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Search Items: CARDIOMYOCYTE, . hits: 169

2023

Fassina, D; M, Costa, C; Bishop, M; Plank, G; Whitaker, J; Harding, SE; Niederer, SA Assessing the arrhythmogenic risk of engineered heart tissue patches through in silico application on infarcted ventricle models.
Comput Biol Med. 2023; 154:106550 Doi: 10.1016/j.compbiomed.2023.106550
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Kiessling, M; Djalinac, N; Voglhuber, J; Ljubojevic-Holzer, S Nuclear Calcium in Cardiac (Patho)Physiology: Small Compartment, Big Impact.
Biomedicines. 2023; 11(3): Doi: 10.3390/biomedicines11030960 [OPEN ACCESS]
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Messerer, J; Wrede, C; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice.
J Anat. 2023; 242(1):91-101 Doi: 10.1111/joa.13618 [OPEN ACCESS]
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Semeraro, MD; Beltrami, AP; Kharrat, F; Almer, G; Sedej, S; Renner, W; Gruber, HJ; Curcio, F; Herrmann, M The impact of moderate endurance exercise on cardiac telomeres and cardiovascular remodeling in obese rats.
Front Cardiovasc Med. 2022; 9: 1080077 Doi: 10.3389/fcvm.2022.1080077 [OPEN ACCESS]
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2022

Abdellatif, M; Eisenberg, T; Heberle, AM; Thedieck, K; Kroemer, G; Sedej, S Cardiac PI3K p110 alpha attenuation delays aging and extends lifespan
CELL STRESS. 2022; 6(8): 72-75. Doi: 10.15698/cst2022.08.270 [OPEN ACCESS]
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Abdellatif, M; Madeo, F; Kroemer, G; Sedej, S Spermidine overrides INSR (insulin receptor)-IGF1R (insulin-like growth factor 1 receptor)-mediated inhibition of autophagy in the aging heart.
Autophagy. 2022; 18(10):2500-2502 Doi: 10.1080/15548627.2022.2095835 [OPEN ACCESS]
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Abdellatif, M; Trummer-Herbst, V; Heberle, AM; Humnig, A; Pendl, T; Durand, S; Cerrato, G; Hofer, SJ; Islam, M; Voglhuber, J; Ramos, Pittol, JM; Kepp, O; Hoefler, G; Schmidt, A; Rainer, PP; Scherr, D; von, Lewinski, D; Bisping, E; McMullen, JR; Diwan, A; Eisenberg, T; Madeo, F; Thedieck, K; Kroemer, G; Sedej, S Fine-Tuning Cardiac Insulin-Like Growth Factor 1 Receptor Signaling to Promote Health and Longevity.
Circulation. 2022; 145(25):1853-1866 Doi: 10.1161/CIRCULATIONAHA.122.059863 [OPEN ACCESS]
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Eaton, DM; Martin, TG; Kasa, M; Djalinac, N; Ljubojevic-Holzer, S; Von, Lewinski, D; Pöttler, M; Kampaengsri, T; Krumphuber, A; Scharer, K; Maechler, H; Zirlik, A; McKinsey, TA; Kirk, JA; Houser, SR; Rainer, PP; Wallner, M HDAC Inhibition Regulates Cardiac Function by Increasing Myofilament Calcium Sensitivity and Decreasing Diastolic Tension.
Pharmaceutics. 2022; 14(7): Doi: 10.3390/pharmaceutics14071509 [OPEN ACCESS]
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Fassina, D; Costa, CM; Longobardi, S; Karabelas, E; Plank, G; Harding, SE; Niederer, SA Modelling the interaction between stem cells derived cardiomyocytes patches and host myocardium to aid non-arrhythmic engineered heart tissue design.
PLoS Comput Biol. 2022; 18(4):e1010030 Doi: 10.1371/journal.pcbi.1010030 [OPEN ACCESS]
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Koyani, CN; Scheruebel, S; Jin, G; Kolesnik, E; Zorn-Pauly, K; Mächler, H; Hoefler, G; von, Lewinski, D; Heinzel, FR; Pelzmann, B; Malle, E Hypochlorite-Modified LDL Induces Arrhythmia and Contractile Dysfunction in Cardiomyocytes.
Antioxidants (Basel). 2021; 11(1): Doi: 10.3390/antiox11010025 [OPEN ACCESS]
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Kuppe, C; Ramirez, Flores, RO; Li, Z; Hayat, S; Levinson, RT; Liao, X; Hannani, MT; Tanevski, J; Wünnemann, F; Nagai, JS; Halder, M; Schumacher, D; Menzel, S; Schäfer, G; Hoeft, K; Cheng, M; Ziegler, S; Zhang, X; Peisker, F; Kaesler, N; Saritas, T; Xu, Y; Kassner, A; Gummert, J; Morshuis, M; Amrute, J; Veltrop, RJA; Boor, P; Klingel, K; Van, Laake, LW; Vink, A; Hoogenboezem, RM; Bindels, EMJ; Schurgers, L; Sattler, S; Schapiro, D; Schneider, RK; Lavine, K; Milting, H; Costa, IG; Saez-Rodriguez, J; Kramann, R Spatial multi-omic map of human myocardial infarction.
Nature. 2022; 608(7924): 766-777. Doi: 10.1038/s41586-022-05060-x [OPEN ACCESS]
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Ljubojević-Holzer, S; Kraler, S; Djalinac, N; Abdellatif, M; Voglhuber, J; Schipke, J; Schmidt, M; Kling, KM; Franke, GT; Herbst, V; Zirlik, A; von, Lewinski, D; Scherr, D; Rainer, PP; Kohlhaas, M; Nickel, A; Mühlfeld, C; Maack, C; Sedej, S Loss of autophagy protein ATG5 impairs cardiac capacity in mice and humans through diminishing mitochondrial abundance and disrupting Ca2+ cycling.
Cardiovasc Res. 2022; 118(6):1492-1505 Doi: 10.1093/cvr/cvab112 [OPEN ACCESS]
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Matzer, I; Voglhuber, J; Kiessling, M; Djalinac, N; Trummer-Herbst, V; Mabotuwana, N; Rech, L; Holzer, M; Sossalla, S; Rainer, PP; Zirlik, A; Ljubojevic-Holzer, S β-Adrenergic Receptor Stimulation Maintains NCX-CaMKII Axis and Prevents Overactivation of IL6R-Signaling in Cardiomyocytes upon Increased Workload.
Biomedicines. 2022; 10(7): Doi: 10.3390/biomedicines10071648 [OPEN ACCESS]
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Pabel, S; Knierim, M; Stehle, T; Alebrand, F; Paulus, M; Sieme, M; Herwig, M; Barsch, F; Körtl, T; Pöppl, A; Wenner, B; Ljubojevic-Holzer, S; Molina, CE; Dybkova, N; Camboni, D; Fischer, TH; Sedej, S; Scherr, D; Schmid, C; Brochhausen, C; Hasenfuß, G; Maier, LS; Hamdani, N; Streckfuss-Bömeke, K; Sossalla, S Effects of Atrial Fibrillation on the Human Ventricle.
Circ Res. 2022; 130(7):994-1010 Doi: 10.1161/CIRCRESAHA.121.319718 [OPEN ACCESS]
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Rech, L; Abdellatif, M; Pöttler, M; Stangl, V; Mabotuwana, N; Hardy, S; Rainer, PP Small molecule STING inhibition improves myocardial infarction remodeling.
Life Sci. 2022; 291:120263 Doi: 10.1016/j.lfs.2021.120263
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Sohljoo, S; Kim, S; Plank, G; O'Rourke, B; Zhou, L Multiscale Modeling of the Mitochondrial Origin of Cardiac Reentrant and Fibrillatory Arrhythmias.
Methods Mol Biol. 2022; 2399: 247-259. Doi: 10.1007/978-1-0716-1831-8_11
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Spyropoulos, F; Sorrentino, A; van, der, Reest, J; Yang, P; Waldeck-Weiermair, M; Steinhorn, B; Eroglu, E; Saeedi, Saravi, SS; Yu, P; Haigis, M; Christou, H; Michel, T Metabolomic and transcriptomic signatures of chemogenetic heart failure.
Am J Physiol Heart Circ Physiol. 2022; 322(3): H451-H465. Doi: 10.1152/ajpheart.00628.2021 [OPEN ACCESS]
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Voglhuber, J; Holzer, M; Radulović, S; Thai, PN; Djalinac, N; Matzer, I; Wallner, M; Bugger, H; Zirlik, A; Leitinger, G; Dedkova, EN; Bers, DM; Ljubojevic-Holzer, S Functional remodelling of perinuclear mitochondria alters nucleoplasmic Ca²⁺ signalling in heart failure.
Philos Trans R Soc Lond B Biol Sci. 2022; 377(1864): 20210320 Doi: 10.1098/rstb.2021.0320 [OPEN ACCESS]
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2021

Abdellatif, M; Sedej, S; Kroemer, G NAD⁺ Metabolism in Cardiac Health, Aging, and Disease.
Circulation. 2021; 144(22): 1795-1817. Doi: 10.1161/CIRCULATIONAHA.121.056589
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Abdellatif, M; Trummer-Herbst, V; Koser, F; Durand, S; Adão, R; Vasques-Nóvoa, F; Freundt, JK; Voglhuber, J; Pricolo, MR; Kasa, M; Türk, C; Aprahamian, F; Herrero-Galán, E; Hofer, SJ; Pendl, T; Rech, L; Kargl, J; Anto-Michel, N; Ljubojevic-Holzer, S; Schipke, J; Brandenberger, C; Auer, M; Schreiber, R; Koyani, CN; Heinemann, A; Zirlik, A; Schmidt, A; von Lewinski, D; Scherr, D; Rainer, PP; von Maltzahn, J; Mühlfeld, C; Krüger, M; Frank, S; Madeo, F; Eisenberg, T; Prokesch, A; Leite-Moreira, AF; Lourenço, AP; Alegre-Cebollada, J; Kiechl, S; Linke, WA; Kroemer, G; Sedej, S Nicotinamide for the treatment of heart failure with preserved ejection fraction.
Sci Transl Med. 2021; 13(580): eabd7064 Doi: 10.1126/scitranslmed.abd7064 [OPEN ACCESS]
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Byrne, NJ; Rajasekaran, NS; Abel, ED; Bugger, H Therapeutic potential of targeting oxidative stress in diabetic cardiomyopathy.
Free Radic Biol Med. 2021; 169: 317-342. Doi: 10.1016/j.freeradbiomed.2021.03.046 [OPEN ACCESS]
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Cellini, A; Höfler, D; Arias-Loza, PA; Bandleon, S; Langsenlehner, T; Kohlhaas, M; Maack, C; Bauer, WR; Eder-Negrin, P The α2-isoform of the Na⁺/K⁺-ATPase protects against pathological remodeling and β-adrenergic desensitization after myocardial infarction.
Am J Physiol Heart Circ Physiol. 2021; 321(4):H650-H662 Doi: 10.1152/ajpheart.00808.2020
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Forte, E; Panahi, M; Baxan, N; Ng, FS; Boyle, JJ; Branca, J; Bedard, O; Hasham, MG; Benson, L; Harding, SE; Rosenthal, N; Sattler, S Type 2 MI induced by a single high dose of isoproterenol in C57BL/6J mice triggers a persistent adaptive immune response against the heart.
J Cell Mol Med. 2021; 25(1): 229-243. Doi: 10.1111/jcmm.15937 [OPEN ACCESS]
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Forte, E; Perkins, B; Sintou, A; Kalkat, HS; Papanikolaou, A; Jenkins, C; Alsubaie, M; Chowdhury, RA; Duffy, TM; Skelly, DA; Branca, J; Bellahcene, M; Schneider, MD; Harding, SE; Furtado, MB; Ng, FS; Hasham, MG; Rosenthal, N; Sattler, S Cross-Priming Dendritic Cells Exacerbate Immunopathology After Ischemic Tissue Damage in the Heart.
Circulation. 2021; 143(8): 821-836. Doi: 10.1161/CIRCULATIONAHA.120.044581 [OPEN ACCESS]
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Gross, P; Johnson, J; Romero, CM; Eaton, DM; Poulet, C; Sanchez-Alonso, J; Lucarelli, C; Ross, J; Gibb, AA; Garbincius, JF; Lambert, J; Varol, E; Yang, Y; Wallner, M; Feldsott, EA; Kubo, H; Berretta, RM; Yu, D; Rizzo, V; Elrod, J; Sabri, A; Gorelik, J; Chen, X; Houser, SR Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca²⁺ Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca²⁺ Dynamics.
Circ Res. 2021; 128(1):92-114 Doi: 10.1161/CIRCRESAHA.119.315715 [OPEN ACCESS]
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Helmstadter, KG; Ljubojevic-Holzer, S; Wood, BM; Taheri, KD; Sedej, S; Erickson, JR; Bossuyt, J; Bers, DM CaMKII and PKA-dependent phosphorylation co-regulate nuclear localization of HDAC4 in adult cardiomyocytes.
Basic Res Cardiol. 2021; 116(1):11-11 Doi: 10.1007/s00395-021-00850-2 [OPEN ACCESS]
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Jakubik, D; Fitas, A; Eyileten, C; Jarosz-Popek, J; Nowak, A; Czajka, P; Wicik, Z; Sourij, H; Siller-Matula, JM; De Rosa, S; Postula, M MicroRNAs and long non-coding RNAs in the pathophysiological processes of diabetic cardiomyopathy: emerging biomarkers and potential therapeutics.
Cardiovasc Diabetol. 2021; 20(1): 55-55. Doi: 10.1186/s12933-021-01245-2 [OPEN ACCESS]
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Jin, G; Manninger, M; Adelsmayr, G; Schwarzl, M; Alogna, A; Schönleitner, P; Zweiker, D; Blaschke, F; Sherif, M; Radulovic, S; Wakula, P; Schauer, S; Höfler, G; Reiter, U; Reiter, G; Post, H; Scherr, D; Acsai, K; Antoons, G; Pieske, B; Heinzel, FR Cellular contribution to left and right atrial dysfunction in chronic arterial hypertension in pigs.
ESC Heart Fail. 2021; 8(1):151-161 Doi: 10.1002/ehf2.13087 [OPEN ACCESS]
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Qi, XY; Vahdahi Hassani, F; Hoffmann, D; Xiao, J; Xiong, F; Villeneuve, LR; Ljubojevic-Holzer, S; Kamler, M; Abu-Taha, I; Heijman, J; Bers, DM; Dobrev, D; Nattel, S Inositol Trisphosphate Receptors and Nuclear Calcium in Atrial Fibrillation.
Circ Res. 2020; Doi: 10.1161/CIRCRESAHA.120.317768 [OPEN ACCESS]
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Tomin, T; Schittmayer, M; Sedej, S; Bugger, H; Gollmer, J; Honeder, S; Darnhofer, B; Liesinger, L; Zuckermann, A; Rainer, PP; Birner-Gruenberger, R Mass Spectrometry-Based Redox and Protein Profiling of Failing Human Hearts.
Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22041787 [OPEN ACCESS]
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Weixler, V; Lapusca, R; Grangl, G; Guariento, A; Saeed, MY; Cowan, DB; Del Nido, PJ; McCully, JD; Friehs, I Autogenous mitochondria transplantation for treatment of right heart failure.
J Thorac Cardiovasc Surg. 2021; 162(1):e111-e121-e111-e121 Doi: 10.1016/j.jtcvs.2020.08.011
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2020

Berulava, T; Buchholz, E; Elerdashvili, V; Pena, T; Islam, MR; Lbik, D; Mohamed, BA; Renner, A; von, Lewinski, D; Sacherer, M; Bohnsack, KE; Bohnsack, MT; Jain, G; Capece, V; Cleve, N; Burkhardt, S; Hasenfuss, G; Fischer, A; Toischer, K Changes in m6A RNA methylation contribute to heart failure progression by modulating translation.
Eur J Heart Fail. 2020; 22(1):54-66 Doi: 10.1002/ejhf.1672 [OPEN ACCESS]
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Djalinac, N; Ljubojevic-Holzer, S; Matzer, I; Kolesnik, E; Jandl, K; Lohberger, B; Rainer, P; Heinemann, A; Sedej, S; von, Lewinski, D; Bisping, E The role of stretch, tachycardia and sodium-calcium exchanger in induction of early cardiac remodelling.
J Cell Mol Med. 2020; 24(15):8732-8743 Doi: 10.1111/jcmm.15504 [OPEN ACCESS]
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Koyani, CN; Plastira, I; Sourij, H; Hallström, S; Schmidt, A; Rainer, PP; Bugger, H; Frank, S; Malle, E; von, Lewinski, D Empagliflozin protects heart from inflammation and energy depletion via AMPK activation.
Pharmacol Res. 2020; 158:104870 Doi: 10.1016/j.phrs.2020.104870
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Ljubojevic-Holzer, S; Herren, AW; Djalinac, N; Voglhuber, J; Morotti, S; Holzer, M; Wood, BM; Abdellatif, M; Matzer, I; Sacherer, M; Radulovic, S; Wallner, M; Ivanov, M; Wagner, S; Sossalla, S; von Lewinski, D; Pieske, B; Brown, JH; Sedej, S; Bossuyt, J; Bers, DM CaMKIIδC Drives Early Adaptive Ca²⁺ Change and Late Eccentric Cardiac Hypertrophy.
Circ Res. 2020; 127(9):1159-1178 Doi: 10.1161/CIRCRESAHA.120.316947 [OPEN ACCESS]
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Mühlfeld, C; Rajces, A; Manninger, M; Alogna, A; Wierich, MC; Scherr, D; Post, H; Schipke, J A transmural gradient of myocardial remodeling in early-stage heart failure with preserved ejection fraction in the pig.
J Anat. 2020; 236(3):531-539 Doi: 10.1111/joa.13117 [OPEN ACCESS]
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Niestrawska, JA; Augustin, CM; Plank, G Computational modeling of cardiac growth and remodeling in pressure overloaded hearts-Linking microstructure to organ phenotype.
Acta Biomater. 2020; 106:34-53 Doi: 10.1016/j.actbio.2020.02.010 [OPEN ACCESS]
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Panov, V; Minigalieva, I; Bushueva, T; Fröhlich, E; Meindl, C; Absenger-Novak, M; Shur, V; Shishkina, E; Gurvich, V; Privalova, L; Katsnelson, BA Some Peculiarities in the Dose Dependence of Separate and Combined In Vitro Cardiotoxicity Effects Induced by CdS and PbS Nanoparticles With Special Attention to Hormesis Manifestations.
Dose Response. 2020; 18(1):1559325820914180-1559325820914180 Doi: 10.1177/1559325820914180 [OPEN ACCESS]
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Prasch, J; Bernhart, E; Reicher, H; Kollroser, M; Rechberger, GN; Koyani, CN; Trummer, C; Rech, L; Rainer, PP; Hammer, A; Malle, E; Sattler, W Myeloperoxidase-Derived 2-Chlorohexadecanal Is Generated in Mouse Heart during Endotoxemia and Induces Modification of Distinct Cardiomyocyte Protein Subsets In Vitro.
Int J Mol Sci. 2020; 21(23): Doi: 10.3390/ijms21239235 [OPEN ACCESS]
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von Lewinski, D; Selvanayagam, JB; Schatz, RA; Jilma, B; Kubica, J; Povsic, TJ; Nix, D; Henauer, S; Wallner, M; REC-DUT-002 study group "Protocol for a phase 2, randomized, double-blind, placebo-controlled, safety and efficacy study of dutogliptin in combination with filgrastim in early recovery post-myocardial infarction": study protocol for a randomized controlled trial.
Trials. 2020; 21(1): 744-754. Doi: 10.1186/s13063-020-04652-0 [OPEN ACCESS]
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2019

Bandleon, S; Strunz, PP; Pickel, S; Tiapko, O; Cellini, A; Miranda-Laferte, E; Eder-Negrin, P FKBP52 regulates TRPC3-dependent Ca²⁺ signals and the hypertrophic growth of cardiomyocyte cultures.
J Cell Sci. 2019; 132(20): Doi: 10.1242/jcs.231506 [OPEN ACCESS]
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Bodi, I; Sorge, J; Castiglione, A; Glatz, SM; Wuelfers, EM; Franke, G; Perez-Feliz, S; Koren, G; Zehender, M; Bugger, H; Seemann, G; Brunner, M; Bode, C; Odening, KE Postpartum hormones oxytocin and prolactin cause pro-arrhythmic prolongation of cardiac repolarization in long QT syndrome type 2.
Europace. 2019; 21(7): 1126-1138. Doi: 10.1093/europace/euz037
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Ferrini, A; Stevens, MM; Sattler, S; Rosenthal, N Toward Regeneration of the Heart: Bioengineering Strategies for Immunomodulation.
Front Cardiovasc Med. 2019; 6: 26 Doi: 10.3389/fcvm.2019.00026 [OPEN ACCESS]
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Heras-Bautista, CO; Mikhael, N; Lam, J; Shinde, V; Katsen-Globa, A; Dieluweit, S; Molcanyi, M; Uvarov, V; Jütten, P; Sahito, RGA; Mederos-Henry, F; Piechot, A; Brockmeier, K; Hescheler, J; Sachinidis, A; Pfannkuche, K Cardiomyocytes facing fibrotic conditions re-express extracellular matrix transcripts.
Acta Biomater. 2019; 89:180-192 Doi: 10.1016/j.actbio.2019.03.017 [OPEN ACCESS]
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Primessnig, U; Bracic, T; Levijoki, J; Otsomaa, L; Pollesello, P; Falcke, M; Pieske, B; Heinzel, FR Long-term effects of Na⁺ /Ca²⁺ exchanger inhibition with ORM-11035 improves cardiac function and remodelling without lowering blood pressure in a model of heart failure with preserved ejection fraction.
Eur J Heart Fail. 2019; 21(12):1543-1552 Doi: 10.1002/ejhf.1619 [OPEN ACCESS]
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Wierich, MC; Schipke, J; Brandenberger, C; Abdellatif, M; Eisenberg, T; Madeo, F; Sedej, S; Mühlfeld, C Cardioprotection by spermidine does not depend on structural characteristics of the myocardial microcirculation in aged mice.
Exp Gerontol. 2019; 119:82-88 Doi: 10.1016/j.exger.2019.01.026
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2018

D'Souza, K; Nzirorera, C; Cowie, AM; Varghese, GP; Trivedi, P; Eichmann, TO; Biswas, D; Touaibia, M; Morris, AJ; Aidinis, V; Kane, DA; Pulinilkunnil, T; Kienesberger, PC Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.
J Lipid Res. 2018; 59(10): 1805-1817. Doi: 10.1194/jlr.M082008 [OPEN ACCESS]
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Dybkova, N; Ahmad, S; Pabel, S; Tirilomis, P; Hartmann, N; Fischer, TH; Bengel, P; Tirilomis, T; Ljubojevic, S; Renner, A; Gummert, J; Ellenberger, D; Wagner, S; Frey, N; Maier, LS; Streckfuss-Bömeke, K; Hasenfuss, G; Sossalla, S Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart.
Cardiovasc Res. 2018; 114(13): 1728-1737. Doi: 10.1093/cvr/cvy152 [OPEN ACCESS]
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Eldabah, N; Nembo, EN; Penner, M; Semmler, J; Swelem, R; Hassab, A; Molcanyi, M; Hescheler, J; Nguemo, F Altered Functional Expression of β-Adrenergic Receptors in Rhesus Monkey Embryonic Stem Cell-Derived Cardiomyocytes.
Stem Cells Dev. 2018; 27(5):336-346 Doi: 10.1089/scd.2017.0053
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Koyani, CN; Trummer, C; Shrestha, N; Scheruebel, S; Bourgeois, B; Plastira, I; Kickmaier, S; Sourij, H; Rainer, PP; Madl, T; Sattler, W; Pelzmann, B; Malle, E; von Lewinski, D Saxagliptin but Not Sitagliptin Inhibits CaMKII and PKC via DPP9 Inhibition in Cardiomyocytes.
Front Physiol. 2018; 9:1622-1622 Doi: 10.3389/fphys.2018.01622 [OPEN ACCESS]
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