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Search Items: PROTEIN KINASE INHIBITORS - PHARMACOLOGY , . hits: 31

2022

Dankner, M; Wang, Y; Fazelzad, R; Johnson, B; Nebhan, CA; Dagogo-Jack, I; Myall, NJ; Richtig, G; Bracht, JWP; Gerlinger, M; Shinozaki, E; Yoshino, T; Kotani, D; Fangusaro, JR; Gautschi, O; Mazieres, J; Sosman, JA; Kopetz, S; Subbiah, V; Davies, MA; Groover, AL; Sullivan, RJ; Flaherty, KT; Johnson, DB; Benedetti, A; Cescon, DW; Spreafico, A; Zogopoulos, G; Rose, AAN Clinical Activity of Mitogen-Activated Protein Kinase-Targeted Therapies in Patients With Non-V600 BRAF-Mutant Tumors.
JCO Precis Oncol. 2022; 6:e2200107 Doi: 10.1200/PO.22.00107
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2021

Berg, JL; Perfler, B; Hatzl, S; Uhl, B; Reinisch, A; Pregartner, G; Berghold, A; Penz, T; Schuster, M; Geissler, K; Prokesch, A; Müller-Tidow, C; Hoefler, G; Kashofer, K; Wölfler, A; Sill, H; Caraffini, V; Zebisch, A EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Leukemia. 2021; 35(5):1521-1526 Doi: 10.1038/s41375-021-01161-0 [OPEN ACCESS]
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Mohamed, AA; Thomsen, A; Follo, M; Zamboglou, C; Bronsert, P; Mostafa, H; Amen, A; Mekawy, M; Grosu, AL; Brunner, TB FAK inhibition radiosensitizes pancreatic ductal adenocarcinoma cells in vitro.
Strahlenther Onkol. 2021; 197(1): 27-38. Doi: 10.1007/s00066-020-01666-0 [OPEN ACCESS]
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Scheipl, S; Barnard, M; Lohberger, B; Zettl, R; Brcic, I; Liegl-Atzwanger, B; Rinner, B; Meindl, C; Fröhlich, E Drug combination screening as a translational approach toward an improved drug therapy for chordoma.
Cell Oncol (Dordr). 2021; 44(6):1231-1242 Doi: 10.1007/s13402-021-00632-x [OPEN ACCESS]
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2019

Eroglu, E; Saravi, SSS; Sorrentino, A; Steinhorn, B; Michel, T Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods.
Proc Natl Acad Sci U S A. 2019; 116(40):20210-20217 Doi: 10.1073/pnas.1910942116 [OPEN ACCESS]
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Menzl, I; Zhang, T; Berger-Becvar, A; Grausenburger, R; Heller, G; Prchal-Murphy, M; Edlinger, L; Knab, VM; Uras, IZ; Grundschober, E; Bauer, K; Roth, M; Skucha, A; Liu, Y; Hatcher, JM; Liang, Y; Kwiatkowski, NP; Fux, D; Hoelbl-Kovacic, A; Kubicek, S; Melo, JV; Valent, P; Weichhart, T; Grebien, F; Zuber, J; Gray, NS; Sexl, V A kinase-independent role for CDK8 in BCR-ABL1⁺ leukemia.
Nat Commun. 2019; 10(1): 4741 Doi: 10.1038/s41467-019-12656-x [OPEN ACCESS]
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2018

Voelkl, J; Luong, TT; Tuffaha, R; Musculus, K; Auer, T; Lian, X; Daniel, C; Zickler, D; Boehme, B; Sacherer, M; Metzler, B; Kuhl, D; Gollasch, M; Amann, K; Müller, DN; Pieske, B; Lang, F; Alesutan, I SGK1 induces vascular smooth muscle cell calcification through NF-κB signaling.
J Clin Invest. 2018; 128(7):3024-3040 Doi: 10.1172/JCI96477 [OPEN ACCESS]
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2017

Byrgazov, K; Kastner, R; Gorna, M; Hoermann, G; Koenig, M; Lucini, CB; Ulreich, R; Benesch, M; Strenger, V; Lackner, H; Schwinger, W; Sovinz, P; Haas, OA; van den Heuvel-Eibrink, M; Niemeyer, CM; Hantschel, O; Valent, P; Superti-Furga, G; Urban, C; Dworzak, MN; Lion, T NDEL1-PDGFRB fusion gene in a myeloid malignancy with eosinophilia associated with resistance to tyrosine kinase inhibitors.
Leukemia. 2017; 31(1):237-240 Doi: 10.1038/leu.2016.250 [OPEN ACCESS]
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Riedl, A; Schlederer, M; Pudelko, K; Stadler, M; Walter, S; Unterleuthner, D; Unger, C; Kramer, N; Hengstschläger, M; Kenner, L; Pfeiffer, D; Krupitza, G; Dolznig, H Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
J Cell Sci. 2017; 130(1):203-218 Doi: 10.1242/jcs.188102 [OPEN ACCESS]
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2016

Sadovnik, I; Hoelbl-Kovacic, A; Herrmann, H; Eisenwort, G; Cerny-Reiterer, S; Warsch, W; Hoermann, G; Greiner, G; Blatt, K; Peter, B; Stefanzl, G; Berger, D; Bilban, M; Herndlhofer, S; Sill, H; Sperr, WR; Streubel, B; Mannhalter, C; Holyoake, TL; Sexl, V; Valent, P Identification of CD25 as STAT5-Dependent Growth Regulator of Leukemic Stem Cells in Ph+ CML.
Clin Cancer Res. 2016; 22(8):2051-2061 Doi: 10.1158/1078-0432.CCR-15-0767 [OPEN ACCESS]
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2015

Obenauf, AC; Zou, Y; Ji, AL; Vanharanta, S; Shu, W; Shi, H; Kong, X; Bosenberg, MC; Wiesner, T; Rosen, N; Lo, RS; Massagué, J Therapy-induced tumour secretomes promote resistance and tumour progression.
Nature. 2015; 520(7547): 368-372. Doi: 10.1038/nature14336 [OPEN ACCESS]
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Sturm, EM; Parzmair, GP; Radnai, B; Frei, RB; Sturm, GJ; Hammer, A; Schuligoi, R; Lippe, IT; Heinemann, A Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Eur J Immunol. 2015; 45(5):1548-1559 Doi: 10.1002/eji.201445196 [OPEN ACCESS]
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2014

Schelch, K; Hoda, MA; Klikovits, T; Münzker, J; Ghanim, B; Wagner, C; Garay, T; Laszlo, V; Setinek, U; Dome, B; Filipits, M; Pirker, C; Heffeter, P; Selzer, E; Tovari, J; Torok, S; Kenessey, I; Holzmann, K; Grasl-Kraupp, B; Marian, B; Klepetko, W; Berger, W; Hegedus, B; Grusch, M Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.
Am J Respir Crit Care Med. 2014; 190(7):763-772 Doi: 10.1164/rccm.201404-0658OC
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Smolle, E; Taucher, V; Petru, E; Haybaeck, J Targeted treatment of ovarian cancer--the multiple - kinase - inhibitor sorafenib as a potential option.
Anticancer Res. 2014; 34(4):1519-1530
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2013

Bernhart, E; Damm, S; Wintersperger, A; DeVaney, T; Zimmer, A; Raynham, T; Ireson, C; Sattler, W Protein kinase D2 regulates migration and invasion of U87MG glioblastoma cells in vitro.
Exp Cell Res. 2013; 319(13):2037-2048 Doi: 10.1016/j.yexcr.2013.03.029 [OPEN ACCESS]
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Opatz, S; Polzer, H; Herold, T; Konstandin, NP; Ksienzyk, B; Zellmeier, E; Vosberg, S; Graf, A; Krebs, S; Blum, H; Hopfner, KP; Kakadia, PM; Schneider, S; Dufour, A; Braess, J; Sauerland, MC; Berdel, WE; Büchner, T; Woermann, BJ; Hiddemann, W; Spiekermann, K; Bohlander, SK; Greif, PA Exome sequencing identifies recurring FLT3 N676K mutations in core-binding factor leukemia.
Blood. 2013; 122(10): 1761-1769. Doi: 10.1182/blood-2013-01-476473
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Shirsath, N; Rathos, M; Chaudhari, U; Sivaramakrishnan, H; Joshi, K Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.
Lung Cancer. 2013; 82(2):214-221 Doi: 10.1016/j.lungcan.2013.08.010
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2012

Brkić, L; Riederer, M; Graier, WF; Malli, R; Frank, S Acyl chain-dependent effect of lysophosphatidylcholine on cyclooxygenase (COX)-2 expression in endothelial cells.
Atherosclerosis. 2012; 224(2):348-354 Doi: 10.1016/j.atherosclerosis.2012.07.038 [OPEN ACCESS]
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Fröhlich, JD; Huppertz, B; Abuja, PM; König, J; Desoye, G Oxygen modulates the response of first-trimester trophoblasts to hyperglycemia.
Am J Pathol. 2012; 180(1): 153-164. Doi: 10.1016/j.ajpath.2011.09.012 [OPEN ACCESS]
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Jayawardena, TM; Egemnazarov, B; Finch, EA; Zhang, L; Payne, JA; Pandya, K; Zhang, Z; Rosenberg, P; Mirotsou, M; Dzau, VJ MicroRNA-mediated in vitro and in vivo direct reprogramming of cardiac fibroblasts to cardiomyocytes.
Circ Res. 2012; 110(11):1465-1473 Doi: 10.1161/CIRCRESAHA.112.269035 [OPEN ACCESS]
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Shirsath, NP; Manohar, SM; Joshi, KS P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines.
Mol Cancer. 2012; 11:77-77 Doi: 10.1186/1476-4598-11-77 [OPEN ACCESS]
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2011

Avcuoglu, S; Wygrecka, M; Marsh, LM; Günther, A; Seeger, W; Weissmann, N; Fink, L; Morty, RE; Kwapiszewska, G Neurotrophic tyrosine kinase receptor B/neurotrophin 4 signaling axis is perturbed in clinical and experimental pulmonary fibrosis.
Am J Respir Cell Mol Biol. 2011; 45(4):768-780 Doi: 10.1165/rcmb.2010-0195OC
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Karki, P; Li, X; Schrama, D; Fliegel, L B-Raf Associates with and Activates the NHE1 Isoform of the Na+/H+ Exchanger.
J Biol Chem. 2011; 286(15): 13096-13105. Doi: 10.1074/jbc.M110.165134 [OPEN ACCESS]
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Luschnig-Schratl, P; Sturm, EM; Konya, V; Philipose, S; Marsche, G; Fröhlich, E; Samberger, C; Lang-Loidolt, D; Gattenlöhner, S; Lippe, IT; Peskar, BA; Schuligoi, R; Heinemann, A EP4 receptor stimulation down-regulates human eosinophil function.
Cell Mol Life Sci. 2011; 68(21): 3573-3587. Doi: 10.1007/s00018-011-0642-5 [OPEN ACCESS]
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Semlitsch, M; Shackelford, RE; Zirkl, S; Sattler, W; Malle, E ATM protects against oxidative stress induced by oxidized low-density lipoprotein.
DNA Repair (Amst). 2011; 10(8):848-860 Doi: 10.1016/j.dnarep.2011.05.004 [OPEN ACCESS]
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2010

Ghofrani, HA; Morrell, NW; Hoeper, MM; Olschewski, H; Peacock, AJ; Barst, RJ; Shapiro, S; Golpon, H; Toshner, M; Grimminger, F; Pascoe, S Imatinib in pulmonary arterial hypertension patients with inadequate response to established therapy.
AMER J RESPIR CRIT CARE MED. 2010; 182(9): 1171-1177. Doi: 10.1164/rccm.201001-0123OC [OPEN ACCESS]
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Orendi, K; Gauster, M; Moser, G; Meiri, H; Huppertz, B The choriocarcinoma cell line BeWo: syncytial fusion and expression of syncytium-specific proteins.
Reproduction. 2010; 140(5):759-766 Doi: 10.1530/REP-10-0221 [OPEN ACCESS]
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Ubaida Mohien, C; Hartler, J; Breitwieser, F; Rix, U; Remsing Rix, L; Winter, GE; Thallinger, GG; Bennett, KL; Superti-Furga, G; Trajanoski, Z; Colinge, J MASPECTRAS 2: An integration and analysis platform for proteomic data.
Proteomics. 2010; 10(14):2719-2722 Doi: 10.1002/pmic.201000075
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2009

Houben, R; Voigt, H; Noelke, C; Hofmeister, V; Becker, JC; Schrama, D MAPK-independent impairment of T-cell responses by the multikinase inhibitor sorafenib.
Mol Cancer Ther. 2009; 8(2):433-440 Doi: 10.1158/1535-7163.MCT-08-1051 [OPEN ACCESS]
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2007

Berna, MJ; Hoffmann, KM; Tapia, JA; Thill, M; Pace, A; Mantey, SA; Jensen, RT CCK causes PKD1 activation in pancreatic acini by signaling through PKC-delta and PKC-independent pathways.
Biochim Biophys Acta. 2007; 1773(4): 483-501. Doi: 10.1016/j.bbamcr.2006.12.008 [OPEN ACCESS]
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2005

Rust, C; Bauchmuller, K; Fickert, P; Fuchsbichler, A; Beuers, U Phosphatidylinositol 3-kinase-dependent signaling modulates taurochenodeoxycholic acid-induced liver injury and cholestasis in perfused rat livers.
AMER J PHYSIOL-GASTROINTEST L. 2005; 289(1): G88-G94. Doi: 10.1152/ajpgi.00450.2004 [OPEN ACCESS]
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