Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: LIPASE, . Treffer: 415

2023

Berger, N; van, der, Wel, T; Hirschmugl, B; Baernthaler, T; Gindlhuber, J; Fawzy, N; Eichmann, T; Birner-Gruenberger, R; Zimmermann, R; van, der, Stelt, M; Wadsack, C Inhibition of diacylglycerol lipase β modulates lipid and endocannabinoid levels in the ex vivo human placenta.
Front Endocrinol (Lausanne). 2023; 14: 1092024 Doi: 10.3389/fendo.2023.1092024 [OPEN ACCESS]
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Bianco, V; Korbelius, M; Vujic, N; Akhmetshina, A; Amor, M; Kolb, D; Pirchheim, A; Bradic, I; Kuentzel, KB; Buerger, M; Schauer, S; Phan, HTT; Bulfon, D; Hoefler, G; Zimmermann, R; Kratky, D Impact of (intestinal) LAL deficiency on lipid metabolism and macrophage infiltration.
Mol Metab. 2023; 73:101737 Doi: 10.1016/j.molmet.2023.101737
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Goeritzer, M; Kuentzel, KB; Beck, S; Korbelius, M; Rainer, S; Bradić, I; Kolb, D; Mussbacher, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Rost, R; Gottschalk, B; Eichmann, TO; Züllig, T; Graier, WF; Vujić, N; Kratky, D Monoglyceride Lipase Deficiency Is Associated with Altered Thrombogenesis in Mice.
Int J Mol Sci. 2023; 24(4): 3116 Doi: 10.3390/ijms24043116 [OPEN ACCESS]
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Klobučar, I; Stadler, JT; Klobučar, L; Lechleitner, M; Trbušić, M; Pregartner, G; Berghold, A; Habisch, H; Madl, T; Marsche, G; Frank, S; Degoricija, V Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients.
Int J Mol Sci. 2023; 24(3): Doi: 10.3390/ijms24032073 [OPEN ACCESS]
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Korbelius, M; Kuentzel, KB; Bradić, I; Vujić, N; Kratky, D Recent insights into lysosomal acid lipase deficiency.
Trends Mol Med. 2023; 29(6):425-438 Doi: 10.1016/j.molmed.2023.03.001
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Kotzbeck, P; Taschler, U; Haudum, C; Foessl, I; Schoiswohl, G; Boulgaropoulos, B; Bounab, K; Einsiedler, J; Pajed, L; Tilp, A; Schwarz, A; Eichmann, TO; Obermayer-Pietsch, B; Giordano, A; Cinti, S; Zechner, R; Pieber, TR Rosiglitazone Reverses Inflammation in Epididymal White Adipose Tissue in Hormone-Sensitive Lipase-Knockout Mice.
J Lipid Res. 2023; 64(1):100305 Doi: 10.1016/j.jlr.2022.100305 [OPEN ACCESS]
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Silbernagel, G; Chen, YQ; Rief, M; Kleber, ME; Hoffmann, MM; Stojakovic, T; Stang, A; Sarzynski, MA; Bouchard, C; März, W; Qian, YW; Scharnagl, H; Konrad, RJ Inverse association between apolipoprotein C-II and cardiovascular mortality: role of lipoprotein lipase activity modulation.
Eur Heart J. 2023; Doi: 10.1093/eurheartj/ehad261
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2022

Berger, N; Allerkamp, H; Wadsack, C Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?
Int J Mol Sci. 2022; 23(12): 6851 Doi: 10.3390/ijms23126851 [OPEN ACCESS]
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Bradić, I; Kuentzel, KB; Honeder, S; Grabner, GF; Vujić, N; Zimmermann, R; Birner-Gruenberger, R; Kratky, D Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases.
Mol Metab. 2022; 61:101510 Doi: 10.1016/j.molmet.2022.101510 [OPEN ACCESS]
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Curcic, S; Erkan-Candag, H; Pilic, J; Malli, R; Wiedner, P; Tiapko, O; Groschner, K TRPC3 governs the spatiotemporal organization of cellular Ca2+ signatures by functional coupling to IP3 receptors.
Cell Calcium. 2022; 108: 102670 Doi: 10.1016/j.ceca.2022.102670
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Fuchs, CD; Radun, R; Dixon, ED; Mlitz, V; Timelthaler, G; Halilbasic, E; Herac, M; Jonker, JW; Ronda, OAHO; Tardelli, M; Haemmerle, G; Zimmermann, R; Scharnagl, H; Stojakovic, T; Verkade, HJ; Trauner, M Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Hepatology. 2022; 75(1):125-139 Doi: 10.1002/hep.32112
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Goeritzer, M; Schlager, S; Kuentzel, KB; Vujić, N; Korbelius, M; Rainer, S; Kolb, D; Mussbacher, M; Salzmann, M; Schrottmaier, WC; Assinger, A; Schlagenhauf, A; Madreiter-Sokolowski, CT; Blass, S; Eichmann, TO; Graier, WF; Kratky, D Adipose Triglyceride Lipase Deficiency Attenuates In Vitro Thrombus Formation without Affecting Platelet Activation and Bleeding In Vivo.
Cells. 2022; 11(5): Doi: 10.3390/cells11050850 [OPEN ACCESS]
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Jahn, N; Voelker, MT; Laudi, S; Stehr, S; Schneeberger, S; Brandacher, G; Sucher, E; Rademacher, S; Seehofer, D; Sucher, R; Hau, HM Correlation of Different Serum Biomarkers with Prediction of Early Pancreatic Graft Dysfunction Following Simultaneous Pancreas and Kidney Transplantation.
J Clin Med. 2022; 11(9): Doi: 10.3390/jcm11092563 [OPEN ACCESS]
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Jahn, N; Völker, MT; Laudi, S; Stehr, S; Schneeberger, S; Brandacher, G; Sucher, E; Rademacher, S; Seehofer, D; Hau, HM; Sucher, R Analysis of Volatile Anesthetic-Induced Organ Protection in Simultaneous Pancreas-Kidney Transplantation.
J Clin Med. 2022; 11(12): Doi: 10.3390/jcm11123385 [OPEN ACCESS]
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Kanti, MM; Striessnig-Bina, I; Wieser, BI; Schauer, S; Leitinger, G; Eichmann, TO; Schweiger, M; Winkler, M; Winter, E; Lana, A; Kufferath, I; Marsh, LM; Kwapiszewska, G; Zechner, R; Hoefler, G; Vesely, PW Adipose triglyceride lipase-mediated lipid catabolism is essential for bronchiolar regeneration.
JCI Insight. 2022; 7(9): Doi: 10.1172/jci.insight.149438 [OPEN ACCESS]
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Kien, B; Kolleritsch, S; Kunowska, N; Heier, C; Chalhoub, G; Tilp, A; Wolinski, H; Stelzl, U; Haemmerle, G Lipid droplet-mitochondria coupling via perilipin 5 augments respiratory capacity but is dispensable for FA oxidation
J LIPID RES. 2022; 63(3): 100172 Doi: 10.1016/j.jlr.2022.100172 [OPEN ACCESS]
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Korbelius, M; Vujić, N; Kuentzel, KB; Obrowsky, S; Rainer, S; Haemmerle, G; Rülicke, T; Kratky, D Enterocyte-specific ATGL overexpression affects intestinal and systemic cholesterol homeostasis.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(4): 159121 Doi: 10.1016/j.bbalip.2022.159121 [OPEN ACCESS]
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Kuentzel, KB; Bradić, I; Mihalič, ZN; Korbelius, M; Rainer, S; Pirchheim, A; Kargl, J; Kratky, D Dysregulation of Placental Lipid Hydrolysis by High-Fat/High-Cholesterol Feeding and Gestational Diabetes Mellitus in Mice.
Int J Mol Sci. 2022; 23(20): 12286 Doi: 10.3390/ijms232012286 [OPEN ACCESS]
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Meinitzer, A; Enko, D; Zelzer, S; Prüller, F; Alonso, N; Fritz-Petrin, E; Herrmann, M Development of a liquid chromatography mass spectrometry method for the determination of vitamin K1, menaquinone-4, menaquinone-7 and vitamin K1-2,3 epoxide in serum of individuals without vitamin K supplements.
Clin Chem Lab Med. 2022; 60(7):1011-1019 Doi: 10.1515/cclm-2022-0192
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Metzner, T; Leitner, DR; Mellitzer, K; Beck, A; Sourij, H; Stojakovic, T; Reishofer, G; März, W; Landmesser, U; Scharnagl, H; Toplak, H; Silbernagel, G Effects of Alirocumab on Triglyceride Metabolism: A Fat-Tolerance Test and Nuclear Magnetic Resonance Spectroscopy Study.
Biomedicines. 2022; 10(1): Doi: 10.3390/biomedicines10010193 [OPEN ACCESS]
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Reisinger, AC; Schuller, M; Sourij, H; Stadler, JT; Hackl, G; Eller, P; Marsche, G Impact of Sepsis on High-Density Lipoprotein Metabolism.
Front Cell Dev Biol. 2021; 9:795460 Doi: 10.3389/fcell.2021.795460 [OPEN ACCESS]
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Riegler-Berket, L; Wechselberger, L; Cerk, IK; Padmanabha, Das, KM; Viertlmayr, R; Kulminskaya, N; Rodriguez, Gamez, CF; Schweiger, M; Zechner, R; Zimmermann, R; Oberer, M Residues of the minimal sequence of G0S2 collectively contribute to ATGL inhibition while C-and N-terminal extensions promote binding to ATGL.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022; 1867(3): 159105 Doi: 10.1016/j.bbalip.2021.159105
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Schadler, P; Lohberger, B; Thauerer, B; Faschingbauer, M; Kullich, W; Stradner, MH; Leithner, A; Ritschl, V; Omara, M; Steinecker-Frohnwieser, B The Association of Blood Biomarkers and Body Mass Index in Knee Osteoarthritis: A Cross-Sectional Study.
Cartilage. 2022; 13(1): 19476035211069251 Doi: 10.1177/19476035211069251 [OPEN ACCESS]
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2021

Chalhoub, G; Kolleritsch, S; Maresch, LK; Taschler, U; Pajed, L; Tilp, A; Eisner, H; Rosina, P; Kien, B; Radner, FPW; Schicho, R; Oberer, M; Schoiswohl, G; Haemmerle, G Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease.
J Lipid Res. 2021; 62:100075 Doi: 10.1016/j.jlr.2021.100075 [OPEN ACCESS]
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Desoye, G; Herrera, E Adipose tissue development and lipid metabolism in the human fetus: The 2020 perspective focusing on maternal diabetes and obesity.
PROG LIPID RES. 2021; 81(1): 101082-101082. Doi: 10.1016/j.plipres.2020.101082 [OPEN ACCESS]
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Gauckler, P; Shin, JI; Alberici, F; Audard, V; Bruchfeld, A; Busch, M; Cheung, CK; Crnogorac, M; Delbarba, E; Eller, K; Faguer, S; Galesic, K; Griffin, S; van den Hoogen, MWF; Hrušková, Z; Jeyabalan, A; Karras, A; King, C; Kohli, HS; Mayer, G; Maas, R; Muto, M; Moiseev, S; Odler, B; Pepper, RJ; Quintana, LF; Radhakrishnan, J; Ramachandran, R; Salama, AD; Schönermarck, U; Segelmark, M; Smith, L; Tesař, V; Wetzels, J; Willcocks, L; Windpessl, M; Zand, L; Zonozi, R; Kronbichler, A; RITERM study group Rituximab in Membranous Nephropathy.
Kidney Int Rep. 2021; 6(4): 881-893. Doi: 10.1016/j.ekir.2020.12.035 [OPEN ACCESS]
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Grininger, C; Leypold, M; Aschauer, P; Pavkov-Keller, T; Riegler-Berket, L; Breinbauer, R; Oberer, M Structural Changes in the Cap of Rv0183/mtbMGL Modulate the Shape of the Binding Pocket.
Biomolecules. 2021; 11(9): Doi: 10.3390/biom11091299 [OPEN ACCESS]
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Helderman, RC; Whitney, DG; Duta-Mare, M; Akhmetshina, A; Vujic, N; Jayapalan, S; Nyman, JS; Misra, BB; Rosen, CJ; Czech, MP; Kratky, D; Rendina-Ruedy, E Loss of function of lysosomal acid lipase (LAL) profoundly impacts osteoblastogenesis and increases fracture risk in humans.
Bone. 2021; 148:115946 Doi: 10.1016/j.bone.2021.115946 [OPEN ACCESS]
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Honeder, S; Tomin, T; Nebel, L; Gindlhuber, J; Fritz-Wallace, K; Schinagl, M; Heininger, C; Schittmayer, M; Ghaffari-Tabrizi-Wizsy, N; Birner-Gruenberger, R Adipose Triglyceride Lipase Loss Promotes a Metabolic Switch in A549 Non-Small Cell Lung Cancer Cell Spheroids.
Mol Cell Proteomics. 2021; 20:100095 Doi: 10.1016/j.mcpro.2021.100095 [OPEN ACCESS]
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Hundahl, C; Kotzbeck, P; Burm, HB; Christiansen, SH; Torz, L; Helge, AW; Madsen, MP; Ratner, C; Serup, AK; Thompson, JJ; Eichmann, TO; Pers, TH; Woldbye, DPD; Piomelli, D; Kiens, B; Zechner, R; Skov, LJ; Holst, B Hypothalamic hormone-sensitive lipase regulates appetite and energy homeostasis.
Mol Metab. 2021; 47:101174 Doi: 10.1016/j.molmet.2021.101174 [OPEN ACCESS]
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Kienzl, M; Hasenoehrl, C; Maitz, K; Sarsembayeva, A; Taschler, U; Valadez-Cosmes, P; Kindler, O; Ristic, D; Raftopoulou, S; Santiso, A; Bärnthaler, T; Brcic, L; Hahnefeld, L; Gurke, R; Thomas, D; Geisslinger, G; Kargl, J; Schicho, R Monoacylglycerol lipase deficiency in the tumor microenvironment slows tumor growth in non-small cell lung cancer.
Oncoimmunology. 2021; 10(1): 1965319 Doi: 10.1080/2162402X.2021.1965319 [OPEN ACCESS]
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Knuplez, E; Sturm, EM; Marsche, G Emerging Role of Phospholipase-Derived Cleavage Products in Regulating Eosinophil Activity: Focus on Lysophospholipids, Polyunsaturated Fatty Acids and Eicosanoids.
Int J Mol Sci. 2021; 22(9): Doi: 10.3390/ijms22094356 [OPEN ACCESS]
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Kuentzel, KB; Bradić, I; Akhmetshina, A; Korbelius, M; Rainer, S; Kolb, D; Gauster, M; Vujić, N; Kratky, D Defective Lysosomal Lipolysis Causes Prenatal Lipid Accumulation and Exacerbates Immediately after Birth.
Int J Mol Sci. 2021; 22(19): Doi: 10.3390/ijms221910416 [OPEN ACCESS]
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Pajed, L; Taschler, U; Tilp, A; Hofer, P; Kotzbeck, P; Kolleritsch, S; Radner, FPW; Pototschnig, I; Wagner, C; Schratter, M; Eder, S; Huetter, S; Schreiber, R; Haemmerle, G; Eichmann, TO; Schweiger, M; Hoefler, G; Kershaw, EE; Lass, A; Schoiswohl, G Advanced lipodystrophy reverses fatty liver in mice lacking adipocyte hormone-sensitive lipase.
Commun Biol. 2021; 4(1):323 Doi: 10.1038/s42003-021-01858-z [OPEN ACCESS]
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Robert, J; Osto, E; von, Eckardstein, A The Endothelium Is Both a Target and a Barrier of HDL's Protective Functions.
Cells. 2021; 10(5): Doi: 10.3390/cells10051041 [OPEN ACCESS]
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Sachdev, V; Duta-Mare, M; Korbelius, M; Vujić, N; Leopold, C; Freark, de, Boer, J; Rainer, S; Fickert, P; Kolb, D; Kuipers, F; Radovic, B; Gorkiewicz, G; Kratky, D Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase.
Cells. 2021; 10(10): Doi: 10.3390/cells10102619 [OPEN ACCESS]
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Schadler, P; Lohberger, B; Thauerer, B; Faschingbauer, M; Kullich, W; Stradner, MH; Husic, R; Leithner, A; Steinecker-Frohnwieser, B Fatty Acid-Binding Protein 4 (FABP4) Is Associated with Cartilage Thickness in End-Stage Knee Osteoarthritis.
Cartilage. 2021; 13(2_suppl): 1165S-1173S. Doi: 10.1177/19476035211011520 [OPEN ACCESS]
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Schilcher, I; Stadler, JT; Lechleitner, M; Hrzenjak, A; Berghold, A; Pregartner, G; Lhomme, M; Holzer, M; Korbelius, M; Reichmann, F; Springer, A; Wadsack, C; Madl, T; Kratky, D; Kontush, A; Marsche, G; Frank, S Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
Int J Mol Sci. 2021; 22(2): Doi: 10.3390/ijms22020719 [OPEN ACCESS]
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Stadler, JT; Wadsack, C; Marsche, G Fetal High-Density Lipoproteins: Current Knowledge on Particle Metabolism, Composition and Function in Health and Disease.
Biomedicines. 2021; 9(4): Doi: 10.3390/biomedicines9040349 [OPEN ACCESS]
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Tardelli, M; Bruschi, FV; Fuchs, CD; Claudel, T; Auer, N; Kunczer, V; Ronda, OAHO; Verkade, HJ; Stojakovic, T; Scharnagl, H; Trauner, M Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Int J Mol Sci. 2021; 22(4): Doi: 10.3390/ijms22042126 [OPEN ACCESS]
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Thai, T; Zhong, F; Dang, L; Chan, E; Ku, J; Malle, E; Geczy, CL; Keaney, JF; Thomas, SR Endothelial-transcytosed myeloperoxidase activates endothelial nitric oxide synthase via a phospholipase C-dependent calcium signaling pathway.
FREE RADICAL BIO MED. 2021; 166(2): 255-264. Doi: 10.1016/j.freeradbiomed.2020.12.448
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Tünnemann-Tarr, A; Scharnagl, H; Katzmann, JL; Stürzebecher, P; Laufs, U Familial chylomicronemia syndrome due to a heterozygous deletion of the chromosome 8 treated with the apoCIII inhibitor volanesorsen: A case report.
Medicine (Baltimore). 2021; 100(42):e27573 Doi: 10.1097/MD.0000000000027573 (- Case Report) [OPEN ACCESS]
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2020

Del Gaudio, I; Sreckovic, I; Zardoya-Laguardia, P; Bernhart, E; Christoffersen, C; Frank, S; Marsche, G; Illanes, SE; Wadsack, C Circulating cord blood HDL-S1P complex preserves the integrity of the feto-placental vasculature.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(4):158632-158632 Doi: 10.1016/j.bbalip.2020.158632 [OPEN ACCESS]
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Hofer, P; Taschler, U; Schreiber, R; Kotzbeck, P; Schoiswohl, G The Lipolysome-A Highly Complex and Dynamic Protein Network Orchestrating Cytoplasmic Triacylglycerol Degradation.
Metabolites. 2020; 10(4): Doi: 10.3390/metabo10040147 [OPEN ACCESS]
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Knuplez, E; Curcic, S; Theiler, A; Bärnthaler, T; Trakaki, A; Trieb, M; Holzer, M; Heinemann, A; Zimmermann, R; Sturm, EM; Marsche, G Lysophosphatidylcholines inhibit human eosinophil activation and suppress eosinophil migration in vivo.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(7):158686-158686 Doi: 10.1016/j.bbalip.2020.158686 [OPEN ACCESS]
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Knuplez, E; Marsche, G An Updated Review of Pro- and Anti-Inflammatory Properties of Plasma Lysophosphatidylcholines in the Vascular System.
Int J Mol Sci. 2020; 21(12): Doi: 10.3390/ijms21124501 [OPEN ACCESS]
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Pfeil, EM; Brands, J; Merten, N; Vögtle, T; Vescovo, M; Rick, U; Albrecht, IM; Heycke, N; Kawakami, K; Ono, Y; Ngako Kadji, FM; Hiratsuka, S; Aoki, J; Häberlein, F; Matthey, M; Garg, J; Hennen, S; Jobin, ML; Seier, K; Calebiro, D; Pfeifer, A; Heinemann, A; Wenzel, D; König, GM; Nieswandt, B; Fleischmann, BK; Inoue, A; Simon, K; Kostenis, E Heterotrimeric G Protein Subunit Gαq Is a Master Switch for Gβγ-Mediated Calcium Mobilization by Gi-Coupled GPCRs.
Mol Cell. 2020; 80(6):940-954 Doi: 10.1016/j.molcel.2020.10.027
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Plastira, I; Bernhart, E; Joshi, L; Koyani, CN; Strohmaier, H; Reicher, H; Malle, E; Sattler, W MAPK signaling determines lysophosphatidic acid (LPA)-induced inflammation in microglia.
J Neuroinflammation. 2020; 17(1): 127-127. Doi: 10.1186/s12974-020-01809-1 [OPEN ACCESS]
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Radulović, S; Gottschalk, B; Hörl, G; Zardoya-Laguardia, P; Schilcher, I; Hallström, S; Vujić, N; Schmidt, K; Trieb, M; Graier, WF; Malli, R; Kratky, D; Marsche, G; Frank, S Endothelial lipase increases eNOS activating capacity of high-density lipoprotein.
Biochim Biophys Acta Mol Cell Biol Lipids. 2020; 1865(4):158612 Doi: 10.1016/j.bbalip.2020.158612 [OPEN ACCESS]
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Stickel, F; Lutz, P; Buch, S; Nischalke, HD; Silva, I; Rausch, V; Fischer, J; Weiss, KH; Gotthardt, D; Rosendahl, J; Marot, A; Elamly, M; Krawczyk, M; Casper, M; Lammert, F; Buckley, TWM; McQuillin, A; Spengler, U; Eyer, F; Vogel, A; Marhenke, S; von Felden, J; Wege, H; Sharma, R; Atkinson, S; Franke, A; Nehring, S; Moser, V; Schafmayer, C; Spahr, L; Lackner, C; Stauber, RE; Canbay, A; Link, A; Valenti, L; Grove, JI; Aithal, GP; Marquardt, JU; Fateen, W; Zopf, S; Dufour, JF; Trebicka, J; Datz, C; Deltenre, P; Mueller, S; Berg, T; Hampe, J; Morgan, MY Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers.
Hepatology. 2020; 72(1):88-102 Doi: 10.1002/hep.30996 [OPEN ACCESS]
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