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Search Items: DOUBLE-BLIND METHOD - , . hits: 295

2019

Lopes, RD; Heizer, G; Aronson, R; Vora, AN; Massaro, T; Mehran, R; Goodman, SG; Windecker, S; Darius, H; Li, J; Averkov, O; Bahit, MC; Berwanger, O; Budaj, A; Hijazi, Z; Parkhomenko, A; Sinnaeve, P; Storey, RF; Thiele, H; Vinereanu, D; Granger, CB; Alexander, JH; AUGUSTUS Investigators Antithrombotic Therapy after Acute Coronary Syndrome or PCI in Atrial Fibrillation.
N Engl J Med. 2019; 380(16):1509-1524
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2018

Aygören-Pürsün, E; Bygum, A; Grivcheva-Panovska, V; Magerl, M; Graff, J; Steiner, UC; Fain, O; Huissoon, A; Kinaciyan, T; Farkas, H; Lleonart, R; Longhurst, HJ; Rae, W; Triggiani, M; Aberer, W; Cancian, M; Zanichelli, A; Smith, WB; Baeza, ML; Du-Thanh, A; Gompels, M; Gonzalez-Quevedo, T; Greve, J; Guilarte, M; Katelaris, C; Dobo, S; Cornpropst, M; Clemons, D; Fang, L; Collis, P; Sheridan, W; Maurer, M; Cicardi, M Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema.
NEW ENGL J MED. 2018; 379(4): 352-362. [OPEN ACCESS]
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Grübler, MR; Gaksch, M; Kienreich, K; Verheyen, ND; Schmid, J; Müllner, C; Richtig, G; Scharnagl, H; Trummer, C; Schwetz, V; Meinitzer, A; Pieske, B; März, W; Tomaschitz, A; Pilz, S Effects of Vitamin D3 on asymmetric- and symmetric dimethylarginine in arterial hypertension.
J Steroid Biochem Mol Biol. 2018; 175(2):157-163
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Pieber, TR; Marso, SP; McGuire, DK; Zinman, B; Poulter, NR; Emerson, SS; Pratley, RE; Woo, V; Heller, S; Lange, M; Brown-Frandsen, K; Moses, A; Barner Lekdorf, J; Lehmann, L; Kvist, K; Buse, JB; DEVOTE Study Group DEVOTE 3: temporal relationships between severe hypoglycaemia, cardiovascular outcomes and mortality.
Diabetologia. 2018; 61(1):58-65 [OPEN ACCESS]
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Pilz, S; Trummer, C; Verheyen, N; Schwetz, V; Pandis, M; Aberer, F; Grübler, MR; Meinitzer, A; Bachmann, A; Voelkl, J; Alesutan, I; Catena, C; Sechi, LA; März, W; Obermayer-Pietsch, B; Tomaschitz, A Mineralocorticoid Receptor Blockers and Aldosterone to Renin Ratio: A Randomized Controlled Trial and Observational Data.
Horm Metab Res. 2018; 50(5):375-382
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Smith, MR; Saad, F; Chowdhury, S; Oudard, S; Hadaschik, BA; Graff, JN; Olmos, D; Mainwaring, PN; Lee, JY; Uemura, H; Lopez-Gitlitz, A; Trudel, GC; Espina, BM; Shu, Y; Park, YC; Rackoff, WR; Yu, MK; Small, EJ; SPARTAN Investigators Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer.
N Engl J Med. 2018; 378(15):1408-1418 [OPEN ACCESS]
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Tripolt, NJ; Aberer, F; Riedl, R; Url, J; Dimsity, G; Meinitzer, A; Stojakovic, T; Aziz, F; Hödl, R; Brachtl, G; Strunk, D; Brodmann, M; Hafner, F; Sourij, H Effects of linagliptin on endothelial function and postprandial lipids in coronary artery disease patients with early diabetes: a randomized, placebo-controlled, double-blind trial.
Cardiovasc Diabetol. 2018; 17(1):71-71 [OPEN ACCESS]
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Zinman, B; Marso, SP; Poulter, NR; Emerson, SS; Pieber, TR; Pratley, RE; Lange, M; Brown-Frandsen, K; Moses, A; Ocampo Francisco, AM; Barner Lekdorf, J; Kvist, K; Buse, JB; DEVOTE Study Group Day-to-day fasting glycaemic variability in DEVOTE: associations with severe hypoglycaemia and cardiovascular outcomes (DEVOTE 2).
Diabetologia. 2018; 61(1):48-57 [OPEN ACCESS]
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2017

Baker, D; Pryce, G; Visintin, C; Sisay, S; Bondarenko, AI; Vanessa Ho, WS; Jackson, SJ; Williams, TE; Al-Izki, S; Sevastou, I; Okuyama, M; Graier, WF; Stevenson, LA; Tanner, C; Ross, R; Pertwee, RG; Henstridge, CM; Irving, AJ; Schulman, J; Powell, K; Baker, MD; Giovannoni, G; Selwood, DL Big conductance calcium-activated potassium channel openers control spasticity without sedation.
Br J Pharmacol. 2017; 174(16):2662-2681 [OPEN ACCESS]
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Bayer, U; Glazachev, OS; Likar, R; Burtscher, M; Kofler, W; Pinter, G; Stettner, H; Demschar, S; Trummer, B; Neuwersch, S [Adaptation to intermittent hypoxia-hyperoxia improves cognitive performance and exercise tolerance in elderly].
Adv Gerontol. 2017; 30(2):255-261
PubMed

 

Berry, V; Basson, L; Bogart, E; Mir, O; Blay, JY; Italiano, A; Bertucci, F; Chevreau, C; Clisant-Delaine, S; Liegl-Antzager, B; Tresch-Bruneel, E; Wallet, J; Taieb, S; Decoupigny, E; Le Cesne, A; Brodowicz, T; Penel, N REGOSARC: Regorafenib versus placebo in doxorubicin-refractory soft-tissue sarcoma-A quality-adjusted time without symptoms of progression or toxicity analysis.
Cancer. 2017; 123(12):2294-2302 [OPEN ACCESS]
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Bone, HG; Wagman, RB; Brandi, ML; Brown, JP; Chapurlat, R; Cummings, SR; Czerwiński, E; Fahrleitner-Pammer, A; Kendler, DL; Lippuner, K; Reginster, JY; Roux, C; Malouf, J; Bradley, MN; Daizadeh, NS; Wang, A; Dakin, P; Pannacciulli, N; Dempster, DW; Papapoulos, S 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension.
Lancet Diabetes Endocrinol. 2017; 5(7):513-523
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Famulla, S; Pieber, TR; Eilbracht, J; Neubacher, D; Soleymanlou, N; Woerle, HJ; Broedl, UC; Kaspers, S Glucose Exposure and Variability with Empagliflozin as Adjunct to Insulin in Patients with Type 1 Diabetes: Continuous Glucose Monitoring Data from a 4-Week, Randomized, Placebo-Controlled Trial (EASE-1).
Diabetes Technol Ther. 2017; 19(1):49-60
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Fickert, P; Hirschfield, GM; Denk, G; Marschall, HU; Altorjay, I; Färkkilä, M; Schramm, C; Spengler, U; Chapman, R; Bergquist, A; Schrumpf, E; Nevens, F; Trivedi, P; Reiter, FP; Tornai, I; Halilbasic, E; Greinwald, R; Pröls, M; Manns, MP; Trauner, M; European PSC norUDCA Study Group norUrsodeoxycholic acid improves cholestasis in primary sclerosing cholangitis.
J Hepatol. 2017; 67(3):549-558 [OPEN ACCESS]
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Hackl, G; Prenner, A; Jud, P; Hafner, F; Rief, P; Seinost, G; Pilger, E; Brodmann, M Auricular vagal nerve stimulation in peripheral arterial disease patients.
Vasa. 2017; 46(6):462-470 [OPEN ACCESS]
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Heise, T; Pieber, TR; Danne, T; Erichsen, L; Haahr, H A Pooled Analysis of Clinical Pharmacology Trials Investigating the Pharmacokinetic and Pharmacodynamic Characteristics of Fast-Acting Insulin Aspart in Adults with Type 1 Diabetes.
Clin Pharmacokinet. 2017; 56(5):551-559 [OPEN ACCESS]
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Holman, RR; Bethel, MA; Mentz, RJ; Thompson, VP; Lokhnygina, Y; Buse, JB; Chan, JC; Choi, J; Gustavson, SM; Iqbal, N; Maggioni, AP; Marso, SP; Öhman, P; Pagidipati, NJ; Poulter, N; Ramachandran, A; Zinman, B; Hernandez, AF; EXSCEL Study Group Effects of Once-Weekly Exenatide on Cardiovascular Outcomes in Type 2 Diabetes.
N Engl J Med. 2017; 377(13): 1228-1239. [OPEN ACCESS]
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Lefevre, M; Racedo, SM; Denayrolles, M; Ripert, G; Desfougères, T; Lobach, AR; Simon, R; Pélerin, F; Jüsten, P; Urdaci, MC Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans.
Regul Toxicol Pharmacol. 2017; 83(2):54-65 [OPEN ACCESS]
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Lerchbaum, E; Pilz, S; Trummer, C; Schwetz, V; Pachernegg, O; Heijboer, AC; Obermayer-Pietsch, B Vitamin D and Testosterone in Healthy Men: A Randomized Controlled Trial.
J Clin Endocrinol Metab. 2017; 102(11):4292-4302
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Marso, SP; McGuire, DK; Zinman, B; Poulter, NR; Emerson, SS; Pieber, TR; Pratley, RE; Haahr, PM; Lange, M; Brown-Frandsen, K; Moses, A; Skibsted, S; Kvist, K; Buse, JB; DEVOTE Study Group Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
N Engl J Med. 2017; 377(8):723-732 [OPEN ACCESS]
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Mehta, RH; Leimberger, JD; van Diepen, S; Meza, J; Wang, A; Jankowich, R; Harrison, RW; Hay, D; Fremes, S; Duncan, A; Soltesz, EG; Luber, J; Park, S; Argenziano, M; Murphy, E; Marcel, R; Kalavrouziotis, D; Nagpal, D; Bozinovski, J; Toller, W; Heringlake, M; Goodman, SG; Levy, JH; Harrington, RA; Anstrom, KJ; Alexander, JH; LEVO-CTS Investigators Levosimendan in Patients with Left Ventricular Dysfunction Undergoing Cardiac Surgery.
NEW ENGL J MED. 2017; 376(21): 2032-2042. [OPEN ACCESS]
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Novak, P; Schmidt, R; Kontsekova, E; Zilka, N; Kovacech, B; Skrabana, R; Vince-Kazmerova, Z; Katina, S; Fialova, L; Prcina, M; Parrak, V; Dal-Bianco, P; Brunner, M; Staffen, W; Rainer, M; Ondrus, M; Ropele, S; Smisek, M; Sivak, R; Winblad, B; Novak, M Safety and immunogenicity of the tau vaccine AADvac1 in patients with Alzheimer's disease: a randomised, double-blind, placebo-controlled, phase 1 trial.
Lancet Neurol. 2017; 16(2):123-134
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Pusceddu, I; Herrmann, M; Kirsch, SH; Werner, C; Hübner, U; Bodis, M; Laufs, U; Widmann, T; Wagenpfeil, S; Geisel, J; Herrmann, W One-carbon metabolites and telomere length in a prospective and randomized study of B- and/or D-vitamin supplementation.
Eur J Nutr. 2017; 56(5):1887-1898
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Rello, J; Krenn, CG; Locker, G; Pilger, E; Madl, C; Balica, L; Dugernier, T; Laterre, PF; Spapen, H; Depuydt, P; Vincent, JL; Bogár, L; Szabó, Z; Völgyes, B; Máñez, R; Cakar, N; Ramazanoglu, A; Topeli, A; Mastruzzo, MA; Jasovich, A; Remolif, CG; Del Carmen Soria, L; Andresen Hernandez, MA; Ruiz Balart, C; Krémer, I; Molnár, Z; von Sonnenburg, F; Lyons, A; Joannidis, M; Burgmann, H; Welte, T; Klingler, A; Hochreiter, R; Westritschnig, K A randomized placebo-controlled phase II study of a Pseudomonas vaccine in ventilated ICU patients.
Crit Care. 2017; 21(1):22-22 [OPEN ACCESS]
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Schwameis, M; Kündig, T; Huber, G; von Bidder, L; Meinel, L; Weisser, R; Aberer, E; Härter, G; Weinke, T; Jelinek, T; Fätkenheuer, G; Wollina, U; Burchard, GD; Aschoff, R; Nischik, R; Sattler, G; Popp, G; Lotte, W; Wiechert, D; Eder, G; Maus, O; Staubach-Renz, P; Gräfe, A; Geigenberger, V; Naudts, I; Sebastian, M; Reider, N; Weber, R; Heckmann, M; Reisinger, EC; Klein, G; Wantzen, J; Jilma, B Topical azithromycin for the prevention of Lyme borreliosis: a randomised, placebo-controlled, phase 3 efficacy trial.
Lancet Infect Dis. 2017; 17(3):322-329
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Schwetz, V; Schnedl, C; Urbanic-Purkart, T; Trummer, C; Dimai, HP; Fahrleitner-Pammer, A; Putz-Bankuti, C; Christopher, KB; Obermayer-Pietsch, B; Pieber, TR; Dobnig, H; Amrein, K Effect of vitamin D3 on bone turnover markers in critical illness: post hoc analysis from the VITdAL-ICU study.
Osteoporos Int. 2017; 28(12):3347-3354 [OPEN ACCESS]
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Schwetz, V; Trummer, C; Pandis, M; Grübler, MR; Verheyen, N; Gaksch, M; Zittermann, A; März, W; Aberer, F; Lang, A; Treiber, G; Friedl, C; Obermayer-Pietsch, B; Pieber, TR; Tomaschitz, A; Pilz, S Effects of Vitamin D Supplementation on Bone Turnover Markers: A Randomized Controlled Trial.
Nutrients. 2017; 9(5): [OPEN ACCESS]
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Trummer, C; Schwetz, V; Pandis, M; Grübler, MR; Verheyen, N; Gaksch, M; Zittermann, A; März, W; Aberer, F; Lang, A; Friedl, C; Tomaschitz, A; Obermayer-Pietsch, B; Pieber, TR; Pilz, S; Treiber, G Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial.
Nutrients. 2017; 9(6): [OPEN ACCESS]
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Zöhrer, E; Alisi, A; Jahnel, J; Mosca, A; Della Corte, C; Crudele, A; Fauler, G; Nobili, V Efficacy of docosahexaenoic acid-choline-vitamin E in paediatric NASH: a randomized controlled clinical trial.
Appl Physiol Nutr Metab. 2017; 42(9):948-954
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2016

Ahrén, B; Hirsch, IB; Pieber, TR; Mathieu, C; Gómez-Peralta, F; Hansen, TK; Philotheou, A; Birch, S; Christiansen, E; Jensen, TJ; Buse, JB; ADJUNCT TWO Investigators Efficacy and Safety of Liraglutide Added to Capped Insulin Treatment in Subjects With Type 1 Diabetes: The ADJUNCT TWO Randomized Trial.
Diabetes Care. 2016; 39(10):1693-1701 [OPEN ACCESS]
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Behr, J; Bendstrup, E; Crestani, B; Günther, A; Olschewski, H; Sköld, CM; Wells, A; Wuyts, W; Koschel, D; Kreuter, M; Wallaert, B; Lin, CY; Beck, J; Albera, C Safety and tolerability of acetylcysteine and pirfenidone combination therapy in idiopathic pulmonary fibrosis: a randomised, double-blind, placebo-controlled, phase 2 trial.
Lancet Respir Med. 2016; 4(6):445-453
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Bethel, MA; Harrison, P; Sourij, H; Sun, Y; Tucker, L; Kennedy, I; White, S; Hill, L; Oulhaj, A; Coleman, RL; Holman, RR Randomized controlled trial comparing impact on platelet reactivity of twice-daily with once-daily aspirin in people with Type 2 diabetes.
Diabet Med. 2016; 33(2):224-230
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Blevins, T; Pieber, TR; Colón Vega, G; Zhang, S; Bastyr, EJ; Chang, AM; IMAGINE 4 Investigators Randomized double-blind clinical trial comparing basal insulin peglispro and insulin glargine, in combination with prandial insulin lispro, in patients with type 2 diabetes: IMAGINE 4.
Diabetes Obes Metab. 2016; 18(11):1072-1080 [OPEN ACCESS]
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Bornemann-Cimenti, H; Wejbora, M; Michaeli, K; Edler, A; Sandner-Kiesling, A The effects of minimal-dose versus low-dose S-ketamine on opioid consumption, hyperalgesia, and postoperative delirium: a triple-blinded, randomized, active- and placebo-controlled clinical trial.
Minerva Anestesiol. 2016; 82(10):1069-1076 [OPEN ACCESS]
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Grübler, MR; Gaksch, M; Kienreich, K; Verheyen, N; Schmid, J; Ó Hartaigh, B; Richtig, G; Scharnagl, H; Meinitzer, A; Fahrleitner-Pammer, A; März, W; Tomaschitz, A; Pilz, S Effects of vitamin D supplementation on glycated haemoglobin and fasting glucose levels in hypertensive patients: a randomized controlled trial.
Diabetes Obes Metab. 2016; 18(10):1006-1012
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Grübler, MR; Gaksch, M; Kienreich, K; Verheyen, N; Schmid, J; Ó Hartaigh, BW; Richtig, G; Scharnagl, H; Meinitzer, A; Pieske, B; Fahrleitner-Pammer, A; März, W; Tomaschitz, A; Pilz, S Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.
J Clin Hypertens (Greenwich). 2016; 18(7):608-613 [OPEN ACCESS]
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Heise, T; Korsatko, S; Nosek, L; Coester, HV; Deller, S; Roepstorff, C; Segel, S; Kapur, R; Haahr, H; Hompesch, M Steady state is reached within 2-3 days of once-daily administration of degludec, a basal insulin with an ultralong duration of action.
J Diabetes. 2016; 8(1):132-138
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Holman, RR; Bethel, MA; George, J; Sourij, H; Doran, Z; Keenan, J; Khurmi, NS; Mentz, RJ; Oulhaj, A; Buse, JB; Chan, JC; Iqbal, N; Kundu, S; Maggioni, AP; Marso, SP; Öhman, P; Pencina, MJ; Poulter, N; Porter, LE; Ramachandran, A; Zinman, B; Hernandez, AF Rationale and design of the EXenatide Study of Cardiovascular Event Lowering (EXSCEL) trial.
Am Heart J. 2016; 174(6):103-110 [OPEN ACCESS]
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Horvath, A; Leber, B; Schmerboeck, B; Tawdrous, M; Zettel, G; Hartl, A; Madl, T; Stryeck, S; Fuchs, D; Lemesch, S; Douschan, P; Krones, E; Spindelboeck, W; Durchschein, F; Rainer, F; Zollner, G; Stauber, RE; Fickert, P; Stiegler, P; Stadlbauer, V Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.
Aliment Pharmacol Ther. 2016; 44(9):926-935 [OPEN ACCESS]
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Kollerits, B; Drechsler, C; Krane, V; Lamina, C; März, W; Dieplinger, H; Ritz, E; Wanner, C; Kronenberg, F; German Diabetes and Dialysis Study Investigators Lipoprotein(a) concentrations, apolipoprotein(a) isoforms and clinical endpoints in haemodialysis patients with type 2 diabetes mellitus: results from the 4D Study.
Nephrol Dial Transplant. 2016; 31(11):1901-1908 [OPEN ACCESS]
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Krane, V; Schmidt, KR; Gutjahr-Lengsfeld, LJ; Mann, JF; März, W; Swoboda, F; Wanner, C; 4D Study Investigators (the German Diabetes and Dialysis Study Investigators) Long-term effects following 4 years of randomized treatment with atorvastatin in patients with type 2 diabetes mellitus on hemodialysis.
Kidney Int. 2016; 89(6):1380-1387
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Kratochvílová, S; Škoch, A; Wohl, P; Švehlíková, E; Dezortová, M; Hill, M; Hájek, M; Pelikánová, T Intramyocellular lipid content in subjects with impaired fasting glucose after telmisartan treatment, a randomised cross-over trial.
Magn Reson Imaging. 2016; 34(3): 353-358.
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Mader, JK; Jensen, L; Ingwersen, SH; Christiansen, E; Heller, S; Pieber, TR Pharmacokinetic Properties of Liraglutide as Adjunct to Insulin in Subjects with Type 1 Diabetes Mellitus.
Clin Pharmacokinet. 2016; 55(11):1457-1463 [OPEN ACCESS]
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Marso, SP; McGuire, DK; Zinman, B; Poulter, NR; Emerson, SS; Pieber, TR; Pratley, RE; Haahr, PM; Lange, M; Frandsen, KB; Rabøl, R; Buse, JB Design of DEVOTE (Trial Comparing Cardiovascular Safety of Insulin Degludec vs Insulin Glargine in Patients With Type 2 Diabetes at High Risk of Cardiovascular Events) - DEVOTE 1.
Am Heart J. 2016; 179(19-20):175-183 [OPEN ACCESS]
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Panés, J; García-Olmo, D; Van Assche, G; Colombel, JF; Reinisch, W; Baumgart, DC; Dignass, A; Nachury, M; Ferrante, M; Kazemi-Shirazi, L; Grimaud, JC; de la Portilla, F; Goldin, E; Richard, MP; Leselbaum, A; Danese, S; ADMIRE CD Study Group Collaborators Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn's disease: a phase 3 randomised, double-blind controlled trial.
Lancet. 2016; 388(10051):1281-1290
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Pilz, S; Putz-Bankuti, C; Gaksch, M; Spindelboeck, W; Haselberger, M; Rainer, F; Posch, A; Kreuzer, P; Stojakovic, T; Stadlbauer, V; Obermayer-Pietsch, B; Stauber, RE Effects of Vitamin D Supplementation on Serum 25-Hydroxyvitamin D Concentrations in Cirrhotic Patients: A Randomized Controlled Trial.
Nutrients. 2016; 8(5): [OPEN ACCESS]
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Roller, RE; Eglseer, D; Eisenberger, A; Wirnsberger, GH The Graz Malnutrition Screening (GMS): a new hospital screening tool for malnutrition.
Br J Nutr. 2016; 115(4):650-657 [OPEN ACCESS]
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Simonis, H; Bornemann-Cimenti, H; Röschel, B; Sandner-Kiesling, A The vertical obturator nerve block: A randomised controlled double-blind pilot trial.
Eur J Anaesthesiol. 2016; 33(8):602-604 [OPEN ACCESS]
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Stoschitzky, K; Stoschitzky, G; Lercher, P; Brussee, H; Lamprecht, G; Lindner, W Propafenone shows class Ic and class II antiarrhythmic effects.
Europace. 2016; 18(4):568-571 [OPEN ACCESS]
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Tomaschitz, A; Verheyen, N; Meinitzer, A; Pieske, B; Belyavskiy, E; Brussee, H; Haas, J; März, W; Pieske-Kraigher, E; Verheyen, S; Ofner-Ziegenfuss, L; Hartaigh, BÓ; Schwetz, V; Aberer, F; Grübler, M; Lang, F; Alesutan, I; Voelkl, J; Gaksch, M; Horina, JH; Dimai, HP; Rus-Machan, J; Stiegler, C; Ritz, E; Fahrleitner-Pammer, A; Pilz, S Effect of eplerenone on parathyroid hormone levels in patients with primary hyperparathyroidism: results from the EPATH randomized, placebo-controlled trial.
J Hypertens. 2016; 34(7):1347-1356
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