Search Items: SARCOPLASMIC RETICULUM - METABOLISM, . hits: 64
Pabel, S; Knierim, M; Stehle, T; Alebrand, F; Paulus, M; Sieme, M; Herwig, M; Barsch, F; Körtl, T; Pöppl, A; Wenner, B; Ljubojevic-Holzer, S; Molina, CE; Dybkova, N; Camboni, D; Fischer, TH; Sedej, S; Scherr, D; Schmid, C; Brochhausen, C; Hasenfuß, G; Maier, LS; Hamdani, N; Streckfuss-Bömeke, K; Sossalla, S
Effects of Atrial Fibrillation on the Human Ventricle.
Circ Res. 2022; 130(7):994-1010
Doi: 10.1161/CIRCRESAHA.121.319718
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Jin, G; Manninger, M; Adelsmayr, G; Schwarzl, M; Alogna, A; Schönleitner, P; Zweiker, D; Blaschke, F; Sherif, M; Radulovic, S; Wakula, P; Schauer, S; Höfler, G; Reiter, U; Reiter, G; Post, H; Scherr, D; Acsai, K; Antoons, G; Pieske, B; Heinzel, FR
Cellular contribution to left and right atrial dysfunction in chronic arterial hypertension in pigs.
ESC Heart Fail. 2021; 8(1):151-161
Doi: 10.1002/ehf2.13087
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Fischer, TH; Eiringhaus, J; Dybkova, N; Saadatmand, A; Pabel, S; Weber, S; Wang, Y; Köhn, M; Tirilomis, T; Ljubojevic, S; Renner, A; Gummert, J; Maier, LS; Hasenfuß, G; El-Armouche, A; Sossalla, S
Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure.
Eur J Heart Fail. 2018; 20(12):1673-1685
Doi: 10.1002/ejhf.1297
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Fameli, N; Evans, AM; van Breemen, C
Tissue Specificity: The Role of Organellar Membrane Nanojunctions in Smooth Muscle Ca2+ Signaling.
Adv Exp Med Biol. 2017; 993(5):321-342
Doi: 10.1007/978-3-319-57732-6_17
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Evans, AM; Fameli, N; Ogunbayo, OA; Duan, J; Navarro-Dorado, J
From contraction to gene expression: nanojunctions of the sarco/endoplasmic reticulum deliver site- and function-specific calcium signals.
Sci China Life Sci. 2016; 59(8):749-763
Doi: 10.1007/s11427-016-5071-0
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Fischer, TH; Eiringhaus, J; Dybkova, N; Förster, A; Herting, J; Kleinwächter, A; Ljubojevic, S; Schmitto, JD; Streckfuß-Bömeke, K; Renner, A; Gummert, J; Hasenfuss, G; Maier, LS; Sossalla, S
Ca(2+) /calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca(2+) leak in human ischaemic and dilated cardiomyopathy.
Eur J Heart Fail. 2014; 16(12):1292-1300
Doi: 10.1002/ejhf.163
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Navarro-Dorado, J; Garcia-Alonso, M; van Breemen, C; Tejerina, T; Fameli, N
Calcium oscillations in human mesenteric vascular smooth muscle.
Biochem Biophys Res Commun. 2014; 445(1): 84-88.
Doi: 10.1016/j.bbrc.2014.01.150
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Sedej, S; Schmidt, A; Denegri, M; Walther, S; Matovina, M; Arnstein, G; Gutschi, EM; Windhager, I; Ljubojević, S; Negri, S; Heinzel, FR; Bisping, E; Vos, MA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B
Subclinical abnormalities in sarcoplasmic reticulum Ca(2+) release promote eccentric myocardial remodeling and pump failure death in response to pressure overload.
J Am Coll Cardiol. 2014; 63(15):1569-1579
Doi: 10.1016/j.jacc.2013.11.010
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Bito, V; Biesmans, L; Gellen, B; Antoons, G; Macquaide, N; Rouet-Benzineb, P; Pezet, M; Mercadier, JJ; Sipido, KR
FKBP12.6 overexpression does not protect against remodelling after myocardial infarction.
Exp Physiol. 2013; 98(1):134-148
Doi: 10.1113/expphysiol.2011.064089
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Dries, E; Bito, V; Lenaerts, I; Antoons, G; Sipido, KR; Macquaide, N
Selective modulation of coupled ryanodine receptors during microdomain activation of calcium/calmodulin-dependent kinase II in the dyadic cleft.
Circ Res. 2013; 113(11):1242-1252
Doi: 10.1161/CIRCRESAHA.113.301896
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Oberhofer, M; Tian, Q; Ruppenthal, S; Wegener, S; Reil, JC; Körbel, C; Hammer, K; Menger, M; Neuberger, HR; Kaestner, L; Lipp, P
Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1.
Cell Calcium. 2013; 54(1):26-36
Doi: 10.1016/j.ceca.2013.03.006
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Sipido, KR; Acsai, K; Antoons, G; Bito, V; Macquaide, N
T-tubule remodelling and ryanodine receptor organization modulate sodium-calcium exchange.
Adv Exp Med Biol. 2013; 961(3):375-383
Doi: 10.1007/978-1-4614-4756-6_32
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Sivakumaran, V; Stanley, BA; Tocchetti, CG; Ballin, JD; Caceres, V; Zhou, L; Keceli, G; Rainer, PP; Lee, DI; Huke, S; Ziolo, MT; Kranias, EG; Toscano, JP; Wilson, GM; O'Rourke, B; Kass, DA; Mahaney, JE; Paolocci, N
HNO enhances SERCA2a activity and cardiomyocyte function by promoting redox-dependent phospholamban oligomerization.
Antioxid Redox Signal. 2013; 19(11):1185-1197
Doi: 10.1089/ars.2012.5057
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Sacherer, M; Sedej, S; Wakuła, P; Wallner, M; Vos, MA; Kockskämper, J; Stiegler, P; Sereinigg, M; von Lewinski, D; Antoons, G; Pieske, BM; Heinzel, FR; CONTICA investigators
JTV519 (K201) reduces sarcoplasmic reticulum Ca²⁺ leak and improves diastolic function in vitro in murine and human non-failing myocardium.
Br J Pharmacol. 2012; 167(3):493-504
Doi: 10.1111/j.1476-5381.2012.01995.x
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Acsai, K; Antoons, G; Livshitz, L; Rudy, Y; Sipido, KR
Microdomain [Ca²⁺] near ryanodine receptors as reported by L-type Ca²⁺ and Na+/Ca²⁺ exchange currents.
J Physiol. 2011; 589(Pt 10):2569-2583
Doi: 10.1113/jphysiol.2010.202663
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Biesmans, L; Macquaide, N; Heinzel, FR; Bito, V; Smith, GL; Sipido, KR
Subcellular heterogeneity of ryanodine receptor properties in ventricular myocytes with low T-tubule density.
PLoS One. 2011; 6(10):e25100-e25100
Doi: 10.1371/journal.pone.0025100
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Heinzel, FR; Macquaide, N; Biesmans, L; Sipido, K
Dyssynchrony of Ca(2+) release from the sarcoplasmic reticulum as subcellular mechanism of cardiac contractile dysfunction.
J Mol Cell Cardiol. 2011; 50(3): 390-400.
Doi: 10.1016/j.yjmcc.2010.11.008
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Sedej, S; Heinzel, FR; Walther, S; Dybkova, N; Wakula, P; Groborz, J; Gronau, P; Maier, LS; Vos, MA; Lai, FA; Napolitano, C; Priori, SG; Kockskämper, J; Pieske, B
Na+-dependent SR Ca2+ overload induces arrhythmogenic events in mouse cardiomyocytes with a human CPVT mutation.
Cardiovasc Res. 2010; 87(1):50-59
Doi: 10.1093/cvr/cvq007
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Goetzenich, A; Schroth, SC; Emmig, U; Autschbach, R; Pieske, B; Rossaint, R; Christiansen, S
Hypothermia exerts negative inotropy in human atrial preparations: in vitro-comparison to rabbit myocardium.
J Cardiovasc Surg (Torino). 2009; 50(2):239-245
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Lenaerts, I; Bito, V; Heinzel, FR; Driesen, RB; Holemans, P; D'hooge, J; Heidbüchel, H; Sipido, KR; Willems, R
Ultrastructural and functional remodeling of the coupling between Ca2+ influx and sarcoplasmic reticulum Ca2+ release in right atrial myocytes from experimental persistent atrial fibrillation.
Circ Res. 2009; 105(9): 876-885.
Doi: 10.1161/CIRCRESAHA.109.206276
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Heinzel, FR; Bito, V; Biesmans, L; Wu, M; Detre, E; von Wegner, F; Claus, P; Dymarkowski, S; Maes, F; Bogaert, J; Rademakers, F; D'hooge, J; Sipido, K
Remodeling of T-tubules and reduced synchrony of Ca2+ release in myocytes from chronically ischemic myocardium.
Circ Res. 2008; 102(3): 338-346.
Doi: 10.1161/CIRCRESAHA.107.160085
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Kockskamper, J; Seidlmayer, L; Walther, S; Hellenkamp, K; Maier, LS; Pieske, B
Endothelin-1 enhances nuclear Ca2+ transients in atrial myocytes through Ins(1,4,5)P3-dependent Ca2+ release from perinuclear Ca2+ stores.
J Cell Sci. 2008; 121(Pt 2):186-195
Doi: 10.1242/jcs.021386
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Antoons, G; Volders, PG; Stankovicova, T; Bito, V; Stengl, M; Vos, MA; Sipido, KR
Window Ca2+ current and its modulation by Ca2+ release in hypertrophied cardiac myocytes from dogs with chronic atrioventricular block.
J Physiol. 2007; 579(Pt 1):147-160
Doi: 10.1113/jphysiol.2006.124222
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Antoons, G; Vangheluwe, P; Volders, PG; Bito, V; Holemans, P; Ceci, M; Wuytack, F; Caroni, P; Mubagwa, K; Sipido, KR
Increased phospholamban phosphorylation limits the force-frequency response in the MLP-/- mouse with heart failure.
J Mol Cell Cardiol. 2006; 40(3):350-360
Doi: 10.1016/j.yjmcc.2005.12.002
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Schillinger, W; Teucher, N; Christians, C; Kohlhaas, M; Sossalla, S; Van Nguyen, P; Schmidt, AG; Schunck, O; Nebendahl, K; Maier, LS; Zeitz, O; Hasenfuss, G
High intracellular Na+ preserves myocardial function at low heart rates in isolated myocardium from failing hearts.
Eur J Heart Fail. 2006; 8(7): 673-680.
Doi: 10.1016/j.ejheart.2006.01.013
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Di Biase, V; Franzini-Armstrong, C
Evolution of skeletal type e-c coupling: a novel means of controlling calcium delivery.
J Cell Biol. 2005; 171(4):695-704
Doi: 10.1083/jcb.200503077
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Knot, HJ; Laher, I; Sobie, EA; Guatimosim, S; Gomez-Viquez, L; Hartmann, H; Song, LS; Lederer, WJ; Graier, WF; Malli, R; Frieden, M; Petersen, OH
Twenty years of calcium imaging: cell physiology to dye for.
MOL INTERV. 2005; 5(2): 112-127.
Doi: 10.1124/mi.5.2.8
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Kockskämper, J; Zima, AV; Blatter, LA
Modulation of sarcoplasmic reticulum Ca2+ release by glycolysis in cat atrial myocytes.
J Physiol. 2005; 564(Pt 3):697-714
Doi: 10.1113/jphysiol.2004.078782
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Maier, LS; Wahl-Schott, C; Horn, W; Weichert, S; Pagel, C; Wagner, S; Dybkova, N; Müller, OJ; Näbauer, M; Franz, WM; Pieske, B
Increased SR Ca2+ cycling contributes to improved contractile performance in SERCA2a-overexpressing transgenic rats.
Cardiovasc Res. 2005; 67(4):636-646
Doi: 10.1016/j.cardiores.2005.05.006
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von Lewinski, D; Bruns, S; Walther, S; Kögler, H; Pieske, B
Insulin causes Ca2+i-dependent and Ca2+i-independent positive inotropic effects in failing human myocardium.
Circulation. 2005; 111(20):2588-2595
Doi: 10.1161/CIRCULATIONAHA.104.497461
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Hong, Z; Olschewski, A; Reeve, HL; Nelson, DP; Hong, F; Weir, EK
Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine.
AMER J PHYSIOL-LUNG CELL M PH 2004 286: L531-L538.
Doi: 10.1152/ajplung.00247.2003
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Liu, X; Groschner, K; Ambudkar, IS
Distinct Ca(2+)-permeable cation currents are activated by internal Ca(2+)-store depletion in RBL-2H3 cells and human salivary gland cells, HSG and HSY.
J Membr Biol. 2004; 200(2):93-104
Doi: 10.1007/s00232-004-0698-3
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Antoons, G; Ver Heyen, M; Raeymaekers, L; Vangheluwe, P; Wuytack, F; Sipido, KR
Ca2+ uptake by the sarcoplasmic reticulum in ventricular myocytes of the SERCA2b/b mouse is impaired at higher Ca2+ loads only.
Circ Res. 2003; 92(8):881-887
Doi: 10.1161/01.RES.0000069032.81501.98
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Brittsan, AG; Ginsburg, KS; Chu, G; Yatani, A; Wolska, BM; Schmidt, AG; Asahi, M; MacLennan, DH; Bers, DM; Kranias, EG
Chronic SR Ca2+-ATPase inhibition causes adaptive changes in cellular Ca2+ transport.
Circ Res. 2003; 92(7): 769-776.
Doi: 10.1161/01.RES.0000066661.49920.59
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Song, Q; Schmidt, AG; Hahn, HS; Carr, AN; Frank, B; Pater, L; Gerst, M; Young, K; Hoit, BD; McConnell, BK; Haghighi, K; Seidman, CE; Seidman, JG; Dorn, GW; Kranias, EG
Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy.
J Clin Invest. 2003; 111(6): 859-867.
Doi: 10.1172/JCI16738
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von Lewinski, D; Stumme, B; Maier, LS; Luers, C; Bers, DM; Pieske, B
Stretch-dependent slow force response in isolated rabbit myocardium is Na+ dependent.
Cardiovasc Res. 2003; 57(4):1052-1061
Doi: 10.1016/S0008-6363(02)00830-1
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von Lewinski, D; Voss, K; Hülsmann, S; Kögler, H; Pieske, B
Insulin-like growth factor-1 exerts Ca2+-dependent positive inotropic effects in failing human myocardium.
Circ Res. 2003; 92(2):169-176
Doi: 10.1161/01.RES.0000051885.70159.12
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Zhao, W; Frank, KF; Chu, G; Gerst, MJ; Schmidt, AG; Ji, Y; Periasamy, M; Kranias, EG
Combined phospholamban ablation and SERCA1a overexpression result in a new hyperdynamic cardiac state.
Cardiovasc Res. 2003; 57(1): 71-81.
Doi: 10.1016/S0008-6363(02)00609-0
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Antoons, G; Mubagwa, K; Nevelsteen, I; Sipido, KR
Mechanisms underlying the frequency dependence of contraction and [Ca(2+)](i) transients in mouse ventricular myocytes.
J Physiol. 2002; 543(Pt 3):889-898
Doi: 10.1113/jphysiol.2002.025619
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Hasenfuss, G; Pieske, B
Calcium cycling in congestive heart failure.
J Mol Cell Cardiol. 2002; 34(8):951-969
Doi: 10.1006/jmcc.2002.2037
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Heinzel, FR; Bito, V; Volders, PG; Antoons, G; Mubagwa, K; Sipido, KR
Spatial and temporal inhomogeneities during Ca2+ release from the sarcoplasmic reticulum in pig ventricular myocytes.
Circ Res. 2002; 91(11):1023-1030
Doi: 10.1161/01.RES.0000045940.67060.DD
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Kiriazis, H; Sato, Y; Kadambi, VJ; Schmidt, AG; Gerst, MJ; Hoit, BD; Kranias, EG
Hypertrophy and functional alterations in hyperdynamic phospholamban-knockout mouse hearts under chronic aortic stenosis.
Cardiovasc Res. 2002; 53(2): 372-381.
Doi: 10.1016/S0008-6363(01)00487-4
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Kockskämper, J; Blatter, LA
Subcellular Ca2+ alternans represents a novel mechanism for the generation of arrhythmogenic Ca2+ waves in cat atrial myocytes.
J Physiol. 2002; 545(Pt 1):65-79
Doi: 10.1113/jphysiol.2002.025502
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Maier, LS; Braunhälter, J; Horn, W; Weichert, S; Pieske, B
The role of SR Ca(2+)-content in blunted inotropic responsiveness of failing human myocardium.
J Mol Cell Cardiol. 2002; 34(4):455-467
Doi: 10.1006/jmcc.2002.1527
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Pieske, B; Kockskämper, J
Alternans goes subcellular: a disease of the ryanodine receptor?
Circ Res. 2002; 91(7):553-555
Doi: 10.1161/01.RES.0000036862.37203.F4
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Pieske, B; Maier, LS; Schmidt-Schweda, S
Sarcoplasmic reticulum Ca2+ load in human heart failure.
Basic Res Cardiol. 2002; 97 Suppl 1: I63-I71.
Doi: 10.1007/s003950200032
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Schmidt, AG; Zhai, J; Carr, AN; Gerst, MJ; Lorenz, JN; Pollesello, P; Annila, A; Hoit, BD; Kranias, EG
Structural and functional implications of the phospholamban hinge domain: impaired SR Ca2+ uptake as a primary cause of heart failure.
Cardiovasc Res. 2002; 56(2): 248-259.
Doi: 10.1016/S0008-6363(02)00541-2
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Kockskämper, J; Sheehan, KA; Bare, DJ; Lipsius, SL; Mignery, GA; Blatter, LA
Activation and propagation of Ca(2+) release during excitation-contraction coupling in atrial myocytes.
Biophys J. 2001; 81(5):2590-2605
Doi: 10.1016/S0006-3495(01)75903-6
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Most, P; Bernotat, J; Ehlermann, P; Pleger, ST; Reppel, M; Börries, M; Niroomand, F; Pieske, B; Janssen, PM; Eschenhagen, T; Karczewski, P; Smith, GL; Koch, WJ; Katus, HA; Remppis, A
S100A1: a regulator of myocardial contractility.
Proc Natl Acad Sci U S A. 2001; 98(24):13889-13894
Doi: 10.1073/pnas.241393598
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Sato, Y; Kiriazis, H; Yatani, A; Schmidt, AG; Hahn, H; Ferguson, DG; Sako, H; Mitarai, S; Honda, R; Mesnard-Rouiller, L; Frank, KF; Beyermann, B; Wu, G; Fujimori, K; Dorn, GW; Kranias, EG
Rescue of contractile parameters and myocyte hypertrophy in calsequestrin overexpressing myocardium by phospholamban ablation.
J Biol Chem. 2001; 276(12): 9392-9399.
Doi: 10.1074/jbc.M006889200
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