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Abstract: The COST Action “EUropean network to tackle METAbolic alterations in HEART failure” (EUMETAHEART) will bring together excellent researchers from Europe to contribute a broad spectrum of scientific expertise, cutting-edge technologies, scientific exchange and education to foster breakthrough science that moves the field forward towards improving the treatment of patients with heart failure. By sharing diverse expertise that cover not only conventional analyses of metabolism and mitochondrial function, but also omics-based approaches towards genetics, epigenetics and metabolism and in particular, integrated assessment of excitation-contraction coupling with mitochondrial redox control and energetics, as well as advanced in vivo imaging technologies, the novelty of this COST Action is that it will allow to develop a comprehensive and cutting-edge approach towards deeper understanding of metabolic dysfunction in heart failure.

Staff: Sedej, Simon, Project Leader; Gölly, Katharina Ingrid, Co-worker; Rausch, Viktoria, Co-worker; Vrebo, Azelma, Co-worker

MUG Research Units: Department of Dermatology and Venereology; Division of Cardiology

Project results published: > Autophagy is required for the therapeutic effects ... Eur Heart J. 2025; 46(19):1863-1866; > Caloric restriction and its mimetics in heart fail... Cardiovasc Diabetol. 2025; 24(1): 21; > Mechano-energetic uncoupling in heart failure.... Nat Rev Cardiol. 2025;; > Autophagy is a key player in NAD+-driven HFpEF tre... 3. Core Member COST-ACTION METAHEART Meeting ; MAR 19-20, 2025; Heraklion, Greece. 2025.; > Inhibition of Adipose Tissue Lipolysis Treats Obes... Circ Res. 2025; 136(11):1519-1522; > Therapeutic potential of atglistatin in heart fail... 21st Annual Scientific Sessions SHVM 2024; SEP 08-11, 2024; St. Louis, USA. 2024.