Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: P62, . Treffer: 36

2019

Czepukojc, B; Abuhaliema, A; Barghash, A; Tierling, S; Nass, N; Simon, Y; Korbel, C; Cadenas, C; van Hul, N; Sachinidis, A; Hengstler, JG; Helms, V; Laschke, MW; Walter, J; Haybaeck, J; Leclercq, I; Kiemer, AK; Kessler, SM IGF2 mRNA Binding Protein 2 Transgenic Mice Are More Prone to Develop a Ductular Reaction and to Progress Toward Cirrhosis
FRONT MED-LAUSANNE. 2019; 6: 179 [OPEN ACCESS]
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Dahlem, C; Barghash, A; Puchas, P; Haybaeck, J; Kessler, SM The Insulin-Like Growth Factor 2 mRNA Binding Protein IMP2/IGF2BP2 is Overexpressed and Correlates with Poor Survival in Pancreatic Cancer.
Int J Mol Sci. 2019; 20(13): [OPEN ACCESS]
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Denk, H; Stumptner, C; Abuja, PM; Zatloukal, K Sequestosome 1/p62-related pathways as therapeutic targets in hepatocellular carcinoma.
Expert Opin Ther Targets. 2019; 23(5):393-406
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2018

Kretschmer, N; Deutsch, A; Durchschein, C; Rinner, B; Stallinger, A; Higareda-Almaraz, JC; Scheideler, M; Lohberger, B; Bauer, R Comparative Gene Expression Analysis in WM164 Melanoma Cells Revealed That β-β-Dimethylacrylshikonin Leads to ROS Generation, Loss of Mitochondrial Membrane Potential, and Autophagy Induction.
Molecules. 2018; 23(11): [OPEN ACCESS]
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Sukseree, S; László, L; Gruber, F; Bergmann, S; Narzt, MS; Nagelreiter, IM; Höftberger, R; Molnár, K; Rauter, G; Birngruber, T; Larue, L; Kovacs, GG; Tschachler, E; Eckhart, L Filamentous Aggregation of Sequestosome-1/p62 in Brain Neurons and Neuroepithelial Cells upon Tyr-Cre-Mediated Deletion of the Autophagy Gene Atg7.
Mol Neurobiol. 2018; 55(11):8425-8437 [OPEN ACCESS]
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2017

Aigelsreiter, A; Neumann, J; Pichler, M; Halasz, J; Zatloukal, K; Berghold, A; Douschan, P; Rainer, F; Stauber, R; Haybaeck, J; Denk, H; Lackner, C Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis.
Liver Int. 2017; 37(4):600-610
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Kessler, SM; Lederer, E; Laggai, S; Golob-Schwarzl, N; Hosseini, K; Petzold, J; Schweiger, C; Reihs, R; Keil, M; Hoffmann, J; Mayr, C; Kiesslich, T; Pichler, M; Kim, KS; Rhee, H; Park, YN; Lax, S; Obrist, P; Kiemer, AK; Haybaeck, J IMP2/IGF2BP2 expression, but not IMP1 and IMP3, predicts poor outcome in patients and high tumor growth rate in xenograft models of gallbladder cancer.
Oncotarget. 2017; 8(52):89736-89745 [OPEN ACCESS]
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Mehta, AK; Hua, K; Whipple, W; Nguyen, MT; Liu, CT; Haybaeck, J; Weidhaas, J; Settleman, J; Singh, A Regulation of autophagy, NF-κB signaling, and cell viability by miR-124 in KRAS mutant mesenchymal-like NSCLC cells.
Sci Signal. 2017; 10(496): [OPEN ACCESS]
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2016

Barghash, A; Golob-Schwarzl, N; Helms, V; Haybaeck, J; Kessler, SM Elevated expression of the IGF2 mRNA binding protein 2 (IGF2BP2/IMP2) is linked to short survival and metastasis in esophageal adenocarcinoma.
Oncotarget. 2016; 7(31):49743-49750 [OPEN ACCESS]
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Lahiri, P; Schmidt, V; Smole, C; Kufferath, I; Denk, H; Strnad, P; Rülicke, T; Fröhlich, LF; Zatloukal, K p62/Sequestosome-1 Is Indispensable for Maturation and Stabilization of Mallory-Denk Bodies.
PLoS One. 2016; 11(8):e0161083-e0161083 [OPEN ACCESS]
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Yang, H; Ni, HM; Guo, F; Ding, Y; Shi, YH; Lahiri, P; Fröhlich, LF; Rülicke, T; Smole, C; Schmidt, VC; Zatloukal, K; Cui, Y; Komatsu, M; Fan, J; Ding, WX Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice.
J Biol Chem. 2016; 291(36):18663-18674 [OPEN ACCESS]
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2015

Goeritzer, M; Vujic, N; Schlager, S; Chandak, PG; Korbelius, M; Gottschalk, B; Leopold, C; Obrowsky, S; Rainer, S; Doddapattar, P; Aflaki, E; Wegscheider, M; Sachdev, V; Graier, WF; Kolb, D; Radovic, B; Kratky, D Active autophagy but not lipophagy in macrophages with defective lipolysis.
Biochim Biophys Acta. 2015; 1851(10):1304-1316 [OPEN ACCESS]
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Kessler, SM; Laggai, S; Barghash, A; Schultheiss, CS; Lederer, E; Artl, M; Helms, V; Haybaeck, J; Kiemer, AK IMP2/p62 induces genomic instability and an aggressive hepatocellular carcinoma phenotype.
Cell Death Dis. 2015; 6(1):e1894-e1894 [OPEN ACCESS]
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2014

Laggai, S; Kessler, SM; Boettcher, S; Lebrun, V; Gemperlein, K; Lederer, E; Leclercq, IA; Mueller, R; Hartmann, RW; Haybaeck, J; Kiemer, AK The IGF2 mRNA binding protein p62/IGF2BP2-2 induces fatty acid elongation as a critical feature of steatosis.
J Lipid Res. 2014; 55(6):1087-1097 [OPEN ACCESS]
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Lunova, M; Goehring, C; Kuscuoglu, D; Mueller, K; Chen, Y; Walther, P; Deschemin, JC; Vaulont, S; Haybaeck, J; Lackner, C; Trautwein, C; Strnad, P Hepcidin knockout mice fed with iron-rich diet develop chronic liver injury and liver fibrosis due to lysosomal iron overload.
J Hepatol. 2014; 61(3):633-641
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Simon, Y; Kessler, SM; Gemperlein, K; Bohle, RM; Müller, R; Haybaeck, J; Kiemer, AK Elevated free cholesterol in a p62 overexpression model of non-alcoholic steatohepatitis.
World J Gastroenterol. 2014; 20(47):17839-17850 [OPEN ACCESS]
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Zatloukal, B; Kufferath, I; Thueringer, A; Landegren, U; Zatloukal, K; Haybaeck, J Sensitivity and specificity of in situ proximity ligation for protein interaction analysis in a model of steatohepatitis with Mallory-Denk bodies.
PLoS One. 2014; 9(5):e96690-e96690 [OPEN ACCESS]
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2013

Nikam, A; Patankar, JV; Lackner, C; Schöck, E; Kratky, D; Zatloukal, K; Abuja, PM Transition between acute and chronic hepatotoxicity in mice is associated with impaired energy metabolism and induction of mitochondrial heme oxygenase-1.
PLoS One. 2013; 8(6):e66094-e66094 [OPEN ACCESS]
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Strnad, P; Nuraldeen, R; Guldiken, N; Hartmann, D; Mahajan, V; Denk, H; Haybaeck, J Broad spectrum of hepatocyte inclusions in humans, animals, and experimental models.
Compr Physiol. 2013; 3(4):1393-1436
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2011

Mahajan, V; Klingstedt, T; Simon, R; Nilsson, KP; Thueringer, A; Kashofer, K; Haybaeck, J; Denk, H; Abuja, PM; Zatloukal, K Cross β-sheet conformation of keratin 8 is a specific feature of Mallory-Denk bodies compared with other hepatocyte inclusions.
Gastroenterology. 2011; 141(3):1080-1090.e1-1080-1090.e7
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Molnar, A; Haybaeck, J; Lackner, C; Strnad, P The cytoskeleton in nonalcoholic steatohepatitis: 100 years old but still youthful.
Expert Rev Gastroenterol Hepatol. 2011; 5(2): 167-177.
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2008

Strnad, P; Stumptner, C; Zatloukal, K; Denk, H Intermediate filament cytoskeleton of the liver in health and disease.
HISTOCHEMISTRY CELL BIOL. 2008; 129(6): 735-749. [OPEN ACCESS]
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Strnad, P; Zatloukal, K; Stumptner, C; Kulaksiz, H; Denk, H Mallory-Denk-bodies: lessons from keratin-containing hepatic inclusion bodies.
Biochim Biophys Acta. 2008; 1782(12): 764-774. [OPEN ACCESS]
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2007

Aigelsreiter, A; Janig, E; Stumptner, C; Fuchsbichler, A; Zatloukal, K; Denk, H How a cell deals with abnormal proteins. Pathogenetic mechanisms in protein aggregation diseases.
Pathobiology. 2007; 74(3): 145-158. [OPEN ACCESS]
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Stumptner, C; Fuchsbichler, A; Zatloukal, K; Denk, H In vitro production of Mallory bodies and intracellular hyaline bodies: the central role of sequestosome 1/p62.
Hepatology. 2007; 46(3): 851-860. [OPEN ACCESS]
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Zatloukal, K; French, SW; Stumptner, C; Strnad, P; Harada, M; Toivola, DM; Cadrin, M; Omary, MB From Mallory to Mallory-Denk bodies: what, how and why?
EXP CELL RES. 2007; 313(10): 2033-2049.
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2006

Denk, H; Stumptner, C; Fuchsbichler, A; Müller, T; Farr, G; Müller, W; Terracciano, L; Zatloukal, K Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related?
J PATHOL. 2006; 208: 653-661.
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2005

Denk, H; Stumptner, C; Fuchsbichler, A; Zatloukal, K Alcoholic and non-alcoholic steatohepatitis
Verh Dtsch Ges Pathol. 2005; 89(6): 137-143.
PubMed

 

Janig, E; Stumptner, C; Fuchsbichler, A; Denk, H; Zatloukal, K Interaction of stress proteins with misfolded keratins.
EUR J CELL BIOL. 2005; 84(2-3): 329-339.
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Lackner, C; Dlaska, D; Fuchsbichler, A; Stumptner, C; Gogg-Kamerer, M; Zatloukal, K; Denk, H p62 protein is expressed in pancreatic beta cells.
J PATHOL. 2005; 206(4): 402-408.
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2004

Müller, T; Langner, C; Fuchsbichler, A; Heinz-Erian, P; Ellemunter, H; Schlenck, B; Bavdekar, AR; Pradhan, AM; Pandit, A; Müller-Höcker, J; Melter, M; Kobayashi, K; Nagasaka, H; Kikuta, H; Müller, W; Tanner, MS; Sternlieb, I; Zatloukal, K; Denk, H Immunohistochemical analysis of Mallory bodies in Wilsonian and non-Wilsonian hepatic copper toxicosis.
HEPATOLOGY. 2004; 39(4): 963-969. [OPEN ACCESS]
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2002

Maderegger, B; Bermel, W; Hrzenjak, A; Kostner, GM; Sterk, H Solution structure of human apolipoprotein(a) kringle IV type 6.
Biochemistry. 2002; 41(2):660-668
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Stumptner, C; Fuchsbichler, A; Heid, H; Zatloukal, K; Denk, H Mallory body--a disease-associated type of sequestosome.
HEPATOLOGY. 2002; 35(5): 1053-1062. [OPEN ACCESS]
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Zatloukal, K; Stumptner, C; Fuchsbichler, A; Heid, H; Schnoelzer, M; Kenner, L; Kleinert, R; Prinz, M; Aguzzi, A; Denk, H p62 Is a common component of cytoplasmic inclusions in protein aggregation diseases.
Am J Pathol. 2002; 160(1):255-263 [OPEN ACCESS]
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1999

Stumptner, C; Heid, H; Fuchsbichler, A; Hauser, H; Mischinger, HJ; Zatloukal, K; Denk, H Analysis of intracytoplasmic hyaline bodies in a hepatocellular carcinoma. Demonstration of p62 as major constituent.
Am J Pathol. 1999; 154(6):1701-1710 (- Case Report) [OPEN ACCESS]
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Stumptner, C; Heid, H; Zatloukal, K; Fuchsbichler, A; Hauser, H; Denk, H Identification of p62, a phosphotyrosine independent ligand of p56lck kinase, as a major component of intracytoplasmic hyaline bodies in hepatocellular carcinoma.
Verh Dtsch Ges Pathol. 1999; 83: 254-259.
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