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In vitro investigation of the ZX00 implants for the cartilage tissue formation
- Abstract
- In children and adolescents, cartilage defects have significant impact on their quality of life due to impairment of joint function in older age. The refixation of loose cartilage, tissue engineering templates or refixation of cartilage after trauma are important to rescue the function of the knee joint. Consequently, the development of innovative techniques for fixation and the optimization of existing ones remain key priorities, driving extensive research efforts from basic science to clinical applications. In the last decade, magnesium (Mg)-based implants become promising alternatives in the orthopedic field because of its biocompatibility, good mechanical properties, biodegradability, and other functional properties. Our research group showed cartilage regeneration after putting an Mg-based screw through the joint surface and the growth plate in ovine model. Besides, tissue regeneration during degradation of the Mg-based screw did not lead to growth disturbances in comparison to titanium-based screws. However, the limited information about effects of Mg-based implants on chondrogenic differentiation, both in direct contact and as extract, point out the need for further investigations. Possible effects due to the alloying elements also need to be better understood. Therefore, this proposed study aims to investigate the potential effects of one of the most commonly used Mg-based implants, ZX00 alloy (Mg-Zn-Ca alloy) on cartilage tissue formation and provide a preliminary data for in vivo experiments.
- Project Leader:
- Okutan Meyer Begüm
- Duration:
- 01.07.2025-30.06.2026
- Type of Research
- basic research
- MUG Research Units
- Department of Orthopaedics and Trauma