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Rosiglitazone Reverses Inflammation in Epididymal White Adipose Tissue in Hormone-Sensitive Lipase-Knockout Mice.
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Liebscher, G; Vujic, N; Schreiber, R; Heine, M; Krebiehl, C; Duta-Mare, M; Lamberti, G; de, Smet, CH; Hess, MW; Eichmann, TO; Hölzl, S; Scheja, L; Heeren, J; Kratky, D; Huber, LA
The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue.
Mol Metab. 2023; 71: 101705
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Bradić, I; Kuentzel, KB; Honeder, S; Grabner, GF; Vujić, N; Zimmermann, R; Birner-Gruenberger, R; Kratky, D
Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases.
Mol Metab. 2022; 61:101510
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Fuchs, CD; Radun, R; Dixon, ED; Mlitz, V; Timelthaler, G; Halilbasic, E; Herac, M; Jonker, JW; Ronda, OAHO; Tardelli, M; Haemmerle, G; Zimmermann, R; Scharnagl, H; Stojakovic, T; Verkade, HJ; Trauner, M
Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Hepatology. 2022; 75(1):125-139
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Kanti, MM; Striessnig-Bina, I; Wieser, BI; Schauer, S; Leitinger, G; Eichmann, TO; Schweiger, M; Winkler, M; Winter, E; Lana, A; Kufferath, I; Marsh, LM; Kwapiszewska, G; Zechner, R; Hoefler, G; Vesely, PW
Adipose triglyceride lipase-mediated lipid catabolism is essential for bronchiolar regeneration.
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Kien, B; Kolleritsch, S; Kunowska, N; Heier, C; Chalhoub, G; Tilp, A; Wolinski, H; Stelzl, U; Haemmerle, G
Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation
J LIPID RES. 2022; 63(3): 100172
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Riegler-Berket, L; Wechselberger, L; Cerk, IK; Padmanabha, Das, KM; Viertlmayr, R; Kulminskaya, N; Rodriguez, Gamez, CF; Schweiger, M; Zechner, R; Zimmermann, R; Oberer, M
Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(3): 159105
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Desoye, G; Herrera, E
Adipose tissue development and lipid metabolism in the human fetus: The 2020 perspective focusing on maternal diabetes and obesity.
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Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
Mol Metab. 2021; 47:101174
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Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.
Int J Mol Sci. 2021; 22(19):
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Pajed, L; Taschler, U; Tilp, A; Hofer, P; Kotzbeck, P; Kolleritsch, S; Radner, FPW; Pototschnig, I; Wagner, C; Schratter, M; Eder, S; Huetter, S; Schreiber, R; Haemmerle, G; Eichmann, TO; Schweiger, M; Hoefler, G; Kershaw, EE; Lass, A; Schoiswohl, G
Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
Commun Biol. 2021; 4(1):323
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Hofer, P; Taschler, U; Schreiber, R; Kotzbeck, P; Schoiswohl, G
The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.
Metabolites. 2020; 10(4):
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Kolleritsch, S; Kien, B; Schoiswohl, G; Diwoky, C; Schreiber, R; Heier, C; Maresch, LK; Schweiger, M; Eichmann, TO; Stryeck, S; Krenn, P; Tomin, T; Schittmayer, M; Kolb, D; Rülicke, T; Hoefler, G; Wolinski, H; Madl, T; Birner-Gruenberger, R; Haemmerle, G
Low cardiac lipolysis reduces mitochondrial fission and prevents lipotoxic heart dysfunction in Perilipin 5 mutant mice.
Cardiovasc Res. 2020; 116(2):339-352
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Blood metabolomics uncovers inflammation-associated mitochondrial dysfunction as a potential mechanism underlying ACLF.
J Hepatol. 2020; 72(4):688-701
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Schittmayer, M; Vujic, N; Darnhofer, B; Korbelius, M; Honeder, S; Kratky, D; Birner-Gruenberger, R
Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases.
Mol Cell Proteomics. 2020; 19(12):2104-2114
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Tang, Z; Xie, H; Heier, C; Huang, J; Zheng, Q; Eichmann, TO; Schoiswohl, G; Ni, J; Zechner, R; Ni, S; Hao, H
Enhanced monoacylglycerol lipolysis by ABHD6 promotes NSCLC pathogenesis.
EBioMedicine. 2020; 53: 102696
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Xie, H; Heier, C; Kien, B; Vesely, PW; Tang, Z; Sexl, V; Schoiswohl, G; Strießnig-Bina, I; Hoefler, G; Zechner, R; Schweiger, M
Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(9):158737-158737
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Zwickl, H; Hackner, K; Köfeler, H; Krzizek, EC; Muqaku, B; Pils, D; Scharnagl, H; Solheim, TS; Zwickl-Traxler, E; Pecherstorfer, M
Reduced LDL-Cholesterol and Reduced Total Cholesterol as Potential Indicators of Early Cancer in Male Treatment-Naïve Cancer Patients With Pre-cachexia and Cachexia.
Front Oncol. 2020; 10(9):1262-1262
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Degoricija, V; Trbušić, M; Potočnjak, I; Radulović, B; Pregartner, G; Berghold, A; Scharnagl, H; Stojakovic, T; Tiran, B; Frank, S
Serum concentrations of free fatty acids are associated with 3-month mortality in acute heart failure patients.
Clin Chem Lab Med. 2019; 57(11): 1799-1804.
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Harreiter, J; Simmons, D; Desoye, G; Corcoy, R; Adelantado, JM; Devlieger, R; Galjaard, S; Damm, P; Mathiesen, ER; Jensen, DM; Andersen, LLT; Dunne, F; Lapolla, A; Dalfra, MG; Bertolotto, A; Wender-Ozegowska, E; Zawiejska, A; Mantaj, U; Hill, D; Jelsma, JGM; Snoek, FJ; Leutner, M; Lackinger, C; Worda, C; Bancher-Todesca, D; Scharnagl, H; van Poppel, MNM; Kautzky-Willer, A
Nutritional Lifestyle Intervention in Obese Pregnant Women, Including Lower Carbohydrate Intake, Is Associated With Increased Maternal Free Fatty Acids, 3-β-Hydroxybutyrate, and Fasting Glucose Concentrations: A Secondary Factorial Analysis of the European Multicenter, Randomized Controlled DALI Lifestyle Intervention Trial.
Diabetes Care. 2019; 42(8): 1380-1389.
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Hofer, DC; Zirkovits, G; Pelzmann, HJ; Huber, K; Pessentheiner, AR; Xia, W; Uno, K; Miyazaki, T; Kon, K; Tsuneki, H; Pendl, T; Al Zoughbi, W; Madreiter-Sokolowski, CT; Trausinger, G; Abdellatif, M; Schoiswohl, G; Schreiber, R; Eisenberg, T; Magnes, C; Sedej, S; Eckhardt, M; Sasahara, M; Sasaoka, T; Nitta, A; Hoefler, G; Graier, WF; Kratky, D; Auwerx, J; Bogner-Strauss, JG
N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health.
FASEB J. 2019; 33(12):13808-13824
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N-acetylaspartate pathway is nutrient responsive and coordinates lipid and energy metabolism in brown adipocytes.
Biochim Biophys Acta Mol Cell Res. 2019; 1866(3): 337-348.
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Maresch, LK; Benedikt, P; Feiler, U; Eder, S; Zierler, KA; Taschler, U; Kolleritsch, S; Eichmann, TO; Schoiswohl, G; Leopold, C; Wieser, BI; Lackner, C; Rülicke, T; van, Klinken, J; Kratky, D; Moustafa, T; Hoefler, G; Haemmerle, G
Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity.
Hepatol Commun. 2019; 3(2):227-245
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Tardelli, M; Bruschi, FV; Claudel, T; Fuchs, CD; Auer, N; Kunczer, V; Stojakovic, T; Scharnagl, H; Habib, A; Grabner, GF; Zimmermann, R; Lotersztajn, S; Trauner, M
Lack of monoacylglycerol lipase prevents hepatic steatosis by favoring lipid storage in adipose tissue and intestinal malabsorption.
J Lipid Res. 2019; 60(7): 1284-1292.
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Anto Michel, N; Colberg, C; Buscher, K; Sommer, B; Pramod, AB; Ehinger, E; Dufner, B; Hoppe, N; Pfeiffer, K; Marchini, T; Willecke, F; Stachon, P; Hilgendorf, I; Heidt, T; von Zur Muhlen, C; von Elverfeldt, D; Pfeifer, D; Schüle, R; Kintscher, U; Brachs, S; Ley, K; Bode, C; Zirlik, A; Wolf, D
Inflammatory Pathways Regulated by Tumor Necrosis Receptor-Associated Factor 1 Protect From Metabolic Consequences in Diet-Induced Obesity.
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Bhutada, G; Kavšček, M; Hofer, F; Gogg-Fassolter, G; Schweiger, M; Darnhofer, B; Kordiš, D; Birner-Gruenberger, R; Natter, K
Characterization of a lipid droplet protein from Yarrowia lipolytica that is required for its oleaginous phenotype.
Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(10):1193-1205
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Higareda-Almaraz, JC; Karbiener, M; Giroud, M; Pauler, FM; Gerhalter, T; Herzig, S; Scheideler, M
Norepinephrine triggers an immediate-early regulatory network response in primary human white adipocytes.
BMC Genomics. 2018; 19(1):794-794
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Jarc, E; Eichmann, TO; Zimmermann, R; Petan, T
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Data Brief. 2018; 18: 234-240.
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Jarc, E; Kump, A; Malavašič, P; Eichmann, TO; Zimmermann, R; Petan, T
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Biochim Biophys Acta Mol Cell Biol Lipids. 2018; 1863(3): 247-265.
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Montani, L; Pereira, JA; Norrmén, C; Pohl, HBF; Tinelli, E; Trötzmüller, M; Figlia, G; Dimas, P; von Niederhäusern, B; Schwager, R; Jessberger, S; Semenkovich, CF; Köfeler, HC; Suter, U
De novo fatty acid synthesis by Schwann cells is essential for peripheral nervous system myelination.
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Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance.
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Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue.
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Pharmacological inhibition of adipose triglyceride lipase corrects high-fat diet-induced insulin resistance and hepatosteatosis in mice.
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Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice.
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Shift to Fatty Substrate Utilization in Response to Sodium-Glucose Cotransporter 2 Inhibition in Subjects Without Diabetes and Patients With Type 2 Diabetes.
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Deficiency of intestinal mucin-2 protects mice from diet-induced fatty liver disease and obesity.
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N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes.
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Jaeger, D; Schoiswohl, G; Hofer, P; Schreiber, R; Schweiger, M; Eichmann, TO; Pollak, NM; Poecher, N; Grabner, GF; Zierler, KA; Eder, S; Kolb, D; Radner, FP; Preiss-Landl, K; Lass, A; Zechner, R; Kershaw, EE; Haemmerle, G
Fasting-induced G0/G1 switch gene 2 and FGF21 expression in the liver are under regulation of adipose tissue derived fatty acids.
J Hepatol. 2015; 63(2):437-45
Doi: 10.1016/j.jhep.2015.02.035
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Sahu-Osen, A; Montero-Moran, G; Schittmayer, M; Fritz, K; Dinh, A; Chang, YF; McMahon, D; Boeszoermenyi, A; Cornaciu, I; Russell, D; Oberer, M; Carman, GM; Birner-Gruenberger, R; Brasaemle, DL
CGI-58/ABHD5 is phosphorylated on Ser239 by protein kinase A: control of subcellular localization.
J Lipid Res. 2015; 56(1):109-121
Doi: 10.1194/jlr.M055004
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Schlager, S; Goeritzer, M; Jandl, K; Frei, R; Vujic, N; Kolb, D; Strohmaier, H; Dorow, J; Eichmann, TO; Rosenberger, A; Wölfler, A; Lass, A; Kershaw, EE; Ceglarek, U; Dichlberger, A; Heinemann, A; Kratky, D
Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis.
J Leukoc Biol. 2015; 98(5):837-50
Doi: 10.1189/jlb.3A0515-206R
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Schreiber, R; Hofer, P; Taschler, U; Voshol, PJ; Rechberger, GN; Kotzbeck, P; Jaeger, D; Preiss-Landl, K; Lord, CC; Brown, JM; Haemmerle, G; Zimmermann, R; Vidal-Puig, A; Zechner, R
Hypophagia and metabolic adaptations in mice with defective ATGL-mediated lipolysis cause resistance to HFD-induced obesity.
Proc Natl Acad Sci U S A. 2015; 112(45):13850-13855
Doi: 10.1073/pnas.1516004112
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