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SHR Neuro Cancer Cardio Metab Microb Lipid

Metabolic Therapy for Managing Diastolic Heart Failure

Project Leader:: Sedej Simon

Duration:: 01.05.2017-31.10.2020

Programme:: FWF andere

Subprogramme: ERA-Net

EU-Project Instruments: Collaborative Project (Small or Medium-Scale focused research Project)

Type of Research: basic research

Staff: Sedej, Simon, Project Leader; Platzer, Bernd, Co-worker; Hasenhüttl, Elias, Co-worker; Voglhuber, Julia, Co-worker; Sacherer, Michael, Co-worker; Abdellatif, Mahmoud, Co-worker; Kainz, André, Co-worker; Kaufmann, Florian, Co-worker; Schafmeister, Jan, Co-worker; Linzner, Jacqueline, Co-worker

MUG Research Units: Division of Cardiology

Project partners: French Institute of Health and Medical Research, France
Contact person: Guido Kroemer;; National Institute of Cardiovascular Research, Spain
Contact person: Jorge Alegre-Cebollada;; University of Fribourg, Switzerland
Contact person: Jörn Dengjel;; University of Porto, Portugal
Contact person: Adelino Leite-Moreira;; Westfälische Wilhelms-Universität Münster, Germany
Contact person: Wolfgang A. Linke;

Funded by: FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria

Project results published: > Stimulating autophagy: A turning point in HFpEF th... Jahrestagung Österreichische Gesellschaft für Kardiologie; JUN 4-7, 2025; Salzburg, AUSTRIA. 2025.; > Autophagy is essential for NAD+ replenishment ther... Create Global Symposium; MAY 10, 2025; Osaka, JAPAN. 2025.; > Autophagy is a key player in NAD+-driven HFpEF tre... 3. Core Member COST-ACTION METAHEART Meeting ; MAR 19-20, 2025; Heraklion, Greece. 2025.; > Lean ZSF1 rats in basic research on heart failure ... ESC Heart Fail. 2025; 12(2):1474-1478; > Caloric restriction mimetics to the rescue for an ... ISHR World Congress; MAY 11-14, 2025; Nara, JAPAN. 2025.; > Autophagy is required for the therapeutic effects ... Eur Heart J. 2025; 46(19):1863-1866; > NAD+ metabolism in heart failure... Targets in heart failure treatment; JUL 15-16, 2022; Würzburg, Germany. 2022.; > Spermidine overrides INSR (insulin receptor)-IGF1R... Autophagy. 2022; 18(10): 2500-2502.; > Nicotinamide and autophagy regulation in HFpEF ... 4. Herzkreislauftage (Cardio Summit); SEP 16-18, 2022; Graz. 2022.; > Basal oxidation of conserved cysteines modulates c... Redox Biol. 2022; 52:102306; > HFpEF: targeting aging mechanisms... ESC Congress; AUG 26-29, 2022; Barcelona, Spain. 2022.; > Metabolic therapy for diastolic heart failure... ERA-CVD Symposium; SEP 19-20, 2022; Riga, LATVIA. 2022.; > Metabolic therapy for managing heart failure with ... J Mol Cell Cardiol. 2022; 168:68-69; > Fine-Tuning Cardiac Insulin-Like Growth Factor 1 R... Circulation. 2022; 145(25):1853-1866; > NAD⁺ Metabolism in Cardiac Health, Agin... Circulation. 2021; 144(22): 1795-1817.; > Novel insights into cardiac aging... Jahrestagung ÖKG; May 27-29, 2021; Salzburg. 2021.; > Effects of physiologic inputs on autophagy... In: Beverly A. Rothermel and Abhinav Diwan editors(s). Autophagy in health and disease. (2nd ed): Elsevier; p. 81-95. 2021(ISBN: 9780128220030); > Accelerated aging of the heart... DGK Herztage; SEP 30-OCT 02, 2021; Bonn, Deutschland. 2021.; > Nicotinamide for the treatment of heart failure wi... Sci Transl Med. 2021; 13(580): eabd7064; > Autophagy in cardiovascular health and disease.... Prog Mol Biol Transl Sci. 2020; 172:87-106; > Caloric Restriction in HFpEF.... Heart Failure Winter Meeting; JAN 22-25, 2020; Les Diablerets, Switzerland. 2020.; > Cardiovascular benefits of intermittent fasting.... Cardiovasc Res. 2020; 116(3): e36-e38-e36-e38.; > NAD+ metabolism and sirtuins in cardiometabolic di... 1st Myocardial Function Symposium: Targets in cardiometabolic disease; JAN 10-11, 2020; Graz, Austria. 2020.; > Autophagy: the fountain of youth for our hearts? ... 1. Herzkreislauftage ; SEP 13-15, 2019; Graz, AUSTRIA. 2019.; > Metabolic Therapy Against Diastolic Heart Failure... ERA-CVD Joint Meeting; 14-16 May, 2019; Riga, Latvia. 2019.; > Cardioprotective effects of autophagy induction in... Ann Transl Med. 2018; 6(Suppl 1):S61-S61; > The role of the polyamine spermidine in cardiovasc... DGK Herztage 2018; OCT 11-12, 2018; Berlin, Germany. 2018.; > Autophagy in Cardiovascular Aging.... Circ Res. 2018; 123(7):803-824