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Publikationen

Suchbegriffe: RAS PROTEINS - GENETICS, . Treffer: 25

2021

Berg, JL; Perfler, B; Hatzl, S; Uhl, B; Reinisch, A; Pregartner, G; Berghold, A; Penz, T; Schuster, M; Geissler, K; Prokesch, A; Müller-Tidow, C; Hoefler, G; Kashofer, K; Wölfler, A; Sill, H; Caraffini, V; Zebisch, A EZH2 inactivation in RAS-driven myeloid neoplasms hyperactivates RAS-signaling and increases MEK inhibitor sensitivity.
Leukemia. 2021; 35(5):1521-1526 Doi: 10.1038/s41375-021-01161-0 [OPEN ACCESS]
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2017

Richtig, G; Hoeller, C; Kashofer, K; Aigelsreiter, A; Heinemann, A; Kwong, LN; Pichler, M; Richtig, E Beyond the BRAF^V600E hotspot: biology and clinical implications of rare BRAF gene mutations in melanoma patients.
Br J Dermatol. 2017; 177(4):936-944 Doi: 10.1111/bjd.15436
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2015

Heitzer, E; Ulz, P; Geigl, JB Circulating tumor DNA as a liquid biopsy for cancer.
Clin Chem. 2015; 61(1):112-123 Doi: 10.1373/clinchem.2014.222679 [OPEN ACCESS]
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Kaczirek, K; Ciuleanu, TE; Vrbanec, D; Marton, E; Messinger, D; Liegl-Atzwanger, B; Wrba, F; Knittelfelder, R; Lindner, E; Zielinski, CC; Streubel, B; Brodowicz, T FOLFOX4 Plus Cetuximab for Patients With Previously Untreated Metastatic Colorectal Cancer According to Tumor RAS and BRAF Mutation Status: Updated Analysis of the CECOG/CORE 1.2.002 Study.
Clin Colorectal Cancer. 2015; 14(2):91-98 Doi: 10.1016/j.clcc.2014.12.003
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Leithner, K; Hrzenjak, A; Trötzmüller, M; Moustafa, T; Köfeler, HC; Wohlkoenig, C; Stacher, E; Lindenmann, J; Harris, AL; Olschewski, A; Olschewski, H PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Oncogene. 2015; 34(8):1044-1050 Doi: 10.1038/onc.2014.47
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Zopf, A; Raim, R; Danzer, M; Niklas, N; Spilka, R; Pröll, J; Gabriel, C; Nechansky, A; Roucka, M Introduction of the hybcell-based compact sequencing technology and comparison to state-of-the-art methodologies for KRAS mutation detection.
Biotechniques. 2015; 58(3):126-134 Doi: 10.2144/000114264 [OPEN ACCESS]
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2014

Pichler, M; Winter, E; Ress, AL; Bauernhofer, T; Gerger, A; Kiesslich, T; Lax, S; Samonigg, H; Hoefler, G miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor.
J Clin Pathol. 2014; 67(3):198-203 Doi: 10.1136/jclinpath-2013-201904
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Rau, TT; Agaimy, A; Gehoff, A; Geppert, C; Jung, K; Knobloch, K; Langner, C; Lugli, A; Groenbus-Lurkin, I; Nagtegaal, ID; Rüschoff, J; Saegert, X; Sarbia, M; Schneider-Stock, R; Vieth, M; Zwarthoff, EC; Hartmann, A Defined morphological criteria allow reliable diagnosis of colorectal serrated polyps and predict polyp genetics.
Virchows Arch. 2014; 464(6):663-672 Doi: 10.1007/s00428-014-1569-7
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2013

Buxhofer-Ausch, V; Ausch, C; Zeillinger, R; Oberkanins, C; Dandachi, N; Reiner-Concin, A; Kriegshäuser, G Duplex reverse-hybridization assay for the simultaneous detection of KRAS/BRAF mutations in FFPE-extracted genomic DNA from colorectal cancer specimens.
Dis Markers. 2013; 34(3):171-177 Doi: 10.3233/DMA-120960 [OPEN ACCESS]
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Dijkstra, JR; Heideman, DA; Meijer, GA; Boers, JE; 't Hart, NA; Diebold, J; Hirschmann, A; Hoefler, G; Winter, G; Miltenberger-Miltenyi, G; Pereira, SV; Richman, SD; Quirke, P; Rouleau, EL; Guinebretiere, JM; Tejpar, S; Biesmans, B; van Krieken, JH KRAS mutation analysis on low percentage of colon cancer cells: the importance of quality assurance.
Virchows Arch. 2013; 462(1):39-46 Doi: 10.1007/s00428-012-1356-2
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Setaffy, L; Högenauer, C; Lemmerer, M; Langner, C Large serrated polyp with KRAS mutation in inflammatory bowel disease: a "nondysplastic dysplasia-associated lesion or mass (DALM)"?
Endoscopy. 2013; 45 Suppl 2 UCTN(19):E235-E236 Doi: 10.1055/s-0033-1344321 (- Case Report) [OPEN ACCESS]
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2012

Dijkstra, JR; Opdam, FJ; Boonyaratanakornkit, J; Schönbrunner, ER; Shahbazian, M; Edsjö, A; Hoefler, G; Jung, A; Kotsinas, A; Gorgoulis, VG; Lpez-Ros, F; de Stricker, K; Rouleau, E; Biesmans, B; van Krieken, JH Implementation of formalin-fixed, paraffin-embedded cell line pellets as high-quality process controls in quality assessment programs for KRAS mutation analysis.
J Mol Diagn. 2012; 14(3):187-191 Doi: 10.1016/j.jmoldx.2012.01.002 [OPEN ACCESS]
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Pichler, M; Winter, E; Stotz, M; Eberhard, K; Samonigg, H; Lax, S; Hoefler, G; Down-regulation of KRAS-interacting miRNA-143 predicts poor prognosis but not response to EGFR-targeted agents in colorectal cancer.
Br J Cancer. 2012; 106(11):1826-1832 Doi: 10.1038/bjc.2012.175 [OPEN ACCESS]
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van Krieken, JH; Hoefler, G The times have changed: molecular pathology is here to stay. A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al. In this issue.
VIRCHOWS ARCH. 2012; 460(2): 129-130. Doi: 10.1007/s00428-012-1197-z [OPEN ACCESS]
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2011

Betge, J; Pollheimer, MJ; Schlemmer, A; Hoefler, G; Langner, C Gastric cancer and concomitant renal cancer: a systematic immunohistochemical and molecular analysis.
Oncol Rep. 2011; 26(3):567-575 Doi: 10.3892/or.2011.1346 [OPEN ACCESS]
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Jahn, SW; Winter, G; Stacher, E; Halbwedl, I; Gattenlöhner, S; Stockinger, R; Spreitzer, S; Waldispuehl-Geigl, J; Geigl, JB; Offner, F; Hoefler, G Multiple intratumoral KRAS mutations can clonally segregate to different lymph node metastases in colon cancer.
Histopathology. 2011; 59(2): 342-345. Doi: 10.1111/j.1365-2559.2011.03902.x (- Case Report)
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Kohlmann, A; Klein, HU; Weissmann, S; Bresolin, S; Chaplin, T; Cuppens, H; Haschke-Becher, E; Garicochea, B; Grossmann, V; Hanczaruk, B; Hebestreit, K; Gabriel, C; Iacobucci, I; Jansen, JH; te Kronnie, G; van de Locht, L; Martinelli, G; McGowan, K; Schweiger, MR; Timmermann, B; Vandenberghe, P; Young, BD; Dugas, M; Haferlach, T The Interlaboratory RObustness of Next-generation sequencing (IRON) study: a deep sequencing investigation of TET2, CBL and KRAS mutations by an international consortium involving 10 laboratories.
Leukemia. 2011; 25(12): 1840-1848. Doi: 10.1038/leu.2011.155 [OPEN ACCESS]
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Kriegshäuser, G; Auner, V; Schuster, E; Holzer, B; Oberkanins, C; Horvat, R; Speiser, P; Zeillinger, R KRAS mutation analysis in genomic DNA isolated from formalin-fixed paraffin-embedded ovarian tissue: evaluation of a strip-based reverse-hybridisation assay.
J Clin Pathol. 2011; 64(3): 252-256. Doi: 10.1136/jcp.2010.081414
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Kriegshäuser, G; Fabjani, G; Ziegler, B; Zöchbauer-Müller, S; End, A; Zeillinger, R Biochip-based detection of KRAS mutation in non-small cell lung cancer.
Int J Mol Sci. 2011; 12(12): 8530-8538. Doi: 10.3390/ijms12128530 [OPEN ACCESS]
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2010

Winder, T; Zhang, W; Yang, D; Ning, Y; Bohanes, P; Gerger, A; Wilson, P; Pohl, A; Mauro, DJ; Langer, C; Rowinsky, EK; Lenz, HJ Germline Polymorphisms in Genes Involved in the IGF1 Pathway Predict Efficacy of Cetuximab in Wild-type KRAS mCRC Patients.
Clin Cancer Res. 2010; 16(22):5591-5602 Doi: 10.1158/1078-0432.CCR-10-2092 [OPEN ACCESS]
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2009

Auner, V; Kriegshäuser, G; Tong, D; Horvat, R; Reinthaller, A; Mustea, A; Zeillinger, R KRAS mutation analysis in ovarian samples using a high sensitivity biochip assay.
BMC Cancer. 2009; 9(1): 111-111. Doi: 10.1186/1471-2407-9-111 [OPEN ACCESS]
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Ausch, C; Buxhofer-Ausch, V; Oberkanins, C; Holzer, B; Minai-Pour, M; Jahn, S; Dandachi, N; Zeillinger, R; Kriegshäuser, G Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.
J Mol Diagn. 2009; 11(6):508-513 Doi: 10.2353/jmoldx.2009.090022 [OPEN ACCESS]
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Erdmann, J; Grosshennig, A; Braund, PS; König, IR; Hengstenberg, C; Hall, AS; Linsel-Nitschke, P; Kathiresan, S; Wright, B; Trégouët, DA; Cambien, F; Bruse, P; Aherrahrou, Z; Wagner, AK; Stark, K; Schwartz, SM; Salomaa, V; Elosua, R; Melander, O; Voight, BF; O'Donnell, CJ; Peltonen, L; Siscovick, DS; Altshuler, D; Merlini, PA; Peyvandi, F; Bernardinelli, L; Ardissino, D; Schillert, A; Blankenberg, S; Zeller, T; Wild, P; Schwarz, DF; Tiret, L; Perret, C; Schreiber, S; El Mokhtari, NE; Schäfer, A; März, W; Renner, W; Bugert, P; Klüter, H; Schrezenmeir, J; Rubin, D; Ball, SG; Balmforth, AJ; Wichmann, HE; Meitinger, T; Fischer, M; Meisinger, C; Baumert, J; Peters, A; Ouwehand, WH; Italian Atherosclerosis, Thrombosis, and Vascular Biology Working Group; Myocardial Infarction Genetics Consortium; Wellcome Trust Case Control Consortium; Cardiogenics Consortium; Deloukas, P; Thompson, JR; Ziegler, A; Samani, NJ; Schunkert, H New susceptibility locus for coronary artery disease on chromosome 3q22.3.
Nat Genet. 2009; 41(3):280-282 Doi: 10.1038/ng.307 [OPEN ACCESS]
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2008

Schulz, AL; Albrecht, B; Arici, C; van der Burgt, I; Buske, A; Gillessen-Kaesbach, G; Heller, R; Horn, D; Hübner, CA; Korenke, GC; König, R; Kress, W; Krüger, G; Meinecke, P; Mücke, J; Plecko, B; Rossier, E; Schinzel, A; Schulze, A; Seemanova, E; Seidel, H; Spranger, S; Tuysuz, B; Uhrig, S; Wieczorek, D; Kutsche, K; Zenker, M Mutation and phenotypic spectrum in patients with cardio-facio-cutaneous and Costello syndrome.
Clin Genet. 2008; 73(1):62-70 Doi: 10.1111/j.1399-0004.2007.00931.x
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van Krieken, JH; Jung, A; Kirchner, T; Carneiro, F; Seruca, R; Bosman, FT; Quirke, P; Fléjou, JF; Plato Hansen, T; de Hertogh, G; Jares, P; Langner, C; Hoefler, G; Ligtenberg, M; Tiniakos, D; Tejpar, S; Bevilacqua, G; Ensari, A KRAS mutation testing for predicting response to anti-EGFR therapy for colorectal carcinoma: proposal for an European quality assurance program.
Virchows Arch. 2008; 453(5): 417-431. Doi: 10.1007/s00428-008-0665-y [OPEN ACCESS]
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