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High-resolution In Silico Models of Total Heart Function

Abstract

Advances in medical imaging have enabled unprecedented ability to image cardiac anatomy and function. So far these technologies have had relatively modest clinical impact as the analysis of such rich multi-modal datasets has proven challenging. In silico models hold vast potential to better harness such datasets by enabling their integration into quantitative frameworks that can aid in gaining better mechanistic insight into cardiac function in health and disease, and thus paving the way towards optimal therapeutic strategies.
Our objective is to develop the most advanced biophysically detailed in-silico model of total electro-mechano-fluidic function of the heart. This model will be parametrized, verified and used to study cause-effect relationships between flow and pressure and their impact upon pumping performance. A novel set of features such as combined models of both heart and attached outflow vessels and the computational efficiency will provide a unique platform for translational research.
This ambitious endeavor is feasible only by combining the expertise of the applicant in modeling soft tissue mechanics and his supervisors in modeling electrophysiology (Gernot Plank, MUG) and blood flow (Shawn Shadden, UC Berkeley). Clinical input and datasets for model parametrization and validation are provided by Titus Kühne (DHZ Berlin) and by clinical collaborators of Prof. Shadden at UCSF. During the return-phase, the applicant will use the infrastructure of Prof. Plank’s lab and the large network of academic and industrial collaborations as an incubator for building up his own research group in computational hemodynamics. This is ideal in many regards, as the expertise of the applicant's group will be entirely orthogonal to the expertise in Prof. Plank's lab, thus promoting a fast pathway towards full indepence, and core expertise necessary for further developing and maintaining a highly complex computing environment is synergistically shared between the labs.

Keywords

Computermodell

Hochaufgelöste, anatomisch detailierte Modelle

MRI-basierte Validierung

Multiphysiksimulationen

Supercomputing

Project Leader:

Augustin Christoph

Duration:

01.03.2017-31.08.2019

Programme:

EU (Horizon 2020)

EU-Project Instruments

Marie Curie

Type of Research

basic research

Staff

Augustin, Christoph, Project Leader

MUG Research Units

Division of Medical Physics and Biophysics

Project partners

University of California, Berkeley, United States (USA)

Funded by

Europäische Kommission, Rue de la Loi, Brussels, Belgium

Project results published

> Reconstructing vascular homeostasis by growth-base... J Mech Behav Biomed Mater. 2021; 114:104161

> Versatile stabilized finite element formulations f... Comput Mech. 2020; 65(1):193-215

> The impact of wall thickness and curvature on wall... Biomech Model Mechanobiol. 2020; 19(3):1015-1034

> Digital Twin Models of Cardiac Function in Precisi... Open Campus - Precision Medicine Day; OCT 22, 2019; Graz, AUSTRIA. 2019.

> Patient-specific electro-mechano-fluidic models of... IEEE Engineering in Medicine and Biology 2019; JUL 23-27, 2019; Berlin, GERMANY. 2019.

> Phosphorylation by the stress-activated MAPK Slt2 ... Genes Dev. 2018; 32(23-24):1576-1590

> Tracking yeast pheromone receptor Ste2 endocytosis... Mol Biol Cell. 2018; 29(22): 2720-2736.

> Clinical personalization of models of left ventric... Virtual Physiological Human Conference (VPH2018); SEP 5-7, 2018; Zaragoza, SPAIN. 2018.

> Personalized In-silico Models of Total Heart Funct... TRANSCARDIO 18; DEC 18-19, 2018; Barcelona, SPAIN. 2018.

> Patient-specific electro-mechano-fluidic models to... 8th World Congress of Biomechanics (WCB2018); JUL 8-12, 2018; Dublin, IRELAND. 2018.

> Computer Models of Cardiac Function: High-resoluti... ARIT: Austrian Research and Innovation Talk 2017; OCT 6-8; Austin, USA. 2017.

> Patient-specific Modeling of the Electro-mechano-f... Berkeley Fluids Seminar; NOV 6, 2017; Berkeley, USA. 2017.

> Multiphysics simulations of the electro-mechano-fl... 7th International Conference on Computational Bioengineering; SEP 6-8, 2017; Compiegne, FRANCE. 2017.

> Patient-specific Modeling of the Electro-mechano-f... SB3C 2017 Summer Biomechanics, Bioengineering & Biotransport Conference; JUN 21-24, 2017; Tucson, USA. 2017.