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PULMOTENSION: "Pulmonary Hypertension: Functional Genomics and Therapy of Lung Vascular Remodelling"

Abstract

Pulmonary hypertension (PH) describes a group of devastating diseases, comprising idiopathic and secondary forms, which cause breathlessness and premature death, representing a major burden on healthcare systems. Extensive lung vascular remodelling with loss of vessel patency is the underlying pathomechanism in PH. PULMOTENSION integrates the top EU Centres in PH and lung vascular biology in a multidisciplinary approach, with the aim to combat and finally cure PH. The expertise of all members fully extends from the initially discovery of gene mutations causative of PH to having established new therapeutic regimen of PH. We will uncover underlying molecular pathways, identify distinct targets for anti-remodelling therapy, foster drug development based on these targets, and test these new treatment options in preclinical and clinical trials.
Gender issues will be particularly addressed, as many PH forms have a female preponderance. Hence, this ambitious translational research programme will span "from molecules to patients" to the benefit of molecular understanding and new treatments of PH, a prototype disease of vascular remodelling.

Local Subprojectlead:

Olschewski Horst

Duration:

01.01.2006-31.12.2009

Programme:

EU (FP-6)

Subprogramme

Biowissenschaften

EU-Project Instruments

Integrated Project (IP)

Type of Research

basic research

Staff

Olschewski, Horst, Project Leader

MUG Research Units

Division of Respiratory Medicine

Project partners

Alphalyse, Denmark

Altanapharma, Germany

BioSpring GmbH, Germany

Bologna Pulmonary Hypertension Centre, Italy

Charite-Universitätsmedizin Berlin, Germany

Dr. Riethmüller MRS GmbH, Germany

Dualsystems GmbH, Switzerland

Genolyze Ltd., Finland

Hannover Medical School, Germany

Hopital Antoine Beclere, Université Paris Sud, France

Hospital Clinic i provincial de Barcelona, Spain

Imperial College London, United Kingdom

INSERM, France

King's College London, United Kingdom

LEA Medizintechnik GmbH, Germany

Luxcel Biosciences Ltd., Ireland

Medizinische Universität Wien (MUW), Austria

Scottish Pulmonary Vascular Unit, United Kingdom

TransMIT GmbH, Germany

Universität Duisburg - Essen, Germany

Universitätsklinikum Heidelberg, Germany

Université Libre de Bruxelles, Belgium

University College, London, United Kingdom

University Giessen, Germany
Contact person: Prof. Dr. Stefan Hormuth, Prof. Dr. Werner Seeger;

University of Cambridge, United Kingdom

University of Glasgow, United Kingdom

University of Ioannina, Greece

University of Oxford, United Kingdom

University of Sevilla, Spain

University of Zurich, Switzerland

Funded by

Europäische Kommission, Rue de la Loi, Brussels, Belgium