Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Abstract: Preeclampsia (PET), de-novo hypertension & proteinuria after mid gestation, affects 5-7% of all pregnancies. Cases may develop life threatening haemolysis-elevated liver enzymes-low platelets (HELLP) or renal failure, cerebral haemorrhages & eclampsia, IUGR, placental abruption & death.
We will identify markers for PET risk prediction in the 1st trimester to allow longer time for tailoring putative medications to prevent PET, and assess & characterize plausible links between marker shortage/access, PET & putative medications in "in-vitro" systems to fit putative medications to pre-defined disease-risk women.
We will develop non-invasive diagnostic kits for 1st trimester PET prediction based on markers, antibodies, oligos & siRNA and others coupled to the power of Doppler ultrasound. Nested case-control clinical studies will test effectiveness of combined diagnosis & drug tailoring. A Trans European prospective clinical study, combining early diagnosis & randomising putative medication will verify findings.
R&D results will be used to train physicians & patients, to implement new prenatal care practice and eradicate preeclampsia.

Mitarbeiter*innen: Huppertz, Berthold, Projektleiter*in; Scheiber, Beate, Projektmitarbeiter*in

Beteiligte MUG-Organisationseinheiten: Lehrstuhl für Zellbiologie, Histologie und Embryologie

Projektpartner: Barking, Havering & Redbridge Hospitals NHS Trust, Großbritannien
Kontaktperson: Prof. Kevin Spencer;; Diagnostic Technologies, Israel
Kontaktperson: Dr. Hamutal Meiri;; Fetal Medicine Foundation, Großbritannien
Kontaktperson: Prof. Kypros H Nicolaides;; Global Research & Financing, Israel
Kontaktperson: Prof. Zohar Ben-Asher;; ImmunoSTAR, Portugal
Kontaktperson: Pedro Seada;; Semmelweis University Budapest, Ungarn
Kontaktperson: Dr. Nandor Gabor Than;; University of Basel, Schweiz
Kontaktperson: Prof. Sinuhe Hahn;; University of Milan, Italien
Kontaktperson: Prof. Irene Cetin;; Wallac, Finnland
Kontaktperson: Yvonne Parker;

Publizierte Projektergebnisse: > Development of early non-invasive markers and mean... PLACENTA. 2011; 32: S1-S3.; > Pregenesys pre-eclampsia markers consensus meeting... PLACENTA. 2011; 32: S4-S16.; > Placenta-bound and Body Fluid PP13 and its mRNA in... PLACENTA. 2011; 32: S30-S36.; > Placental and trophoblastic in vitro models to stu... PLACENTA. 2011; 32: S49-S54.; > Cryogenic and low temperature preservation of huma... PLACENTA. 2011; 32: S65-S76.; > Effects of calcium, magnesium, low-dose aspirin an... PLACENTA. 2011; 32: S55-S64.