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Exploring the Cellular Signal Cascade incuced by Sphingosine-1-Phosphate in Osteoarthritis Chondrocytes

Abstract

The aim of the project is to characterise the cellular signalling pathway by which sphingosine-1-phosphate (S1P) inibits the transcription of degradative enzymes in chondrocytes. Based on preliminary data and the literature we hypothesize that S1P performs this action via the gene product of PTEN (phosphatase and tensin homolog deleted on chromosome 10). This protein is well characterized as a tumour suppressor, bu has so far not been implicated in Osteoarthritis (OA). Therefore this study will identify new potential drug targets in OA and will add to our understanding of the disease process.

Project Leader:

Graninger Winfried

Duration:

01.04.2008-31.07.2010

Programme:

Einzelprojekt

Type of Research

basic research

Staff

Graninger, Winfried, Project Leader

Kremser, Maria-Luise, Co-worker

Peischler, Daniela, Co-worker

Stradner, Martin Helmut, Co-worker

Krischan, Verena, Co-worker

Fessler, Johannes, Co-worker

MUG Research Units

Division of Rheumatology and Immunology

Funded by

FWF, Fonds zur Förderung der Wissenschaftlichen Forschung, Wien, Austria

FWF-Grant-DOI: 10.55776/P21065

Project results published

> Sphingosine 1-phosphate counteracts the effects of... Arthritis Rheum. 2013; 65(8):2113-2122

> The immunosuppressant FTY720 (fingolimod) enhances... BMC Musculoskelet Disord. 2011; 12(11):279-279