Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
SHR
Neuro
Krebs
Kardio
Stoffw
Microb
Lipid
Chordomas: A retrospective clinical immunohistochemical study
- Abstract
- Chordomas are very rare, low to intermediate-grade malignant tumours, which behave locally aggressive and destructive. They develop from remnants of the notochord in the axial skeleton. Notochordal cells are ectodermally originated. During the embryologic development, when bone and cartilage formation starts, these primitive ectodermal cells become enmeshed by the endochondral ossification, and remanin as remnants in the nucleus pulposus of the intervertebral disk.
Usually, this notochordal tissue regresses between the sixth fetal month and second decade of life. If it still remains as asymptomatic, nonneoplastic rest it is denoted as "ecchordosis physaliphora". However, the option of development of a classic chordoma out of this precursor lesion exists.
The aims of this study are:
*Analysis of the factors predicting survival
*Analysis of immunohistochemical features
- Schlagworte
- Allgemeine Pathologie
- Krebsforschung
- Onkologie
- Hals-, Nasen-, Ohrenkrankheiten
- Orthopädie
- Neurochirurgie
- chordom
- Immunohistochemie
- Projektleitung:
- Leithner Andreas
- Laufzeit:
- 15.06.2007-14.06.2008
- Art der Forschung
- sonstige
- Mitarbeiter*innen
- Leithner, Andreas, Projektleiter*in
- Radl, Roman, Projektmitarbeiter*in
- Bodo, Koppány Bonifác, Projektmitarbeiter*in
- Schmid, Christoph Michael, Projektmitarbeiter*in
- Barth, Alain, Projektmitarbeiter*in
- Windhager, Reinhard, Projektmitarbeiter*in
- Stammberger, Heinz, Projektmitarbeiter*in
- Beham, Alfred, Projektmitarbeiter*in