Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Leithner Katharina |

** = Publikationen gelistet in SCI/SSCI/Pubmed

2022

Originalarbeit (Zeitschrift)

** Robinson, I; Bertsch, A; Leithner, K; Stiegler, P; Olschewski, H; Hrzenjak, A Circulating microRNAs as molecular biomarkers for lung adenocarcinoma.
Cancer Biomark. 2022; 34(4):591-606 Doi: 10.3233/CBM-210205
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Biographical-Item

** Blaszczak, W; Ahmed, A; Leithner, K; Schubert, A; Leech, M; Bonder, C; Tsagakis, I Outlook of women in science: an interview with our authors.
Mol Oncol. 2022; 16(5):1047-1056 Doi: 10.1002/1878-0261.13189 [OPEN ACCESS]
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2021

Originalarbeit (Zeitschrift)

** Bluemel, G; Planque, M; Madreiter-Sokolowski, CT; Haitzmann, T; Hrzenjak, A; Graier, WF; Fendt, SM; Olschewski, H; Leithner, K PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells.
Free Radic Biol Med. 2021; 176:34-45 Doi: 10.1016/j.freeradbiomed.2021.09.007
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** Lesko, J; Triebl, A; Stacher-Priehse, E; Fink-Neuböck, N; Lindenmann, J; Smolle-Jüttner, FM; Köfeler, HC; Hrzenjak, A; Olschewski, H; Leithner, K Phospholipid dynamics in ex vivo lung cancer and normal lung explants.
Exp Mol Med. 2021; 53(1):81-90 Doi: 10.1038/s12276-020-00547-x [OPEN ACCESS]
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Übersichtsarbeit

** Grasmann, G; Mondal, A; Leithner, K Flexibility and Adaptation of Cancer Cells in a Heterogenous Metabolic Microenvironment.
Int J Mol Sci. 2021; 22(3): Doi: 10.3390/ijms22031476 [OPEN ACCESS]
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** Leithner, K New roles for gluconeogenesis in vertebrates.
Current opinion in systems biology. 2021; 28: 100389 Doi: 10.1016/j.coisb.2021.100389
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Abstract (Zeitschrift)

** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, H; Olschewski, H; Leithner, K Expression Pattern and Prognostic Significance of Gluconeogenesis Enzymes in Lung Cancer.
J THORAC ONCOL. 2021; 16(3):S550-S550. [Poster]
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2020

Originalarbeit (Zeitschrift)

** Seidl, C; Panzitt, K; Bertsch, A; Brcic, L; Schein, S; Mack, M; Leithner, K; Prinz, F; Olschewski, H; Kornmueller, K; Hrzenjak, A MicroRNA-182-5p regulates hedgehog signaling pathway and chemosensitivity of cisplatin-resistant lung adenocarcinoma cells via targeting GLI2.
Cancer Lett. 2020; 469: 266-276. Doi: 10.1016/j.canlet.2019.10.044
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** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, HH; Olschewski, H; Leithner, K Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
Mol Oncol. 2020; 14(11):2853-2867 Doi: 10.1002/1878-0261.12780 [OPEN ACCESS]
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Übersichtsarbeit

** Smolle, E; Leithner, K; Olschewski, H Oncogene addiction and tumor mutational burden in non-small-cell lung cancer: Clinical significance and limitations.
Thorac Cancer. 2020; 11(2):205-215 Doi: 10.1111/1759-7714.13246 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, H; Olschewski, H; Leithner, K Distribution and prognostic significance of gluconeogenic and glycolytic phenotypes in non-small cell lung cancer.
WIEN KLIN WOCHENSCHR. 2020; 132(19-20):621-622.-Annual Meeting of the Austrian Society of Pulmonology; OCT 14-16, 2020; virtual. [Oral Communication]
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Kommentar

** Leithner, K Epigenetic Marks Repressing Gluconeogenesis in Liver and Kidney Cancer.
Cancer Res. 2020; 80(4): 657-658. Doi: 10.1158/0008-5472.CAN-19-3953
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2019

Übersichtsarbeit

** Grasmann, G; Smolle, E; Olschewski, H; Leithner, K Gluconeogenesis in cancer cells - Repurposing of a starvation-induced metabolic pathway?
Biochim Biophys Acta Rev Cancer. 2019; 1872(1):24-36 Doi: 10.1016/j.bbcan.2019.05.006 [OPEN ACCESS]
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2018

Originalarbeit (Zeitschrift)

** Frille, A; Leithner, K; Olschewski, A; Olschewski, H; Wohlkönig, C; Hrzenjak, A No erythropoietin-induced growth is observed in non-small cell lung cancer cells.
Int J Oncol. 2018; 52(2): 518-526. Doi: 10.3892/ijo.2017.4225 [OPEN ACCESS]
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** Leithner, K; Triebl, A; Trötzmüller, M; Hinteregger, B; Leko, P; Wieser, BI; Grasmann, G; Bertsch, AL; Züllig, T; Stacher, E; Valli, A; Prassl, R; Olschewski, A; Harris, AL; Köfeler, HC; Olschewski, H; Hrzenjak, A The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Proc Natl Acad Sci U S A. 2018; 115(24):6225-6230 Doi: 10.1073/pnas.1719871115 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Fadejeva, I; Bertsch, A; Panzitt, K; Leithner, K; Olschewski, H; Hrzenjak, A MicroRNA expression in A549 NSCLC cells and non-malignant bronchial epithelial cells under normoxic and hypoxic conditions
WIEN KLIN WOCHENSCHR. 2018; 130(19-20):601-602.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie (ÖGP); OKT 18-20, 2018; Linz, AUSTRIA. [Poster]
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2017

Originalarbeit (Zeitschrift)

** Wohlkoenig, C; Leithner, K; Olschewski, A; Olschewski, H; Hrzenjak, A TR3 is involved in hypoxia-induced apoptosis resistance in lung cancer cells downstream of HIF-1α.
Lung Cancer. 2017; 111(3):15-22 Doi: 10.1016/j.lungcan.2017.06.013
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2016

Originalarbeit (Zeitschrift)

** Leithner, K; Hirschmugl, B; Li, Y; Tang, B; Papp, R; Nagaraj, C; Stacher, E; Stiegler, P; Lindenmann, J; Olschewski, A; Olschewski, H; Hrzenjak, A TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers.
PLoS One. 2016; 11(6):e0157453-e0157453 Doi: 10.1371/journal.pone.0157453 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Nagy, BM; Nagaraj, C; Mangge, H; Meinitzer, A; Leithner, K; Kwapiszewska, G; Kovacs, G; Foris, V; Olschewski, A; Olschewski, H Kynurenine Causes Pulmonary Arterial Relaxation In Pulmonary Hypertension
AM J RESP CRIT CARE. 2016; 193: -International Conference of the American-Thoracic-Society (ATS); MAY 13-18, 2016; San Francisco, CA. [Poster]
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2015

Originalarbeit (Zeitschrift)

** Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Bertsch, A; Olschewski, A; Olschewski, H; Hrzenjak, A Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization.
Mol Cancer. 2015; 14(8):4-4 Doi: 10.1186/1476-4598-14-4 [OPEN ACCESS]
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** Leithner, K PEPCK in cancer cell starvation.
Oncoscience. 2015; 2(10):805-806 Doi: 10.18632/oncoscience.252 [OPEN ACCESS]
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** Leithner, K; Hrzenjak, A; Trötzmüller, M; Moustafa, T; Köfeler, HC; Wohlkoenig, C; Stacher, E; Lindenmann, J; Harris, AL; Olschewski, A; Olschewski, H PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Oncogene. 2015; 34(8):1044-1050 Doi: 10.1038/onc.2014.47
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Abstract (Zeitschrift)

** Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Bertsch, A; Olschewski, A; Olschewski, H; Hrzenjak, A Histone deacetylase inhibitor panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma via HIF-1α destabilisation
Wiener Klinische Wochenschrift. 2015; 127: 816-817.-Annual Meeting of the Austrian Society of Pneumology; Oct 15-17, 2015; Graz, Austria. [Poster]
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** Leithner, K; Hrzenjak, A; Trötzmüller, M; Köfeler, HC; Harris, AL; Olschewski, A; Olschewski, H Beyond Wrburg effect: Adaptation to low glucose involves use of glutamine as alternative carbon source in lung cancer cells
Wiener Klinische Wochenschrift. 2015; 127: 816-816.-Annual Meeting of the Austrian Society of Pneumology; Oct 15-17, 2015; Graz, Austria. [Poster]
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2014

Originalarbeit (Zeitschrift)

** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Hofmann, NA; Gallé, B; Guelly, C; Quehenberger, F; Stiegler, P; Smolle-Jüttner, FM; Philipsen, S; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.
BMC Cancer. 2014; 14(1):40-40 Doi: 10.1186/1471-2407-14-40 [OPEN ACCESS]
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Kurzbericht/Letter

** Leithner, K; Hrzenjak, A; Olschewski, H Gluconeogenesis in cancer: Door wide open.
Proc Natl Acad Sci U S A. 2014; 111(42):E4394-E4394 Doi: 10.1073/pnas.1415680111 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Hrzenjak, A; Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Olschewski, A; Olschewski, H Panobinostat reduces hypoxia-related cisplatin resistance of non-small cell lung carcinoma cells via HIF-1alpha destabilization.
EUR J CANCER. 2014; 50: S203-S204. Doi: 10.1016/S0959-8049(14)50741-1 [Poster]
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** Leithner, K; Hrzenjak, A; Trotzmuller, M; Moustafa, T; Kofeler, HC; Wohlkoenig, C; Stacher, E; Harris, AL; Olschewski, A; Olschewski, H; Role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase in lung cancer.
EUR J CANCER. 2014; 50: S84-S84.-EACR 23; Doi: 10.1016/S0959-8049(14)50315-2 [Poster]
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2013

Abstract (Zeitschrift)

** Wohlkonig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H; Cytosporone B, an nr4a1 specific cytotoxic agent, is not prone to hypoxia-induced apoptosis resistance in A549 cells.
WIEN KLIN WOCHENSCHR. 2013; 125(19-20):663-663.-ÖGP; OKT 24-26, 2013; Vienna, AUSTRIA. [Poster]
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2012

Originalarbeit (Zeitschrift)

** Li, Y; Connolly, M; Nagaraj, C; Tang, B; Bálint, Z; Popper, H; Smolle-Juettner, FM; Lindenmann, J; Kwapiszewska, G; Aaronson, PI; Wohlkoenig, C; Leithner, K; Olschewski, H; Olschewski, A Peroxisome proliferator-activated receptor-β/δ, the acute signaling factor in prostacyclin-induced pulmonary vasodilation.
Am J Respir Cell Mol Biol. 2012; 46(3):372-379 Doi: 10.1165/rcmb.2010-0428OC
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2011

Originalarbeit (Zeitschrift)

** Wohlkoenig, C; Leithner, K; Deutsch, A; Hrzenjak, A; Olschewski, A; Olschewski, H Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells.
Cancer Lett. 2011; 308(2): 134-143. Doi: 10.1016/j.canlet.2011.03.014
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Abstract (Zeitschrift)

** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Ebner, B; Guelly, C; Smolle-Jüttner, FM; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H Neprilysin is induced by hypoxia and is a prognostic factor in non-small cell lung cancer
WIEN KLIN WOCHENSCHR. 2011; 123(17-18):A24-A24.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie; SEPT 8-10, 2011; Vienna, AUSTRIA. [Oral Communication]
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** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H Down-regulation of the pro-apoptotic BCL-2 family member protein Bax by hypoxia may contribute to hypoxia-induced chemotherapy resistance in A549 lung cancer cells
WIEN KLIN WOCHENSCHR. 2011; 123(17-18):A33-A33.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie; SEPT 8-10, 2011; Vienna, AUSTRIA. [Oral Communication]
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2010

Originalarbeit (Zeitschrift)

** Leithner, A; Maurer-Ertl, W; Glehr, M; Friesenbichler, J; Leithner, K; Windhager, R Wikipedia and osteosarcoma: a trustworthy patients' information?
J Am Med Inform Assoc. 2010; 17(4): 373-374. Doi: 10.1136/jamia.2010.004507 [OPEN ACCESS]
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Abstract (Zeitschrift)

** Frille, A; Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H. The influence of erythropoietin on proliferation in lung cancer cell lines
Wiener Klinische Wochenschrift2010; 122(21-2):A51--Jahrestagung 2010 der Österreichischen Gesellschaft für Pneumologie; OKT 7-9, 2010; Graz, AUSTRIA. [Poster]
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** Leithner, K; Wohlkoenig, C; Li, Y; Tang, B; Nagaraj, C; Stacher, E; Balint, Z; Olschewski, A; Olschewski, H Expression of TASK-1 and TASK-3 channels in non-small cell lung cancer
EJC SUPPL. 2010; 8(5): 576 Doi: 10.1016/S1359-6349(10)71377-X [Poster]
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** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Smolle-Juttner, F; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H Constitutive expression of carbonic anhydrase IX in hypoxic and normoxic non-small cell lung cancer fragments
EJC SUPPL. 2010; 8(5): 192 Doi: 10.1016/S1359-6349(10)70999-X [Poster]
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** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Smolle-Juttner, FM; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H Expression of key enzymes for gluconeogenesis and glycogen deposition in lung cancer
WIEN KLIN WOCHENSCHR. 2010; 122(21-22): A50-A50. [Poster]
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** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H Blocking autocrine secreted vascular endothelial growth factor does not enhance cisplatin-induced apoptosis in non-small cell lung cancer cell lines
Wiener Klinische Wochenschrift 2010; 122(21-2):A53--Jahrestagung 2010 der Österreichischen Gesellschaft für Pneumologie; OKT 7-9, 2010; Graz. [Oral Communication]
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** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H Autocrine vascular endothelial growth factor signaling has no influence on the apoptosis induction by cisplatin in non-small cell lung cancer cell lines
EJC SUPPL. 2010; 8(5): 538 Doi: 10.1016/S1359-6349(10)71339-2 [Poster]
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2009

Originalarbeit (Zeitschrift)

** Leithner, K; Stacher, E; Wurm, R; Ploner, F; Quehenberger, F; Wohlkoenig, C; Bálint, Z; Polachova, J; Olschewski, A; Samonigg, H; Popper, HH; Olschewski, H Nuclear and cytoplasmic death receptor 5 as prognostic factors in patients with non-small cell lung cancer treated with chemotherapy.
Lung Cancer. 2009; 65(1):98-104 Doi: 10.1016/j.lungcan.2008.10.015
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** Tang, B; Li, Y; Nagaraj, C; Morty, RE; Gabor, S; Stacher, E; Voswinckel, R; Weissmann, N; Leithner, K; Olschewski, H; Olschewski, A Endothelin-1 inhibits background two-pore domain channel TASK-1 in primary human pulmonary artery smooth muscle cells.
Am J Respir Cell Mol Biol. 2009; 41(4): 476-483. Doi: 10.1165/rcmb.2008-0412OC
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Abstract (Zeitschrift)

** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H Moderate hypoxia induces hypoxic adaptation in an ex-vivo non-small cell lung cancer model
Wiener Klinische Wochenschrift 2009; 121(17-1):A50--ÖGP Annual Congress; JUN 11-13; Salzburg, AUSTRIA. [Poster]
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2008

Originalarbeit (Zeitschrift)

** Leithner, A; Radl, R; Gruber, G; Hochegger, M; Leithner, K; Welkerling, H; Rehak, P; Windhager, R Predictive value of seven preoperative prognostic scoring systems for spinal metastases.
Eur Spine J. 2008; 17(11): 1488-1495. Doi: 10.1007/s00586-008-0763-1 [OPEN ACCESS]
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2006

Originalarbeit (Zeitschrift)

** Leithner, K; Leithner, A; Clar, H; Weinhaeusel, A; Radl, R; Krippl, P; Rehak, P; Windhager, R; Haas, OA; Olschewski, H Mesothelioma mortality in Europe: impact of asbestos consumption and simian virus 40.
Orphanet J Rare Dis. 2006; 1(3): 44-44. Doi: 10.1186/1750-1172-1-44 [OPEN ACCESS]
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2005

Originalarbeit (Zeitschrift)

** Leithner, A; Gapp, M; Radl, R; Pascher, A; Krippl, P; Leithner, K; Windhager, R; Beham, A Immunohistochemical analysis of desmoid tumours.
J CLIN PATHOL. 2005; 58(11): 1152-1156. Doi: 10.1136/jcp.2005.026278 [OPEN ACCESS]
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2004

Originalarbeit (Zeitschrift)

** Leithner, A; Gapp, M; Leithner, K; Radl, R; Krippl, P; Beham, A; Windhager, R Margins in extra-abdominal desmoid tumors: a comparative analysis.
J Surg Oncol. 2004; 86(3):152-156 Doi: 10.1002/jso.20057
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2001

Originalarbeit (Zeitschrift)

** Leithner, A; Lang, S; Windhager, R; Leithner, K; Karlic, H; Kotz, R; Haas, OA Expression of insulin-like growth factor-I (IGF-I) in aneurysmal bone cyst.
Mod Pathol. 2001; 14(11):1100-1104 Doi: 10.1038/modpathol.3880443 [OPEN ACCESS]
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