Medizinische Universität Graz - Research portal
SHR
Neuro
Cancer
Cardio
Metab
Microb
Lipid
IMPACT OF DIALYSIS MODALITY ON HDL FUNCTION
- Abstract
- The survival of individuals with end stage renal disease (ESRD) compared to the general population is dramatically reduced. There is much debate over which dialysis modality – hemodialysis (HD) or peritoneal dialysis (PD) – is better in terms of morbidity and mortality. Low levels of high-density lipoprotein (HDL), such as found in renal patients, correlate with an increased risk of atherosclerotic vascular disease. Recently, it became evident that besides HDL cholesterol the functionality of HDL is of crucial importance in regard to cardiovascular protection. A recent clinical study has provided compelling evidence that cholesterol efflux capability of HDL, a functional measure of HDL, is a better predictor or cardiovascular mortality than LDL- or HDL-cholesterol levels. We and others have provided consistent evidence that HDL composition is altered in uremic patients leading to the formation of dysfunctional HDL. However, data on the effect of dialysis on HDL composition and function are very limited for HD and entirely absent for PD. We, hypothesize that HD and PD differentially affect HDL composition and function, which might explain - at least in part - differences in cardiovascular outcomes.
- Project Leader:
- Holzer Michael
- Duration:
- 01.08.2014-30.09.2016
- Programme:
- Jubiläumsfonds (ÖNB)
- Type of Research
- basic research
- MUG Research Units
- Division of Pharmacology