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Abstract: Anandamide (ANA), also known as N-arachidonoylethanolamine, is a prominent substance of endocannabinoids, and exhibits multiple physiological functions in the brain, the immune system and the cardiovasculature. Although ANA is well known to contribute to human behavior, like eating and sleeping, and pain relief, evidence accumulated that ANA is an important vascular mediator that is released during tissue stress. LPI (lysophosphatidylinositol is another putatively important lipid mediator in the vessel wall.
The overall aim of this project is to explore ANA/LPI as important vascular mediators, to characterize their respective signal transduction, their interrelation and consequences to endothelial cell functions. In the end, our proposal aims to provide the scientific basis of consideration of the ANA/LPI system as therapeutic target for vascular-related medicine.

Funded by: FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria

Project results published: > N-Arachidonoyl glycine suppresses Na⁺/Ca²⁺ exchang... Br J Pharmacol. 2013; 169(4):933-948; > The endocannabinoid N-arachidonoyl glycine (NAGly)... J Cell Sci. 2013; 126(Pt 4):879-888; > Molecularly distinct routes of mitochondrial Ca2+ ... J Biol Chem. 2013; 288(21):15367-15379; > Characterization of distinct single-channel proper... Pflugers Arch. 2013; 465(7):997-1010; > Spatiotemporal Correlations between Cytosolic and ... PLoS One. 2012; 7(9):e45917-e45917; > Mitochondrial Ca2+ uptake 1 (MICU1) and mitochondr... J Biol Chem. 2012; 287(41):34445-34454; > Endothelial mitochondria--less respiration, more i... Pflugers Arch. 2012; 464(1):63-76; > Studying mitochondrial Ca(2+) uptake - a revisit.... Mol Cell Endocrinol. 2012; 353(1-2):114-127; > Inhibition of autophagy rescues palmitic acid indu... J Biol Chem. 2012; 287(25):21110-21120; > Leucine Zipper EF Hand-containing Transmembrane Pr... J Biol Chem. 2011; 286(32):28444-28455; > GPR55-dependent and -independent ion signalling in... Br J Pharmacol. 2010; 161(2): 308-320.; > The contribution of UCP2 and UCP3 to mitochondrial... Cell Calcium. 2010; 47(5): 433-440.