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Taschler Ulrike |

** = Publications listed in SCI/SSCI/Pubmed

2025

Full paper/article (Journal)

** Gruden, E; Kienzl, M; Danner, L; Kaspret, DM; Pammer, A; Ristic, D; Kindler, O; Doyle, AD; Wright, BL; Taschler, U; Thomas, D; Gurke, R; Baumann-Durchschein, F; Konrad, J; Blesl, A; Schlager, H; Bärnthaler, T; Kargl, J; Schicho, R The endocannabinoid system drives eosinophil infiltration during eosinophilic esophagitis.
Cell Mol Gastroenterol Hepatol. 2025; 101515 Doi: 10.1016/j.jcmgh.2025.101515
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2024

Full paper/article (Journal)

** Breithofer, J; Bulfon, D; Fawzy, N; Tischitz, M; Zitta, C; Hartig, L; Grabner, GF; Pirchheim, A; Hackl, H; Taschler, U; Lass, A; Tam-Amersdorfer, C; Strobl, H; Kratky, D; Zimmermann, R Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols.
J Lipid Res. 2024; 65(12):100685 Doi: 10.1016/j.jlr.2024.100685 [OPEN ACCESS]
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** Bulfon, D; Breithofer, J; Grabner, GF; Fawzy, N; Pirchheim, A; Wolinski, H; Kolb, D; Hartig, L; Tischitz, M; Zitta, C; Bramerdorfer, G; Lass, A; Taschler, U; Kratky, D; Greimel, P; Zimmermann, R Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells.
Nat Commun. 2024; 15(1): 9937 Doi: 10.1038/s41467-024-54213-1 [OPEN ACCESS]
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** Steinhoff, JS; Wagner, C; Dähnhardt, HE; Košić, K; Meng, Y; Taschler, U; Pajed, L; Yang, N; Wulff, S; Kiefer, MF; Petricek, KM; Flores, RE; Li, C; Dittrich, S; Sommerfeld, M; Guillou, H; Henze, A; Raila, J; Wowro, SJ; Schoiswohl, G; Lass, A; Schupp, M Adipocyte HSL is required for maintaining circulating vitamin A and RBP4 levels during fasting.
EMBO Rep. 2024; Doi: 10.1038/s44319-024-00158-x [OPEN ACCESS]
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2023

Full paper/article (Journal)

** Chalhoub, G; Jamnik, A; Pajed, L; Kolleritsch, S; Hois, V; Bagaric, A; Prem, D; Tilp, A; Kolb, D; Wolinski, H; Taschler, U; Zullig, T; Rechberger, GN; Fuchs, C; Trauner, M; Schoiswohl, G; Haemmerle, G Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism
MOL METAB. 2023; 72: 101725 Doi: 10.1016/j.molmet.2023.101725 [OPEN ACCESS]
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** Gruden, E; Kienzl, M; Hasenoehrl, C; Sarsembayeva, A; Ristic, D; Schmid, ST; Maitz, K; Taschler, U; Hahnefeld, L; Gurke, R; Thomas, D; Kargl, J; Schicho, R Tumor microenvironment-derived monoacylglycerol lipase provokes tumor-specific immune responses and lipid profiles.
Prostaglandins Leukot Essent Fatty Acids. 2023; 196: 102585 Doi: 10.1016/j.plefa.2023.102585
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** Kotzbeck, P; Taschler, U; Haudum, C; Foessl, I; Schoiswohl, G; Boulgaropoulos, B; Bounab, K; Einsiedler, J; Pajed, L; Tilp, A; Schwarz, A; Eichmann, TO; Obermayer-Pietsch, B; Giordano, A; Cinti, S; Zechner, R; Pieber, TR Rosiglitazone Reverses Inflammation in Epididymal White Adipose Tissue in Hormone-Sensitive Lipase-Knockout Mice.
J Lipid Res. 2023; 64(1):100305 Doi: 10.1016/j.jlr.2022.100305 [OPEN ACCESS]
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2022

Review

** Pusch, LM; Riegler-Berket, L; Oberer, M; Zimmermann, R; Taschler, U α/β-Hydrolase Domain-Containing 6 (ABHD6)- A Multifunctional Lipid Hydrolase.
Metabolites. 2022; 12(8): Doi: 10.3390/metabo12080761 [OPEN ACCESS]
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** Wagner, C; Hois, V; Taschler, U; Schupp, M; Lass, A KIAA1363-A Multifunctional Enzyme in Xenobiotic Detoxification and Lipid Ester Hydrolysis
METABOLITES. 2022; 12(6): 516 Doi: 10.3390/metabo12060516 [OPEN ACCESS]
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2021

Full paper/article (Journal)

** Chalhoub, G; Kolleritsch, S; Maresch, LK; Taschler, U; Pajed, L; Tilp, A; Eisner, H; Rosina, P; Kien, B; Radner, FPW; Schicho, R; Oberer, M; Schoiswohl, G; Haemmerle, G Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease.
J Lipid Res. 2021; 62:100075 Doi: 10.1016/j.jlr.2021.100075 [OPEN ACCESS]
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** Kienzl, M; Hasenoehrl, C; Maitz, K; Sarsembayeva, A; Taschler, U; Valadez-Cosmes, P; Kindler, O; Ristic, D; Raftopoulou, S; Santiso, A; Bärnthaler, T; Brcic, L; Hahnefeld, L; Gurke, R; Thomas, D; Geisslinger, G; Kargl, J; Schicho, R Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Oncoimmunology. 2021; 10(1): 1965319 Doi: 10.1080/2162402X.2021.1965319 [OPEN ACCESS]
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** Pajed, L; Taschler, U; Tilp, A; Hofer, P; Kotzbeck, P; Kolleritsch, S; Radner, FPW; Pototschnig, I; Wagner, C; Schratter, M; Eder, S; Huetter, S; Schreiber, R; Haemmerle, G; Eichmann, TO; Schweiger, M; Hoefler, G; Kershaw, EE; Lass, A; Schoiswohl, G Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
Commun Biol. 2021; 4(1):323 Doi: 10.1038/s42003-021-01858-z [OPEN ACCESS]
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2020

Full paper/article (Journal)

** Jha, S; Taschler, U; Domenig, O; Poglitsch, M; Bourgeois, B; Pollheimer, M; Pusch, LM; Malovan, G; Frank, S; Madl, T; Gruber, K; Zimmermann, R; Macheroux, P Dipeptidyl peptidase 3 modulates the renin-angiotensin system in mice.
J Biol Chem. 2020; 295(40):13711-13723 Doi: 10.1074/jbc.RA120.014183 [OPEN ACCESS]
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** Wagner, C; Hois, V; Pajed, L; Pusch, LM; Wolinski, H; Trauner, M; Zimmermann, R; Taschler, U; Lass, A Lysosomal acid lipase is the major acid retinyl ester hydrolase in cultured human hepatic stellate cells but not essential for retinyl ester degradation.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(8): 158730-158730. Doi: 10.1016/j.bbalip.2020.158730 [OPEN ACCESS]
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Review

** Hofer, P; Taschler, U; Schreiber, R; Kotzbeck, P; Schoiswohl, G The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.
Metabolites. 2020; 10(4): Doi: 10.3390/metabo10040147 [OPEN ACCESS]
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2019

Full paper/article (Journal)

** Grabner, GF; Fawzy, N; Pribasnig, MA; Trieb, M; Taschler, U; Holzer, M; Schweiger, M; Wolinski, H; Kolb, D; Horvath, A; Breinbauer, R; Rülicke, T; Rabl, R; Lass, A; Stadlbauer, V; Hutter-Paier, B; Stauber, RE; Fickert, P; Zechner, R; Marsche, G; Eichmann, TO; Zimmermann, R Metabolic disease and ABHD6 alter the circulating bis(monoacylglycerol)phosphate profile in mice and humans.
J Lipid Res. 2019; 60(5):1020-1031 Doi: 10.1194/jlr.M093351 [OPEN ACCESS]
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** Maresch, LK; Benedikt, P; Feiler, U; Eder, S; Zierler, KA; Taschler, U; Kolleritsch, S; Eichmann, TO; Schoiswohl, G; Leopold, C; Wieser, BI; Lackner, C; Rülicke, T; van, Klinken, J; Kratky, D; Moustafa, T; Hoefler, G; Haemmerle, G Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.
Hepatol Commun. 2019; 3(2):227-245 Doi: 10.1002/hep4.1292 [OPEN ACCESS]
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** Pajed, L; Wagner, C; Taschler, U; Schreiber, R; Kolleritsch, S; Fawzy, N; Pototschnig, I; Schoiswohl, G; Pusch, LM; Wieser, BI; Vesely, P; Hoefler, G; Eichmann, TO; Zimmermann, R; Lass, A Hepatocyte-specific deletion of lysosomal acid lipase leads to cholesteryl ester but not triglyceride or retinyl ester accumulation.
J Biol Chem. 2019; 294(23):9118-9133 Doi: 10.1074/jbc.RA118.007201 [OPEN ACCESS]
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2017

Review

** Grabner, GF; Zimmermann, R; Schicho, R; Taschler, U Monoglyceride lipase as a drug target: At the crossroads of arachidonic acid metabolism and endocannabinoid signaling.
Pharmacol Ther. 2017; 175:35-46 Doi: 10.1016/j.pharmthera.2017.02.033 [OPEN ACCESS]
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** Taschler, U; Hasenoehrl, C; Storr, M; Schicho, R Cannabinoid Receptors in Regulating the GI Tract: Experimental Evidence and Therapeutic Relevance.
Handb Exp Pharmacol. 2017; 239(6):343-362 Doi: 10.1007/164_2016_105
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2016

Full paper/article (Journal)

** Grabner, GF; Eichmann, TO; Wagner, B; Gao, Y; Farzi, A; Taschler, U; Radner, FP; Schweiger, M; Lass, A; Holzer, P; Zinser, E; Tschöp, MH; Yi, CX; Zimmermann, R Deletion of Monoglyceride Lipase in Astrocytes Attenuates Lipopolysaccharide-induced Neuroinflammation.
J Biol Chem. 2016; 291(2):913-23 Doi: 10.1074/jbc.M115.683615 [OPEN ACCESS]
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** Grumet, L; Eichmann, TO; Taschler, U; Zierler, KA; Leopold, C; Moustafa, T; Radovic, B; Romauch, M; Yan, C; Du, H; Haemmerle, G; Zechner, R; Fickert, P; Kratky, D; Zimmermann, R; Lass, A Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover.
J Biol Chem. 2016; 291(34):17977-87 Doi: 10.1074/jbc.M116.724054 [OPEN ACCESS]
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** Heier, C; Taschler, U; Radulovic, M; Aschauer, P; Eichmann, TO; Grond, S; Wolinski, H; Oberer, M; Zechner, R; Kohlwein, SD; Zimmermann, R Monoacylglycerol Lipases Act as Evolutionarily Conserved Regulators of Non-oxidative Ethanol Metabolism.
J Biol Chem. 2016; 291(22):11865-75 Doi: 10.1074/jbc.M115.705541 [OPEN ACCESS]
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** Trieb, M; Horvath, A; Birner-Gruenberger, R; Spindelboeck, W; Stadlbauer, V; Taschler, U; Curcic, S; Stauber, RE; Holzer, M; Pasterk, L; Heinemann, A; Marsche, G Liver disease alters high-density lipoprotein composition, metabolism and function.
Biochim Biophys Acta. 2016; 1861(7):630-638 Doi: 10.1016/j.bbalip.2016.04.013 [OPEN ACCESS]
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Review

** Hasenoehrl, C; Taschler, U; Storr, M; Schicho, R The gastrointestinal tract - a central organ of cannabinoid signaling in health and disease.
Neurogastroenterol Motil. 2016; 28(12):1765-1780 Doi: 10.1111/nmo.12931 [OPEN ACCESS]
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2015

Full paper/article (Journal)

** Eichmann, TO; Grumet, L; Taschler, U; Hartler, J; Heier, C; Woblistin, A; Pajed, L; Kollroser, M; Rechberger, G; Thallinger, GG; Zechner, R; Haemmerle, G; Zimmermann, R; Lass, A ATGL and CGI-58 are lipid droplet proteins of the hepatic stellate cell line HSC-T6.
J Lipid Res. 2015; 56(10):1972-84 Doi: 10.1194/jlr.M062372 [OPEN ACCESS]
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** Imperatore, R; Morello, G; Luongo, L; Taschler, U; Romano, R; De Gregorio, D; Belardo, C; Maione, S; Di Marzo, V; Cristino, L Genetic deletion of monoacylglycerol lipase leads to impaired cannabinoid receptor CB₁R signaling and anxiety-like behavior.
J Neurochem. 2015; 135(4):799-813 Doi: 10.1111/jnc.13267 [OPEN ACCESS]
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** Navia-Paldanius, D; Aaltonen, N; Lehtonen, M; Savinainen, JR; Taschler, U; Radner, FP; Zimmermann, R; Laitinen, JT Increased tonic cannabinoid CB1R activity and brain region-specific desensitization of CB1R Gi/o signaling axis in mice with global genetic knockout of monoacylglycerol lipase.
Eur J Pharm Sci. 2015; 77(7):180-188 Doi: 10.1016/j.ejps.2015.06.005
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** Pribasnig, MA; Mrak, I; Grabner, GF; Taschler, U; Knittelfelder, O; Scherz, B; Eichmann, TO; Heier, C; Grumet, L; Kowaliuk, J; Romauch, M; Holler, S; Anderl, F; Wolinski, H; Lass, A; Breinbauer, R; Marsche, G; Brown, JM; Zimmermann, R α/β Hydrolase Domain-containing 6 (ABHD6) Degrades the Late Endosomal/Lysosomal Lipid Bis(monoacylglycero)phosphate.
J Biol Chem. 2015; 290(50):29869-81 Doi: 10.1074/jbc.M115.669168 [OPEN ACCESS]
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** Schreiber, R; Hofer, P; Taschler, U; Voshol, PJ; Rechberger, GN; Kotzbeck, P; Jaeger, D; Preiss-Landl, K; Lord, CC; Brown, JM; Haemmerle, G; Zimmermann, R; Vidal-Puig, A; Zechner, R Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Proc Natl Acad Sci U S A. 2015; 112(45):13850-13855 Doi: 10.1073/pnas.1516004112 [OPEN ACCESS]
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** Taschler, U; Eichmann, TO; Radner, FP; Grabner, GF; Wolinski, H; Storr, M; Lass, A; Schicho, R; Zimmermann, R Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.
Br J Pharmacol. 2015; 172(17):4419-29 Doi: 10.1111/bph.13224 [OPEN ACCESS]
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** Taschler, U; Schreiber, R; Chitraju, C; Grabner, GF; Romauch, M; Wolinski, H; Haemmerle, G; Breinbauer, R; Zechner, R; Lass, A; Zimmermann, R Adipose triglyceride lipase is involved in the mobilization of triglyceride and retinoid stores of hepatic stellate cells.
Biochim Biophys Acta. 2015; 1851(7):937-45 Doi: 10.1016/j.bbalip.2015.02.017 [OPEN ACCESS]
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2014

Full paper/article (Journal)

** Schweiger, M; Eichmann, TO; Taschler, U; Zimmermann, R; Zechner, R; Lass, A Measurement of lipolysis.
Methods Enzymol. 2014; 538:171-93 Doi: 10.1016/B978-0-12-800280-3.00010-4 [OPEN ACCESS]
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2013

Full paper/article (Journal)

** Thomas, G; Betters, JL; Lord, CC; Brown, AL; Marshall, S; Ferguson, D; Sawyer, J; Davis, MA; Melchior, JT; Blume, LC; Howlett, AC; Ivanova, PT; Milne, SB; Myers, DS; Mrak, I; Leber, V; Heier, C; Taschler, U; Blankman, JL; Cravatt, BF; Lee, RG; Crooke, RM; Graham, MJ; Zimmermann, R; Brown, HA; Brown, JM The serine hydrolase ABHD6 Is a critical regulator of the metabolic syndrome.
Cell Rep. 2013; 5(2):508-520 Doi: 10.1016/j.celrep.2013.08.047 [OPEN ACCESS]
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2012

Full paper/article (Journal)

** Rengachari, S; Bezerra, GA; Riegler-Berket, L; Gruber, CC; Sturm, C; Taschler, U; Boeszoermenyi, A; Dreveny, I; Zimmermann, R; Gruber, K; Oberer, M The structure of monoacylglycerol lipase from Bacillus sp. H257 reveals unexpected conservation of the cap architecture between bacterial and human enzymes.
Biochim Biophys Acta. 2012; 1821(7): 1012-1021. Doi: 10.1016/j.bbalip.2012.04.006 [OPEN ACCESS]
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Review

** Schreiber, R; Taschler, U; Preiss-Landl, K; Wongsiriroj, N; Zimmermann, R; Lass, A Retinyl ester hydrolases and their roles in vitamin A homeostasis.
Biochim Biophys Acta. 2012; 1821(1):113-123 Doi: 10.1016/j.bbalip.2011.05.001 [OPEN ACCESS]
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2011

Full paper/article (Journal)

** Taschler, U; Radner, FP; Heier, C; Schreiber, R; Schweiger, M; Schoiswohl, G; Preiss-Landl, K; Jaeger, D; Reiter, B; Koefeler, HC; Wojciechowski, J; Theussl, C; Penninger, JM; Lass, A; Haemmerle, G; Zechner, R; Zimmermann, R Monoglyceride lipase deficiency in mice impairs lipolysis and attenuates diet-induced insulin resistance.
J Biol Chem. 2011; 286(20):17467-17477 Doi: 10.1074/jbc.M110.215434 [OPEN ACCESS]
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2010

Full paper/article (Journal)

** Heier, C; Taschler, U; Rengachari, S; Oberer, M; Wolinski, H; Natter, K; Kohlwein, SD; Leber, R; Zimmermann, R Identification of Yju3p as functional orthologue of mammalian monoglyceride lipase in the yeast Saccharomycescerevisiae.
Biochim Biophys Acta. 2010; 1801(9):1063-1071 Doi: 10.1016/j.bbalip.2010.06.001 [OPEN ACCESS]
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** Schoiswohl, G; Schweiger, M; Schreiber, R; Gorkiewicz, G; Preiss-Landl, K; Taschler, U; Zierler, KA; Radner, FP; Eichmann, TO; Kienesberger, PC; Eder, S; Lass, A; Haemmerle, G; Alsted, TJ; Kiens, B; Hoefler, G; Zechner, R; Zimmermann, R Adipose triglyceride lipase plays a key role in the supply of the working muscle with fatty acids.
J Lipid Res. 2010; 51(3): 490-9. Doi: 10.1194/jlr.M001073 [OPEN ACCESS]
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2009

Full paper/article (Journal)

** Schreiber, R; Taschler, U; Wolinski, H; Seper, A; Tamegger, SN; Graf, M; Kohlwein, SD; Haemmerle, G; Zimmermann, R; Zechner, R; Lass, A Esterase 22 and beta-glucuronidase hydrolyze retinoids in mouse liver.
J Lipid Res. 2009; 50(12):2514-2523 Doi: 10.1194/jlr.M000950 [OPEN ACCESS]
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