Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz
Publikationen
Suchbegriffe: MTOR, . Treffer: 92
2023
Dai, Q; Zhang, J; Long, W; Haybaeck, J; Yang, Z
Genetic alterations of GI-NECs involving three main signaling pathways.
Cancer Med. 2023;
Doi: 10.1002/cam4.5633
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Liebscher, G; Vujic, N; Schreiber, R; Heine, M; Krebiehl, C; Duta-Mare, M; Lamberti, G; de, Smet, CH; Hess, MW; Eichmann, TO; Hölzl, S; Scheja, L; Heeren, J; Kratky, D; Huber, LA
The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue.
Mol Metab. 2023; 101705
Doi: 10.1016/j.molmet.2023.101705
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2022
Chao, X; Wang, S; Fulte, S; Ma, X; Ahamed, F; Cui, W; Liu, Z; Rülicke, T; Zatloukal, K; Zong, WX; Liu, W; Ni, HM; Ding, WX
Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy.
J Hepatol. 2022; 76(3):639-651
Doi: 10.1016/j.jhep.2021.10.014
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Driva, TS; Schatz, C; Sobočan, M; Haybaeck, J
The Role of mTOR and eIF Signaling in Benign Endometrial Diseases.
Int J Mol Sci. 2022; 23(7):
Doi: 10.3390/ijms23073416
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Gufler, S; Seeboeck, R; Schatz, C; Haybaeck, J
The Translational Bridge between Inflammation and Hepatocarcinogenesis.
Cells. 2022; 11(3):
Doi: 10.3390/cells11030533
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Huang, R; Dai, Q; Yang, R; Duan, Y; Zhao, Q; Haybaeck, J; Yang, Z
A Review: PI3K/AKT/mTOR Signaling Pathway and Its Regulated Eukaryotic Translation Initiation Factors May Be a Potential Therapeutic Target in Esophageal Squamous Cell Carcinoma.
Front Oncol. 2022; 12: 817916
Doi: 10.3389/fonc.2022.817916
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Krstic, J; Reinisch, I; Schindlmaier, K; Galhuber, M; Riahi, Z; Berger, N; Kupper, N; Moyschewitz, E; Auer, M; Michenthaler, H; Nössing, C; Depaoli, MR; Ramadani-Muja, J; Usluer, S; Stryeck, S; Pichler, M; Rinner, B; Deutsch, AJA; Reinisch, A; Madl, T; Chiozzi, RZ; Heck, AJR; Huch, M; Malli, R; Prokesch, A
Fasting improves therapeutic response in hepatocellular carcinoma through p53-dependent metabolic synergism.
Sci Adv. 2022; 8(3):eabh2635
Doi: 10.1126/sciadv.abh2635
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Lindenmann, J; Kamolz, L; Graier, W; Smolle, J; Smolle-Juettner, FM
Hyperbaric Oxygen Therapy and Tissue Regeneration: A Literature Survey.
Biomedicines. 2022; 10(12):
Doi: 10.3390/biomedicines10123145
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Pandey, S; Madreiter-Sokolowski, CT; Mangmool, S; Parichatikanond, W
High Glucose-Induced Cardiomyocyte Damage Involves Interplay between Endothelin ET-1/ETA/ETB Receptor and mTOR Pathway
INT J MOL SCI. 2022; 23(22): 13816
Doi: 10.3390/ijms232213816
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Wicik, Z; Nowak, A; Jarosz-Popek, J; Wolska, M; Eyileten, C; Siller-Matula, JM; von, Lewinski, D; Sourij, H; Filipiak, KJ; Postuła, M
Characterization of the SGLT2 Interaction Network and Its Regulation by SGLT2 Inhibitors: A Bioinformatic Analysis.
Front Pharmacol. 2022; 13: 901340
Doi: 10.3389/fphar.2022.901340
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2021
Álvarez, RM; García, AB; Riesco-Fagundo, C; Martín, JI; Varela, C; Rodríguez, Hergueta, A; González, Cantalapiedra, E; Oyarzabal, J; Di, Geronimo, B; Lorenzo, M; Albarrán, MI; Cebriá, A; Cebrián, D; Martínez-González, S; Blanco-Aparicio, C; Pastor, J
Omipalisib inspired macrocycles as dual PI3K/mTOR inhibitors.
Eur J Med Chem. 2021; 211: 113109
Doi: 10.1016/j.ejmech.2020.113109
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Bracic, Tomazic, S; Schatz, C; Haybaeck, J
Translational Regulation in Hepatocellular Carcinogenesis.
Drug Des Devel Ther. 2021; 15: 4359-4369.
Doi: 10.2147/DDDT.S255582
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Joshi, L; Plastira, I; Bernhart, E; Reicher, H; Koyani, CN; Madl, T; Madreiter-Sokolowski, C; Koshenov, Z; Graier, WF; Hallström, S; Sattler, W
Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia.
Int J Mol Sci. 2021; 22(4):
Doi: 10.3390/ijms22041968
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Krassnig, S; Wohlrab, C; Golob-Schwarzl, N; Raicht, A; Schatz, C; Birkl-Toeglhofer, AM; Skofler, C; Gantenbein, N; Leoni, M; Asslaber, M; Leber, SL; Mahdy-Ali, K; von Campe, G; Mayer, M; Borenich, A; Weis, S; Benesch, M; Haybaeck, J
A Profound Basic Characterization of eIFs in Gliomas: Identifying eIF3I and 4H as Potential Novel Target Candidates in Glioma Therapy.
Cancers (Basel). 2021; 13(6):
Doi: 10.3390/cancers13061482
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Laskaratos, FM; Levi, A; Schwach, G; Pfragner, R; Hall, A; Xia, D; von Stempel, C; Bretherton, J; Thanapirom, K; Alexander, S; Ogunbiyi, O; Watkins, J; Luong, TV; Toumpanakis, C; Mandair, D; Caplin, M; Rombouts, K
Transcriptomic Profiling of In Vitro Tumor-Stromal Cell Paracrine Crosstalk Identifies Involvement of the Integrin Signaling Pathway in the Pathogenesis of Mesenteric Fibrosis in Human Small Intestinal Neuroendocrine Neoplasms.
Front Oncol. 2021; 11(6):629665-629665
Doi: 10.3389/fonc.2021.629665
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Maccari, ME; Fuchs, S; Kury, P; Andrieux, G; Völkl, S; Bengsch, B; Lorenz, MR; Heeg, M; Rohr, J; Jägle, S; Castro, CN; Groß, M; Warthorst, U; König, C; Fuchs, I; Speckmann, C; Thalhammer, J; Kapp, FG; Seidel, MG; Dückers, G; Schönberger, S; Schütz, C; Führer, M; Kobbe, R; Holzinger, D; Klemann, C; Smisek, P; Owens, S; Horneff, G; Kolb, R; Naumann-Bartsch, N; Miano, M; Staniek, J; Rizzi, M; Kalina, T; Schneider, P; Erxleben, A; Backofen, R; Ekici, A; Niemeyer, CM; Warnatz, K; Grimbacher, B; Eibel, H; Mackensen, A; Frei, AP; Schwarz, K; Boerries, M; Ehl, S; Rensing-Ehl, A
A distinct CD38+CD45RA+ population of CD4+, CD8+, and double-negative T cells is controlled by FAS.
J Exp Med. 2021; 218(2):
Doi: 10.1084/jem.20192191
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Martinez, RS; Salji, MJ; Rushworth, L; Ntala, C; Rodriguez, Blanco, G; Hedley, A; Clark, W; Peixoto, P; Hervouet, E; Renaude, E; Kung, SHY; Galbraith, LCA; Nixon, C; Lilla, S; MacKay, GM; Fazli, L; Gaughan, L; Sumpton, D; Gleave, ME; Zanivan, S; Blomme, A; Leung, HY
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer.
Cancer Res. 2021; 81(13):3664-3678
Doi: 10.1158/0008-5472.CAN-20-3694
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Martínez-González, S; Alvarez, RM; Martín, JI; García, AB; Riesco-Fagundo, C; Varela, C; Rodríguez, Hergueta, A; González, Cantalapiedra, E; Albarrán, MI; Gómez-Casero, E; Cebriá, A; Aguirre, E; Ajenjo, N; Cebrián, D; Di, Geronimo, B; Cunningham, D; O'Neill, M; Dave, HPG; Blanco-Aparicio, C; Pastor, J
Macrocyclization as a Source of Desired Polypharmacology. Discovery of Triple PI3K/mTOR/PIM Inhibitors.
ACS Med Chem Lett. 2021; 12(11): 1794-1801.
Doi: 10.1021/acsmedchemlett.1c00412
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Mathilakathu, A; Borchert, S; Wessolly, M; Mairinger, E; Beckert, H; Steinborn, J; Hager, T; Christoph, DC; Kollmeier, J; Wohlschlaeger, J; Mairinger, T; Schmid, KW; Walter, RFH; Brcic, L; Mairinger, FD
Mitogen signal-associated pathways, energy metabolism regulation, and mediation of tumor immunogenicity play essential roles in the cellular response of malignant pleural mesotheliomas to platinum-based treatment: a retrospective study
TRANSL LUNG CANCER R. 2021;
Doi: 10.21037/tlcr-21-201
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Merle, DA; Provenzano, F; Jarboui, MA; Kilger, E; Clark, SJ; Deleidi, M; Armento, A; Ueffing, M
mTOR Inhibition via Rapamycin Treatment Partially Reverts the Deficit in Energy Metabolism Caused by FH Loss in RPE Cells.
Antioxidants (Basel). 2021; 10(12):
Doi: 10.3390/antiox10121944
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Najumudeen, AK; Ceteci, F; Fey, SK; Hamm, G; Steven, RT; Hall, H; Nikula, CJ; Dexter, A; Murta, T; Race, AM; Sumpton, D; Vlahov, N; Gay, DM; Knight, JRP; Jackstadt, R; Leach, JDG; Ridgway, RA; Johnson, ER; Nixon, C; Hedley, A; Gilroy, K; Clark, W; Malla, SB; Dunne, PD; Rodriguez-Blanco, G; Critchlow, SE; Mrowinska, A; Malviya, G; Solovyev, D; Brown, G; Lewis, DY; Mackay, GM; Strathdee, D; Tardito, S; Gottlieb, E; Takats, Z; Barry, ST; Goodwin, RJA; Bunch, J; Bushell, M; Campbell, AD; Sansom, OJ, , CRUK, Rosetta, Grand, Challenge, Consortium
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer.
Nat Genet. 2021; 53(1):16-26
Doi: 10.1038/s41588-020-00753-3
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Qian, H; Bai, Q; Yang, X; Akakpo, JY; Ji, L; Yang, L; Rülicke, T; Zatloukal, K; Jaeschke, H; Ni, HM; Ding, WX
Dual roles of p62/SQSTM1 in the injury and recovery phases of acetaminophen-induced liver injury in mice.
Acta Pharm Sin B. 2021; 11(12):3791-3805
Doi: 10.1016/j.apsb.2021.11.010
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Skofler, C; Kleinegger, F; Krassnig, S; Birkl-Toeglhofer, AM; Singer, G; Till, H; Benesch, M; Cencic, R; Porco, JA; Pelletier, J; Castellani, C; Raicht, A; Izycka-Swieszewska, E; Czapiewski, P; Haybaeck, J
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma.
Cells. 2021; 10(2):
Doi: 10.3390/cells10020301
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Zhu, C; Boucheron, N; Müller, AC; Májek, P; Claudel, T; Halilbasic, E; Baazim, H; Lercher, A; Viczenczova, C; Hainberger, D; Preglej, T; Sandner, L; Alteneder, M; Gülich, AF; Khan, M; Hamminger, P; Remetic, J; Ohradanova-Repic, A; Schatzlmaier, P; Donner, C; Fuchs, CD; Stojakovic, T; Scharnagl, H; Sakaguchi, S; Weichhart, T; Bergthaler, A; Stockinger, H; Ellmeier, W; Trauner, M
24-Norursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation.
J Hepatol. 2021; 75(5):1164-1176
Doi: 10.1016/j.jhep.2021.06.036
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2020
Duan, Y; Haybaeck, J; Yang, Z
Therapeutic Potential of PI3K/AKT/mTOR Pathway in Gastrointestinal Stromal Tumors: Rationale and Progress.
Cancers (Basel). 2020; 12(10):
Doi: 10.3390/cancers12102972
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Engelmann, C; Sterneck, M; Weiss, KH; Templin, S; Zopf, S; Denk, G; Eurich, D; Pratschke, J; Weiss, J; Braun, F; Welker, MW; Zimmermann, T; Knipper, P; Nierhoff, D; Lorf, T; Jäckel, E; Hau, HM; Tsui, TY; Perrakis, A; Schlitt, HJ; Herzer, K; Tacke, F
Prevention and Management of CMV Infections after Liver Transplantation: Current Practice in German Transplant Centers.
J Clin Med. 2020; 9(8):
Doi: 10.3390/jcm9082352
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Golob-Schwarzl, N; Puchas, P; Gogg-Kamerer, M; Weichert, W; Göppert, B; Haybaeck, J
New Pancreatic Cancer Biomarkers eIF1, eIF2D, eIF3C and eIF6 Play a Major Role in Translational Control in Ductal Adenocarcinoma.
Anticancer Res. 2020; 40(6):3109-3118
Doi: 10.21873/anticanres.14292
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Passerini, L; Barzaghi, F; Curto, R; Sartirana, C; Barera, G; Tucci, F; Albarello, L; Mariani, A; Testoni, PA; Bazzigaluppi, E; Bosi, E; Lampasona, V; Neth, O; Zama, D; Hoenig, M; Schulz, A; Seidel, MG; Rabbone, I; Olek, S; Roncarolo, MG; Cicalese, MP; Aiuti, A; Bacchetta, R
Treatment with rapamycin can restore regulatory T-cell function in IPEX patients.
J Allergy Clin Immunol. 2020; 145(4):1262-1271
Doi: 10.1016/j.jaci.2019.11.043
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Sobočan, M; Bračič, S; Knez, J; Takač, I; Haybaeck, J
The Communication Between the PI3K/AKT/mTOR Pathway and Y-box Binding Protein-1 in Gynecological Cancer.
Cancers (Basel). 2020; 12(1):
Doi: 10.3390/cancers12010205
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Terbuch, A; Tiu, C; Candilejo, IM; Scaranti, M; Curcean, A; Bar, D; Estevez Timon, M; Ameratunga, M; Ang, JE; Ratoff, J; Minchom, AR; Banerji, U; de Bono, JS; Tunariu, N; Lopez, JS
Radiological Patterns of Drug-induced Interstitial Lung Disease (DILD) in Early-phase Oncology Clinical Trials.
Clin Cancer Res. 2020; 26(18):4805-4813
Doi: 10.1158/1078-0432.CCR-20-0454
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Xie, H; Heier, C; Kien, B; Vesely, PW; Tang, Z; Sexl, V; Schoiswohl, G; Strießnig-Bina, I; Hoefler, G; Zechner, R; Schweiger, M
Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(9):158737-158737
Doi: 10.1016/j.bbalip.2020.158737
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2019
Katholnig, K; Schütz, B; Fritsch, SD; Schörghofer, D; Linke, M; Sukhbaatar, N; Matschinger, JM; Unterleuthner, D; Hirtl, M; Lang, M; Herac, M; Spittler, A; Bergthaler, A; Schabbauer, G; Bergmann, M; Dolznig, H; Hengstschläger, M; Magnuson, MA; Mikula, M; Weichhart, T
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
JCI Insight. 2019; 4(20):
Doi: 10.1172/jci.insight.124164
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Menzl, I; Zhang, T; Berger-Becvar, A; Grausenburger, R; Heller, G; Prchal-Murphy, M; Edlinger, L; Knab, VM; Uras, IZ; Grundschober, E; Bauer, K; Roth, M; Skucha, A; Liu, Y; Hatcher, JM; Liang, Y; Kwiatkowski, NP; Fux, D; Hoelbl-Kovacic, A; Kubicek, S; Melo, JV; Valent, P; Weichhart, T; Grebien, F; Zuber, J; Gray, NS; Sexl, V
A kinase-independent role for CDK8 in BCR-ABL1+ leukemia.
Nat Commun. 2019; 10(1): 4741
Doi: 10.1038/s41467-019-12656-x
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Seeboeck, R; Sarne, V; Haybaeck, J
Current Coverage of the mTOR Pathway by Next-Generation Sequencing Oncology Panels.
Int J Mol Sci. 2019; 20(3):
Doi: 10.3390/ijms20030690
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2018
Blesl, A; Krones, E; Pollheimer, MJ; Haybaeck, J; Wiesspeiner, U; Lipp, RW; Kump, P
Downgrading of a G3 Neuroendocrine Tumor to a G2 Tumor: Can First-Line Cytotoxic Chemotherapy Change the Tumor Biology?
Case Rep Oncol. 2018; 10(3):1121-1126
Doi: 10.1159/000484473
(- Case Report)
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Gantenbein, N; Wodlej, C; Smolle, E; Thalhammer, M; Kornprat, P; Lackner, K; Brcic, I; Spindelboeck, W; Kump, P; Lipp, R; Haybaeck, J
Are eIFs Ingredients for Neuroendocrine Tumorigenesis?
NEUROENDOCRINOLOGY. 2018; 106: 5-5.-15th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease; MAR 07-09, 2018; Barcelona, SPAIN.
[Poster]
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Gao, Y; Arfat, Y; Wang, H; Goswami, N
Muscle Atrophy Induced by Mechanical Unloading: Mechanisms and Potential Countermeasures.
Front Physiol. 2018; 9: 235-235.
Doi: 10.3389/fphys.2018.00235
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Kirste, S; Kayser, G; Zipfel, A; Grosu, AL; Brunner, T
Unresectable hepatic PEComa: a rare malignancy treated with stereotactic body radiation therapy (SBRT) followed by complete resection.
Radiat Oncol. 2018; 13(1):28
Doi: 10.1186/s13014-018-0974-5
(- Case Report)
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Shen, P; Reineke, LC; Knutsen, E; Chen, M; Pichler, M; Ling, H; Calin, GA
Metformin blocks MYC protein synthesis in colorectal cancer via mTOR-4EBP-eIF4E and MNK1-eIF4G-eIF4E signaling.
Mol Oncol. 2018; 12(11): 1856-1870.
Doi: 10.1002/1878-0261.12384
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Tang, Y; Blomenkamp, KS; Fickert, P; Trauner, M; Teckman, JH
NorUDCA promotes degradation of α1-antitrypsin mutant Z protein by inducing autophagy through AMPK/ULK1 pathway.
PLoS One. 2018; 13(8):e0200897-e0200897
Doi: 10.1371/journal.pone.0200897
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Zboray, K; Mohrherr, J; Stiedl, P; Pranz, K; Wandruszka, L; Grabner, B; Eferl, R; Moriggl, R; Stoiber, D; Sakamoto, K; Wagner, KU; Popper, H; Casanova, E; Moll, HP
AKT3 drives adenoid cystic carcinoma development in salivary glands.
Cancer Med. 2018; 7(2):445-453
Doi: 10.1002/cam4.1293
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2017
Buerger, C; Shirsath, N; Lang, V; Berard, A; Diehl, S; Kaufmann, R; Boehncke, WH; Wolf, P
Inflammation dependent mTORC1 signaling interferes with the switch from keratinocyte proliferation to differentiation.
PLoS One. 2017; 12(7):e0180853-e0180853
Doi: 10.1371/journal.pone.0180853
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Bürger, C; Shirsath, N; Lang, V; Diehl, S; Kaufmann, R; Weigert, A; Han, YY; Ringel, C; Wolf, P
Blocking mTOR Signalling with Rapamycin Ameliorates Imiquimod-induced Psoriasis in Mice.
Acta Derm Venereol. 2017; 97(9):1087-1094
Doi: 10.2340/00015555-2724
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Cuppens, T; Annibali, D; Coosemans, A; Trovik, J; Ter Haar, N; Colas, E; Garcia-Jimenez, A; Van de Vijver, K; Kruitwagen, RP; Brinkhuis, M; Zikan, M; Dundr, P; Huvila, J; Carpén, O; Haybaeck, J; Moinfar, F; Salvesen, HB; Stukan, M; Mestdagh, C; Zweemer, RP; Massuger, LF; Mallmann, MR; Wardelmann, E; Mints, M; Verbist, G; Thomas, D; Gommé, E; Hermans, E; Moerman, P; Bosse, T; Amant, F
Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative.
Clin Cancer Res. 2017; 23(5):1274-1285
Doi: 10.1158/1078-0432.CCR-16-2149
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Gantenbein, N; Bernhart, E; Anders, I; Lindenmann, J; Fink-Neubock, N; Brcic, L; Gollowitsch, F; Stacher-Priehse, E; Rolff, J; Hoffmann, J; Reinhard, C; Popper, H; Sattler, W; Haybaeck, J
Eukaryotic Translation Initiation Factors Impact Non-Small Cell Lung Cancer
J THORAC ONCOL. 2017; 12(1):S1141-S1142.
Doi: 10.1016/j.jtho.2016.11.1602
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Golob-Schwarzl, N; Krassnig, S; Toeglhofer, AM; Park, YN; Gogg-Kamerer, M; Vierlinger, K; Schröder, F; Rhee, H; Schicho, R; Fickert, P; Haybaeck, J
New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors.
Eur J Cancer. 2017; 83(60):56-70
Doi: 10.1016/j.ejca.2017.06.003
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Golob-Schwarzl, N; Schweiger, C; Koller, C; Krassnig, S; Gogg-Kamerer, M; Gantenbein, N; Toeglhofer, AM; Wodlej, C; Bergler, H; Pertschy, B; Uranitsch, S; Holter, M; El-Heliebi, A; Fuchs, J; Punschart, A; Stiegler, P; Keil, M; Hoffmann, J; Henderson, D; Lehrach, H; Reinhard, C; Regenbrecht, C; Schicho, R; Fickert, P; Lax, S; Haybaeck, J
Separation of low and high grade colon and rectum carcinoma by eukaryotic translation initiation factors 1, 5 and 6.
Oncotarget. 2017; 8(60):101224-101243
Doi: 10.18632/oncotarget.20642
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Riedl, A; Schlederer, M; Pudelko, K; Stadler, M; Walter, S; Unterleuthner, D; Unger, C; Kramer, N; Hengstschläger, M; Kenner, L; Pfeiffer, D; Krupitza, G; Dolznig, H
Comparison of cancer cells in 2D vs 3D culture reveals differences in AKT-mTOR-S6K signaling and drug responses.
J Cell Sci. 2017; 130(1):203-218
Doi: 10.1242/jcs.188102
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Stefanzl, G; Berger, D; Cerny-Reiterer, S; Blatt, K; Eisenwort, G; Sperr, WR; Hoermann, G; Lind, K; Hauswirth, AW; Bettelheim, P; Sill, H; Melo, JV; Jager, U; Valent, P
The pan-BCL-2-blocker obatoclax (GX15-070) and the PI3-kinase/mTOR-inhibitor BEZ235 produce cooperative growth-inhibitory effects in ALL cells
ONCOTARGET. 2017; 8(40): 67709-67722.
Doi: 10.18632/oncotarget.18810
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Zeitelhofer, M; Adzemovic, MZ; Gomez-Cabrero, D; Bergman, P; Hochmeister, S; N'diaye, M; Paulson, A; Ruhrmann, S; Almgren, M; Tegnér, JN; Ekström, TJ; Guerreiro-Cacais, AO; Jagodic, M
Functional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis .
Proc Natl Acad Sci U S A. 2017; 114(9):E1678-E1687
Doi: 10.1073/pnas.1615783114
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