Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Suchbegriffe: XENOGRAFT MODEL ANTITUMOR ASSAYS - , . Treffer: 50

Dengler, MA; Teh, CE; Thijssen, R; Gangoda, L; Lan, P; Herold, MJ; Gray, DH; Kelly, GL; Roberts, AW; Adams, JM Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Oncogene. 2020; 39(9):2009-2023 Doi: 10.1038/s41388-019-1122-x
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2019

Barbosa, K; Deshpande, A; Chen, BR; Ghosh, A; Sun, Y; Dutta, S; Weetall, M; Dixon, J; Armstrong, SA; Bohlander, SK; Deshpande, AJ Acute myeloid leukemia driven by the CALM-AF10 fusion gene is dependent on BMI1.
Exp Hematol. 2019; 74: 42-51.e3. Doi: 10.1016/j.exphem.2019.04.003
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Kollmann, S; Grundschober, E; Maurer, B; Warsch, W; Grausenburger, R; Edlinger, L; Huuhtanen, J; Lagger, S; Hennighausen, L; Valent, P; Decker, T; Strobl, B; Mueller, M; Mustjoki, S; Hoelbl-Kovacic, A; Sexl, V Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia.
Leukemia. 2019; 33(7): 1583-1597. Doi: 10.1038/s41375-018-0369-5 [OPEN ACCESS]
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2017

Bayraktar, R; Pichler, M; Kanlikilicer, P; Ivan, C; Bayraktar, E; Kahraman, N; Aslan, B; Oguztuzun, S; Ulasli, M; Arslan, A; Calin, G; Lopez-Berestein, G; Ozpolat, B MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase.
Oncotarget. 2017; 8(7): 11641-11658. Doi: 10.18632/oncotarget.14264 [OPEN ACCESS]
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Cuppens, T; Annibali, D; Coosemans, A; Trovik, J; Ter Haar, N; Colas, E; Garcia-Jimenez, A; Van de Vijver, K; Kruitwagen, RP; Brinkhuis, M; Zikan, M; Dundr, P; Huvila, J; Carpén, O; Haybaeck, J; Moinfar, F; Salvesen, HB; Stukan, M; Mestdagh, C; Zweemer, RP; Massuger, LF; Mallmann, MR; Wardelmann, E; Mints, M; Verbist, G; Thomas, D; Gommé, E; Hermans, E; Moerman, P; Bosse, T; Amant, F Potential Targets' Analysis Reveals Dual PI3K/mTOR Pathway Inhibition as a Promising Therapeutic Strategy for Uterine Leiomyosarcomas-an ENITEC Group Initiative.
Clin Cancer Res. 2017; 23(5):1274-1285 Doi: 10.1158/1078-0432.CCR-16-2149 [OPEN ACCESS]
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Deutsch, AJA; Rinner, B; Pichler, M; Prochazka, K; Pansy, K; Bischof, M; Fechter, K; Hatzl, S; Feichtinger, J; Wenzl, K; Frisch, MT; Stiegelbauer, V; Prokesch, A; Krogsdam, A; Sill, H; Thallinger, GG; Greinix, HT; Wang, C; Beham-Schmid, C; Neumeister, P NR4A3 Suppresses Lymphomagenesis through Induction of Proapoptotic Genes.
Cancer Res. 2017; 77(9):2375-2386 Doi: 10.1158/0008-5472.CAN-16-2320 [OPEN ACCESS]
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Pichler, M; Stiegelbauer, V; Vychytilova-Faltejskova, P; Ivan, C; Ling, H; Winter, E; Zhang, X; Goblirsch, M; Wulf-Goldenberg, A; Ohtsuka, M; Haybaeck, J; Svoboda, M; Okugawa, Y; Gerger, A; Hoefler, G; Goel, A; Slaby, O; Calin, GA Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis.
Clin Cancer Res. 2017; 23(5):1323-1333 Doi: 10.1158/1078-0432.CCR-16-0497 [OPEN ACCESS]
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Planells-Palop, V; Hazazi, A; Feichtinger, J; Jezkova, J; Thallinger, G; Alsiwiehri, NO; Almutairi, M; Parry, L; Wakeman, JA; McFarlane, RJ Human germ/stem cell-specific gene TEX19 influences cancer cell proliferation and cancer prognosis.
Mol Cancer. 2017; 16(1): 84-84. Doi: 10.1186/s12943-017-0653-4 [OPEN ACCESS]
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Rashed, MH; Kanlikilicer, P; Rodriguez-Aguayo, C; Pichler, M; Bayraktar, R; Bayraktar, E; Ivan, C; Filant, J; Silva, A; Aslan, B; Denizli, M; Mitra, R; Ozpolat, B; Calin, GA; Sood, AK; Abd-Ellah, MF; Helal, GK; Berestein, GL Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs.
Oncotarget. 2017; 8(12):20145-20164 Doi: 10.18632/oncotarget.15525 [OPEN ACCESS]
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Schütte, M; Risch, T; Abdavi-Azar, N; Boehnke, K; Schumacher, D; Keil, M; Yildiriman, R; Jandrasits, C; Borodina, T; Amstislavskiy, V; Worth, CL; Schweiger, C; Liebs, S; Lange, M; Warnatz, HJ; Butcher, LM; Barrett, JE; Sultan, M; Wierling, C; Golob-Schwarzl, N; Lax, S; Uranitsch, S; Becker, M; Welte, Y; Regan, JL; Silvestrov, M; Kehler, I; Fusi, A; Kessler, T; Herwig, R; Landegren, U; Wienke, D; Nilsson, M; Velasco, JA; Garin-Chesa, P; Reinhard, C; Beck, S; Schäfer, R; Regenbrecht, CR; Henderson, D; Lange, B; Haybaeck, J; Keilholz, U; Hoffmann, J; Lehrach, H; Yaspo, ML Molecular dissection of colorectal cancer in pre-clinical models identifies biomarkers predicting sensitivity to EGFR inhibitors.
Nat Commun. 2017; 8(2):14262-14262 Doi: 10.1038/ncomms14262 [OPEN ACCESS]
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Stiegelbauer, V; Vychytilova-Faltejskova, P; Karbiener, M; Pehserl, AM; Reicher, A; Resel, M; Heitzer, E; Ivan, C; Bullock, M; Ling, H; Deutsch, A; Wulf-Goldenberg, A; Adiprasito, JB; Stoeger, H; Haybaeck, J; Svoboda, M; Stotz, M; Hoefler, G; Slaby, O; Calin, GA; Gerger, A; Pichler, M miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5.
Clin Cancer Res. 2017; 23(17):5255-5266 Doi: 10.1158/1078-0432.CCR-17-0023 [OPEN ACCESS]
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Su, Y; Hu, Y; Wang, Y; Xu, X; Yuan, Y; Li, Y; Wang, Z; Chen, K; Zhang, F; Ding, X; Li, M; Zhou, J; Liu, Y; Wang, W A precision-guided MWNT mediated reawakening the sunk synergy in RAS for anti-angiogenesis lung cancer therapy.
Biomaterials. 2017; 139(28):75-90 Doi: 10.1016/j.biomaterials.2017.05.046
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2016

Arvidsson, Y; Johanson, V; Pfragner, R; Wängberg, B; Nilsson, O Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells.
Neuroendocrinology. 2016; 103(5):578-591 Doi: 10.1159/000441849
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He, JC; Yao, W; Wang, JM; Schemmer, P; Yang, Y; Liu, Y; Qian, YW; Qi, WP; Zhang, J; Shen, Q; Yang, T TACC3 overexpression in cholangiocarcinoma correlates with poor prognosis and is a potential anti-cancer molecular drug target for HDAC inhibitors.
Oncotarget. 2016; 7(46):75441-75456 Doi: 10.18632/oncotarget.12254 [OPEN ACCESS]
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Jagadeeshan, S; Subramanian, A; Tentu, S; Beesetti, S; Singhal, M; Raghavan, S; Surabhi, RP; Mavuluri, J; Bhoopalan, H; Biswal, J; Pitani, RS; Chidambaram, S; Sundaram, S; Malathi, R; Jeyaraman, J; Nair, AS; Venkatraman, G; Rayala, SK P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer.
Ann Oncol. 2016; 27(8): 1546-1556. Doi: 10.1093/annonc/mdw184 [OPEN ACCESS]
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Jeric, I; Maurer, G; Cavallo, AL; Raguz, J; Desideri, E; Tarkowski, B; Parrini, M; Fischer, I; Zatloukal, K; Baccarini, M A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis.
Nat Commun. 2016; 7(12):13781-13781 Doi: 10.1038/ncomms13781 [OPEN ACCESS]
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Ritter, C; Fan, K; Paulson, KG; Nghiem, P; Schrama, D; Becker, JC Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma.
Sci Rep. 2016; 6:21678-21678 Doi: 10.1038/srep21678 [OPEN ACCESS]
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Scheipl, S; Barnard, M; Cottone, L; Jorgensen, M; Drewry, DH; Zuercher, WJ; Turlais, F; Ye, H; Leite, AP; Smith, JA; Leithner, A; Möller, P; Brüderlein, S; Guppy, N; Amary, F; Tirabosco, R; Strauss, SJ; Pillay, N; Flanagan, AM EGFR inhibitors identified as a potential treatment for chordoma in a focused compound screen.
J Pathol. 2016; 239(3):320-334 Doi: 10.1002/path.4729 [OPEN ACCESS]
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Zhang, F; Li, M; Su, Y; Zhou, J; Wang, W A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy.
Mater Sci Eng C Mater Biol Appl. 2016; 64(28): 208-218. Doi: 10.1016/j.msec.2016.03.083
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2015

Aguiriano-Moser, V; Svejda, B; Li, ZX; Sturm, S; Stuppner, H; Ingolic, E; Höger, H; Siegl, V; Meier-Allard, N; Sadjak, A; Pfragner, R Ursolic acid from Trailliaedoxa gracilis induces apoptosis in medullary thyroid carcinoma cells.
Mol Med Rep. 2015; 12(4):5003-5011 Doi: 10.3892/mmr.2015.4053 [OPEN ACCESS]
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Cerny-Reiterer, S; Rabenhorst, A; Stefanzl, G; Herndlhofer, S; Hoermann, G; Müllauer, L; Baumgartner, S; Beham-Schmid, C; Sperr, WR; Mannhalter, C; Sill, H; Linkesch, W; Arock, M; Hartmann, K; Valent, P Long-term treatment with imatinib results in profound mast cell deficiency in Ph+ chronic myeloid leukemia.
Oncotarget. 2015; 6(5):3071-3084 Doi: 10.18632/oncotarget.3074 [OPEN ACCESS]
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Hammer, K; Kazcorowski, A; Liu, L; Behr, M; Schemmer, P; Herr, I; Nettelbeck, DM Engineered adenoviruses combine enhanced oncolysis with improved virus production by mesenchymal stromal carrier cells.
Int J Cancer. 2015; 137(4):978-990 Doi: 10.1002/ijc.29442 [OPEN ACCESS]
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Schwarzenbacher, D; Stiegelbauer, V; Deutsch, A; Ress, AL; Aigelsreiter, A; Schauer, S; Wagner, K; Langsenlehner, T; Resel, M; Gerger, A; Ling, H; Ivan, C; Calin, GA; Hoefler, G; Rinner, B; Pichler, M Low spinophilin expression enhances aggressive biological behavior of breast cancer.
Oncotarget. 2015; 6(13):11191-11202 Doi: 10.18632/oncotarget.3586 [OPEN ACCESS]
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2014

Adam, C; Baeurle, A; Brodsky, JL; Wipf, P; Schrama, D; Becker, JC; Houben, R The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.
PLoS One. 2014; 9(4):e92041-e92041 Doi: 10.1371/journal.pone.0092041 [OPEN ACCESS]
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Herz, C; Hertrampf, A; Zimmermann, S; Stetter, N; Wagner, M; Kleinhans, C; Erlacher, M; Schüler, J; Platz, S; Rohn, S; Mersch-Sundermann, V; Lamy, E The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC.
J Cell Mol Med. 2014; 18(12): 2393-2403. Doi: 10.1111/jcmm.12412 [OPEN ACCESS]
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Kiesslich, T; Mayr, C; Wachter, J; Bach, D; Fuereder, J; Wagner, A; Alinger, B; Pichler, M; Di Fazio, P; Ocker, M; Berr, F; Neureiter, D Activated hedgehog pathway is a potential target for pharmacological intervention in biliary tract cancer.
Mol Cell Biochem. 2014; 396(1-2):257-268 Doi: 10.1007/s11010-014-2161-9
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Liu, L; Salnikov, AV; Bauer, N; Aleksandrowicz, E; Labsch, S; Nwaeburu, C; Mattern, J; Gladkich, J; Schemmer, P; Werner, J; Herr, I Triptolide reverses hypoxia-induced epithelial-mesenchymal transition and stem-like features in pancreatic cancer by NF-κB downregulation.
Int J Cancer. 2014; 134(10):2489-2503 Doi: 10.1002/ijc.28583 [OPEN ACCESS]
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Wiesner, T; He, J; Yelensky, R; Esteve-Puig, R; Botton, T; Yeh, I; Lipson, D; Otto, G; Brennan, K; Murali, R; Garrido, M; Miller, VA; Ross, JS; Berger, MF; Sparatta, A; Palmedo, G; Cerroni, L; Busam, KJ; Kutzner, H; Cronin, MT; Stephens, PJ; Bastian, BC Kinase fusions are frequent in Spitz tumours and spitzoid melanomas.
Nat Commun. 2014; 5(5):3116-3116 Doi: 10.1038/ncomms4116 [OPEN ACCESS]
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2013

Eißmann, M; Melzer, IM; Fernández, SB; Michel, G; Hrabě de Angelis, M; Hoefler, G; Finkenwirth, P; Jauch, A; Schoell, B; Grez, M; Schmidt, M; Bartholomae, CC; Newrzela, S; Haetscher, N; Rieger, MA; Zachskorn, C; Mittelbronn, M; Zörnig, M Overexpression of the anti-apoptotic protein AVEN contributes to increased malignancy in hematopoietic neoplasms.
Oncogene. 2013; 32(20):2586-2591 Doi: 10.1038/onc.2012.263 [OPEN ACCESS]
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Rangger, C; Helbok, A; Sosabowski, J; Kremser, C; Koehler, G; Prassl, R; Andreae, F; Virgolini, IJ; von Guggenberg, E; Decristoforo, C Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles.
Int J Nanomedicine. 2013; 8(6):4659-4671 Doi: 10.2147/IJN.S51927 [OPEN ACCESS]
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Shirsath, N; Rathos, M; Chaudhari, U; Sivaramakrishnan, H; Joshi, K Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines.
Lung Cancer. 2013; 82(2):214-221 Doi: 10.1016/j.lungcan.2013.08.010
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2012

Ning, Y; Labonte, MJ; Zhang, W; Bohanes, PO; Gerger, A; Yang, D; Benhaim, L; Paez, D; Rosenberg, DO; Nagulapalli Venkata, KC; Louie, SG; Petasis, NA; Ladner, RD; Lenz, HJ The CXCR2 antagonist, SCH-527123, shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models.
Mol Cancer Ther. 2012; 11(6):1353-1364 Doi: 10.1158/1535-7163.MCT-11-0915 [OPEN ACCESS]
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Shirsath, NP; Manohar, SM; Joshi, KS P276-00, a cyclin-dependent kinase inhibitor, modulates cell cycle and induces apoptosis in vitro and in vivo in mantle cell lymphoma cell lines.
Mol Cancer. 2012; 11:77-77 Doi: 10.1186/1476-4598-11-77 [OPEN ACCESS]
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2011

Lussier, YA; Xing, HR; Salama, JK; Khodarev, NN; Huang, Y; Zhang, Q; Khan, SA; Yang, X; Hasselle, MD; Darga, TE; Malik, R; Fan, H; Perakis, S; Filippo, M; Corbin, K; Lee, Y; Posner, MC; Chmura, SJ; Hellman, S; Weichselbaum, RR MicroRNA expression characterizes oligometastasis(es).
PLoS One. 2011; 6(12): e28650-e28650. Doi: 10.1371/journal.pone.0028650 [OPEN ACCESS]
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2010

Gattenlöhner, S; Jörissen, H; Huhn, M; Vincent, A; Beeson, D; Tzartos, S; Mamalaki, A; Etschmann, B; Muller-Hermelink, HK; Koscielniak, E; Barth, S; Marx, A A human recombinant autoantibody-based immunotoxin specific for the fetal acetylcholine receptor inhibits rhabdomyosarcoma growth in vitro and in a murine transplantation model.
J Biomed Biotechnol. 2010; 2010(8):187621-187621 Doi: 10.1155/2010/187621 [OPEN ACCESS]
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Hrzenjak, A; Moinfar, F; Kremser, ML; Strohmeier, B; Petru, E; Zatloukal, K; Denk, H Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo.
Mol Cancer. 2010; 9(10): 49-49. Doi: 10.1186/1476-4598-9-49 [OPEN ACCESS]
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Kopp, KL; Dabelsteen, S; Krejsgaard, T; Eriksen, KW; Geisler, C; Becker, JC; Wasik, M; Odum, N; Woetmann, A COX-2 is a novel target in therapy of mycosis fungoides.
Leukemia. 2010; 24(12):2127-2129 Doi: 10.1038/leu.2010.221 [OPEN ACCESS]
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Rausch, V; Liu, L; Kallifatidis, G; Baumann, B; Mattern, J; Gladkich, J; Wirth, T; Schemmer, P; Büchler, MW; Zöller, M; Salnikov, AV; Herr, I Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics.
Cancer Res. 2010; 70(12):5004-5013 Doi: 10.1158/0008-5472.CAN-10-0066 [OPEN ACCESS]
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Svejda, B; Aguiriano-Moser, V; Sturm, S; Höger, H; Ingolic, E; Siegl, V; Stuppner, H; Pfragner, R Anticancer activity of novel plant extracts from Trailliaedoxa gracilis (W. W. Smith and Forrest) in human carcinoid KRJ-I Cells.
Anticancer Res. 2010; 30(1):55-64
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2009

Mischek, D; Steinborn, R; Petznek, H; Bichler, C; Zatloukal, K; Stürzl, M; Günzburg, WH; Hohenadl, C Molecularly characterised xenograft tumour mouse models: valuable tools for evaluation of new therapeutic strategies for secondary liver cancers.
J Biomed Biotechnol. 2009; 2009(5): 437284-437284. Doi: 10.1155/2009/437284 [OPEN ACCESS]
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Pfragner, R; Behmel, A; Höger, H; Beham, A; Ingolic, E; Stelzer, I; Svejda, B; Moser, VA; Obenauf, AC; Siegl, V; Haas, O; Niederle, B Establishment and characterization of three novel cell lines - P-STS, L-STS, H-STS - derived from a human metastatic midgut carcinoid.
ANTICANCER RES. 2009; 29(6): 1951-1961. [OPEN ACCESS]
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Yu, Z; Li, S; Brader, P; Chen, N; Yu, YA; Zhang, Q; Szalay, AA; Fong, Y; Wong, RJ Oncolytic vaccinia therapy of squamous cell carcinoma.
Mol Cancer. 2009; 8(4): 45-45. Doi: 10.1186/1476-4598-8-45 [OPEN ACCESS]
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2008

Bergmann, F; Stepp, H; Metzger, R; Rolle, U; Johansson, A; Till, H; In vitro and in vivo evaluation of photodynamic techniques for the experimental treatment of human hepatoblastoma and neuroblastoma: preliminary results.
Pediatr Surg Int. 2008; 24(12):1331-1333 Doi: 10.1007/s00383-008-2275-9
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2006

Cam, H; Griesmann, H; Beitzinger, M; Hofmann, L; Beinoraviciute-Kellner, R; Sauer, M; Huttinger-Kirchhof, N; Oswald, C; Friedl, P; Gattenlohner, S; Burek, C; Rosenwald, A; Stiewe, T p53 family members in myogenic differentiation and rhabdomyosarcoma development.
Cancer Cell. 2006; 10(4):281-293 Doi: 10.1016/j.ccr.2006.08.024 [OPEN ACCESS]
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2002

Weber, T; Lu, M; Andera, L; Lahm, H; Gellert, N; Fariss, MW; Korinek, V; Sattler, W; Ucker, DS; Terman, A; Schröder, A; Erl, W; Brunk, UT; Coffey, RJ; Weber, C; Neuzil, J Vitamin E succinate is a potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand) in vivo.
Clin Cancer Res. 2002; 8(3):863-869 [OPEN ACCESS]
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