische Universität Graz - Research portal
SHR
Neuro
Cancer
Cardio
Metab
Microb
Lipid
Impact of endothelial lipase-generated lipolytic products on inflammatory response in vasulcar endothelial cells
- Abstract
- Inflammatory reactions in endothelial cells are regulated primarily through activation of
inflammatory genes encoding adhesion molecules, inflammatory cytokines and chemokines.
An excessive activation of inflammatory genes promotes enhanced adhesion of monocytes
to the vascular endothelium, which is one of the first events in the development of
atherosclerosis [1, 2]. The rate of inflammatory gene expression might be modulated by a
variety of biologically active substances including lipid molecules derived by the action of the
serum lipases on lipoproteins. A likely candidate capable of modulating inflammatory gene
expression is endothelial lipase (EL), which by hydrolyzing its preferential substrate HDLphosphatidylcholine
(HDL-PC) generates bioactive molecules, free fatty acids (FFAs) and
lysophosphatidylcholine (lyso-PC) species.
- Keywords
- biochemistry
- genetic engineering
- atherosclerosis
- endothelium
- fatty acids
- inflammation
- lipases
- lysophospholipids
- Project Leader:
- Frank Sasa
- Duration:
- 01.01.2007-10.02.2010
- Programme:
- Einzelprojekt
- Type of Research
- basic research
- MUG Research Units
- Division of Molecular Biology and Biochemistry
- Funded by
- FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria
FWF-Grant-DOI: 10.55776/P19473
- Project results published
- > Acyl chain-dependent effect of lysophosphatidylcho... PLoS One. 2013; 8(5):e65155-e65155
- > Docosahexaenoic acid-induced unfolded protein resp... Free Radic Biol Med. 2012; 52(9):1786-1795
- > Acyl chain-dependent effect of lysophosphatidylcho... Atherosclerosis. 2012; 224(2):348-354
- > Increased expression of endothelial lipase in symp... J Neurol. 2012; 259(3):448-456
- > Impact of endothelial lipase on cellular lipid com... Biochim Biophys Acta. 2012; 1821(7):1003-1011
- > Laropiprant Attenuates EP3 and TP Prostanoid Recep... PLoS One. 2012; 7(8):e40222-e40222
- > Endothelial lipase (EL) and EL-generated lysophosp... Atherosclerosis. 2011; 214(2):338-344
- > Acyl chain-dependent effect of lysophosphatidylcho... J Lipid Res. 2010; 51(10):2957-2966