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Hrzenjak Andelko |
** = Publications listed in SCI/SSCI/Pubmed
2024
Full paper/article (Journal)
** Haitzmann, T; Schindlmaier, K; Frech, T; Mondal, A; Bubalo, V; Konrad, B; Bluemel, G; Stiegler, P; Lackner, S; Hrzenjak, A; Eichmann, T; Köfeler, HC; Leithner, K
Serine synthesis and catabolism in starved lung cancer and primary bronchial epithelial cells.
Cancer Metab. 2024; 12(1): 9
Doi: 10.1186/s40170-024-00337-3
[OPEN ACCESS]
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** Slanovc, J; Mikulčić, M; Jahn, N; Wizsy, NGT; Sattler, W; Malle, E; Hrzenjak, A
Prostaglandin 15d-PGJ2 inhibits proliferation of lung adenocarcinoma cells by inducing ROS production and activation of apoptosis via sirtuin-1.
Biochim Biophys Acta Mol Basis Dis. 2024; 1870(1):166924
Doi: 10.1016/j.bbadis.2023.166924
Web of Science
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2023
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** Paar, M; Aziz, F; Sourij, C; Tripolt, NJ; Kojzar, H; Müller, A; Pferschy, P; Obermayer, A; Banfic, T; Di, Geronimo, Quintero, B; Goswami, N; Schlagenhauf, A; Köstenberger, M; Bärnthaler, T; Wagner, T; Hrzenjak, A; Wonisch, W; Reibnegger, G; Raggam, RB; Sourij, H; Cvirn, G
Only Subclinical Alterations in the Haemostatic System of People with Diabetes after COVID-19 Vaccination.
Viruses. 2023; 15(1): 10
Doi: 10.3390/v15010010
[OPEN ACCESS]
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** Rossmann, C; Ranz, C; Kager, G; Ledinski, G; Koestenberger, M; Wonisch, W; Wagner, T; Schwaminger, SP; Di, Geronimo, B; Hrzenjak, A; Hallstöm, S; Reibnegger, G; Cvirn, G; Paar, M
Metformin Impedes Oxidation of LDL In Vitro.
Pharmaceutics. 2023; 15(8):
Doi: 10.3390/pharmaceutics15082111
[OPEN ACCESS]
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2022
Full paper/article (Journal)
** Klingseisen, V; Slanovc, J; Regouc, M; Hrzenjak, A
Bisdemethoxycurcumin sensitizes the response of cisplatin resistant non-small cell lung carcinoma cell lines by activating apoptosis and autophagy
J NUTR BIOCHEM. 2022; 106: 109003
Doi: 10.1016/j.jnutbio.2022.109003
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** Robinson, I; Bertsch, A; Leithner, K; Stiegler, P; Olschewski, H; Hrzenjak, A
Circulating microRNAs as molecular biomarkers for lung adenocarcinoma.
Cancer Biomark. 2022; 34(4):591-606
Doi: 10.3233/CBM-210205
Web of Science
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Abstract (Journal)
** Slanovc, J; Mikulcic, M; Jahn, N; Tabrizi-Wizsy, NG; Hrzenjak, A
Prostaglandin 15d-PGJ2 is a potent compound for treatment of lung adenocarcinoma
WIEN KLIN WOCHENSCHR. 2022; 134(19-20): 724-724.
[Poster]
Web of Science
2021
Full paper/article (Journal)
** Bluemel, G; Planque, M; Madreiter-Sokolowski, CT; Haitzmann, T; Hrzenjak, A; Graier, WF; Fendt, SM; Olschewski, H; Leithner, K
PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells.
Free Radic Biol Med. 2021; 176:34-45
Doi: 10.1016/j.freeradbiomed.2021.09.007
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** Lesko, J; Triebl, A; Stacher-Priehse, E; Fink-Neuböck, N; Lindenmann, J; Smolle-Jüttner, FM; Köfeler, HC; Hrzenjak, A; Olschewski, H; Leithner, K
Phospholipid dynamics in ex vivo lung cancer and normal lung explants.
Exp Mol Med. 2021; 53(1):81-90
Doi: 10.1038/s12276-020-00547-x
[OPEN ACCESS]
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** Mikulčić, M; Tabrizi-Wizsy, NG; Bernhart, EM; Asslaber, M; Trummer, C; Windischhofer, W; Sattler, W; Malle, E; Hrzenjak, A
15d-PGJ2 Promotes ROS-Dependent Activation of MAPK-Induced Early Apoptosis in Osteosarcoma Cell In Vitro and in an Ex Ovo CAM Assay.
Int J Mol Sci. 2021; 22(21):
Doi: 10.3390/ijms222111760
[OPEN ACCESS]
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** Schilcher, I; Stadler, JT; Lechleitner, M; Hrzenjak, A; Berghold, A; Pregartner, G; Lhomme, M; Holzer, M; Korbelius, M; Reichmann, F; Springer, A; Wadsack, C; Madl, T; Kratky, D; Kontush, A; Marsche, G; Frank, S
Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
Int J Mol Sci. 2021; 22(2):
Doi: 10.3390/ijms22020719
[OPEN ACCESS]
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Abstract (Journal)
** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, H; Olschewski, H; Leithner, K
Expression Pattern and Prognostic Significance of Gluconeogenesis Enzymes in Lung Cancer.
J THORAC ONCOL. 2021; 16(3):S550-S550.
[Poster]
Web of Science
2020
Full paper/article (Journal)
** Seidl, C; Panzitt, K; Bertsch, A; Brcic, L; Schein, S; Mack, M; Leithner, K; Prinz, F; Olschewski, H; Kornmueller, K; Hrzenjak, A
MicroRNA-182-5p regulates hedgehog signaling pathway and chemosensitivity of cisplatin-resistant lung adenocarcinoma cells via targeting GLI2.
Cancer Lett. 2020; 469: 266-276.
Doi: 10.1016/j.canlet.2019.10.044
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** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, HH; Olschewski, H; Leithner, K
Distribution and prognostic significance of gluconeogenesis and glycolysis in lung cancer.
Mol Oncol. 2020; 14(11):2853-2867
Doi: 10.1002/1878-0261.12780
[OPEN ACCESS]
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Abstract (Journal)
** Smolle, E; Leko, P; Stacher-Priehse, E; Brcic, L; El-Heliebi, A; Hofmann, L; Quehenberger, F; Hrzenjak, A; Popper, H; Olschewski, H; Leithner, K
Distribution and prognostic significance of gluconeogenic and glycolytic phenotypes in non-small cell lung cancer.
WIEN KLIN WOCHENSCHR. 2020; 132(19-20):621-622.-Annual Meeting of the Austrian Society of Pulmonology; OCT 14-16, 2020; virtual.
[Oral Communication]
Web of Science
2019
Full paper/article (Journal)
** Papp, R; Nagaraj, C; Zabini, D; Nagy, BM; Lengyel, M; Skofic Maurer, D; Sharma, N; Egemnazarov, B; Kovacs, G; Kwapiszewska, G; Marsh, LM; Hrzenjak, A; Höfler, G; Didiasova, M; Wygrecka, M; Sievers, LK; Szucs, P; Enyedi, P; Ghanim, B; Klepetko, W; Olschewski, H; Olschewski, A
Targeting TMEM16A to reverse vasoconstriction and remodelling in idiopathic pulmonary arterial hypertension.
Eur Respir J. 2019; 53(6): 1800965
Doi: 10.1183/13993003.00965-2018
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Short report/Letter
** Müller, M; Graf, R; Kashofer, K; Macher, S; Wölfler, A; Zebisch, A; Hrzenjak, A; Heitzer, E; Sill, H
Detection of AML-specific TP53 mutations in bone marrow-derived mesenchymal stromal cells cultured under hypoxia conditions.
Ann Hematol. 2019; 98(8):2019-2020
Doi: 10.1007/s00277-019-03680-4
[OPEN ACCESS]
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2018
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** Frille, A; Leithner, K; Olschewski, A; Olschewski, H; Wohlkönig, C; Hrzenjak, A
No erythropoietin-induced growth is observed in non-small cell lung cancer cells.
Int J Oncol. 2018; 52(2): 518-526.
Doi: 10.3892/ijo.2017.4225
[OPEN ACCESS]
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** Leithner, K; Triebl, A; Trötzmüller, M; Hinteregger, B; Leko, P; Wieser, BI; Grasmann, G; Bertsch, AL; Züllig, T; Stacher, E; Valli, A; Prassl, R; Olschewski, A; Harris, AL; Köfeler, HC; Olschewski, H; Hrzenjak, A
The glycerol backbone of phospholipids derives from noncarbohydrate precursors in starved lung cancer cells.
Proc Natl Acad Sci U S A. 2018; 115(24):6225-6230
Doi: 10.1073/pnas.1719871115
[OPEN ACCESS]
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Abstract (Journal)
** Fadejeva, I; Bertsch, A; Panzitt, K; Leithner, K; Olschewski, H; Hrzenjak, A
MicroRNA expression in A549 NSCLC cells and non-malignant bronchial epithelial cells under normoxic and hypoxic conditions
WIEN KLIN WOCHENSCHR. 2018; 130(19-20):601-602.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie (ÖGP); OKT 18-20, 2018; Linz, AUSTRIA.
[Poster]
Web of Science
2017
Full paper/article (Journal)
** Schilcher, I; Kern, S; Hrzenjak, A; Eichmann, TO; Stojakovic, T; Scharnagl, H; Duta-Mare, M; Kratky, D; Marsche, G; Frank, S
Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein.
Sci Rep. 2017; 7(1):12485-12485
Doi: 10.1038/s41598-017-12882-7
[OPEN ACCESS]
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** Wohlkoenig, C; Leithner, K; Olschewski, A; Olschewski, H; Hrzenjak, A
TR3 is involved in hypoxia-induced apoptosis resistance in lung cancer cells downstream of HIF-1α.
Lung Cancer. 2017; 111(3):15-22
Doi: 10.1016/j.lungcan.2017.06.013
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Review
** Fadejeva, I; Olschewski, H; Hrzenjak, A
MicroRNAs as regulators of cisplatin-resistance in non-small cell lung carcinomas.
Oncotarget. 2017; 8(70):115754-115773
Doi: 10.18632/oncotarget.22975
[OPEN ACCESS]
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2016
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** Leithner, K; Hirschmugl, B; Li, Y; Tang, B; Papp, R; Nagaraj, C; Stacher, E; Stiegler, P; Lindenmann, J; Olschewski, A; Olschewski, H; Hrzenjak, A
TASK-1 Regulates Apoptosis and Proliferation in a Subset of Non-Small Cell Lung Cancers.
PLoS One. 2016; 11(6):e0157453-e0157453
Doi: 10.1371/journal.pone.0157453
[OPEN ACCESS]
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Review
** Hrzenjak, A
JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas.
Orphanet J Rare Dis. 2016; 11(6):15-15
Doi: 10.1186/s13023-016-0400-8
[OPEN ACCESS]
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Abstract (Journal)
** Schilcher, I; Hrzenjak, A; Eichmann, T; Stojakovic, T; Scharnagl, H; Marsche, G; Frank, S
IMPACT OF ENDOTHELIAL LIPASE OVEREXPRESSION ON CHOLESTEROL EFFLUX CAPACITY OF SERUM, APOLIPOPROTEIN B-DEPLETED SERUM AND HDL
ATHEROSCLEROSIS. 2016; 252: E207-E207.-Congress of the European-Atherosclerosis-Society (EAS); MAY 29-JUN 01, 2016; Innsbruck, AUSTRIA.
Doi: 10.1016/j.atherosclerosis.2016.07.140
[Poster]
Web of Science
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2015
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** Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Bertsch, A; Olschewski, A; Olschewski, H; Hrzenjak, A
Panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma cells via HIF-1α destabilization.
Mol Cancer. 2015; 14(8):4-4
Doi: 10.1186/1476-4598-14-4
[OPEN ACCESS]
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** Leithner, K; Hrzenjak, A; Trötzmüller, M; Moustafa, T; Köfeler, HC; Wohlkoenig, C; Stacher, E; Lindenmann, J; Harris, AL; Olschewski, A; Olschewski, H
PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Oncogene. 2015; 34(8):1044-1050
Doi: 10.1038/onc.2014.47
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Abstract (Journal)
** Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Bertsch, A; Olschewski, A; Olschewski, H; Hrzenjak, A
Histone deacetylase inhibitor panobinostat reduces hypoxia-induced cisplatin resistance of non-small cell lung carcinoma via HIF-1α destabilisation
Wiener Klinische Wochenschrift. 2015; 127: 816-817.-Annual Meeting of the Austrian Society of Pneumology; Oct 15-17, 2015; Graz, Austria.
[Poster]
Web of Science
** Frille, A; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H; Wohlkoenig, C
The influence of erythropoietin on growth and survival in non-small cell lung cancer cell lines
EUR RESPIR J. 2015; 46:
Doi: 10.1183/13993003.congress-2015.PA4260
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** Leithner, K; Hrzenjak, A; Trötzmüller, M; Köfeler, HC; Harris, AL; Olschewski, A; Olschewski, H
Beyond Wrburg effect: Adaptation to low glucose involves use of glutamine as alternative carbon source in lung cancer cells
Wiener Klinische Wochenschrift. 2015; 127: 816-816.-Annual Meeting of the Austrian Society of Pneumology; Oct 15-17, 2015; Graz, Austria.
[Poster]
Web of Science
2014
Full paper/article (Journal)
** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Hofmann, NA; Gallé, B; Guelly, C; Quehenberger, F; Stiegler, P; Smolle-Jüttner, FM; Philipsen, S; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
Hypoxia increases membrane metallo-endopeptidase expression in a novel lung cancer ex vivo model - role of tumor stroma cells.
BMC Cancer. 2014; 14(1):40-40
Doi: 10.1186/1471-2407-14-40
[OPEN ACCESS]
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Short report/Letter
** Leithner, K; Hrzenjak, A; Olschewski, H
Gluconeogenesis in cancer: Door wide open.
Proc Natl Acad Sci U S A. 2014; 111(42):E4394-E4394
Doi: 10.1073/pnas.1415680111
[OPEN ACCESS]
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Review
** Hrzenjak, A; Dieber-Rotheneder, M; Moinfar, F; Petru, E; Zatloukal, K
Molecular mechanisms of endometrial stromal sarcoma and undifferentiated endometrial sarcoma as premises for new therapeutic strategies.
Cancer Lett. 2014; 354(1):21-27
Doi: 10.1016/j.canlet.2014.08.013
Web of Science
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Abstract (Journal)
** Frank, S; Opresnik, S; Rao, SP; Hrzenjak, A; Hallstrom, S; Kozina, A; Sreckovic, I; Wadsack, CH; Holzer, M; Marsche, G; Birner-Gruenberger, R; Stojakovic, T; Scharnagl, H
ENDOTHELIAL LIPASE ATTENUATES VASORELAXING CAPACITY OF HDL
ATHEROSCLEROSIS. 2014; 235(2): E45-E45.
Doi: 10.1016/j.atherosclerosis.2014.05.102
[Poster]
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** Hrzenjak, A; Fischer, C; Leithner, K; Wohlkoenig, C; Quehenberger, F; Olschewski, A; Olschewski, H
Panobinostat reduces hypoxia-related cisplatin resistance of non-small cell lung carcinoma cells via HIF-1alpha destabilization.
EUR J CANCER. 2014; 50: S203-S204.
Doi: 10.1016/S0959-8049(14)50741-1
[Poster]
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** Leithner, K; Hrzenjak, A; Trotzmuller, M; Moustafa, T; Kofeler, HC; Wohlkoenig, C; Stacher, E; Harris, AL; Olschewski, A; Olschewski, H;
Role of the gluconeogenic enzyme phosphoenolpyruvate carboxykinase in lung cancer.
EUR J CANCER. 2014; 50: S84-S84.-EACR 23;
Doi: 10.1016/S0959-8049(14)50315-2
[Poster]
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2013
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** Nagaraj, C; Tang, B; Balint, Z; Wygrecka, M; Hrzenjak, A; Kwapiszewska, G; Stacher, E; Lindenmann, J; Weir, EK; Olschewski, H; Olschewski, A
Src tyrosine kinase is crucial for potassium channel function in human pulmonary arteries.
Eur Respir J. 2013; 41(1):85-95
Doi: 10.1183/09031936.00211811
[OPEN ACCESS]
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Abstract (Journal)
** Fischer, C; Leithner, K; Wohlkoenig, C; Stacher, E; Olschewski, A; Olschewski, H; Hrzenjak, A
Histone deacetylase inhibitor panobinostat reduces hypoxia-related cisplatin resistance in NSCLC cells by HDAC-mediated Hif alpha destabilization
EUR RESPIR J. 2013; 42:
Web of Science
** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H
Possible role of nuclear receptor nr4a1 in hypoxia-induced cisplatin resistance
EUR RESPIR J. 2013; 42:
Web of Science
** Wohlkonig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H;
Cytosporone B, an nr4a1 specific cytotoxic agent, is not prone to hypoxia-induced apoptosis resistance in A549 cells.
WIEN KLIN WOCHENSCHR. 2013; 125(19-20):663-663.-ÖGP; OKT 24-26, 2013; Vienna, AUSTRIA.
[Poster]
Web of Science
2012
Abstract (Journal)
** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Hofmann, NA; Ebner, B; Quehenberger, F; Smolle-Juttner, FM; Philipsen, S; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
The metallopeptidase neprilysin is a hypoxia-induced prognostic factor in lung adenocarcinoma
EUR RESPIR J. 2012; 40:
Web of Science
2011
Full paper/article (Journal)
** Crnkovic, S; Hrzenjak, A; Marsh, LM; Olschewski, A; Kwapiszewska, G
Origin of neomuscularized vessels in mice exposed to chronic hypoxia.
Respir Physiol Neurobiol. 2011; 179(2-3):342-345
Doi: 10.1016/j.resp.2011.09.016
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** Riederer, M; Lechleitner, M; Hrzenjak, A; Koefeler, H; Desoye, G; Heinemann, A; Frank, S
Endothelial lipase (EL) and EL-generated lysophosphatidylcholines promote IL-8 expression in endothelial cells.
Atherosclerosis. 2011; 214(2):338-344
Doi: 10.1016/j.atherosclerosis.2010.11.007
[OPEN ACCESS]
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** Wohlkoenig, C; Leithner, K; Deutsch, A; Hrzenjak, A; Olschewski, A; Olschewski, H
Hypoxia-induced cisplatin resistance is reversible and growth rate independent in lung cancer cells.
Cancer Lett. 2011; 308(2): 134-143.
Doi: 10.1016/j.canlet.2011.03.014
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Correction
** Riederer, M; Ojala, PJ; Hrzenjak, A; Graier, WF; Malli, R; Tritscher, M; Hermansson, M; Watzer, B; Schweer, H; Desoye, G; Heinemann, A; Frank, S
Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production (vol 51, pg 2957, 2010)
J LIPID RES. 2011; 52(1): 185-185.
Doi: 10.1194/jlr.M006536ERR
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Abstract (Journal)
** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Ebner, B; Guelly, C; Smolle-Jüttner, FM; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
Neprilysin is induced by hypoxia and is a prognostic factor in non-small cell lung cancer
WIEN KLIN WOCHENSCHR. 2011; 123(17-18):A24-A24.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie; SEPT 8-10, 2011; Vienna, AUSTRIA.
[Oral Communication]
Web of Science
** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H
Down-regulation of the pro-apoptotic BCL-2 family member protein Bax by hypoxia may contribute to hypoxia-induced chemotherapy resistance in A549 lung cancer cells
WIEN KLIN WOCHENSCHR. 2011; 123(17-18):A33-A33.-Jahrestagung der Österreichischen Gesellschaft für Pneumologie; SEPT 8-10, 2011; Vienna, AUSTRIA.
[Oral Communication]
Web of Science
2010
Full paper/article (Journal)
** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Petru, E; Zatloukal, K; Denk, H
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.
Mol Cancer. 2010; 9(10): 49-49.
Doi: 10.1186/1476-4598-9-49
[OPEN ACCESS]
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Google Scholar
** Nusshold, C; Kollroser, M; Köfeler, H; Rechberger, G; Reicher, H; Ullen, A; Bernhart, E; Waltl, S; Kratzer, I; Hermetter, A; Hackl, H; Trajanoski, Z; Hrzenjak, A; Malle, E; Sattler, W
Hypochlorite modification of sphingomyelin generates chlorinated lipid species that induce apoptosis and proteome alterations in dopaminergic PC12 neurons in vitro.
Free Radic Biol Med. 2010; 48(12): 1588-1600.
Doi: 10.1016/j.freeradbiomed.2010.02.037
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** Riederer, M; Ojala, PJ; Hrzenjak, A; Graier, WF; Malli, R; Tritscher, M; Hermansson, M; Watzer, B; Schweer, H; Desoye, G; Heinemann, A; Frank, S
Acyl chain-dependent effect of lysophosphatidylcholine on endothelial prostacyclin production.
J Lipid Res. 2010; 51(10):2957-2966
Doi: 10.1194/jlr.M006536
[OPEN ACCESS]
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Google Scholar
Abstract (Journal)
** Frille, A; Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H.
The influence of erythropoietin on proliferation in lung cancer cell lines
Wiener Klinische Wochenschrift2010; 122(21-2):A51--Jahrestagung 2010 der Österreichischen Gesellschaft für Pneumologie; OKT 7-9, 2010; Graz, AUSTRIA.
[Poster]
Web of Science
** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Petru, E; Zatloukal, K; Denk, H
Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo
EJC SUPPL. 2010; 8(5): 248
Doi: 10.1016/S1359-6349(10)71055-7
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** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Smolle-Juttner, F; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
Constitutive expression of carbonic anhydrase IX in hypoxic and normoxic non-small cell lung cancer fragments
EJC SUPPL. 2010; 8(5): 192
Doi: 10.1016/S1359-6349(10)70999-X
[Poster]
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** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Smolle-Juttner, FM; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
Expression of key enzymes for gluconeogenesis and glycogen deposition in lung cancer
WIEN KLIN WOCHENSCHR. 2010; 122(21-22): A50-A50.
[Poster]
Web of Science
** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H
Blocking autocrine secreted vascular endothelial growth factor does not enhance cisplatin-induced apoptosis in non-small cell lung cancer cell lines
Wiener Klinische Wochenschrift
2010; 122(21-2):A53--Jahrestagung 2010 der Österreichischen Gesellschaft für Pneumologie; OKT 7-9, 2010; Graz.
[Oral Communication]
Web of Science
** Wohlkoenig, C; Leithner, K; Hrzenjak, A; Olschewski, A; Olschewski, H
Autocrine vascular endothelial growth factor signaling has no influence on the apoptosis induction by cisplatin in non-small cell lung cancer cell lines
EJC SUPPL. 2010; 8(5): 538
Doi: 10.1016/S1359-6349(10)71339-2
[Poster]
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2009
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** Marsche, G; Frank, S; Hrzenjak, A; Holzer, M; Dirnberger, S; Wadsack, C; Scharnagl, H; Stojakovic, T; Heinemann, A; Oettl, K
Plasma-advanced oxidation protein products are potent high-density lipoprotein receptor antagonists in vivo.
Circ Res. 2009; 104(6): 750-757.
Doi: 10.1161/CIRCRESAHA.108.193169
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** Leithner, K; Wohlkoenig, C; Stacher, E; Lindenmann, J; Popper, HH; Hrzenjak, A; Olschewski, A; Olschewski, H
Moderate hypoxia induces hypoxic adaptation in an ex-vivo non-small cell lung cancer model
Wiener Klinische Wochenschrift 2009; 121(17-1):A50--ÖGP Annual Congress; JUN 11-13; Salzburg, AUSTRIA.
[Poster]
Web of Science
** Zabini, D; Bálint, Z; Graier, WF; Hrzenjak, A; Olschewski, H; Olschewski, A
Double-stranded RNA affects the TRPC channel expression in human pulmonary artery endothelial cells
WIEN KLIN WOCHENSCHR. 2009; 121(17-18):A57-A58.-ÖGP; JUN 11-13, 2009; Salzburg, AUSTRIA.
[Oral Communication]
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2008
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** Hrzenjak, A; Kremser, ML; Strohmeier, B; Moinfar, F; Zatloukal, K; Denk, H
SAHA induces caspase-independent, autophagic cell death of endometrial stromal sarcoma cells by influencing the mTOR pathway.
J Pathol. 2008; 216(4):495-504
Doi: 10.1002/path.2434
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** Moinfar, F; Beham, A; Friedrich, G; Deutsch, A; Hrzenjak, A; Luschin, G; Tavassoli, FA
Macro-environment of breast carcinoma: frequent genetic alterations in the normal appearing skins of patients with breast cancer.
Mod Pathol. 2008; 21(5):639-646
Doi: 10.1038/modpathol.2008.28
[OPEN ACCESS]
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2007
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** Staber, PB; Vesely, P; Haq, N; Ott, RG; Funato, K; Bambach, I; Fuchs, C; Schauer, S; Linkesch, W; Hrzenjak, A; Dirks, WG; Sexl, V; Bergler, H; Kadin, ME; Sternberg, DW; Kenner, L; Hoefler, G
The oncoprotein NPM-ALK of anaplastic large-cell lymphoma induces JUNB transcription via ERK1/2 and JunB translation via mTOR signaling.
Blood. 2007; 110(9):3374-3383
Doi: 10.1182/blood-2007-02-071258
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** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Zatloukal, K; Denk, H
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, selectively induces growth suppression and cell death of endometrial stromal sarcoma cells in vitro
VIRCHOWS ARCHIV. 2007; 451(2):401-401.-21th European Congress of Pathology; SEPT 8-13, 2007; Istanbul, Turkey.
[Oral Communication]
Web of Science
** Pichler, M; Mischinger, HJ; Ratschek, M; Hatz, M; Hrzenjak, A; Zatloukal, K
A real-time qPCR-based assay for assessment of mRNA quality derived from paraffin-embedded tissues
PATHOL RES PRACT. 2007; 203(5):396-396.-91. Jahrestagung der Deutschen Gesellschaft für Pathologie.; MAY 30 - JUN 2, 2007; Magedeburg, GERMANY.
[Poster]
Web of Science
2006
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** Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Staber, PB; Zatloukal, K; Denk, H
Valproate inhibition of histone deacetylase 2 affects differentiation and decreases proliferation of endometrial stromal sarcoma cells.
Mol Cancer Ther. 2006; 5(9):2203-2210
Doi: 10.1158/1535-7163.MCT-05-0480
[OPEN ACCESS]
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** Kovacevic, A; Hammer, A; Sundl, M; Pfister, B; Hrzenjak, A; Ray, A; Ray, BK; Sattler, W; Malle, E
Expression of serum amyloid A transcripts in human trophoblast and fetal-derived trophoblast-like choriocarcinoma cells.
FEBS LETT. 2006; 580(1): 161-167.
Doi: 10.1016/j.febslet.2005.11.067
[OPEN ACCESS]
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** Leibl, S; Bodo, K; Gogg-Kammerer, M; Hrzenjak, A; Petru, E; Winter, R; Denk, H; Moinfar, F
Ovarian granulosa cell tumors frequently express EGFR (Her-1), Her-3, and Her-4: An immunohistochemical study.
Gynecol Oncol. 2006; 101(1): 18-23.
Doi: 10.1016/j.ygyno.2005.10.009
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** Staber, PB; Vesely, P; Ott, R; Haq, N; Linkesch, W; Schauer, S; Hrzenjak, A; Kenner, L; Dirks, W; Kadin, ME; Sternberg, DW; Hoefler, G
NPM-ALK fusion tyrosine kinase of anaplastic large cell lymphoma exerts its transforming potential by increasing translation of JUNB through mTOR and S6K1.
BLOOD. 2006; 108(11): 414A-415A.
Doi: 10.1182/blood.V108.11.1428.1428
[Poster]
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** Vesely, P; Staber, PB; Ott, R; Pinent, M; Linkesch, W; Schauer, S; Hrzenjak, A; Kadin, ME; Sternberg, DW; Hoefler, G
NPM-ALK converts JUNB from a tumor suppressor to an oncogene.
BLOOD. 2006; 108(11): 419A-420A.
Doi: 10.1182/blood.V108.11.1448.1448
[Poster]
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2005
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** Gauster, M; Hrzenjak, A; Schick, K; Frank, S
Endothelial lipase is inactivated upon cleavage by the members of the proprotein convertase family.
J LIPID RES. 2005; 46(5): 977-987.
Doi: 10.1194/jlr.M400500-JLR200
[OPEN ACCESS]
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Review
** Hrzenjak, A; Moinfar, F; Tavassoli, FA; Strohmeier, B; Kremser, ML; Zatloukal, K; Denk, H
JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue.
J MOL DIAGN. 2005; 7(3): 388-395.
Doi: 10.1016/S1525-1578(10)60568-5
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2004
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** Hrzenjak, A; Reicher, H; Wintersperger, A; Steinecker-Frohnwieser, B; Sedlmayr, P; Schmidt, H; Nakamura, T; Malle, E; Sattler, W
Inhibition of lung carcinoma cell growth by high density lipoprotein-associated alpha-tocopheryl-succinate.
CELL MOL LIFE SCI. 2004; 61(12): 1520-1531.
Doi: 10.1007/s00018-004-4101-4
Web of Science
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** Hrzenjak, A; Tippl, M; Kremser, ML; Strohmeier, B; Guelly, C; Neumeister, D; Lax, S; Moinfar, F; Tabrizi, AD; Isadi-Moud, N; Zatloukal, K; Denk, H
Inverse correlation of secreted frizzled-related protein 4 and beta-catenin expression in endometrial stromal sarcomas.
J PATHOL. 2004; 204(1): 19-27.
Doi: 10.1002/path.1616
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** Sovic, A; Balazs, Z; Hrzenjak, A; Reicher, H; Panzenboeck, U; Malle, E; Sattler, W
Scavenger receptor class B, type I mediates uptake of lipoprotein-associated phosphatidylcholine by primary porcine cerebrovascular endothelial cells.
NEUROSCI LETT. 2004; 368(1): 11-14.
Doi: 10.1016/j.neulet.2004.04.097
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** Wagner, EM; Kratky, D; Haemmerle, G; Hrzenjak, A; Kostner, GM; Steyrer, E; Zechner, R
Defective uptake of triglyceride-associated fatty acids in adipose tissue causes the SREBP-1c-mediated induction of lipogenesis.
J LIPID RES. 2004; 45(2): 356-365.
Doi: 10.1194/jlr.M300293-JLR200
[OPEN ACCESS]
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2003
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** Hrzenjak, A; Frank, S; Wo, X; Zhou, Y; Van Berkel, T; Kostner, GM
Galactose-specific asialoglycoprotein receptor is involved in lipoprotein (a) catabolism.
Biochem J. 2003; 376(Pt 3):765-771
Doi: 10.1042/BJ20030932
[OPEN ACCESS]
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** Wadsack, C; Hrzenjak, A; Hammer, A; Hirschmugl, B; Levak-Frank, S; Desoye, G; Sattler, W; Malle, E
Trophoblast-like human choriocarcinoma cells serve as a suitable in vitro model for selective cholesteryl ester uptake from high density lipoproteins.
Eur J Biochem. 2003; 270(3):451-462
Doi: 10.1046%2Fj.1432-1033.2003.03394.x
[OPEN ACCESS]
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Abstract (Journal)
** Hrzenjak, A; Frank, S; Zhou, Y; Van Berkel, T; Kostner, GM
Galactose specific asialo glycoprotein receptor is involved in lipoprotein(a) catabolism
ATHEROSCLER SUPPL 2003 4: 284-284.
Doi: 10.1016/S1567-5688(03)91214-1
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** Kostner, GM; Hrzenjak, A; Frank, S; Wo, X
The catabolism of Lp(a)
ATHEROSCLER SUPPL 2003 4: 269-269.
Doi: 10.1016/S1567-5688(03)91154-8
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2002
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** Goti, D; Balazs, Z; Panzenboeck, U; Hrzenjak, A; Reicher, H; Wagner, E; Zechner, R; Malle, E; Sattler, W
Effects of lipoprotein lipase on uptake and transcytosis of low density lipoprotein (LDL) and LDL-associated alpha-tocopherol in a porcine in vitro blood-brain barrier model.
J Biol Chem. 2002; 277(32):28537-28544
Doi: 10.1074/jbc.M203989200
[OPEN ACCESS]
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** Maderegger, B; Bermel, W; Hrzenjak, A; Kostner, GM; Sterk, H
Solution structure of human apolipoprotein(a) kringle IV type 6.
Biochemistry. 2002; 41(2):660-668
Doi: 10.1021%2Fbi011430k
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** Panzenboeck, U; Balazs, Z; Sovic, A; Hrzenjak, A; Levak-Frank, S; Wintersperger, A; Malle, E; Sattler, W
ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells.
J Biol Chem. 2002; 277(45):42781-42789
Doi: 10.1074/jbc.M207601200
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** Strauss, JG; Zimmermann, R; Hrzenjak, A; Zhou, Y; Kratky, D; Levak-Frank, S; Kostner, GM; Zechner, R; Frank, S
Endothelial cell-derived lipase mediates uptake and binding of high-density lipoprotein (HDL) particles and the selective uptake of HDL-associated cholesterol esters independent of its enzymic activity.
Biochem J. 2002; 368(Pt 1):69-79
Doi: 10.1042/BJ20020306
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2001
Full paper/article (Journal)
** Frank, S; Gauster, M; Strauss, J; Hrzenjak, A; Kostner, GM
Adenovirus-mediated apo(a)-antisense-RNA expression efficiently inhibits apo(a) synthesis in vitro and in vivo.
Gene Ther. 2001; 8(6):425-430
Doi: 10.1038/sj.gt.3301434
[OPEN ACCESS]
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** Frank, S; Hrzenjak, A; Blaschitz, A; Dohr, G; Kostner, GM
Role of various tissues in apo(a) fragmentation and excretion of fragments by the kidney.
Eur J Clin Invest. 2001; 31(6):504-512
Doi: 10.1046%2Fj.1365-2362.2001.00811.x
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** Goti, D; Hrzenjak, A; Levak-Frank, S; Frank, S; van der Westhuyzen, DR; Malle, E; Sattler, W
Scavenger receptor class B, type I is expressed in porcine brain capillary endothelial cells and contributes to selective uptake of HDL-associated vitamin E.
J Neurochem. 2001; 76(2):498-508
Doi: 10.1046%2Fj.1471-4159.2001.00100.x
[OPEN ACCESS]
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** Hrzenjak, A; Artl, A; Knipping, G; Kostner, G; Sattler, W; Malle, E
Silent mutations in secondary Shine-Dalgarno sequences in the cDNA of human serum amyloid A4 promotes expression of recombinant protein in Escherichia coli.
Protein Eng. 2001; 14(12):949-952
Doi: 10.1093%2Fprotein%2F14.12.949
[OPEN ACCESS]
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** Kostner, K; Spitzauer, S; Rumpold, H; Maurer, G; Knipping, G; Hrzenjak, A; Frank, S; Kostner, GM
Urinary excretion of apolipoprotein(a): relation to other plasma proteins.
Clin Chim Acta. 2001; 304(1-2):29-37
Doi: 10.1016%2FS0009-8981%2800%2900394-6
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** Schulter, V; Koolwijk, P; Peters, E; Frank, S; Hrzenjak, A; Graier, WF; van Hinsbergh, VW; Kostner, GM
Impact of apolipoprotein(a) on in vitro angiogenesis.
Arterioscler Thromb Vasc Biol. 2001; 21(3):433-438
Doi: 10.1161/01.ATV.21.3.433
[OPEN ACCESS]
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** Strauss, JG; Frank, S; Kratky, D; Hämmerle, G; Hrzenjak, A; Knipping, G; von Eckardstein, A; Kostner, GM; Zechner, R
Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice.
J Biol Chem. 2001; 276(39):36083-36090
Doi: 10.1074/jbc.M104430200
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2000
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** Hrzenjak, A; Frank, S; Maderegger, B; Sterk, H; Kostner, GM
Apo(a)-kringle IV-type 6: expression in Escherichia coli, purification and in vitro refolding.
Protein Eng. 2000; 13(9):661-666
Doi: 10.1093%2Fprotein%2F13.9.661
[OPEN ACCESS]
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1999
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** Frank, S; Hrzenjak, A; Kostner, K; Sattler, W; Kostner, GM
Effect of tranexamic acid and delta-aminovaleric acid on lipoprotein(a) metabolism in transgenic mice.
BBA, MOL CELL BIOL LIPIDS. 1999; 1438(1): 99-110.
Doi: 10.1016/S1388-1981(99)00044-X
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** Hrzenjak, A; Perica, MC; Krajacic, M; Mamula, D
Spontaneous infection of Chelidonium majus and Ligustrum sp. with cucumber mosaic Cucumovirus (CMV) encapsidating satellite RNA
PERIOD BIOL. 1999; 101: 229-232.
Web of Science
Abstract (Journal)
** Hrzenjak, A; Frank, S; Kostner, GM
Expression, purification and in vitro refolding of kringle IV-type 6 and kringle V of human apolipoprotein-(a)
ATHEROSCLEROSIS 1999 144: 105-105.
Doi: 10.1016/S0021-9150(99)80404-3
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