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GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling
Subproject of: GOLD3 - Genomics Of Lipid Droplet Biology, Component 5: Discovery of lipolytic activities by in vivo proteomic profiling
- Abstract
- Lipid-associated disorders constitute a major health treat wordlwide. Currently more than one billion individuals are overweight or obese and it is estimated that by 2010 more than 300 million patients will be affected by insulin resistance and type-II diabetes.
The general aim of GOLD 3 is to elucidate processes that govern the biology of lipid droplets (LD), their synthesis and mobilization under normal and pathological conditions.
The proposed project will discover genes, proteins, and metabolites involved in the generation and catabolsim of LD in human cells. The characterization of their biochemical function, regulation od their expression, and 3-D structure will reveal currently unknown mechanisms and pathways that control the generation of lipid signalling molecules, energy substrates and membrane components affecting cell tissue function as well as energy homeostasis.
- Local Subprojectlead:
- Birner-Grünberger Ruth
- Duration:
- 01.02.2009-30.04.2012
- Programme:
- GENAU
- Type of Research
- applied research
- MUG Research Units
- Center for Medical Research (ZMF)
- Division of Molecular Biology and Biochemistry
- Project partners
- Department for Social Studies of Science, University of Vienna, Austria
- Division of Genetic Epidemiology, Medical University Innsbruck, Austria
- Institut für Biochemie/Technische Universität Graz, Austria
- Institut für Chemie, Universität Graz, Austria
- Institute for Molecular Biosciences, Austria
- Institute of Medical Biochemistry, Medical University of Vienna, Austria
- Technische Universität Graz, Institut für Genomik und Bioinformatik , Austria
- Project results published
- > Conformational plasticity and ligand binding of ba... J Biol Chem. 2013; 288(43):31093-31104
- > Lipolytic proteomics.... Mass Spectrom Rev. 2012; 31(5):570-582
- > Adiponutrin functions as a nutritionally regulated... Cell Metab. 2012; 15(5):691-702
- > Activity based subcellular resolution imaging of l... Bioorg Med Chem. 2012; 20(2):628-632
- > Functional mapping of CGI-58/ABHD5... Proccedings of the 10th Austrian Proteomic Research Symposium. 2012; -10th Austrian Proteomic Research Symposium, Special Focus on Functional Proteomics; SEP 24-26, 2012; Graz, AUSTRIA. (ISBN: 978-3-200-02789-3 )
- > Altered activity-based profiles of lipases in muri... Proceedings of the Keystone Symposium Cancer and Metabolism. 2012; -Keystone Symposium Cancer and Metabolism; Feb 12-17; Banff, Canada.
- > Activity-based imaging of lipases... 5th EU-Summer school "Proteomic Basics"; Jul 31 - Aug 6, 2011; Brixen, Italy. 2011.
- > Activity-based imaging of lipases... 18th Annual Meeting of the Austrian Atherosclerosis Society; MAY 6-7, 2011; St. Gilgen, Austria. 2011.
- > Lipo-proteomics: functional proteomics in lipid re... IMP Seminar Series; Mar 30, 2011; Vienna, AUSTRIA. 2011.
- > Highlights of the MUG Proteomics Core Facility... Dionex BioanalytiClub; Mar 29, 2011; Graz, Austria. 2011.
- > In vivo profiling of lipases by CLICK-DABGE... 5th EU-Summer school "Proteomic Basics"; Jul 31 - Aug 6, 2011; Brixen, Italy. 2011.
- > Functional proteomic analysis of lipases and ester... J Proteome Res. 2010; 9(12): 6334-6344.
- > Chemical tools in lipid metabolism functional prot... 3rd International Symposium on Lipid and Membrane Biology. 2010; -3rd International Symposium on Lipid and Membrane Biology; Mar 18-20, 2010; Graz, Austria.
- > Activity-based profiling of lipases in living cell... Methods Mol Biol. 2009; 580: 251-266.
- > Functional proteomics in lipid research: lipases, ... J Proteomics. 2009; 72(6): 1006-1018.