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Search Items: MITOCHONDRIA, . hits: 507

2023

Abdellatif, M; Rainer, PP; Sedej, S; Kroemer, G Hallmarks of cardiovascular ageing.
Nat Rev Cardiol. 2023; Doi: 10.1038/s41569-023-00881-3
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Boy, N; Mühlhausen, C; Maier, EM; Ballhausen, D; Baumgartner, MR; Beblo, S; Burgard, P; Chapman, KA; Dobbelaere, D; Heringer-Seifert, J; Fleissner, S; Grohmann-Held, K; Hahn, G; Harting, I; Hoffmann, GF; Jochum, F; Karall, D; Konstantopoulous, V; Krawinkel, MB; Lindner, M; Märtner, EMC; Nuoffer, JM; Okun, JG; Plecko, B; Posset, R; Sahm, K; Scholl-Bürgi, S; Thimm, E; Walter, M; Williams, M; Vom, Dahl, S; Ziagaki, A; Zschocke, J; Kölker, S Recommendations for diagnosing and managing individuals with glutaric aciduria type 1: Third revision.
J Inherit Metab Dis. 2023; 46(3):482-519 Doi: 10.1002/jimd.12566
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Giaglis, S; Daoudlarian, D; Thiel, J; Rizzi, M; Kyburz, D; Venhoff, N; Walker, UA Mitochondrial DNA: a novel indicator of active inflammation in ANCA-associated vasculitides.
Rheumatology (Oxford). 2023; Doi: 10.1093/rheumatology/kead015
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Kendzia, S; Franke, S; Kröhler, T; Golob-Schwarzl, N; Schweiger, C; Toeglhofer, AM; Skofler, C; Uranitsch, S; El-Heliebi, A; Fuchs, J; Punschart, A; Stiegler, P; Keil, M; Hoffmann, J; Henderson, D; Lehrach, H; Yaspo, ML; Reinhard, C; Schäfer, R; Keilholz, U; Regenbrecht, C; Schicho, R; Fickert, P; Lax, SF; Erdmann, F; Schulz, MH; Kiemer, AK; Haybaeck, J; Kessler, SM A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer.
Mol Cancer. 2023; 22(1):89 Doi: 10.1186/s12943-023-01787-x
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Kohshour, MO; Schulte, EC; Heilbronner, U; Budde, M; Kalman, JL; Senner, F; Heilbronner, M; Reich-Erkelenz, D; Schaupp, SK; Vogl, T; Adorjan, K; Anghelescu, IG; Arolt, V; Baune, BT; Dannlowski, U; Dietrich, D; Fallgatter, A; Figge, C; Jager, M; Lang, FU; Juckel, G; Konrad, C; Reimer, J; Reininghaus, EZ; Schmauss, M; Spitzer, C; von Hagen, M; Wiltfang, J; Zimmermann, J; Andlauer, TFM; Nothen, MM; Degenhardt, F; Forstner, AJ; Rietschel, M; Witt, SH; Fischer, A; Falkai, P; Papiol, S; Schulze, TG Association between mitochondria-related genes and cognitive performance in the PsyCourse Study
J AFFECT DISORDERS. 2023; 325: 1-6. Doi: 10.1016/j.jad.2023.01.013
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Messerer, J; Wrede, C; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice.
J Anat. 2023; 242(1):91-101 Doi: 10.1111/joa.13618 [OPEN ACCESS]
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Oflaz, FE; Koshenov, Z; Hirtl, M; Bachkoenig, OA; Graier, WF; Gottschalk, B Synergy of uncoupling proteins (1 and 2) with mitochondrial Ca2+ uptake machinery potentiate mitochondrial uncoupling.
Cell Calcium. 2023; 112:102736 Doi: 10.1016/j.ceca.2023.102736
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Ryan, EM; Sadiku, P; Coelho, P; Watts, ER; Zhang, A; Howden, AJM; Sanchez-Garcia, MA; Bewley, M; Cole, J; McHugh, BJ; Vermaelen, W; Ghesquiere, B; Carmeliet, P; Rodriguez, Blanco, G; Von, Kriegsheim, A; Sanchez, Y; Rumsey, W; Callahan, JF; Cooper, G; Parkinson, N; Baillie, K; Cantrell, DA; McCafferty, J; Choudhury, G; Singh, D; Dockrell, DH; Whyte, MKB; Walmsley, SR NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Am J Respir Crit Care Med. 2023; 207(8):998-1011 Doi: 10.1164/rccm.202203-0482OC [OPEN ACCESS]
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2022

Abdellatif, M; Bugger, H; Kroemer, G; Sedej, S NAD+ and Vascular Dysfunction: From Mechanisms to Therapeutic Opportunities.
J Lipid Atheroscler. 2022; 11(2): 111-132. Doi: 10.12997/jla.2022.11.2.111 [OPEN ACCESS]
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Abdellatif, M; Eisenberg, T; Heberle, AM; Thedieck, K; Kroemer, G; Sedej, S Cardiac PI3K p110 alpha attenuation delays aging and extends lifespan
CELL STRESS. 2022; 6(8): 72-75. Doi: 10.15698/cst2022.08.270 [OPEN ACCESS]
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Abdellatif, M; Madeo, F; Kroemer, G; Sedej, S Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
Autophagy. 2022; 18(10):2500-2502 Doi: 10.1080/15548627.2022.2095835 [OPEN ACCESS]
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Abdellatif, M; Trummer-Herbst, V; Heberle, AM; Humnig, A; Pendl, T; Durand, S; Cerrato, G; Hofer, SJ; Islam, M; Voglhuber, J; Ramos, Pittol, JM; Kepp, O; Hoefler, G; Schmidt, A; Rainer, PP; Scherr, D; von, Lewinski, D; Bisping, E; McMullen, JR; Diwan, A; Eisenberg, T; Madeo, F; Thedieck, K; Kroemer, G; Sedej, S Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Circulation. 2022; 145(25):1853-1866 Doi: 10.1161/CIRCULATIONAHA.122.059863 [OPEN ACCESS]
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Anand, U; Shteinfer-Kuzmine, A; Sela, G; Santhanam, M; Gottschalk, B; Boujemaa-Paterski, R; Medalia, O; Graier, WF; Shoshan-Barmatz, V The Multicellular Effects of VDAC1 N-Terminal-Derived Peptide.
Biomolecules. 2022; 12(10): Doi: 10.3390/biom12101387 [OPEN ACCESS]
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Bachkoenig, OA; Gottschalk, B; Malli, R; Graier, WF An unexpected effect of risperidone reveals a nonlinear relationship between cytosolic Ca2+ and mitochondrial Ca2+ uptake.
Curr Top Membr. 2022; 90: 13-35. Doi: 10.1016/bs.ctm.2022.09.001
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Balihodzic, A; Prinz, F; Dengler, MA; Calin, GA; Jost, PJ; Pichler, M Non-coding RNAs and ferroptosis: potential implications for cancer therapy.
Cell Death Differ. 2022; 29(6):1094-1106 Doi: 10.1038/s41418-022-00998-x [OPEN ACCESS]
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Berghold, VM; Koko, M; Berutti, R; Plecko, B Case report: Novel SCN4A variant associated with a severe congenital myasthenic syndrome/myopathy phenotype.
Front Pediatr. 2022; 10: 944784 Doi: 10.3389/fped.2022.944784 (- Case Report) [OPEN ACCESS]
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Blombery, P; Lew, TE; Dengler, MA; Thompson, ER; Lin, VS; Chen, X; Nguyen, T; Panigrahi, A; Handunnetti, SM; Carney, DA; Westerman, DA; Tam, CS; Adams, JM; Wei, AH; Huang, DCS; Seymour, JF; Roberts, AW; Anderson, MA Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Blood. 2022; 139(8):1198-1207 Doi: 10.1182/blood.2021012775
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Bolsterli, BK; Boltshauser, E; Palmieri, L; Spenger, J; Brunner-Krainz, M; Distelmaier, F; Freisinger, P; Geis, T; Gropman, AL; Haberle, J; Hentschel, J; Jeandidier, B; Karall, D; Keren, B; Klabunde-Cherwon, A; Konstantopoulou, V; Kottke, R; Lasorsa, FM; Makowski, C; Mignot, C; Tuura, RO; Porcelli, V; Santer, R; Sen, K; Steinbrucker, K; Syrbe, S; Wagner, M; Ziegler, A; Zoggeler, T; Mayr, JA; Prokisch, H; Wortmann, SB Ketogenic Diet Treatment of Defects in the Mitochondrial Malate Aspartate Shuttle and Pyruvate Carrier
NUTRIENTS. 2022; 14(17): 3605 Doi: 10.3390/nu14173605 [OPEN ACCESS]
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Bugger, H; Byrne, NJ; Abel, ED Animal Models of Dysregulated Cardiac Metabolism
CIRC RES. 2022; 130(12): 1965-1993. Doi: 10.1161/CIRCRESAHA.122.320334 [OPEN ACCESS]
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Goeritzer, M; Schlager, S; Kuentzel, KB; Vujić, N; Korbelius, M; Rainer, S; Kolb, D; Mussbacher, M; Salzmann, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Madreiter-Sokolowski, CT; Blass, S; Eichmann, TO; Graier, WF; Kratky, D Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Cells. 2022; 11(5): Doi: 10.3390/cells11050850 [OPEN ACCESS]
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Gottschalk, B; Koshenov, Z; Bachkoenig, OA; Rost, R; Malli, R; Graier, WF MFN2 mediates ER-mitochondrial coupling during ER stress through specialized stable contact sites.
Front Cell Dev Biol. 2022; 10: 918691 Doi: 10.3389/fcell.2022.918691 [OPEN ACCESS]
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Gottschalk, B; Koshenov, Z; Waldeck-Weiermair, M; Radulović, S; Oflaz, FE; Hirtl, M; Bachkoenig, OA; Leitinger, G; Malli, R; Graier, WF MICU1 controls spatial membrane potential gradients and guides Ca2+ fluxes within mitochondrial substructures.
Commun Biol. 2022; 5(1): 649 Doi: 10.1038/s42003-022-03606-3 [OPEN ACCESS]
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Gottschalk, B; Madreiter-Sokolowski, CT; Graier, WF Cristae junction as a fundamental switchboard for mitochondrial ion signaling and bioenergetics.
Cell Calcium. 2022; 101:102517 Doi: 10.1016/j.ceca.2021.102517
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Greilberger, J; Herwig, R; Kacar, M; Brajshori, N; Feigl, G; Stiegler, P; Wintersteiger, R Alpha-Ketoglutarate or 5-HMF: Single Compounds Effectively Eliminate Leukemia Cells via Caspase-3 Apoptosis and Antioxidative Pathways.
Int J Mol Sci. 2022; 23(16): Doi: 10.3390/ijms23169034 [OPEN ACCESS]
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Gross, D; Bischof, H; Maier, S; Sporbeck, K; Birkenfeld, AL; Malli, R; Ruth, P; Proikas-Cezanne, T; Lukowski, R IKCa channels control breast cancer metabolism including AMPK-driven autophagy.
Cell Death Dis. 2022; 13(10): 902 Doi: 10.1038/s41419-022-05329-z [OPEN ACCESS]
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Joshi, L; Plastira, I; Bernhart, E; Reicher, H; Koshenov, Z; Graier, WF; Vujic, N; Kratky, D; Rivera, R; Chun, J; Sattler, W Lysophosphatidic Acid Receptor 5 (LPA5) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro.
Cells. 2022; 11(7): Doi: 10.3390/cells11071071 [OPEN ACCESS]
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Kanti, MM; Striessnig-Bina, I; Wieser, BI; Schauer, S; Leitinger, G; Eichmann, TO; Schweiger, M; Winkler, M; Winter, E; Lana, A; Kufferath, I; Marsh, LM; Kwapiszewska, G; Zechner, R; Hoefler, G; Vesely, PW Adipose triglyceride lipase-mediated lipid catabolism is essential for bronchiolar regeneration.
JCI Insight. 2022; 7(9): Doi: 10.1172/jci.insight.149438 [OPEN ACCESS]
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Kien, B; Kolleritsch, S; Kunowska, N; Heier, C; Chalhoub, G; Tilp, A; Wolinski, H; Stelzl, U; Haemmerle, G Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation
J LIPID RES. 2022; 63(3): 100172 Doi: 10.1016/j.jlr.2022.100172 [OPEN ACCESS]
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Kieninger, S; Xiao, T; Weisschuh, N; Kohl, S; Rüther, K; Kroisel, PM; Brockmann, T; Knappe, S; Kellner, U; Lagrèze, W; Mazzola, P; Haack, TB; Wissinger, B; Tonagel, F DNAJC30 disease-causing gene variants in a large Central European cohort of patients with suspected Leber's hereditary optic neuropathy and optic atrophy.
J Med Genet. 2022; Doi: 10.1136/jmedgenet-2021-108235 [OPEN ACCESS]
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Klec, C; Knutsen, E; Schwarzenbacher, D; Jonas, K; Pasculli, B; Heitzer, E; Rinner, B; Krajina, K; Prinz, F; Gottschalk, B; Ulz, P; Deutsch, A; Prokesch, A; Jahn, SW; Lellahi, SM; Perander, M; Barbano, R; Graier, WF; Parrella, P; Calin, GA; Pichler, M ALYREF, a novel factor involved in breast carcinogenesis, acts through transcriptional and post-transcriptional mechanisms selectively regulating the short NEAT1 isoform.
Cell Mol Life Sci. 2022; 79(7): 391 Doi: 10.1007/s00018-022-04402-2 [OPEN ACCESS]
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Koser, F; Hobbach, AJ; Abdellatif, M; Herbst, V; Türk, C; Reinecke, H; Krüger, M; Sedej, S; Linke, WA Acetylation and phosphorylation changes to cardiac proteins in experimental HFpEF due to metabolic risk reveal targets for treatment.
Life Sci. 2022; 309:120998 Doi: 10.1016/j.lfs.2022.120998
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Koshenov, Z; Oflaz, FE; Hirtl, M; Gottschalk, B; Rost, R; Malli, R; Graier, WF Citrin mediated metabolic rewiring in response to altered basal subcellular Ca2+ homeostasis.
Commun Biol. 2022; 5(1): 76 Doi: 10.1038/s42003-022-03019-2 [OPEN ACCESS]
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Krstic, J; Reinisch, I; Schindlmaier, K; Galhuber, M; Riahi, Z; Berger, N; Kupper, N; Moyschewitz, E; Auer, M; Michenthaler, H; Nössing, C; Depaoli, MR; Ramadani-Muja, J; Usluer, S; Stryeck, S; Pichler, M; Rinner, B; Deutsch, AJA; Reinisch, A; Madl, T; Chiozzi, RZ; Heck, AJR; Huch, M; Malli, R; Prokesch, A Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism.
Sci Adv. 2022; 8(3):eabh2635 Doi: 10.1126/sciadv.abh2635 [OPEN ACCESS]
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Liebert, A; Seyedsadjadi, N; Pang, V; Litscher, G; Kiat, H Evaluation of Gender Differences in Response to Photobiomodulation Therapy, Including Laser Acupuncture: A Narrative Review and Implication to Precision Medicine.
Photobiomodul Photomed Laser Surg. 2022; 40(2):78-87 Doi: 10.1089/photob.2021.0066
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Ljubojević-Holzer, S; Kraler, S; Djalinac, N; Abdellatif, M; Voglhuber, J; Schipke, J; Schmidt, M; Kling, KM; Franke, GT; Herbst, V; Zirlik, A; von, Lewinski, D; Scherr, D; Rainer, PP; Kohlhaas, M; Nickel, A; Mühlfeld, C; Maack, C; Sedej, S Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Cardiovasc Res. 2022; 118(6):1492-1505 Doi: 10.1093/cvr/cvab112 [OPEN ACCESS]
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Oflaz, FE; Koshenov, Z; Hirtl, M; Rost, R; Malli, R; Graier, WF Sigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism.
Biomolecules. 2022; 12(6): Doi: 10.3390/biom12060762 [OPEN ACCESS]
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Pandey, AK; Waldeck-Weiermair, M; Wells, QS; Xiao, W; Yadav, S; Eroglu, E; Michel, T; Loscalzo, J Expression of CD70 Modulates Nitric Oxide and Redox Status in Endothelial Cells.
Arterioscler Thromb Vasc Biol. 2022; 42(9): 1169-1185. Doi: 10.1161/ATVBAHA.122.317866 [OPEN ACCESS]
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Pandey, S; Madreiter-Sokolowski, CT; Mangmool, S; Parichatikanond, W High Glucose-Induced Cardiomyocyte Damage Involves Interplay between Endothelin ET-1/ETA/ETB Receptor and mTOR Pathway
INT J MOL SCI. 2022; 23(22): 13816 Doi: 10.3390/ijms232213816 [OPEN ACCESS]
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Reinke, SN; Naz, S; Chaleckis, R; Gallart-Ayala, H; Kolmert, J; Kermani, NZ; Tiotiu, A; Broadhurst, DI; Lundqvist, A; Olsson, H; Ström, M; Wheelock, ÅM; Gómez, C; Ericsson, M; Sousa, AR; Riley, JH; Bates, S; Scholfield, J; Loza, M; Baribaud, F; Bakke, PS; Caruso, M; Chanez, P; Fowler, SJ; Geiser, T; Howarth, P; Horváth, I; Krug, N; Montuschi, P; Behndig, A; Singer, F; Musial, J; Shaw, DE; Dahlén, B; Hu, S; Lasky-Su, J; Sterk, PJ; Chung, KF; Djukanovic, R; Dahlén, SE; Adcock, IM; Wheelock, CE, , U-BIOPRED, Study, Group Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study.
Eur Respir J. 2022; 59(6): Doi: 10.1183/13993003.01733-2021 [OPEN ACCESS]
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Sevimli, G; Alston, AE; Funk, F; Flühmann, B; Malli, R; Graier, WF; Eroglu, E Probing Subcellular Iron Availability with Genetically Encoded Nitric Oxide Biosensors.
Biosensors (Basel). 2022; 12(10): Doi: 10.3390/bios12100903 [OPEN ACCESS]
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Shi, W; Li, C; Wartmann, T; Kahlert, C; Du, R; Perrakis, A; Brunner, T; Croner, RS; Kahlert, UD Sensory Ion Channel Candidates Inform on the Clinical Course of Pancreatic Cancer and Present Potential Targets for Repurposing of FDA-Approved Agents.
J Pers Med. 2022; 12(3): Doi: 10.3390/jpm12030478 [OPEN ACCESS]
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Sigurdsson, MI; Kobayashi, H; Amrein, K; Nakahira, K; Rogers, AJ; Pinilla-Vera, M; Baron, RM; Fredenburgh, LE; Lasky-Su, JA; Christopher, KB Circulating N-formylmethionine and metabolic shift in critical illness: a multicohort metabolomics study.
CRIT CARE. 2022; 26(1): 321 Doi: 10.1186/s13054-022-04174-y [OPEN ACCESS]
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Singh, B; Avula, K; Sufi, SA; Parwin, N; Das, S; Alam, MF; Samantaray, S; Bankapalli, L; Rani, A; Poornima, K; Prusty, B; Mallick, TP; Shaw, SK; Dodia, H; Kabi, S; Pagad, TT; Mohanty, S; Syed, GH Defective Mitochondrial Quality Control during Dengue Infection Contributes to Disease Pathogenesis
J VIROL. 2022; Doi: 10.1128/jvi.00828-22 [OPEN ACCESS]
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Skorvanek, M; Rektorova, I; Mandemakers, W; Wagner, M; Steinfeld, R; Orec, L; Han, V; Pavelekova, P; Lackova, A; Kulcsarova, K; Ostrozovicova, M; Gdovinova, Z; Plecko, B; Brunet, T; Berutti, R; Kuipers, DJS; Boumeester, V; Havrankova, P; Tijssen, MAJ; Kaiyrzhanov, R; Rizig, M; Houlden, H; Winkelmann, J; Bonifati, V; Zech, M; Jech, R WARS2 mutations cause dopa-responsive early-onset parkinsonism and progressive myoclonus ataxia.
Parkinsonism Relat Disord. 2021; 94: 54-61. Doi: 10.1016/j.parkreldis.2021.11.030
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Sohljoo, S; Kim, S; Plank, G; O'Rourke, B; Zhou, L Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias.
Methods Mol Biol. 2022; 2399: 247-259. Doi: 10.1007/978-1-0716-1831-8_11
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Spyropoulos, F; Sorrentino, A; van, der, Reest, J; Yang, P; Waldeck-Weiermair, M; Steinhorn, B; Eroglu, E; Saeedi, Saravi, SS; Yu, P; Haigis, M; Christou, H; Michel, T Metabolomic and transcriptomic signatures of chemogenetic heart failure.
Am J Physiol Heart Circ Physiol. 2022; 322(3): H451-H465. Doi: 10.1152/ajpheart.00628.2021 [OPEN ACCESS]
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Tarkhnishvili, A; Koentges, C; Pfeil, K; Gollmer, J; Byrne, NJ; Vosko, I; Lueg, J; Vogelbacher, L; Birkle, S; Tang, S; Bon-Nawul, Mwinyella, T; Hoffmann, MM; Odening, KE; Michel, NA; Wolf, D; Stachon, P; Hilgendorf, I; Wallner, M; Ljubojevic-Holzer, S; von, Lewinski, D; Rainer, P; Sedej, S; Sourij, H; Bode, C; Zirlik, A; Bugger, H Effects of Short Term Adiponectin Receptor Agonism on Cardiac Function and Energetics in Diabetic db/db Mice.
J Lipid Atheroscler. 2022; 11(2):161-177 Doi: 10.12997/jla.2022.11.2.161 [OPEN ACCESS]
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Tawfik, I; Gottschalk, B; Jarc, A; Bresilla, D; Rost, R; Obermayer-Pietsch, B; Graier, WF; Madreiter-Sokolowski, CT T3-induced enhancement of mitochondrial Ca2+ uptake as a boost for mitochondrial metabolism.
Free Radic Biol Med. 2022; 181:197-208 Doi: 10.1016/j.freeradbiomed.2022.01.024
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Tsybrovskyy, O; De, Luise, M; de, Biase, D; Caporali, L; Fiorini, C; Gasparre, G; Carelli, V; Hackl, D; Imamovic, L; Haim, S; Sobrinho-Simões, M; Tallini, G Papillary thyroid carcinoma tall cell variant shares accumulation of mitochondria, mitochondrial DNA mutations, and loss of oxidative phosphorylation complex I integrity with oncocytic tumors.
J Pathol Clin Res. 2022; 8(2):155-168 Doi: 10.1002/cjp2.247 [OPEN ACCESS]
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Voglhuber, J; Holzer, M; Radulović, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca2+ signalling in heart failure.
Philos Trans R Soc Lond B Biol Sci. 2022; 377(1864): 20210320 Doi: 10.1098/rstb.2021.0320 [OPEN ACCESS]
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