Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Abstract: Neuroblastoma (NB) remains still one of the most complex challenges in paediatric oncology. In the past decades most efforts have been made to find potential multimodal therapeutic options in these patients. One lesson we learned from NB was the importance of the biology of NB subtypes for response and duration of remission. There is a lot of evidence that biologically unfavourable types of NBs tend to be more aggressive in local tumor growth and ability to set metastasis. It is generally agreed that these biological attributes are caused by an enhanced ability to escape the specific immunological attack by induction of T-cell mediated tolerance, NB-cell mediated immune escape or dentritic cell (DC) mediated tumor ignorance.

Questions to be answered:
*Does procession of NB cell detritus by DCs lead to monoclonal, oligoclonal or polyclonal epitope presentation?
*Is a reproducible pattern of tumor-associated antigens detectable?
*Is the peptide presentation influenced by either amplification or negativity of N-myc expression on NB cells used in this experiment?

Mitarbeiter*innen: Schwinger, Wolfgang, Projektleiter*in; Birner-Grünberger, Ruth, Projektmitarbeiter*in

Beteiligte MUG-Organisationseinheiten: Abteilung Zentrum für Medizinische Forschung (ZMF); Klinische Abteilung für pädiatrische Hämato-Onkologie

Gefördert durch: Steirische Kinderkrebshilfe, Wickenburggasse 32, 8010 Graz, Österreich