Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: CIRCULATING TUMOR DNA, . Treffer: 35

2023

Moser, T; Kühberger, S; Lazzeri, I; Vlachos, G; Heitzer, E Bridging biological cfDNA features and machine learning approaches.
Trends Genet. 2023; 39(4):285-307 Doi: 10.1016/j.tig.2023.01.004
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2022

Donker, HC; Schuuring, E; Heitzer, E; Groen, HJM Decoding circulating tumor DNA to identify durable benefit from immunotherapy in lung cancer
LUNG CANCER. 2022; 170: 52-57. Doi: 10.1016/j.lungcan.2022.05.013
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Eisenhardt, AE; Brugger, Z; Lausch, U; Kiefer, J; Zeller, J; Runkel, A; Schmid, A; Bronsert, P; Wehrle, J; Leithner, A; Liegl-Atzwanger, B; Giunta, RE; Eisenhardt, SU; Braig, D Genotyping of Circulating Free DNA Enables Monitoring of Tumor Dynamics in Synovial Sarcomas.
Cancers (Basel). 2022; 14(9): 2078 Doi: 10.3390/cancers14092078 [OPEN ACCESS]
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Eisenhardt, AE; Schmid, A; Esser, J; Brugger, Z; Lausch, U; Kiefer, J; Braig, M; Runkel, A; Wehrle, J; Claus, R; Bronsert, P; Leithner, A; Liegl-Atzwanger, B; Zeller, J; Papini, R; von, Laffert, M; Pfitzner, BM; Koulaxouzidis, G; Giunta, RE; Eisenhardt, SU; Braig, D Targeted next-generation sequencing of circulating free DNA enables non-invasive tumor detection in myxoid liposarcomas.
Mol Cancer. 2022; 21(1): 50 Doi: 10.1186/s12943-022-01523-x [OPEN ACCESS]
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Hasenleithner, SO; Speicher, MR A clinician's handbook for using ctDNA throughout the patient journey.
Mol Cancer. 2022; 21(1): 81 Doi: 10.1186/s12943-022-01551-7 [OPEN ACCESS]
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Seidel, MG; Kashofer, K; Moser, T; Thueringer, A; Liegl-Atzwanger, B; Leithner, A; Szkandera, J; Benesch, M; El-Heliebi, A; Heitzer, E Clinical implementation of plasma cell-free circulating tumor DNA quantification by digital droplet PCR for the monitoring of Ewing sarcoma in children and adolescents.
Front Pediatr. 2022; 10: 926405 Doi: 10.3389/fped.2022.926405 [OPEN ACCESS]
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Zhou, Q; Gampenrieder, SP; Frantal, S; Rinnerthaler, G; Singer, CF; Egle, D; Pfeiler, G; Bartsch, R; Wette, V; Pichler, A; Petru, E; Dubsky, PC; Bago-Horvath, Z; Fesl, C; Rudas, M; Ståhlberg, A; Graf, R; Weber, S; Dandachi, N; Filipits, M; Gnant, M; Balic, M; Heitzer, E Persistence of ctDNA in Patients with Breast Cancer During Neoadjuvant Treatment Is a Significant Predictor of Poor Tumor Response.
Clin Cancer Res. 2022; 28(4):697-707 Doi: 10.1158/1078-0432.CCR-21-3231 [OPEN ACCESS]
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2021

Berger, M; Thueringer, A; Franz, D; Dandachi, N; Talakić, E; Richtig, G; Richtig, E; Rohrer, PM; Koch, L; Wolf, IH; Koch, C; Rainer, BM; Koeller, M; Pichler, M; Gerritsmann, H; Kashofer, K; Aigelsreiter, A Circulating Tumor DNA as a Marker for Treatment Response in Metastatic Melanoma Patients Using Next-Generation Sequencing-A Prospective Feasibility Study.
Cancers (Basel). 2021; 13(12): Doi: 10.3390/cancers13123101 [OPEN ACCESS]
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Buder, A; Heitzer, E; Waldispühl-Geigl, J; Weber, S; Moser, T; Hochmair, MJ; Hackner, K; Errhalt, P; Setinek, U; Filipits, M Somatic Copy-Number Alterations in Plasma Circulating Tumor DNA from Advanced EGFR-Mutated Lung Adenocarcinoma Patients.
BIOMOLECULES. 2021; 11(5): Doi: 10.3390/biom11050618 [OPEN ACCESS]
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Dandachi, N; Posch, F; Graf, R; Suppan, C; Klocker, EV; Müller, HD; Lindenmann, J; Terbuch, A; Heitzer, E; Balic, M Longitudinal tumor fraction trajectories predict risk of progression in metastatic HR+ breast cancer patients undergoing CDK4/6 treatment.
Mol Oncol. 2021; 15(9):2390-2400 Doi: 10.1002/1878-0261.12870 [OPEN ACCESS]
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Riedl, JM; Hasenleithner, SO; Pregartner, G; Scheipner, L; Posch, F; Groller, K; Kashofer, K; Jahn, SW; Bauernhofer, T; Pichler, M; Stöger, H; Berghold, A; Hoefler, G; Speicher, MR; Heitzer, E; Gerger, A Profiling of circulating tumor DNA and tumor tissue for treatment selection in patients with advanced and refractory carcinoma: a prospective, two-stage phase II Individualized Cancer Treatment trial.
Ther Adv Med Oncol. 2021; 13:1758835920987658 Doi: 10.1177/1758835920987658 [OPEN ACCESS]
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Unseld, M; Belic, J; Pierer, K; Zhou, Q; Moser, T; Bauer, R; Piringer, G; Gerger, A; Siebenhüner, A; Speicher, M; Heitzer, E; Prager, GW A higher ctDNA fraction decreases survival in regorafenib-treated metastatic colorectal cancer patients. Results from the regorafenib's liquid biopsy translational biomarker phase II pilot study.
Int J Cancer. 2021; 148(6):1452-1461 Doi: 10.1002/ijc.33303 [OPEN ACCESS]
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Weber, S; van der Leest, P; Donker, HC; Schlange, T; Timens, W; Tamminga, M; Hasenleithner, SO; Graf, R; Moser, T; Spiegl, B; Yaspo, ML; Terstappen, LWMM; Sidorenkov, G; Hiltermann, TJN; Speicher, MR; Schuuring, E; Heitzer, E; Groen, HJM Dynamic Changes of Circulating Tumor DNA Predict Clinical Outcome in Patients With Advanced Non-Small-Cell Lung Cancer Treated With Immune Checkpoint Inhibitors
JCO PRECIS ONCOL. 2021; 5: 1540-1553. Doi: 10.1200/PO.21.00182
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2020

Bourrier, C; Pierga, JY; Xuereb, L; Salaun, H; Proudhon, C; Speicher, MR; Belic, J; Heitzer, E; Lockhart, BP; Guigal-Stephan, N Shallow Whole-Genome Sequencing from Plasma Identifies FGFR1 Amplified Breast Cancers and Predicts Overall Survival.
Cancers (Basel). 2020; 12(6): Doi: 10.3390/cancers12061481 [OPEN ACCESS]
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Gerber, T; Taschner-Mandl, S; Saloberger-Sindhöringer, L; Popitsch, N; Heitzer, E; Witt, V; Geyeregger, R; Hutter, C; Schwentner, R; Ambros, IM; Ambros, PF Assessment of Pre-Analytical Sample Handling Conditions for Comprehensive Liquid Biopsy Analysis.
J Mol Diagn. 2020; 22(8):1070-1086 Doi: 10.1016/j.jmoldx.2020.05.006 [OPEN ACCESS]
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Moser, T; Waldispuehl-Geigl, J; Belic, J; Weber, S; Zhou, Q; Hasenleithner, SO; Graf, R; Terzic, JA; Posch, F; Sill, H; Lax, S; Kashofer, K; Hoefler, G; Schoellnast, H; Heitzer, E; Geigl, JB; Bauernhofer, T; Speicher, MR On-treatment measurements of circulating tumor DNA during FOLFOX therapy in patients with colorectal cancer.
NPJ Precis Oncol. 2020; 4(1):30 Doi: 10.1038/s41698-020-00134-3 [OPEN ACCESS]
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Weber, S; Spiegl, B; Perakis, SO; Ulz, CM; Abuja, PM; Kashofer, K; Leest, PV; Azpurua, MA; Tamminga, M; Brudzewsky, D; Rothwell, DG; Mohan, S; Sartori, A; Lampignano, R; Konigshofer, Y; Sprenger-Haussels, M; Wikman, H; Bergheim, IR; Kloten, V; Schuuring, E; Speicher, MR; Heitzer, E Technical Evaluation of Commercial Mutation Analysis Platforms and Reference Materials for Liquid Biopsy Profiling.
Cancers (Basel). 2020; 12(6): 1588 Doi: 10.3390/cancers12061588 [OPEN ACCESS]
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2019

de Wit, S; Rossi, E; Weber, S; Tamminga, M; Manicone, M; Swennenhuis, JF; Groothuis-Oudshoorn, CGM; Vidotto, R; Facchinetti, A; Zeune, LL; Schuuring, E; Zamarchi, R; Hiltermann, TJN; Speicher, MR; Heitzer, E; Terstappen, LWMM; Groen, HJM Single tube liquid biopsy for advanced non-small cell lung cancer.
Int J Cancer. 2019; 144(12): 3127-3137. Doi: 10.1002/ijc.32056 [OPEN ACCESS]
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Jilg, S; Rassner, M; Maier, J; Waldeck, S; Kehl, V; Follo, M; Philipp, U; Sauter, A; Specht, K; Mitschke, J; Lange, T; Bauer, S; Jost, PJ; Peschel, C; Duyster, J; Gaiser, T; Hohenberger, P; von Bubnoff, N Circulating cKIT and PDGFRA DNA indicates disease activity in Gastrointestinal Stromal Tumor (GIST).
Int J Cancer. 2019; 145(8):2292-2303 Doi: 10.1002/ijc.32282
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Marcuello, M; Vymetalkova, V; Neves, RPL; Duran-Sanchon, S; Vedeld, HM; Tham, E; van Dalum, G; Flügen, G; Garcia-Barberan, V; Fijneman, RJ; Castells, A; Vodicka, P; Lind, GE; Stoecklein, NH; Heitzer, E; Gironella, M Circulating biomarkers for early detection and clinical management of colorectal cancer.
MOL ASPECTS MED. 2019; 69(9): 107-122. Doi: 10.1016/j.mam.2019.06.002 [OPEN ACCESS]
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Suppan, C; Brcic, I; Tiran, V; Mueller, HD; Posch, F; Auer, M; Ercan, E; Ulz, P; Cote, RJ; Datar, RH; Dandachi, N; Heitzer, E; Balic, M Untargeted Assessment of Tumor Fractions in Plasma for Monitoring and Prognostication from Metastatic Breast Cancer Patients Undergoing Systemic Treatment.
Cancers (Basel). 2019; 11(8): Doi: 10.3390/cancers11081171 [OPEN ACCESS]
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2018

Belic, J; Graf, R; Bauernhofer, T; Cherkas, Y; Ulz, P; Waldispuehl-Geigl, J; Perakis, S; Gormley, M; Patel, J; Li, W; Geigl, JB; Smirnov, D; Heitzer, E; Gross, M; Speicher, MR Genomic alterations in plasma DNA from patients with metastasized prostate cancer receiving abiraterone or enzalutamide.
Int J Cancer. 2018; 143(5): 1236-1248. Doi: 10.1002/ijc.31397 [OPEN ACCESS]
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Zhou, Q; Moser, T; Perakis, S; Heitzer, E Untargeted profiling of cell-free circulating DNA
TRANSL CANCER RES. 2018; 7: S140-S152. Doi: 10.21037/tcr.2017.10.11
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2017

Heitzer, E; Perakis, S; Geigl, JB; Speicher, MR The potential of liquid biopsies for the early detection of cancer.
NPJ Precis Oncol. 2017; 1(1):36-36 Doi: 10.1038/s41698-017-0039-5 [OPEN ACCESS]
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Nadal, C; Winder, T; Gerger, A; Tougeron, D Future perspectives of circulating tumor DNA in colorectal cancer.
Tumour Biol. 2017; 39(5):1010428317705749-1010428317705749 Doi: 10.1177/1010428317705749 [OPEN ACCESS]
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Perakis, S; Auer, M; Belic, J; Heitzer, E Advances in Circulating Tumor DNA Analysis.
Adv Clin Chem. 2017; 80(10):73-153 Doi: 10.1016/bs.acc.2016.11.005
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Perakis, S; Speicher, MR Emerging concepts in liquid biopsies.
BMC Med. 2017; 15(1):75-75 Doi: 10.1186/s12916-017-0840-6 [OPEN ACCESS]
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Ulz, P; Heitzer, E; Geigl, JB; Speicher, MR Patient monitoring through liquid biopsies using circulating tumor DNA.
Int J Cancer. 2017; 141(5):887-896 Doi: 10.1002/ijc.30759 [OPEN ACCESS]
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2016

Belic, J; Koch, M; Ulz, P; Auer, M; Gerhalter, T; Mohan, S; Fischereder, K; Petru, E; Bauernhofer, T; Geigl, JB; Speicher, MR; Heitzer, E mFast-SeqS as a Monitoring and Pre-screening Tool for Tumor-Specific Aneuploidy in Plasma DNA.
Adv Exp Med Biol. 2016; 924:147-155 Doi: 10.1007/978-3-319-42044-8_28
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Heitzer, E; Ulz, P; Geigl, JB; Speicher, MR Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies.
Mol Oncol. 2016; 10(3):494-502 Doi: 10.1016/j.molonc.2015.12.004 [OPEN ACCESS]
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Speicher, MR; Gerger, A; Hoefler, G Liquid biopsies. A multidisciplinary challenge for human geneticists, oncologists, and pathologists
MED GENET-BERLIN. 2016; 28(2): 245-250. Doi: 10.1007/s11825-016-0090-6 [OPEN ACCESS]
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2015

Belic, J; Koch, M; Ulz, P; Auer, M; Gerhalter, T; Mohan, S; Fischereder, K; Petru, E; Bauernhofer, T; Geigl, JB; Speicher, MR; Heitzer, E Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach.
Clin Chem. 2015; 61(6):838-849 Doi: 10.1373/clinchem.2014.234286 [OPEN ACCESS]
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Heitzer, E; Ulz, P; Geigl, JB Circulating tumor DNA as a liquid biopsy for cancer.
Clin Chem. 2015; 61(1):112-123 Doi: 10.1373/clinchem.2014.222679 [OPEN ACCESS]
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2014

Heidary, M; Auer, M; Ulz, P; Heitzer, E; Petru, E; Gasch, C; Riethdorf, S; Mauermann, O; Lafer, I; Pristauz, G; Lax, S; Pantel, K; Geigl, JB; Speicher, MR The dynamic range of circulating tumor DNA in metastatic breast cancer.
Breast Cancer Res. 2014; 16(4):421-421 Doi: 10.1186/s13058-014-0421-y [OPEN ACCESS]
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2013

Heitzer, E; Auer, M; Ulz, P; Geigl, JB; Speicher, MR Circulating tumor cells and DNA as liquid biopsies.
Genome Med. 2013; 5(8):73-73 Doi: 10.1186/gm477 [OPEN ACCESS]
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