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Cancer
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Lipid
Doktoratskolleg: "Metabolic and cardiovascular disease"
Subproject of: Doktoratskolleg "Metabolic and cardiovascular disease" (1. funding periode)
- Abstract
- Identifying the molecular and regulatory mechanisms of HDL metabolism at the BBB will help to uncover the protective role of HDL against lipid-related neurodegenerative diseases such as Alzheimers disease.
During the first funding period of the DK-Plus, students in U. Panzenboecks group will characterize phospholipid transfer protein function at the BBB to test the hypothesis if PLTP expression in cerebrovascular endothelial cells (EC) can be modulated and is involved in HDL remodelling and in lipid transport between the brain and the circulation. In a second show case the student will investigate the capacity of HDL particles to mediate/facilitate bidirectional oxysterol transport across the BBB and will aim to identify oxysterol transporting proteins in brain capillary EC.
- Keywords
- pathophysiology
- medical biochemistry
- medical molecular biology
- Lipidomics research
- Blut-Hirn-Schranke
- Endothelzellen
- High-Density Lipoproteine
- LXR
- Phospholipid Transfer Protein
- Local Subprojectlead:
- Panzenboeck Ute
- Duration:
- 01.07.2010-30.06.2014
- Programme:
- Doktoratskolleg
- Type of Research
- basic research
- Staff
- Panzenboeck, Ute, Project Leader
- Chirackal Manavalan, Anil Paul, Co-worker
- Kober, Alexandra, Co-worker
- MUG Research Units
- Division of Immunology
- Funded by
- FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria
FWF-Grant-DOI: 10.55776/W1226
- Project results published
- > Regulatory effects of simvastatin and apoJ on APP ... Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(1):40-60
- > Amyloid beta impairs cerebrovascular insulin respo... DOCTORAL DAY 2018 @ Med Uni Graz; NOV 27, 2018; Graz, Austria. 2018.
- > Astaxanthin and bexarotene exert protective effect... DOCTORAL DAY 2018 @ Med Uni Graz; NOV 27, 2018; Graz, AUSTRIA. 2018.
- > Phospholipid transfer protein is expressed in cere... J Biol Chem. 2014; 289(8):4683-4698
- > Phospholipid transfer protein is expressed in cere... The 8th International Congress on Vascular Dementia & the First Cognitive Impairment European Meeting; OCT 17-20; Athens, GREECE. 2013.