Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: ACUTE MYELOID LEUKEMIA, . Treffer: 89

2020

Caraffini, V; Geiger, O; Rosenberger, A; Hatzl, S; Perfler, B; Berg, JL; Lim, C; Strobl, H; Kashofer, K; Schauer, S; Beham-Schmid, C; Hoefler, G; Geissler, K; Quehenberger, F; Kolch, W; Athineos, D; Blyth, K; Wölfler, A; Sill, H; Zebisch, A Loss of RAF kinase inhibitor protein is involved in myelomonocytic differentiation and aggravates RAS-driven myeloid leukemogenesis.
Haematologica. 2020; 105(2):375-386 [OPEN ACCESS]
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Daga, S; Rosenberger, A; Kashofer, K; Heitzer, E; Quehenberger, F; Halbwedl, I; Graf, R; Krisper, N; Prietl, B; Höfler, G; Reinisch, A; Zebisch, A; Sill, H; Wölfler, A Sensitive and broadly applicable residual disease detection in acute myeloid leukemia using flow cytometry-based leukemic cell enrichment followed by mutational profiling.
Am J Hematol. 2020;
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Dutta, S; Pregartner, G; Rücker, FG; Heitzer, E; Zebisch, A; Bullinger, L; Berghold, A; Döhner, K; Sill, H Functional Classification of TP53 Mutations in Acute Myeloid Leukemia.
Cancers (Basel). 2020; 12(3): [OPEN ACCESS]
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Geissler, K; Jäger, E; Barna, A; Gurbisz, M; Graf, T; Graf, E; Nösslinger, T; Pfeilstöcker, M; Tüchler, H; Sliwa, T; Keil, F; Geissler, C; Heibl, S; Thaler, J; Machherndl-Spandl, S; Zach, O; Weltermann, A; Bettelheim, P; Stauder, R; Zebisch, A; Sill, H; Schwarzinger, I; Schneeweiss, B; Öhler, L; Ulsperger, E; Kusec, R; Germing, U; Sperr, WR; Knöbl, P; Jäger, U; Hörmann, G; Valent, P Correlation of RAS-Pathway Mutations and Spontaneous Myeloid Colony Growth with Progression and Transformation in Chronic Myelomonocytic Leukemia-A Retrospective Analysis in 337 Patients.
Int J Mol Sci. 2020; 21(8): [OPEN ACCESS]
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Hatzl, S; Perfler, B; Wurm, S; Uhl, B; Quehenberger, F; Ebner, S; Troppmair, J; Reinisch, A; Wölfler, A; Sill, H; Zebisch, A Increased Expression of Micro-RNA-23a Mediates Chemoresistance to Cytarabine in Acute Myeloid Leukemia.
Cancers (Basel). 2020; 12(2): [OPEN ACCESS]
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Kuendgen, A; Nomdedeu, M; Tuechler, H; Garcia-Manero, G; Komrokji, RS; Sekeres, MA; Della Porta, MG; Cazzola, M; DeZern, AE; Roboz, GJ; Steensma, DP; Van de Loosdrecht, AA; Schlenk, RF; Grau, J; Calvo, X; Blum, S; Pereira, A; Valent, P; Costa, D; Giagounidis, A; Xicoy, B; Döhner, H; Platzbecker, U; Pedro, C; Lübbert, M; Oiartzabal, I; Díez-Campelo, M; Cedena, MT; Machherndl-Spandl, S; López-Pavía, M; Baldus, CD; Martinez-de-Sola, M; Stauder, R; Merchan, B; List, A; Ganster, C; Schroeder, T; Voso, MT; Pfeilstöcker, M; Sill, H; Hildebrandt, B; Esteve, J; Nomdedeu, B; Cobo, F; Haas, R; Sole, F; Germing, U; Greenberg, PL; Haase, D; Sanz, G Therapy-related myelodysplastic syndromes deserve specific diagnostic sub-classification and risk-stratification-an approach to classification of patients with t-MDS.
Leukemia. 2020;
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2019

Aigner, P; Mizutani, T; Horvath, J; Eder, T; Heber, S; Lind, K; Just, V; Moll, HP; Yeroslaviz, A; Fischer, MJM; Kenner, L; Győrffy, B; Sill, H; Grebien, F; Moriggl, R; Casanova, E; Stoiber, D STAT3β is a tumor suppressor in acute myeloid leukemia.
Blood Adv. 2019; 3(13): 1989-2002. [OPEN ACCESS]
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Daga, S; Rosenberger, A; Quehenberger, F; Krisper, N; Prietl, B; Reinisch, A; Zebisch, A; Sill, H; Wölfler, A High GPR56 surface expression correlates with a leukemic stem cell gene signature in CD34-positive AML.
Cancer Med. 2019; 8(4):1771-1778 [OPEN ACCESS]
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Gluexam, T; Grandits, AM; Schlerka, A; Nguyen, CH; Etzler, J; Finkes, T; Fuchs, M; Scheid, C; Heller, G; Hackl, H; Harrer, N; Sill, H; Koller, E; Stoiber, D; Sommergruber, W; Wieser, R CGRP Signaling via CALCRL Increases Chemotherapy Resistance and Stem Cell Properties in Acute Myeloid Leukemia.
Int J Mol Sci. 2019; 20(23): [OPEN ACCESS]
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Jenks, JD; Mehta, SR; Hoenigl, M Broad spectrum triazoles for invasive mould infections in adults: Which drug and when?
Med Mycol. 2019; 57(Supplement_2): S168-S178.
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Prochazka, KT; Pregartner, G; Rücker, FG; Heitzer, E; Pabst, G; Wölfler, A; Zebisch, A; Berghold, A; Döhner, K; Sill, H Clinical implications of subclonal TP53 mutations in acute myeloid leukemia.
Haematologica. 2019; 104(3):516-523 [OPEN ACCESS]
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Zebisch, A; Caraffini, V; Sill, H RAF Kinase Inhibitor Protein in Myeloid Leukemogenesis.
Int J Mol Sci. 2019; 20(22): [OPEN ACCESS]
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2018

Burgstaller, S; Buxhofer-Ausch, V; Sliwa, T; Beham-Schmid, C; Gastl, G; Geissler, K; Melchardt, T; Krauth, M; Krippl, P; Petzer, A; Rumpold, H; Wölfler, A; Gisslinger, H Austrian recommendations for the management of polycythemia vera.
Wien Klin Wochenschr. 2018; 130(17-18):535-542 [OPEN ACCESS]
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2017

Chao, MP; Gentles, AJ; Chatterjee, S; Lan, F; Reinisch, A; Corces, MR; Xavy, S; Shen, J; Haag, D; Chanda, S; Sinha, R; Morganti, RM; Nishimura, T; Ameen, M; Wu, H; Wernig, M; Wu, JC; Majeti, R Human AML-iPSCs Reacquire Leukemic Properties after Differentiation and Model Clonal Variation of Disease.
Cell Stem Cell. 2017; 20(3): 329-344. [OPEN ACCESS]
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Heidenreich, S; Ziagkos, D; de Wreede, LC; van Biezen, A; Finke, J; Platzbecker, U; Niederwieser, D; Einsele, H; Bethge, W; Schleuning, M; Beelen, DW; Tischer, J; Nagler, A; Glass, B; Maertens, J; Yáñez, L; Beguin, Y; Sill, H; Scheid, C; Stelljes, M; Ganser, A; Zachée, P; Selleslag, D; de Witte, T; Robin, M; Kröger, N Allogeneic Stem Cell Transplantation for Patients Age ≥ 70 Years with Myelodysplastic Syndrome: A Retrospective Study of the MDS Subcommittee of the Chronic Malignancies Working Party of the EBMT.
Biol Blood Marrow Transplant. 2017; 23(1):44-52 [OPEN ACCESS]
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Peschel, I; Podmirseg, SR; Taschler, M; Duyster, J; Götze, KS; Sill, H; Nachbaur, D; Jäkel, H; Hengst, L FLT3 and FLT3-ITD phosphorylate and inactivate the cyclin-dependent kinase inhibitor p27Kip1 in acute myeloid leukemia.
Haematologica. 2017; 102(8):1378-1389 [OPEN ACCESS]
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Prieto-Torres, L; Boggio, F; Gruber-Wackernagel, A; Cerroni, L Nodular Sclerodermatous Chronic Cutaneous Graft-Versus-Host Disease (GvHD): A New Clinicopathological Variant of Cutaneous Sclerodermatous GvHD Resembling Nodular/Keloidal Scleroderma.
Am J Dermatopathol. 2017; 39(12): 910-913.
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Reinisch, A; Hernandez, DC; Schallmoser, K; Majeti, R Generation and use of a humanized bone-marrow-ossicle niche for hematopoietic xenotransplantation into mice.
Nat Protoc. 2017; 12(10): 2169-2188. [OPEN ACCESS]
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2016

Arriga, R; Caratelli, S; Coppola, A; Spagnoli, GC; Venditti, A; Amadori, S; Lanzilli, G; Lauro, D; Palomba, P; Sconocchia, T; Del Principe, MI; Maurillo, L; Buccisano, F; Capuani, B; Ferrone, S; Sconocchia, G Enhancement of anti-leukemia activity of NK cells in vitro and in vivo by inhibition of leukemia cell-induced NK cell damage.
Oncotarget. 2016; 7(2): 2070-2079. [OPEN ACCESS]
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Bainschab, A; Quehenberger, F; Greinix, HT; Krause, R; Wölfler, A; Sill, H; Zebisch, A Infections in patients with acute myeloid leukemia treated with low-intensity therapeutic regimens: Risk factors and efficacy of antibiotic prophylaxis.
Leuk Res. 2016; 42(3):47-51
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Dutta, S; Krause, A; Vosberg, S; Herold, T; Ksienzyk, B; Quintanilla-Martinez, L; Tizazu, B; Chopra, M; Graf, A; Krebs, S; Blum, H; Greif, PA; Vetter, A; Metzeler, K; Rothenberg-Thurley, M; Schneider, MR; Dahlhoff, M; Spiekermann, K; Zimber-Strobl, U; Wolf, E; Bohlander, SK The target cell of transformation is distinct from the leukemia stem cell in murine CALM/AF10 leukemia models.
Leukemia. 2016; 30(5):1166-1176
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Hell, L; Thaler, J; Martinod, K; Ay, C; Posch, F; Wagner, DD; Pabinger, I OC-16 - Neutrophil extracellular traps and tissue factor-bearing microvesicles: a liaison dangereuse causing overt DIC in cancer patients?
Thromb Res. 2016; 140 Suppl 1(1):S174-S175
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Pajtler, KW; Tippelt, S; Siegler, N; Reichling, S; Zimmermann, M; Mikasch, R; Bode, U; Gnekow, A; Pietsch, T; Benesch, M; Rutkowski, S; Fleischhack, G Intraventricular etoposide safety and toxicity profile in children and young adults with refractory or recurrent malignant brain tumors.
J Neurooncol. 2016; 128(3):463-471
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Reinisch, A; Majeti, R Sticking It to the Niche: CD98 Mediates Critical Adhesive Signals in AML.
Cancer Cell. 2016; 30(5): 662-664. [OPEN ACCESS]
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Reinisch, A; Thomas, D; Corces, MR; Zhang, X; Gratzinger, D; Hong, WJ; Schallmoser, K; Strunk, D; Majeti, R A humanized bone marrow ossicle xenotransplantation model enables improved engraftment of healthy and leukemic human hematopoietic cells.
Nat Med. 2016; 22(7): 812-821. [OPEN ACCESS]
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Uttarkar, S; Dassé, E; Coulibaly, A; Steinmann, S; Jakobs, A; Schomburg, C; Trentmann, A; Jose, J; Schlenke, P; Berdel, WE; Schmidt, TJ; Müller-Tidow, C; Frampton, J; Klempnauer, KH Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.
Blood. 2016; 127(9):1173-1182 [OPEN ACCESS]
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Uttarkar, S; Piontek, T; Dukare, S; Schomburg, C; Schlenke, P; Berdel, WE; Müller-Tidow, C; Schmidt, TJ; Klempnauer, KH Small-Molecule Disruption of the Myb/p300 Cooperation Targets Acute Myeloid Leukemia Cells.
Mol Cancer Ther. 2016; 15(12):2905-2915 [OPEN ACCESS]
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Verbrugge, SE; Al, M; Assaraf, YG; Kammerer, S; Chandrupatla, DM; Honeywell, R; Musters, RP; Giovannetti, E; O'Toole, T; Scheffer, GL; Krige, D; de Gruijl, TD; Niessen, HW; Lems, WF; Kramer, PA; Scheper, RJ; Cloos, J; Ossenkoppele, GJ; Peters, GJ; Jansen, G Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK/Akt/mTOR.
Oncotarget. 2016; 7(5):5240-5257 [OPEN ACCESS]
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Zebisch, A; Hatzl, S; Pichler, M; Wölfler, A; Sill, H Therapeutic Resistance in Acute Myeloid Leukemia: The Role of Non-Coding RNAs.
Int J Mol Sci. 2016; 17(12): [OPEN ACCESS]
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2015

Fisser, MC; Rommer, A; Steinleitner, K; Heller, G; Herbst, F; Wiese, M; Glimm, H; Sill, H; Wieser, R Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.
Mol Carcinog. 2015; 54(12):1815-1819 [OPEN ACCESS]
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Mazumdar, C; Shen, Y; Xavy, S; Zhao, F; Reinisch, A; Li, R; Corces, MR; Flynn, RA; Buenrostro, JD; Chan, SM; Thomas, D; Koenig, JL; Hong, WJ; Chang, HY; Majeti, R Leukemia-Associated Cohesin Mutants Dominantly Enforce Stem Cell Programs and Impair Human Hematopoietic Progenitor Differentiation.
Cell Stem Cell. 2015; 17(6): 675-688. [OPEN ACCESS]
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Reinisch, A; Chan, SM; Thomas, D; Majeti, R Biology and Clinical Relevance of Acute Myeloid Leukemia Stem Cells.
Semin Hematol. 2015; 52(3): 150-164. [OPEN ACCESS]
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Robier, C; Schoberl, M; Reiher, H; Neubauer, M Bacteria on a peripheral blood smear as presenting sign of overwhelming post-splenectomy infection in a patient with secondary acute myeloid leukemia.
Clin Chem Lab Med. 2015; 53(8):e203-e205 (- Case Report)
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Sinha, S; Thomas, D; Yu, L; Gentles, AJ; Jung, N; Corces-Zimmerman, MR; Chan, SM; Reinisch, A; Feinberg, AP; Dill, DL; Majeti, R Mutant WT1 is associated with DNA hypermethylation of PRC2 targets in AML and responds to EZH2 inhibition.
Blood. 2015; 125(2): 316-326. [OPEN ACCESS]
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Wenzl, K; Troppan, K; Neumeister, P; Deutsch, AJ The nuclear orphan receptor NR4A1 and NR4A3 as tumor suppressors in hematologic neoplasms.
Curr Drug Targets. 2015; 16(1):38-46
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2014

Boehm, A; Sperr, WR; Kalhs, P; Greinix, H; Valent, P; Worel, N; Kainz, A; Mitterbauer, M; Bojic, M; Rabitsch, W Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience.
Wien Klin Wochenschr. 2014; 126(1-2): 23-29. [OPEN ACCESS]
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Boztug, H; Mühlegger, N; Glogova, E; Mann, G; Urban, C; Meister, B; Schmitt, K; Jones, N; Attarbaschi, A; Haas, O; Strehl, S; Lion, T; Pötschger, U; Fink, FM; Gadner, H; Dworzak, M Development of treatment and clinical results in childhood AML in Austria (1993-2013).
Memo. 2014; 7(1):63-74 [OPEN ACCESS]
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Deutsch, AJ; Rinner, B; Wenzl, K; Pichler, M; Troppan, K; Steinbauer, E; Schwarzenbacher, D; Reitter, S; Feichtinger, J; Tierling, S; Prokesch, A; Scheideler, M; Krogsdam, A; Thallinger, GG; Schaider, H; Beham-Schmid, C; Neumeister, P NR4A1-mediated apoptosis suppresses lymphomagenesis and is associated with a favorable cancer-specific survival in patients with aggressive B-cell lymphomas.
Blood. 2014; 123(15):2367-2377 [OPEN ACCESS]
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Pleyer, L; Burgstaller, S; Girschikofsky, M; Linkesch, W; Stauder, R; Pfeilstocker, M; Schreder, M; Tinchon, C; Sliwa, T; Lang, A; Sperr, WR; Krippl, P; Geissler, D; Voskova, D; Schlick, K; Thaler, J; Machherndl-Spandl, S; Theiler, G; Eckmüllner, O; Greil, R Azacitidine in 302 patients with WHO-defined acute myeloid leukemia: results from the Austrian Azacitidine Registry of the AGMT-Study Group.
Ann Hematol. 2014; 93(11):1825-1838 [OPEN ACCESS]
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Robin, M; Giannotti, F; Deconinck, E; Mohty, M; Michallet, M; Sanz, G; Chevallier, P; Cahn, JY; Legrand, F; Rovira, M; Passweg, J; Sierra, J; Nguyen, S; Maillard, N; Yakoub-Agha, I; Linkesch, W; Cannell, P; Marcatti, M; Bay, JO; Chalandon, Y; Kröger, N; Gluckman, E; Rocha, V; Olavarria, E; Ruggeri, A; Eurocord and Chronic Malignancies Working Party-European Group for Blood and Marrow Transplantation (CMWP-EBMT) Unrelated cord blood transplantation for patients with primary or secondary myelofibrosis.
Biol Blood Marrow Transplant. 2014; 20(11):1841-1846 [OPEN ACCESS]
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2013

Paar, C; Herber, G; Voskova, D; Fridrik, M; Stekel, H; Berg, J A case of acute myeloid leukemia (AML) with an unreported combination of chromosomal abnormalities: gain of isochromosome 5p, tetrasomy 8 and unbalanced translocation der(19)t(17;19)(q23;p13).
Mol Cytogenet. 2013; 6(1):40-40 [OPEN ACCESS]
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Pfeiffer, T; Schleuning, M; Mayer, J; Haude, KH; Tischer, J; Buchholz, S; Bunjes, D; Bug, G; Holler, E; Meyer, RG; Greinix, H; Scheid, C; Christopeit, M; Schnittger, S; Braess, J; Schlimok, G; Spiekermann, K; Ganser, A; Kolb, HJ; Schmid, C Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse.
Haematologica. 2013; 98(4):518-525 [OPEN ACCESS]
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Rommer, A; Steinleitner, K; Hackl, H; Schneckenleithner, C; Engelmann, M; Scheideler, M; Vlatkovic, I; Kralovics, R; Cerny-Reiterer, S; Valent, P; Sill, H; Wieser, R Overexpression of primary microRNA 221/222 in acute myeloid leukemia.
BMC Cancer. 2013; 13(8):364-364 [OPEN ACCESS]
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2012

Agrawal-Singh, S; Isken, F; Agelopoulos, K; Klein, HU; Thoennissen, NH; Koehler, G; Hascher, A; Bäumer, N; Berdel, WE; Thiede, C; Ehninger, G; Becker, A; Schlenke, P; Wang, Y; McClelland, M; Krug, U; Koschmieder, S; Büchner, T; Yu, DY; Singh, SV; Hansen, K; Serve, H; Dugas, M; Müller-Tidow, C Genome-wide analysis of histone H3 acetylation patterns in AML identifies PRDX2 as an epigenetically silenced tumor suppressor gene.
Blood. 2012; 119(10): 2346-2357. [OPEN ACCESS]
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Deutsch, AJ; Angerer, H; Fuchs, TE; Neumeister, P The nuclear orphan receptors NR4A as therapeutic target in cancer therapy.
Anticancer Agents Med Chem. 2012; 12(9):1001-1014
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Fried, I; Bodner, C; Pichler, MM; Lind, K; Beham-Schmid, C; Quehenberger, F; Sperr, WR; Linkesch, W; Sill, H; Wölfler, A Frequency, onset and clinical impact of somatic DNMT3A mutations in therapy-related and secondary acute myeloid leukemia.
Haematologica. 2012; 97(2):246-250 [OPEN ACCESS]
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Zebisch, A; Wölfler, A; Fried, I; Wolf, O; Lind, K; Bodner, C; Haller, M; Drasche, A; Pirkebner, D; Matallanas, D; Rath, O; Blyth, K; Delwel, R; Taskesen, E; Quehenberger, F; Kolch, W; Troppmair, J; Sill, H Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemia.
Leukemia. 2012; 26(8):1842-1849 [OPEN ACCESS]
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2011

Matutes, E; Pickl, WF; Van't Veer, M; Morilla, R; Swansbury, J; Strobl, H; Attarbaschi, A; Hopfinger, G; Ashley, S; Bene, MC; Porwit, A; Orfao, A; Lemez, P; Schabath, R; Ludwig, WD Mixed-phenotype acute leukemia: clinical and laboratory features and outcome in 100 patients defined according to the WHO 2008 classification.
Blood. 2011; 117(11):3163-3171 [OPEN ACCESS]
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2010

Müller-Tidow, C; Klein, HU; Hascher, A; Isken, F; Tickenbrock, L; Thoennissen, N; Agrawal-Singh, S; Tschanter, P; Disselhoff, C; Wang, Y; Becker, A; Thiede, C; Ehninger, G; zur Stadt, U; Koschmieder, S; Seidl, M; Müller, FU; Schmitz, W; Schlenke, P; McClelland, M; Berdel, WE; Dugas, M; Serve, H; Study Alliance Leukemia Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Blood. 2010; 116(18): 3564-3571. [OPEN ACCESS]
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Steiner, M; Attarbaschi, A; Dworzak, M; Strobl, H; Pickl, W; Kornmüller, R; Haas, O; Gadner, H; Mann, G; Austrian Berlin-Frankfurt-Münster Study Group Cytochemically myeloperoxidase positive childhood acute leukemia with lymphoblastic morphology treated as lymphoblastic leukemia.
J Pediatr Hematol Oncol. 2010; 32(1):e4-e7
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