Medizinische Universität Graz Austria/Österreich - Forschungsportal - Medical University of Graz

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Publikationen

Suchbegriffe: TUMOR SUPPRESSOR PROTEIN P53 - GENETICS, . Treffer: 55

2023

Michaelis, S; Pichler, A; Beham-Schmid, C; Stelzer, I; Schöffmann, L; Tinchon, C; Enko, D Early cerebrospinal fluid infiltration in TP53-mutated blastic plasmacytoid dendritic cell neoplasm.
Ann Hematol. 2023; 102(2):491-493 Doi: 10.1007/s00277-022-05078-1
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2022

Dutta, S; Moritz, J; Pregartner, G; Thallinger, GG; Brandstätter, I; Lind, K; Rezania, S; Lyssy, F; Reinisch, A; Zebisch, A; Berghold, A; Wölfler, A; Sill, H Comparison of acute myeloid leukemia and myelodysplastic syndromes with TP53 aberrations.
Ann Hematol. 2022; 101(4):837-846 Doi: 10.1007/s00277-022-04766-2 [OPEN ACCESS]
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Galhuber, M; Michenthaler, H; Heininger, C; Reinisch, I; Nössing, C; Krstic, J; Kupper, N; Moyschewitz, E; Auer, M; Heitzer, E; Ulz, P; Birner-Gruenberger, R; Liesinger, L; Lenihan-Geels, GN; Oster, M; Spreitzer, E; Zenezini, Chiozzi, R; Schulz, TJ; Schupp, M; Madl, T; Heck, AJR; Prokesch, A Complementary omics strategies to dissect p53 signaling networks under nutrient stress.
Cell Mol Life Sci. 2022; 79(6):326 Doi: 10.1007/s00018-022-04345-8 [OPEN ACCESS]
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Oster, M; Galhuber, M; Krstic, J; Steinhoff, JS; Lenihan-Geels, G; Wulff, S; Kiefer, MF; Petricek, KM; Wowro, SJ; Flores, RE; Yang, N; Li, C; Meng, Y; Reinisch, I; Sommerfeld, M; Weger, S; Habisch, H; Madl, T; Schulz, TJ; Prokesch, A; Schupp, M Hepatic p53 is regulated by transcription factor FOXO1 and acutely controls glycogen homeostasis.
J Biol Chem. 2022; 298(9):102287 Doi: 10.1016/j.jbc.2022.102287 [OPEN ACCESS]
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Penkert, J; Strüwe, FJ; Dutzmann, CM; Doergeloh, BB; Montellier, E; Freycon, C; Keymling, M; Schlemmer, HP; Sänger, B; Hoffmann, B; Gerasimov, T; Blattmann, C; Fetscher, S; Frühwald, M; Hettmer, S; Kordes, U; Ridola, V; Kroiss, Benninger, S; Mastronuzzi, A; Schott, S; Nees, J; Prokop, A; Redlich, A; Seidel, MG; Zimmermann, S; Pajtler, KW; Pfister, SM; Hainaut, P; Kratz, CP Genotype-phenotype associations within the Li-Fraumeni spectrum: a report from the German Registry.
J Hematol Oncol. 2022; 15(1): 107 Doi: 10.1186/s13045-022-01332-1 [OPEN ACCESS]
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2021

Middeke, JM; Teipel, R; Röllig, C; Stasik, S; Zebisch, A; Sill, H; Kramer, M; Scholl, S; Hochhaus, A; Jost, E; Brümmendorf, TH; Naumann, R; Steffen, B; Serve, H; Altmann, H; Kunzmann, V; Einsele, H; Parmentier, S; Schaich, M; Burchert, A; Neubauer, A; Schliemann, C; Berdel, WE; Sockel, K; Stölzel, F; Platzbecker, U; Ehninger, G; Bornhäuser, M; Schetelig, J; Thiede, C, , Study, Alliance, Leukemia, (SAL) Decitabine treatment in 311 patients with acute myeloid leukemia: outcome and impact of TP53 mutations - a registry based analysis.
Leuk Lymphoma. 2021; 62(6):1432-1440 Doi: 10.1080/10428194.2020.1864354
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Usluer, S; Spreitzer, E; Bourgeois, B; Madl, T p53 Transactivation Domain Mediates Binding and Phase Separation with Poly-PR/GR.
Int J Mol Sci. 2021; 22(21): Doi: 10.3390/ijms222111431 [OPEN ACCESS]
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Zalyte, E; Dedonyte, V; Kurlinkus, B; Sileikis, A; Schemmer, P; Valius, M Establishment and Characterization of a New Pancreatic Ductal Adenocarcinoma Cell Line Capan-26.
ANTICANCER RES. 2021; 41(3): 1401-1406. Doi: 10.21873/anticanres.14897
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2020

Munkhbaatar, E; Dietzen, M; Agrawal, D; Anton, M; Jesinghaus, M; Boxberg, M; Pfarr, N; Bidola, P; Uhrig, S; Höckendorf, U; Meinhardt, AL; Wahida, A; Heid, I; Braren, R; Mishra, R; Warth, A; Muley, T; Poh, PSP; Wang, X; Fröhling, S; Steiger, K; Slotta-Huspenina, J; van, Griensven, M; Pfeiffer, F; Lange, S; Rad, R; Spella, M; Stathopoulos, GT; Ruland, J; Bassermann, F; Weichert, W; Strasser, A; Branca, C; Heikenwalder, M; Swanton, C; McGranahan, N; Jost, PJ MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically.
Nat Commun. 2020; 11(1):4527 Doi: 10.1038/s41467-020-18372-1 [OPEN ACCESS]
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Pabst, G; Lind, K; Graf, R; Zebisch, A; Stölzel, F; Döhner, K; Heitzer, E; Reinisch, A; Sill, H TP53 mutated AML subclones exhibit engraftment in a humanized bone marrow ossicle mouse model.
Ann Hematol. 2020; 99(3):653-655 Doi: 10.1007/s00277-020-03920-y [OPEN ACCESS]
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Sladky, VC; Knapp, K; Szabo, TG; Braun, VZ; Bongiovanni, L; van den Bos, H; Spierings, DC; Westendorp, B; Curinha, A; Stojakovic, T; Scharnagl, H; Timelthaler, G; Tsuchia, K; Pinter, M; Semmler, G; Foijer, F; de Bruin, A; Reiberger, T; Rohr-Udilova, N; Villunger, A PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis.
EMBO Rep. 2020; 21(12):e50893-e50893 Doi: 10.15252/embr.202050893 [OPEN ACCESS]
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2019

Müller, M; Graf, R; Kashofer, K; Macher, S; Wölfler, A; Zebisch, A; Hrzenjak, A; Heitzer, E; Sill, H Detection of AML-specific TP53 mutations in bone marrow-derived mesenchymal stromal cells cultured under hypoxia conditions.
Ann Hematol. 2019; 98(8):2019-2020 Doi: 10.1007/s00277-019-03680-4 [OPEN ACCESS]
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2018

Kindler, O; Quehenberger, F; Benesch, M; Seidel, MG The Iceberg Map of germline mutations in childhood cancer: focus on primary immunodeficiencies.
Curr Opin Pediatr. 2018; 30(6):855-863 Doi: 10.1097/MOP.0000000000000680
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Krstic, J; Reinisch, I; Schupp, M; Schulz, TJ; Prokesch, A p53 Functions in Adipose Tissue Metabolism and Homeostasis.
Int J Mol Sci. 2018; 19(9): Doi: 10.3390/ijms19092622 [OPEN ACCESS]
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2017

González-Vela, MDC; Curiel-Olmo, S; Derdak, S; Beltran, S; Santibañez, M; Martínez, N; Castillo-Trujillo, A; Gut, M; Sánchez-Pacheco, R; Almaraz, C; Cereceda, L; Llombart, B; Agraz-Doblas, A; Revert-Arce, J; López Guerrero, JA; Mollejo, M; Marrón, PI; Ortiz-Romero, P; Fernandez-Cuesta, L; Varela, I; Gut, I; Cerroni, L; Piris, MÁ; Vaqué, JP Shared Oncogenic Pathways Implicated in Both Virus-Positive and UV-Induced Merkel Cell Carcinomas.
J Invest Dermatol. 2017; 137(1):197-206 Doi: 10.1016/j.jid.2016.08.015 [OPEN ACCESS]
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Kashofer, K; Regauer, S Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy.
GYNECOL ONCOL. 2017; 146(2): 314-318. Doi: 10.1016/j.ygyno.2017.05.018
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Kashofer, K; Winter, E; Halbwedl, I; Thueringer, A; Kreiner, M; Sauer, S; Regauer, S HPV-negative penile squamous cell carcinoma: disruptive mutations in the TP53 gene are common.
Mod Pathol. 2017; 30(7):1013-1020 Doi: 10.1038/modpathol.2017.26 [OPEN ACCESS]
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Prokesch, A; Graef, FA; Madl, T; Kahlhofer, J; Heidenreich, S; Schumann, A; Moyschewitz, E; Pristoynik, P; Blaschitz, A; Knauer, M; Muenzner, M; Bogner-Strauss, JG; Dohr, G; Schulz, TJ; Schupp, M Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis.
FASEB J. 2017; 31(2):732-742 Doi: 10.1096/fj.201600845R [OPEN ACCESS]
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Woischke, C; Schaaf, CW; Yang, HM; Vieth, M; Veits, L; Geddert, H; Märkl, B; Stömmer, P; Schaeffer, DF; Frölich, M; Blum, H; Vosberg, S; Greif, PA; Jung, A; Kirchner, T; Horst, D In-depth mutational analyses of colorectal neuroendocrine carcinomas with adenoma or adenocarcinoma components.
Mod Pathol. 2017; 30(1): 95-103. Doi: 10.1038/modpathol.2016.150
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2016

Arvidsson, Y; Johanson, V; Pfragner, R; Wängberg, B; Nilsson, O Cytotoxic Effects of Valproic Acid on Neuroendocrine Tumour Cells.
Neuroendocrinology. 2016; 103(5):578-591 Doi: 10.1159/000441849
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Sigl, V; Owusu-Boaitey, K; Joshi, PA; Kavirayani, A; Wirnsberger, G; Novatchkova, M; Kozieradzki, I; Schramek, D; Edokobi, N; Hersl, J; Sampson, A; Odai-Afotey, A; Lazaro, C; Gonzalez-Suarez, E; Pujana, MA; Cimba, F; Heyn, H; Vidal, E; Cruickshank, J; Berman, H; Sarao, R; Ticevic, M; Uribesalgo, I; Tortola, L; Rao, S; Tan, Y; Pfeiler, G; Lee, EY; Bago-Horvath, Z; Kenner, L; Popper, H; Singer, C; Khokha, R; Jones, LP; Penninger, JM RANKL/RANK control Brca1 mutation- .
Cell Res. 2016; 26(7):761-774 Doi: 10.1038/cr.2016.69 [OPEN ACCESS]
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Zhang, F; Li, M; Su, Y; Zhou, J; Wang, W A dual-targeting drug co-delivery system for tumor chemo- and gene combined therapy.
Mater Sci Eng C Mater Biol Appl. 2016; 64(28): 208-218. Doi: 10.1016/j.msec.2016.03.083
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2015

Kandioler, D; Mittlböck, M; Kappel, S; Puhalla, H; Herbst, F; Langner, C; Wolf, B; Tschmelitsch, J; Schippinger, W; Steger, G; Hofbauer, F; Samonigg, H; Gnant, M; Teleky, B; Kührer, I; p53 Research Group and the Austrian Breast and Colorectal Study Group (ABCSG) TP53 Mutational Status and Prediction of Benefit from Adjuvant 5-Fluorouracil in Stage III Colon Cancer Patients.
EBioMedicine. 2015; 2(8):825-830 Doi: 10.1016/j.ebiom.2015.06.003 [OPEN ACCESS]
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Leithner, K; Hrzenjak, A; Trötzmüller, M; Moustafa, T; Köfeler, HC; Wohlkoenig, C; Stacher, E; Lindenmann, J; Harris, AL; Olschewski, A; Olschewski, H PCK2 activation mediates an adaptive response to glucose depletion in lung cancer.
Oncogene. 2015; 34(8):1044-1050 Doi: 10.1038/onc.2014.47
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Schulz, E; Kashofer, K; Heitzer, E; Mhatre, KN; Speicher, MR; Hoefler, G; Sill, H Preexisting TP53 mutation in therapy-related acute myeloid leukemia.
Ann Hematol. 2015; 94(3):527-529 Doi: 10.1007/s00277-014-2191-0 (- Case Report) [OPEN ACCESS]
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Zuckermann, M; Hovestadt, V; Knobbe-Thomsen, CB; Zapatka, M; Northcott, PA; Schramm, K; Belic, J; Jones, DT; Tschida, B; Moriarity, B; Largaespada, D; Roussel, MF; Korshunov, A; Reifenberger, G; Pfister, SM; Lichter, P; Kawauchi, D; Gronych, J Somatic CRISPR/Cas9-mediated tumour suppressor disruption enables versatile brain tumour modelling.
Nat Commun. 2015; 6(3):7391-7391 Doi: 10.1038/ncomms8391 [OPEN ACCESS]
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2014

Herz, C; Hertrampf, A; Zimmermann, S; Stetter, N; Wagner, M; Kleinhans, C; Erlacher, M; Schüler, J; Platz, S; Rohn, S; Mersch-Sundermann, V; Lamy, E The isothiocyanate erucin abrogates telomerase in hepatocellular carcinoma cells in vitro and in an orthotopic xenograft tumour model of HCC.
J Cell Mol Med. 2014; 18(12): 2393-2403. Doi: 10.1111/jcmm.12412 [OPEN ACCESS]
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Ma, X; Rousseau, V; Sun, H; Lantuejoul, S; Filipits, M; Pirker, R; Popper, H; Mendiboure, J; Vataire, AL; Le Chevalier, T; Soria, JC; Brambilla, E; Dunant, A; Hainaut, P; IALT-Bio working group Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.
Mol Oncol. 2014; 8(3):555-564 Doi: 10.1016/j.molonc.2013.12.015 [OPEN ACCESS]
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Morisaki, T; Müller, WG; Golob, N; Mazza, D; McNally, JG Single-molecule analysis of transcription factor binding at transcription sites in live cells.
NAT COMMUN. 2014; 5: 4456-4456. Doi: 10.1038/ncomms5456 [OPEN ACCESS]
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Rao, S; Tortola, L; Perlot, T; Wirnsberger, G; Novatchkova, M; Nitsch, R; Sykacek, P; Frank, L; Schramek, D; Komnenovic, V; Sigl, V; Aumayr, K; Schmauss, G; Fellner, N; Handschuh, S; Glösmann, M; Pasierbek, P; Schlederer, M; Resch, GP; Ma, Y; Yang, H; Popper, H; Kenner, L; Kroemer, G; Penninger, JM A dual role for autophagy in a murine model of lung cancer.
Nat Commun. 2014; 5(5):3056-3056 Doi: 10.1038/ncomms4056 [OPEN ACCESS]
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Ress, AL; Stiegelbauer, V; Schwarzenbacher, D; Deutsch, A; Perakis, S; Ling, H; Ivan, C; Calin, GA; Rinner, B; Gerger, A; Pichler, M Spinophilin expression determines cellular growth, cancer stemness and 5-flourouracil resistance in colorectal cancer.
Oncotarget. 2014; 5(18):8492-8502 Doi: 10.18632/oncotarget.2329 [OPEN ACCESS]
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2013

Gottschalk, B; Klein, A Restoration of wild-type p53 in drug-resistant mouse breast cancer cells leads to differential gene expression, but is not sufficient to overcome the malignant phenotype.
Mol Cell Biochem. 2013; 379(1-2): 213-227. Doi: 10.1007/s11010-013-1643-5
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Heitzer, E; Lax, S; Lafer, I; Müller, SM; Pristauz, G; Ulz, P; Jahn, S; Högenauer, C; Petru, E; Speicher, MR; Geigl, JB Multiplex genetic cancer testing identifies pathogenic mutations in TP53 and CDH1 in a patient with bilateral breast and endometrial adenocarcinoma.
BMC Med Genet. 2013; 14(1):129-129 Doi: 10.1186/1471-2350-14-129 (- Case Report) [OPEN ACCESS]
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Houben, R; Dreher, C; Angermeyer, S; Borst, A; Utikal, J; Haferkamp, S; Peitsch, WK; Schrama, D; Hesbacher, S Mechanisms of p53 restriction in Merkel cell carcinoma cells are independent of the Merkel cell polyoma virus T antigens.
J Invest Dermatol. 2013; 133(10):2453-2460 Doi: 10.1038/jid.2013.169 [OPEN ACCESS]
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Lajin, B; Alachkar, A; Michati, R; Alhaj Sakur, A Association between polymorphisms in the genes for tumor suppressor protein p53 and its regulator NAD(P)H: quinone oxidoreductase 1 (NQO1) and schizophrenia in a Syrian study cohort.
Arch Med Res. 2013; 44(2):121-126 Doi: 10.1016/j.arcmed.2012.12.009
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Lajin, B; Alhaj Sakur, A; Alachkar, A Association between polymorphisms in apoptotic genes and susceptibility for developing breast cancer in Syrian women.
Breast Cancer Res Treat. 2013; 138(2):611-619 Doi: 10.1007/s10549-013-2467-4
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Lohberger, B; Rinner, B; Stuendl, N; Kaltenegger, H; Steinecker-Frohnwieser, B; Bernhart, E; Bonyadi Rad, E; Weinberg, AM; Leithner, A; Bauer, R; Kretschmer, N Sesquiterpene lactones downregulate G2/M cell cycle regulator proteins and affect the invasive potential of human soft tissue sarcoma cells.
PLoS One. 2013; 8(6):e66300-e66300 Doi: 10.1371/journal.pone.0066300 [OPEN ACCESS]
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Schupp, M; Chen, F; Briggs, ER; Rao, S; Pelzmann, HJ; Pessentheiner, AR; Bogner-Strauss, JG; Lazar, MA; Baldwin, D; Prokesch, A Metabolite and transcriptome analysis during fasting suggest a role for the p53-Ddit4 axis in major metabolic tissues.
BMC Genomics. 2013; 14(11):758-758 Doi: 10.1186/1471-2164-14-758 [OPEN ACCESS]
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2012

Rinner, B; Gallè, B; Trajanoski, S; Fischer, C; Hatz, M; Maierhofer, T; Michelitsch, G; Moinfar, F; Stelzer, I; Pfragner, R; Guelly, C Molecular evidence for the bi-clonal origin of neuroendocrine tumor derived metastases.
BMC Genomics. 2012; 13(6):594-594 Doi: 10.1186/1471-2164-13-594 [OPEN ACCESS]
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Schulz, E; Valentin, A; Ulz, P; Beham-Schmid, C; Lind, K; Rupp, V; Lackner, H; Wölfler, A; Zebisch, A; Olipitz, W; Geigl, J; Berghold, A; Speicher, MR; Sill, H Germline mutations in the DNA damage response genes BRCA1, BRCA2, BARD1 and TP53 in patients with therapy related myeloid neoplasms.
J Med Genet. 2012; 49(7):422-428 Doi: 10.1136/jmedgenet-2011-100674
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Szkandera, J; Absenger, G; Dandachi, N; Regitnig, P; Lax, S; Stotz, M; Samonigg, H; Renner, W; Gerger, A Analysis of functional germline polymorphisms for prediction of response to anthracycline-based neoadjuvant chemotherapy in breast cancer.
Mol Genet Genomics. 2012; 287(9):755-764 Doi: 10.1007/s00438-012-0715-7
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2011

Gutekunst, M; Oren, M; Weilbacher, A; Dengler, MA; Markwardt, C; Thomale, J; Aulitzky, WE; van der Kuip, H p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.
PLoS One. 2011; 6(4):e19198-e19198 Doi: 10.1371/journal.pone.0019198 [OPEN ACCESS]
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Houben, R; Hesbacher, S; Schmid, CP; Kauczok, CS; Flohr, U; Haferkamp, S; Müller, CS; Schrama, D; Wischhusen, J; Becker, JC High-level expression of wild-type p53 in melanoma cells is frequently associated with inactivity in p53 reporter gene assays.
PLoS One. 2011; 6(7):e22096-e22096 Doi: 10.1371/journal.pone.0022096 [OPEN ACCESS]
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Langner, C Non-serrated precursor lesions of colorectal tumours.
Pathologe. 2011; 32 Suppl 2(1):206-210 Doi: 10.1007/s00292-011-1495-2
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Morselli, E; Shen, S; Ruckenstuhl, C; Bauer, MA; Mariño, G; Galluzzi, L; Criollo, A; Michaud, M; Maiuri, MC; Chano, T; Madeo, F; Kroemer, G p53 inhibits autophagy by interacting with the human ortholog of yeast Atg17, RB1CC1/FIP200.
Cell Cycle. 2011; 10(16):2763-2769 Doi: 10.4161/cc.10.16.16868 [OPEN ACCESS]
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Sperka, T; Song, Z; Morita, Y; Nalapareddy, K; Guachalla, LM; Lechel, A; Begus-Nahrmann, Y; Burkhalter, MD; Mach, M; Schlaudraff, F; Liss, B; Ju, Z; Speicher, MR; Rudolph, KL Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction.
Nat Cell Biol. 2011; 14(1):73-79 Doi: 10.1038/ncb2388
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2010

Voortman, J; Goto, A; Mendiboure, J; Sohn, JJ; Schetter, AJ; Saito, M; Dunant, A; Pham, TC; Petrini, I; Lee, A; Khan, MA; Hainaut, P; Pignon, JP; Brambilla, E; Popper, HH; Filipits, M; Harris, CC; Giaccone, G MicroRNA Expression and Clinical Outcomes in Patients Treated with Adjuvant Chemotherapy after Complete Resection of Non-Small Cell Lung Carcinoma.
Cancer Res. 2010; 70(21): 8288-8298. Doi: 10.1158/0008-5472.CAN-10-1348 [OPEN ACCESS]
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2009

Schwarzbraun, T; Obenauf, A; Langmann, A; Gruber-Sedlmayr, U; Wagner, K; Speicher, M; Kroisel, P Predictive diagnosis of the cancer prone Li-Fraumeni syndrome by accident: new challenges through whole genome array testing.
J Med Genet. 2009; 46(5): 341-344. Doi: 10.1136/jmg.2008.064972 (- Case Report) [OPEN ACCESS]
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2008

Bohlig, L; Metzger, R; Rother, K; Till, H; Engeland, K The CCN3 gene coding for an extracellular adhesion-related protein is transcriptionally activated by the p53 tumor suppressor
Cell Cycle. 2008; 7(9):1254-1261 Doi: 10.4161/cc.7.9.5812 [OPEN ACCESS]
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2006

Goel, A; Fuerst, F; Hotchkiss, E; Boland, CR Selenomethionine induces p53 mediated cell cycle arrest and apoptosis in human colon cancer cells.
Cancer Biol Ther. 2006; 5(5):529-535 Doi: 10.4161/cbt.5.5.2654 [OPEN ACCESS]
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