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Interatrial gradients in I(f) and I(K1) and their contribution to focal activity in atrial fibrillation
- Abstract
- Atrial fibrillation (AF) is the most common arrhythmia tightly associated with an increased morbidity and mortality. Alterations in ion channel function are pivotal for the generation of arrhythmias. Besides the pulmonary veins, the left atrial appendage is increasingly recognized as an important source of focal ectopic activity. This study aims to investigate the role of the pacemaker current If – a potential contributor to ectopic activity, and the inward rectifier potassium current IK1 – a key determinant for a stable resting membrane potential in the generation of abnormal automaticity in AF. Special focus is given to interatrial differences in human AF patients. The experimental results will be implemented in a 3D computational model of the atria in order to assess the contribution of If and IK1 to focal activity in AF. Findings obtained in this study will lead to a better understanding of the mechanisms underlying AF and thereby provide important information for treatment of AF.
- Project Leader:
- Pelzmann Brigitte
- Duration:
- 01.09.2015-31.12.2017
- Programme:
- Jubiläumsfonds (ÖNB)
- Type of Research
- other
- Staff
- Pelzmann, Brigitte, Project Leader
- Hallström, Seth, Co-worker
- Plank, Gernot, Co-worker
- Zorn-Pauly, Klaus, Co-worker
- Bernhart, Eva Maria, Co-worker
- Scherübel-Posch, Susanne, Co-worker
- Mächler, Heinrich, Co-worker