Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
SHR
Neuro
Krebs
Kardio
Stoffw
Microb
Lipid
In vivo aging as regenerative defect. Effects of adrenergic and oxidative stress on stem cell functions
- Abstract
- We plan to study stem cell biology in the context of the aging process. Besides a gross characterization of stem cells with regard to tissue regeneration, we will also investigate, if and how oxidative stress and catecholamines influence the growth and regenartive capcity of adult stem cells in the bone marrow, and, by the same token, affect aging, age-associated disease and life span. Experimentally, this will be tested in the Senescence-Accelerated-Mouse-Prone/Resistant Model. Several substrains with differing in age-associated pathology are available.
In particular, we will determine *the regenerative capacity of b one marrow stem cells in the context of aging and age-associated pathology, *if stem cell survival and functions can be affected by catecholamines and/or oxidative stress, *if aging and age associated pathology can be reduced by transplantation of bone marrow cells from young but not old donors.
- Lokale Teilprojektleitung:
- Liebmann-Holzmann Peter
- Laufzeit:
- 01.01.2005-31.12.2007
- Programm:
- FWF Einzelprojekt
- Art der Forschung
- Grundlagenforschung
- Mitarbeiter*innen
- Liebmann-Holzmann, Peter, Projektleiter*in
- Preisegger, Karl Heinz, Projektmitarbeiter*in
- Schwarzenberger, Elke, Projektmitarbeiter*in
- Supanz, Sabine, Projektmitarbeiter*in
- Beteiligte MUG-Organisationseinheiten
- Diagnostik und Forschungsinstitut für Pathologie
- Lehrstuhl für Immunologie
- Projektpartner
-
Eccocell Biotechnologie GmbH, Österreich
Kontaktperson: Mag. Clemens Kittinger; -
Institut für Genomik und Bioinformatik/Technische Universität Graz, Österreich
Kontaktperson: Prof. Zlatko Trajanoski; -
Institut für Pharmazeutische Chemie und Technologie/Karl-Franzens-Universität Graz, Österreich
Kontaktperson: Prof. Andreas Kungl; -
Institute of Biomedical Aging Research, Österreich
Kontaktperson: B. Grubeck-Lobenstein and Günter Lepperdinger;