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Neuro
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Microb
Lipid
GOLD II -Genomics Of Lipid-associated Disorders II
- Abstract
- This component focuses on a genome-wide search for as yet unknown genes that are involved in cellular cholesterol metabolism, including its biosynthesis, absorption, mobilization and trafficking. We aim at identifying all cholesteryl ester hydrolases in the mouse and human genome as well as target genes of nuclear receptors as potential therapeutic targets for the treatment of cholesterol and bile acid disorders. Studies will be performed mainly in cells form intestine, macrophages and liver utilizing microarray hybridization and ChIP on chip experiments, inhibitor screening, and in silico search for homologues.
- Local Subprojectlead:
- Kostner Gerhard
- Kratky Dagmar
- Duration:
- 01.12.2005-30.11.2008
- Programme:
- GENAU
- Type of Research
- basic research
- Staff
- Kostner, Gerhard, Project Leader
- Kratky, Dagmar, Project Leader
- Kollroser, Manfred, Sub Projectleader
- MUG Research Units
- Division of Molecular Biology and Biochemistry
- Project partners
- Karl-Franzens-Universität Graz, Austria
- Medizinische Universität Innsbruck, Austria
- Medizinische Universität Wien (MUW), Austria
- Technische Universität Graz, Austria
- Universität Wien, Austria